Adenosine triphosphate (PAMDB000148)

General function:

Involved in ATP binding

Specific function:

Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L- threonine nor L-serine are substrates of the enzyme

Gene Name:

thrB

Locus Tag:

PA5495

Molecular weight:

35.4 kDa

Reactions

General function:

Involved in adenylate cyclase activity

Specific function:

ATP = 3',5'-cyclic AMP + diphosphate

Gene Name:

cyaA

Locus Tag:

PA5272

Molecular weight:

108.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)

Gene Name:

trpS

Locus Tag:

PA4439

Molecular weight:

49 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)

Gene Name:

ileS

Locus Tag:

PA4560

Molecular weight:

105.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr)

Gene Name:

alaS

Locus Tag:

PA0903

Molecular weight:

94.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation

Gene Name:

metG

Locus Tag:

PA3482

Molecular weight:

74.9 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyQ

Locus Tag:

PA0009

Molecular weight:

36.1 kDa

Reactions

General function:

Involved in arginine-tRNA ligase activity

Specific function:

ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)

Gene Name:

glyS

Locus Tag:

PA0008

Molecular weight:

74 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

Gene Name:

glnS

Locus Tag:

PA1794

Molecular weight:

62.9 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Locus Tag:

PA4756

Molecular weight:

117.3 kDa

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpA

Locus Tag:

PA1633

Molecular weight:

59.9 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpB

Locus Tag:

PA1634

Molecular weight:

73 kDa

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex

Gene Name:

kdpC

Locus Tag:

PA1635

Molecular weight:

19.3 kDa

Reactions

General function:

Involved in GMP synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes the synthesis of GMP from XMP

Gene Name:

guaA

Locus Tag:

PA3769

Molecular weight:

58 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Locus Tag:

PA0407

Molecular weight:

35.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

Gene Name:

gltX

Locus Tag:

PA3134

Molecular weight:

56.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system

Gene Name:

rbsA

Locus Tag:

PA1947

Molecular weight:

55.8 kDa

Reactions

General function:

Involved in bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Specific function:

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

Gene Name:

apaH

Locus Tag:

PA0590

Molecular weight:

32 kDa

Reactions

General function:

Involved in biotin-[acetyl-CoA-carboxylase] ligase activity

Specific function:

BirA acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5'- adenylate and transfers the biotin moiety to biotin-accepting proteins

Gene Name:

birA

Locus Tag:

PA4280

Molecular weight:

34 kDa

Reactions

General function:

Involved in RNA binding

Specific function:

Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows highest phosphatase activity in the presence of Ni(2+) and hydrolyzes pyrophosphate, canonical 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi. Displays a metal-independent phosphodiesterase activity toward 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP. Without metal or in the presence of Mg(2+), this protein hydrolyzes 2',3'-cyclic substrates with the formation of 2'-nucleotides, whereas in the presence of Ni(2+), it also produces some 3'-nucleotides. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases

Gene Name:

cca

Locus Tag:

PA0584

Molecular weight:

45.6 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system

Gene Name:

hisP

Locus Tag:

PA2926

Molecular weight:

28.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a "posttransfer" editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner

Gene Name:

valS

Locus Tag:

PA3834

Molecular weight:

107.7 kDa

Reactions

General function:

Involved in RNA binding

Specific function:

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Gene Name:

pheT

Locus Tag:

PA2739

Molecular weight:

86.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)

Gene Name:

leuS

Locus Tag:

PA3987

Molecular weight:

97.6 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlB

Locus Tag:

PA4410

Molecular weight:

34.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole

Gene Name:

purM

Locus Tag:

PA0945

Molecular weight:

37.1 kDa

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Locus Tag:

PA3111

Molecular weight:

46.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)

Gene Name:

pheS

Locus Tag:

PA2740

Molecular weight:

38.1 kDa

Reactions

General function:

Involved in amino acid binding

Specific function:

ATP + L-aspartate = ADP + 4-phospho-L- aspartate

Gene Name:

lysC

Locus Tag:

PA0904

Molecular weight:

44.4 kDa

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Gene Name:

purK

Locus Tag:

PA5425

Molecular weight:

38.5 kDa

Reactions

General function:

Involved in kinase activity

Specific function:

Involved in the activation of acetate to acetyl CoA and the secretion of acetate. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically

Gene Name:

ackA

Locus Tag:

PA0836

Molecular weight:

42.4 kDa

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Locus Tag:

PA3814

Molecular weight:

44.7 kDa

Reactions

General function:

Involved in acetylglutamate kinase activity

Specific function:

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L- glutamate 5-phosphate

Gene Name:

argB

Locus Tag:

PA5323

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in shikimate kinase activity

Specific function:

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

Gene Name:

aroK

Locus Tag:

PA5039

Molecular weight:

19.2 kDa

Reactions

General function:

Involved in argininosuccinate synthase activity

Specific function:

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate

Gene Name:

argG

Locus Tag:

PA3525

Molecular weight:

45.3 kDa

Reactions

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane

Gene Name:

atpC

Locus Tag:

PA5553

Molecular weight:

14.7 kDa

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Locus Tag:

PA4758

Molecular weight:

40.8 kDa

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Key enzyme in the regulation of glycerol uptake and metabolism

Gene Name:

glpK

Locus Tag:

PA3582

Molecular weight:

56 kDa

Reactions

General function:

Involved in cytidylate kinase activity

Specific function:

ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors

Gene Name:

cmk

Locus Tag:

PA3163

Molecular weight:

24.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate

Gene Name:

coaD

Locus Tag:

PA0363

Molecular weight:

17.8 kDa

Reactions

General function:

Involved in dephospho-CoA kinase activity

Specific function:

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

Gene Name:

coaE

Locus Tag:

PA4529

Molecular weight:

22.8 kDa

Reactions

General function:

Involved in adenylylsulfate kinase activity

Specific function:

Catalyzes the synthesis of activated sulfate

Gene Name:

cysC

Locus Tag:

PA1393

Molecular weight:

22.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlA

Locus Tag:

PA4201

Molecular weight:

36.5 kDa

Reactions

General function:

Involved in glucokinase activity

Specific function:

Not highly important in Pseudomonas aeruginosa as glucose is transported into the cell by the PTS system already as glucose 6-phosphate

Gene Name:

glk

Locus Tag:

PA3193

Molecular weight:

34.6 kDa

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Locus Tag:

PA5203

Molecular weight:

59.2 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + D-ribose 5-phosphate = AMP + 5-phospho- alpha-D-ribose 1-diphosphate

Gene Name:

prs

Locus Tag:

PA4670

Molecular weight:

34 kDa

Reactions

General function:

Involved in thymidylate kinase activity

Specific function:

Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth

Gene Name:

tmk

Locus Tag:

PA2962

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)

Gene Name:

nadD

Locus Tag:

PA4006

Molecular weight:

23.8 kDa

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Locus Tag:

PA3807

Molecular weight:

15.6 kDa

Reactions

General function:

Involved in phosphoglycerate kinase activity

Specific function:

ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate

Gene Name:

pgk

Locus Tag:

PA0552

Molecular weight:

40.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can also act in the reverse direction to form ATP in the presence of excess ADP. Can also use GTP instead of ATP; but the efficiency of GTP is 5% that of ATP

Gene Name:

ppk

Locus Tag:

PA5242

Molecular weight:

83.2 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline

Gene Name:

proB

Locus Tag:

PA4565

Molecular weight:

39.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

Gene Name:

purC

Locus Tag:

PA1013

Molecular weight:

26.8 kDa

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Locus Tag:

PA3637

Molecular weight:

59.6 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor

Gene Name:

pyrH

Locus Tag:

PA3654

Molecular weight:

26.3 kDa

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme

Gene Name:

rpoA

Locus Tag:

PA4238

Molecular weight:

36.6 kDa

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits

Gene Name:

rpoZ

Locus Tag:

PA5337

Molecular weight:

9.8 kDa

Reactions

General function:

Involved in methionine adenosyltransferase activity

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth

Gene Name:

metK

Locus Tag:

PA0546

Molecular weight:

42.7 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Locus Tag:

PA1588

Molecular weight:

41.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

Gene Name:

serS

Locus Tag:

PA2612

Molecular weight:

47.2 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA

Gene Name:

thrS

Locus Tag:

PA2744

Molecular weight:

73.1 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)

Gene Name:

lysS

Locus Tag:

PA3700

Molecular weight:

57.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

With YjeK might be involved in the post-translational modification of elongation factor P (EF-P)

Gene Name:

poxA

Locus Tag:

PA5513

Molecular weight:

32.4 kDa

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoC

Locus Tag:

PA4269

Molecular weight:

154.4 kDa

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoB

Locus Tag:

PA4270

Molecular weight:

150.8 kDa

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Locus Tag:

PA5119

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-ribose = ADP + D-ribose 5-phosphate

Gene Name:

rbsK

Locus Tag:

PA1950

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Locus Tag:

PA1919

Molecular weight:

25.7 kDa

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity

Gene Name:

accD

Locus Tag:

PA3112

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system

Gene Name:

pstB

Locus Tag:

PA5366

Molecular weight:

31 kDa

Reactions

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

Gene Name:

atpB

Locus Tag:

PA5560

Molecular weight:

31.9 kDa

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)

Gene Name:

atpF

Locus Tag:

PA5558

Molecular weight:

16.9 kDa

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction

Gene Name:

atpH

Locus Tag:

PA5557

Molecular weight:

19.3 kDa

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex

Gene Name:

atpG

Locus Tag:

PA5555

Molecular weight:

31.6 kDa

General function:

Involved in ATP binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

Gene Name:

atpA

Locus Tag:

PA5556

Molecular weight:

55.4 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits

Gene Name:

atpD

Locus Tag:

PA5554

Molecular weight:

49.5 kDa

Reactions

General function:

Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Specific function:

Mediates magnesium influx to the cytosol

Gene Name:

mgtA

Locus Tag:

PA4825

Molecular weight:

100.1 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

Gene Name:

accA

Locus Tag:

PA3639

Molecular weight:

34.9 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accB

Locus Tag:

PA4847

Molecular weight:

16.5 kDa

General function:

Involved in RNA binding

Specific function:

Polymerase that creates the 3' poly(A) tail found in some mRNA's. Seems to be involved in plasmid copy number control

Gene Name:

pcnB

Locus Tag:

PA4727

Molecular weight:

53.3 kDa

Reactions

General function:

Involved in diacylglycerol kinase activity

Specific function:

Recycling of diacylglycerol produced during the turnover of membrane phospholipid

Gene Name:

dgkA

Locus Tag:

PA3603

Molecular weight:

13.1 kDa

Reactions

General function:

Involved in phosphopantothenate--cysteine ligase activity

Specific function:

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

Gene Name:

coaBC

Locus Tag:

PA5320

Molecular weight:

43.1 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Locus Tag:

PA1498

Molecular weight:

51.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate

Gene Name:

cobU

Locus Tag:

PA1279

Molecular weight:

36.5 kDa

Reactions

General function:

Involved in 1-phosphofructokinase activity

Specific function:

ATP + D-fructose 1-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

fruK

Locus Tag:

PA3561

Molecular weight:

33.4 kDa

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Locus Tag:

PA0935

Molecular weight:

31.2 kDa

Reactions

General function:

Involved in amino acid binding

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp

Gene Name:

relA

Locus Tag:

PA0934

Molecular weight:

83.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it

Gene Name:

spoT

Locus Tag:

PA5338

Molecular weight:

78.9 kDa

Reactions

General function:

Involved in FMN adenylyltransferase activity

Specific function:

ATP + riboflavin = ADP + FMN

Gene Name:

ribF

Locus Tag:

PA4561

Molecular weight:

34.3 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Locus Tag:

PA1589

Molecular weight:

30.3 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + thiamine phosphate = ADP + thiamine diphosphate

Gene Name:

thiL

Locus Tag:

PA4051

Molecular weight:

32.9 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)

Gene Name:

tyrS

Locus Tag:

PA4138

Molecular weight:

45.1 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters

Gene Name:

ugpC

Locus Tag:

PA3187

Molecular weight:

42.2 kDa

Reactions

General function:

Involved in [isocitrate dehydrogenase (NADP+)] kinase activity

Specific function:

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation

Gene Name:

aceK

Locus Tag:

PA1376

Molecular weight:

66.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)

Gene Name:

argS

Locus Tag:

PA5051

Molecular weight:

65.2 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

Gene Name:

murF

Locus Tag:

PA4416

Molecular weight:

47.4 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

bioD

Locus Tag:

PA0504

Molecular weight:

23.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline

Gene Name:

proV

Locus Tag:

PA5094

Molecular weight:

30.7 kDa

General function:

Involved in ATP binding

Specific function:

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

Gene Name:

murD

Locus Tag:

PA4414

Molecular weight:

48.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

purL

Locus Tag:

PA3763

Molecular weight:

140.6 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide

Gene Name:

purD

Locus Tag:

PA4855

Molecular weight:

45.2 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesizes selenophosphate from selenide and ATP

Gene Name:

selD

Locus Tag:

PA1642

Molecular weight:

36.4 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction:proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). Misacylated Cys-tRNA(Pro) is not edited by ProRS, but instead may be edited in trans by ybaK

Gene Name:

proS

Locus Tag:

PA0956

Molecular weight:

63.1 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system

Gene Name:

cysA

Locus Tag:

PA0280

Molecular weight:

36.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

murC

Locus Tag:

PA4411

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in nicotinate phosphoribosyltransferase activity

Specific function:

Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate

Gene Name:

pncB

Locus Tag:

PA4919

Molecular weight:

46.1 kDa

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Gene Name:

nadE

Locus Tag:

PA4920

Molecular weight:

29.7 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + sulfate = diphosphate + adenylyl sulfate

Gene Name:

cysD

Locus Tag:

PA4443

Molecular weight:

35.5 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Locus Tag:

PA4329

Molecular weight:

52.3 kDa

Reactions

General function:

Involved in cysteine-tRNA ligase activity

Specific function:

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)

Gene Name:

cysS

Locus Tag:

PA1795

Molecular weight:

51.2 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

Gene Name:

aspS

Locus Tag:

PA0963

Molecular weight:

66.2 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine

Gene Name:

murE

Locus Tag:

PA4417

Molecular weight:

51.3 kDa

Reactions

General function:

Involved in phosphoenolpyruvate carboxykinase (ATP) activity

Specific function:

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)

Gene Name:

pckA

Locus Tag:

PA5192

Molecular weight:

55.7 kDa

Reactions

General function:

Involved in glycerate kinase activity

Specific function:

ATP + (R)-glycerate = ADP + 3-phospho-(R)- glycerate

Gene Name:

garK

Locus Tag:

PA1052

Molecular weight:

38.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate

Gene Name:

ppsA

Locus Tag:

PA1770

Molecular weight:

85.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Member of the two-component regulatory system phoQ/phoP involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to phoP, which results in the expression of phoP-activated genes (PAG) and repression of phoP-repressed genes (PRG). In presence of high periplasmic Mg(2+) concentrations, acts as a protein phosphatase that dephosphorylates phospho-phoP, which results in the repression of phoP-activated genes and may lead to expression of some phoP- repressed genes. Mediates magnesium influx to the cytosol by activation of mgtA. Promotes expression of the two- component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes

Gene Name:

phoQ

Locus Tag:

PA1180

Molecular weight:

50.2 kDa

Reactions

General function:

Involved in GTPase activity

Specific function:

May be the GTPase, regulating ATP sulfurylase activity

Gene Name:

cysN

Locus Tag:

PA4442

Molecular weight:

69.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system

Gene Name:

fepC

Locus Tag:

PA4158

Molecular weight:

28.6 kDa

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Locus Tag:

PA4848

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in sulfurtransferase activity

Specific function:

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by iscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs

Gene Name:

mnmA

Locus Tag:

PA2626

Molecular weight:

41.9 kDa

General function:

Involved in 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity

Specific function:

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8- dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6- yl)methyl diphosphate

Gene Name:

folK

Locus Tag:

PA4728

Molecular weight:

18 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

Gene Name:

lpxK

Locus Tag:

PA2981

Molecular weight:

36.7 kDa

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

Gene Name:

acs

Locus Tag:

PA0887

Molecular weight:

71.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Locus Tag:

PA1920

Molecular weight:

76.1 kDa

Reactions

General function:

Involved in [glutamate-ammonia-ligase] adenylyltransferase activity

Specific function:

Adenylation and deadenylation of glutamate--ammonia ligase

Gene Name:

glnE

Locus Tag:

PA5014

Molecular weight:

110.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

Gene Name:

panC

Locus Tag:

PA4730

Molecular weight:

30.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP

Gene Name:

purT

Locus Tag:

PA3751

Molecular weight:

42.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

Gene Name:

ccmA

Locus Tag:

PA1475

Molecular weight:

25 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate

Gene Name:

arcC

Locus Tag:

PA5173

Molecular weight:

33.1 kDa

Reactions

General function:

Involved in RNA processing

Specific function:

Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing

Gene Name:

rtcA

Locus Tag:

PA4585

Molecular weight:

36.6 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage

Gene Name:

fliI

Locus Tag:

PA1104

Molecular weight:

48.6 kDa

Reactions

General function:

Involved in protein binding

Specific function:

Essential for recycling GMP and indirectly, cGMP

Gene Name:

gmk

Locus Tag:

PA5336

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in ATP phosphoribosyltransferase activity

Specific function:

Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity

Gene Name:

hisG

Locus Tag:

PA4449

Molecular weight:

22.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)

Gene Name:

hisS

Locus Tag:

PA3802

Molecular weight:

47.5 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Phosphorylates isopentenyl phosphate at low rates. Also acts on isopentenol, and, much less efficiently, dimethylallyl alcohol. Dimethylallyl monophosphate does not serve as a substrate

Gene Name:

ispE

Locus Tag:

PA4669

Molecular weight:

30.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system

Gene Name:

malK

Locus Tag:

PA2341

Molecular weight:

40.2 kDa

Reactions

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 10 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits

Gene Name:

atpE

Locus Tag:

PA5559

Molecular weight:

8.6 kDa

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Locus Tag:

PA3686

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids

Gene Name:

fadD

Locus Tag:

PA3299

Molecular weight:

61.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system

Gene Name:

potA

Locus Tag:

PA3607

Molecular weight:

40 kDa

Reactions

General function:

Involved in phosphomethylpyrimidine kinase activity

Specific function:

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine

Gene Name:

thiD

Locus Tag:

PA3975

Molecular weight:

28 kDa

Reactions

General function:

Involved in pyridoxal kinase activity

Specific function:

Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine, but has negligible activity toward pyridoxal and pyridoxine as substrates

Gene Name:

pdxY

Locus Tag:

PA5516

Molecular weight:

31.3 kDa

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core

Gene Name:

rfaP

Locus Tag:

PA5009

Molecular weight:

31.3 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

pstA

Locus Tag:

PA5367

Molecular weight:

61.2 kDa

General function:

Involved in lipopolysaccharide transport

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptG

Locus Tag:

PA3827

Molecular weight:

39.2 kDa

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

cysW

Locus Tag:

PA0281

Molecular weight:

31.3 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

dppB

Locus Tag:

PA4503

Molecular weight:

37 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

dppC

Locus Tag:

PA4504

Molecular weight:

32.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltJ

Locus Tag:

PA1341

Molecular weight:

27.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltK

Locus Tag:

PA1340

Molecular weight:

24.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane

Gene Name:

hisM

Locus Tag:

PA2925

Molecular weight:

26.7 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livH

Locus Tag:

PA1073

Molecular weight:

32.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane

Gene Name:

modB

Locus Tag:

PA1862

Molecular weight:

24.4 kDa

General function:

Involved in lipopolysaccharide-transporting ATPase acti

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptF

Locus Tag:

PA3828

Molecular weight:

41.3 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine

Gene Name:

potB

Locus Tag:

PA3608

Molecular weight:

32.7 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine

Gene Name:

potC

Locus Tag:

PA3609

Molecular weight:

27.7 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine

Gene Name:

potI

Locus Tag:

PA0304

Molecular weight:

31.9 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

pstC

Locus Tag:

PA5368

Molecular weight:

73.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

rbsC

Locus Tag:

PA1948

Molecular weight:

34 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livM

Locus Tag:

PA1072

Molecular weight:

45.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

fepD

Locus Tag:

PA4160

Molecular weight:

34.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

fepG

Locus Tag:

PA4161

Molecular weight:

34.8 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine

Gene Name:

potH

Locus Tag:

PA0303

Molecular weight:

32.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane

Gene Name:

hisQ

Locus Tag:

PA2924

Molecular weight:

24.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Gene Name:

msbA

Locus Tag:

PA4997

Molecular weight:

66.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

ssuC

Locus Tag:

PA3443

Molecular weight:

28.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for taurine. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

tauC

Locus Tag:

PA3936

Molecular weight:

29.4 kDa

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

Gene Name:

hldE

Locus Tag:

PA4996

Molecular weight:

50.3 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

This protein specifically binds sulfate and is involved in its transmembrane transport

Gene Name:

sbp

Locus Tag:

PA0283

Molecular weight:

36.4 kDa

General function:

Involved in GTP binding

Specific function:

GTP-driven Fe(2+) uptake system

Gene Name:

feoB

Locus Tag:

PA4358

Molecular weight:

82.5 kDa

General function:

Involved in binding

Specific function:

Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin

Gene Name:

fepB

Locus Tag:

PA4159

Molecular weight:

32.1 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system

Gene Name:

znuC

Locus Tag:

PA5500

Molecular weight:

29.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system

Gene Name:

dppD

Locus Tag:

PA4505

Molecular weight:

35.4 kDa

General function:

Involved in RNA binding

Specific function:

Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by iscS

Gene Name:

thiI

Locus Tag:

PA5118

Molecular weight:

54.8 kDa

Reactions

General function:

Involved in protein complex assembly

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmC

Locus Tag:

PA1477

Molecular weight:

28.3 kDa

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport

Gene Name:

cysP

Locus Tag:

PA1493

Molecular weight:

36.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system

Gene Name:

lptB

Locus Tag:

PA4461

Molecular weight:

26.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system

Gene Name:

dppF

Locus Tag:

PA4506

Molecular weight:

36.3 kDa

General function:

Involved in phosphate ion binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import

Gene Name:

pstS

Locus Tag:

PA5369

Molecular weight:

34.5 kDa

General function:

Involved in heme transporter activity

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmB

Locus Tag:

PA1476

Molecular weight:

23.4 kDa

General function:

Involved in lipopolysaccharide transmembrane transporter activity

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptC

Locus Tag:

PA4459

Molecular weight:

21.4 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system

Gene Name:

gltL

Locus Tag:

PA1339

Molecular weight:

26.9 kDa

General function:

Involved in lipopolysaccharide binding

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain of LPS

Gene Name:

lptA

Locus Tag:

PA0005

Molecular weight:

28.7 kDa

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the high-affinity D-ribose membrane transport system and also serves as the primary chemoreceptor for chemotaxis

Gene Name:

rbsB

Locus Tag:

PA1946

Molecular weight:

33.9 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livG

Locus Tag:

PA1071

Molecular weight:

28.3 kDa

General function:

Involved in transporter activity

Specific function:

Component of the high-affinity histidine permease, a binding-protein-dependent transport system. The other components are proteins hisQ, hisM, and hisP

Gene Name:

hisJ

Locus Tag:

PA2923

Molecular weight:

28.2 kDa

General function:

Energy production and conversion

Specific function:

A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex

Gene Name:

atpI

Locus Tag:

PA5561

Molecular weight:

13.7 kDa

General function:

Involved in arsenite transmembrane transporter activity

Specific function:

Involved in arsenical resistance. Thought to form the channel of an arsenite pump

Gene Name:

arsB

Locus Tag:

PA2278

Molecular weight:

45.1 kDa

General function:

Involved in ATP binding

Specific function:

Involved in the high-affinity zinc uptake transport system

Gene Name:

znuB

Locus Tag:

PA5501

Molecular weight:

27.3 kDa

General function:

Involved in protein-heme linkage

Specific function:

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

Gene Name:

ccmE

Locus Tag:

PA1479

Molecular weight:

17.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livF

Locus Tag:

PA1070

Molecular weight:

25.6 kDa

General function:

Involved in Mo-molybdopterin cofactor biosynthetic process

Specific function:

Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD

Gene Name:

moeB

Locus Tag:

PA4663

Molecular weight:

26.7 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis

Gene Name:

dppA

Locus Tag:

PA4496

Molecular weight:

60.1 kDa

General function:

Not Available

Specific function:

Specific function unknown

Gene Name:

kdpF

Locus Tag:

PA1632

Molecular weight:

3.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system

Gene Name:

tauB

Locus Tag:

PA3937

Molecular weight:

28.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system

Gene Name:

modC

Locus Tag:

PA1861

Molecular weight:

39.8 kDa

Reactions

General function:

Involved in metal ion binding

Specific function:

Involved in the high-affinity zinc uptake transport system

Gene Name:

znuA

Locus Tag:

PA5498

Molecular weight:

33.6 kDa

General function:

Amino acid transport and metabolism

Specific function:

Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system

Gene Name:

potG

Locus Tag:

PA0302

Molecular weight:

42.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for taurine

Gene Name:

tauA

Locus Tag:

PA3938

Molecular weight:

35.9 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable)

Gene Name:

ssuB

Locus Tag:

PA3442

Molecular weight:

29.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate

Gene Name:

gltI

Locus Tag:

PA1342

Molecular weight:

33.1 kDa

General function:

Involved in amino acid transport

Specific function:

This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in Pseudomonas aeruginosa

Gene Name:

livK

Locus Tag:

PA1074

Molecular weight:

39.8 kDa

General function:

Involved in fatty acid biosynthetic process

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Name:

acpP

Locus Tag:

PA2966

Molecular weight:

8.7 kDa

General function:

Involved in ATP binding

Specific function:

Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid

Gene Name:

mpl

Locus Tag:

PA4020

Molecular weight:

48.5 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein

Gene Name:

potF

Locus Tag:

PA1410

Molecular weight:

40.5 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein

Gene Name:

potD

Locus Tag:

PA3610

Molecular weight:

39.3 kDa

General function:

Involved in molybdate transmembrane-transporting ATPase activity

Specific function:

Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity

Gene Name:

modA

Locus Tag:

PA1863

Molecular weight:

26.4 kDa

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576

Gene Name:

arcB

Locus Tag:

PA5172

Molecular weight:

38.1 kDa

Reactions

General function:

Cell motility

Specific function:

Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY

Gene Name:

cheA

Locus Tag:

PA0178

Molecular weight:

68.9 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system creC/creB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates creB in response to environmental signals. CreC can also phosphorylate phoB

Gene Name:

creC

Locus Tag:

PA0464

Molecular weight:

52.3 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Has a helix-destabilizing activity, which is not coupled to the ATPase activity. Can unwind the 23S rRNA as well as 16S rRNA. Exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA. Could play a major role in ribosome assembly, specifically in the assembly process of the active center of 50S ribosomal subunits

Gene Name:

dbpA

Locus Tag:

PA0455

Molecular weight:

49.8 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with dnaC protein, primase, and other prepriming proteins

Gene Name:

dnaB

Locus Tag:

PA4931

Molecular weight:

51.6 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals

Gene Name:

kdpD

Locus Tag:

PA1636

Molecular weight:

97 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the narL protein and of both nitrate/nitrite to the narP protein. NarX probably activates narL and narP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling narL activity, probably through dephosphorylation in the absence of nitrate

Gene Name:

narX

Locus Tag:

PA3878

Molecular weight:

69.3 kDa

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system

Gene Name:

phnC

Locus Tag:

PA3384

Molecular weight:

30.3 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals

Gene Name:

phoR

Locus Tag:

PA5361

Molecular weight:

50.1 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Critical role in recombination and DNA repair. Help process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3' to 5' polarity. recG unwind branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (csdR) and R-loop formation

Gene Name:

recG

Locus Tag:

PA5345

Molecular weight:

76.2 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase

Gene Name:

recQ

Locus Tag:

PA3344

Molecular weight:

79.4 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction

Gene Name:

rep

Locus Tag:

PA5296

Molecular weight:

77 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Can carry out ATP-dependent unwinding of double stranded RNA. Has a role in RNA decay. Involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation

Gene Name:

rhlB

Locus Tag:

PA3478

Molecular weight:

47.1 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Acts as an ATP-dependent RNA helicase, able to unwind ds-RNA

Gene Name:

rhlE

Locus Tag:

PA0428

Molecular weight:

70.1 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of ruvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA

Gene Name:

ruvA

Locus Tag:

PA0966

Molecular weight:

21.9 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing

Gene Name:

ruvB

Locus Tag:

PA0967

Molecular weight:

38.9 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair

Gene Name:

uvrD

Locus Tag:

PA5443

Molecular weight:

81.5 kDa

Reactions

General function:

threonylcarbamoyladenosine biosynthetic process

Specific function:

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.

Gene Name:

tsaC

Locus Tag:

PA0022

Molecular weight:

20.4 kDa

Reactions

General function:

organic phosphonate catabolic process

Specific function:

Together with PhnG, PhnH and PhnI is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate.

Gene Name:

phnL

Locus Tag:

PA3375

Molecular weight:

26.2 kDa

Reactions

General function:

organic phosphonate catabolic process

Specific function:

Together with PhnG, PhnH and PhnL is required for the transfer of the ribose triphosphate moiety from ATP to methyl phosphonate. PhnI alone has nucleosidase activity, catalyzing the hydrolysis of ATP or GTP forming alpha-D-ribose 5-triphosphate and adenine or guanine, respectively.

Gene Name:

phnI

Locus Tag:

PA3378

Molecular weight:

40.6 kDa

Reactions