Identification
Name: Lipid A export ATP-binding/permease protein msbA
Synonyms: Not Available
Gene Name: msbA
Enzyme Class: Not Available
Biological Properties
General Function: Involved in nucleotide binding
Specific Function: Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation
Cellular Location: Cell inner membrane; Multi-pass membrane protein
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+core oligosaccharide lipid A+ThumbThumb+Thumb+Thumb+core oligosaccharide lipid A
Adenosine triphosphate + core oligosaccharide lipid A + WaterADP + Hydrogen ion + Phosphate + core oligosaccharide lipid A
ReactionCard
Thumb+Thumb+cold adapted KDO(2)-lipid (A)Thumb+Thumb+Thumb+cold adapted KDO(2)-lipid (A)
Adenosine triphosphate + Water + cold adapted KDO(2)-lipid (A) → ADP + Hydrogen ion + Phosphate + cold adapted KDO(2)-lipid (A)
ReactionCard
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
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Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbAdenosine diphosphate+Thumb+Thumb+Thumb+Thumb
Complex Reactions: Not Available
Transports:
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001643KDO(2)-lipid IV(A)MetaboCard
PAMDB001447KDO2-Lipid AMetaboCard
PAMDB001507Lipid AMetaboCard
PAMDB001343Lipid A-coreMetaboCard
PAMDB000169PA(16:0/16:0)MetaboCard
PAMDB000751PE(14:0/14:0)MetaboCard
PAMDB004022PG(10:0(3-OH)/10:0(3-OH))MetaboCard
PAMDB004021PG(10:0(3-OH)/10:0)MetaboCard
PAMDB004024PG(10:0(3-OH)/12:0(3-OH))MetaboCard
PAMDB004023PG(10:0(3-OH)/12:0)MetaboCard
PAMDB004026PG(10:0(3-OH)/14:0(3-OH))MetaboCard
PAMDB004025PG(10:0(3-OH)/14:0)MetaboCard
PAMDB004027PG(10:0(3-OH)/15:0)MetaboCard
PAMDB004028PG(10:0(3-OH)/15:0cyclo)MetaboCard
PAMDB004029PG(10:0(3-OH)/16:0)MetaboCard
PAMDB004030PG(10:0(3-OH)/16:1(9Z))MetaboCard
PAMDB004031PG(10:0(3-OH)/17:0cycw7c)MetaboCard
PAMDB004032PG(10:0(3-OH)/18:1(9Z))MetaboCard
PAMDB004033PG(10:0(3-OH)/19:0cycv8c)MetaboCard
PAMDB004034PG(10:0(3-OH)/19:iso)MetaboCard
PAMDB004035PG(10:0/10:0(3-OH))MetaboCard
PAMDB004036PG(10:0/12:0(3-OH))MetaboCard
PAMDB004037PG(10:0/14:0(3-OH))MetaboCard
PAMDB004038PG(10:0/19:iso)MetaboCard
PAMDB004040PG(12:0(3-OH)/10:0(3-OH))MetaboCard
PAMDB004039PG(12:0(3-OH)/10:0)MetaboCard
PAMDB004042PG(12:0(3-OH)/12:0(3-OH))MetaboCard
PAMDB004041PG(12:0(3-OH)/12:0)MetaboCard
PAMDB004044PG(12:0(3-OH)/14:0(3-OH))MetaboCard
PAMDB004043PG(12:0(3-OH)/14:0)MetaboCard
PAMDB004045PG(12:0(3-OH)/15:0)MetaboCard
PAMDB004046PG(12:0(3-OH)/15:0cyclo)MetaboCard
PAMDB004047PG(12:0(3-OH)/16:0)MetaboCard
PAMDB004048PG(12:0(3-OH)/16:1(9Z))MetaboCard
PAMDB004049PG(12:0(3-OH)/17:0cycw7c)MetaboCard
PAMDB004050PG(12:0(3-OH)/18:1(9Z))MetaboCard
PAMDB004051PG(12:0(3-OH)/19:0cycv8c)MetaboCard
PAMDB004052PG(12:0(3-OH)/19:iso)MetaboCard
PAMDB004053PG(12:0/10:0(3-OH))MetaboCard
PAMDB004054PG(12:0/12:0(3-OH))MetaboCard
PAMDB001672PG(12:0/12:0)MetaboCard
PAMDB004055PG(12:0/14:0(3-OH))MetaboCard
PAMDB004056PG(12:0/19:iso)MetaboCard
PAMDB004058PG(14:0(3-OH)/10:0(3-OH))MetaboCard
PAMDB004057PG(14:0(3-OH)/10:0)MetaboCard
PAMDB004060PG(14:0(3-OH)/12:0(3-OH))MetaboCard
PAMDB004059PG(14:0(3-OH)/12:0)MetaboCard
PAMDB004062PG(14:0(3-OH)/14:0(3-OH))MetaboCard
PAMDB004061PG(14:0(3-OH)/14:0)MetaboCard
PAMDB004063PG(14:0(3-OH)/15:0)MetaboCard
PAMDB004064PG(14:0(3-OH)/15:0cyclo)MetaboCard
PAMDB004065PG(14:0(3-OH)/16:0)MetaboCard
PAMDB004066PG(14:0(3-OH)/16:1(9Z))MetaboCard
PAMDB004067PG(14:0(3-OH)/17:0cycw7c)MetaboCard
PAMDB004068PG(14:0(3-OH)/18:1(9Z))MetaboCard
PAMDB004069PG(14:0(3-OH)/19:0cycv8c)MetaboCard
PAMDB004070PG(14:0(3-OH)/19:iso)MetaboCard
PAMDB004071PG(14:0/10:0(3-OH))MetaboCard
PAMDB004072PG(14:0/12:0(3-OH))MetaboCard
PAMDB004073PG(14:0/14:0(3-OH))MetaboCard
PAMDB001429PG(14:0/14:0)MetaboCard
PAMDB004074PG(14:0/19:iso)MetaboCard
PAMDB001673PG(14:1(7Z)/14:1(7Z))MetaboCard
PAMDB004075PG(15:0/10:0(3-OH))MetaboCard
PAMDB004076PG(15:0/12:0(3-OH))MetaboCard
PAMDB004077PG(15:0/14:0(3-OH))MetaboCard
PAMDB004078PG(15:0/19:iso)MetaboCard
PAMDB004079PG(15:0cyclo/10:0(3-OH))MetaboCard
PAMDB004080PG(15:0cyclo/12:0(3-OH))MetaboCard
PAMDB004081PG(15:0cyclo/14:0(3-OH))MetaboCard
PAMDB004082PG(15:0cyclo/19:iso)MetaboCard
PAMDB004083PG(16:0/10:0(3-OH))MetaboCard
PAMDB004084PG(16:0/12:0(3-OH))MetaboCard
PAMDB004085PG(16:0/14:0(3-OH))MetaboCard
PAMDB000791PG(16:0/16:0)MetaboCard
PAMDB004086PG(16:0/19:iso)MetaboCard
PAMDB004087PG(16:1(9Z)/10:0(3-OH))MetaboCard
PAMDB004088PG(16:1(9Z)/12:0(3-OH))MetaboCard
PAMDB004089PG(16:1(9Z)/14:0(3-OH))MetaboCard
PAMDB000795PG(16:1(9Z)/16:1(9Z))MetaboCard
PAMDB004090PG(16:1(9Z)/19:iso)MetaboCard
PAMDB004091PG(17:0cycw7c/10:0(3-OH))MetaboCard
PAMDB004092PG(17:0cycw7c/12:0(3-OH))MetaboCard
PAMDB004093PG(17:0cycw7c/14:0(3-OH))MetaboCard
PAMDB004094PG(17:0cycw7c/19:iso)MetaboCard
PAMDB001674PG(18:0/18:0)MetaboCard
PAMDB000799PG(18:1(11Z)/18:1(11Z))MetaboCard
PAMDB004095PG(18:1(9Z)/10:0(3-OH))MetaboCard
PAMDB004096PG(18:1(9Z)/12:0(3-OH))MetaboCard
PAMDB004097PG(18:1(9Z)/14:0(3-OH))MetaboCard
PAMDB004098PG(18:1(9Z)/19:iso)MetaboCard
PAMDB004099PG(19:0cycv8c/10:0(3-OH))MetaboCard
PAMDB004100PG(19:0cycv8c/12:0(3-OH))MetaboCard
PAMDB004101PG(19:0cycv8c/14:0(3-OH))MetaboCard
PAMDB004102PG(19:0cycv8c/19:iso)MetaboCard
PAMDB004104PG(19:iso/10:0(3-OH))MetaboCard
PAMDB004103PG(19:iso/10:0)MetaboCard
PAMDB004106PG(19:iso/12:0(3-OH))MetaboCard
PAMDB004105PG(19:iso/12:0)MetaboCard
PAMDB004108PG(19:iso/14:0(3-OH))MetaboCard
PAMDB004107PG(19:iso/14:0)MetaboCard
PAMDB004109PG(19:iso/15:0)MetaboCard
PAMDB004110PG(19:iso/15:0cyclo)MetaboCard
PAMDB004111PG(19:iso/16:0)MetaboCard
PAMDB004112PG(19:iso/16:1(9Z))MetaboCard
PAMDB004113PG(19:iso/17:0cycw7c)MetaboCard
PAMDB004114PG(19:iso/18:1(9Z))MetaboCard
PAMDB004115PG(19:iso/19:0cycv8c)MetaboCard
PAMDB004116PG(19:iso/19:iso)MetaboCard
PAMDB001675PGP(12:0/12:0)MetaboCard
PAMDB001676PGP(14:0/14:0)MetaboCard
PAMDB001677PGP(14:1(7Z)/14:1(7Z))MetaboCard
PAMDB001678PGP(16:0/16:0)MetaboCard
PAMDB001679PGP(16:1(9Z)/16:1(9Z))MetaboCard
PAMDB001680PGP(18:0/18:0)MetaboCard
PAMDB001681PGP(18:1(11Z)/18:1(11Z))MetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
active transmembrane transporter activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
P-P-bond-hydrolysis-driven transmembrane transporter activity
primary active transmembrane transporter activity
purine nucleoside binding
pyrophosphatase activity
transmembrane transporter activity
transporter activity
Process
establishment of localization
lipid transport
transmembrane transport
transport
Gene Properties
Locus tag: PA4997
Strand: -
Entrez Gene ID: 881672
Accession: NP_253684.1
GI: 15600190
Sequence start: 5613733
Sequence End: 5615544
Sequence Length: 1811
Gene Sequence:
>PA4997
ATGAGCGATAGTCCTCAGAATCCCGGACCTTCCAGTCTCAAGATCTATTTCCGCCTGTTGGGTTACGTGAAGCCCTACATCGGAATGTTCCTACTCAGCATCGTCGGTTTCCTGATCTTCGCGTCGACCCAGCCGATGCTGGCGGGCATCCTCAAGTATTTCGTCGACGGCCTCTCCAATCCTGACGCGGCATTGTTTCCGAATGTGCAGTGGCCCTGGTTGCGCGACTTGCACCTGGTCTACGCGGTGCCGTTGCTGATCATCCTGATCGCTGCCTGGCAGGGGCTGGGCTCGTTCCTCGGCAACTTCTTCCTCGCCAAGGTTTCCCTGGGGCTGGTGCATGACCTGCGGGTCGCCCTGTTCAACAAGCTGCTGGTGCTGCCGAACCGCTATTTCGACACGCACAGCTCCGGCCACCTGATCTCGCGCATCACCTTCAACGTGACCATGGTCACCGGAGCGGCCACGGATGCCATCAAGGTGGTGATCCGTGAGGGCCTGACCGTGGTCTTCCTGTTCCTCTACCTGCTGTGGATGAACTGGAAGCTGACCCTGGTGATGCTGGCGATCCTGCCGGTCATCGCGGTGATGGTGACTACCGCCAGCCGCAAGTTCCGCAAGCAGAGCAAGAAGATCCAGGTGGCCATGGGCGACGTCACCCACGTCGCCTCGGAAACCATCCAGGGCTACCGGGTGGTGCGCAGCTTCGGCGGCGAAGCCTATGAAGAGAAGCGCTTCCTCGACGCCAGCCAGAGCAATACCGACAAGCAGTTGCGGATGACCAAGACCGGCGCGGTCTACACGCCGATGCTGCAATTGGTGATCTACGTCGCCATGGCGATACTGATGTTCCTCGTGCTGTGGCTGCGCGGGGACGCCTCGGCCGGCGACCTGGTGGCCTATATCACCGCGGCGGGCCTGTTGCCCAAGCCGATCCGCCAGCTTTCCGAAGTCAGTTCCACGGTCCAGCGCGGCGTCGCCGGCGCCGAGAGCATCTTCGAGCAGCTCGACGAAGCGGCGGAGGAAGACCAGGGTACCGTCGAGAAGGAGCGGGTCAGCGGGCGCCTGGAAGTGCGCAACCTGAGCTTCCGTTATCCCGGAACCGACAAGCAGGTGCTGGATGACATCAGTTTCATCGCCGAGCCCGGGCAGATGATCGCCCTGGTCGGCCGTTCCGGTAGCGGCAAATCGACCCTGGCCAACCTGGTTCCGCGCTTTTACCAGCACAATGACGGCAAGATCCTCCTTGATGGCGTTGAAGTCGAGGATTATCGCCTGCGCAACCTGCGCCGCCACATCGCCCTGGTGACCCAGCAGGTCACGCTGTTCAACGACAGCGTGGCCAACAACATCGCCTACGGCGACCTGGCTGGCGCGCCGCGCGAGGAAATCGAGCGGGCGGCGAAGGCTGCCAACGCCAAGGAGTTCATCGACAACCTGCCGCAAGGCTTCGACACCGAGGTCGGCGAGAATGGCGTGCTGCTTTCCGGCGGCCAGCGCCAGCGTCTGGCGATCGCCCGGGCGCTGCTCAAGGACGCGCCCCTGCTGATCCTCGACGAGGCGACCTCGGCGCTGGACACCGAGTCGGAGCGGCATATCCAGGCGGCGCTGGACGAAGTGATGAAGGGGCGCACCACCCTGGTGATCGCCCACCGCCTGTCGACCATCGAGAAGGCCGACCTGATCCTGGTGATGGACCAGGGGCAGATCGTCGAGCGCGGCAGCCACGCCGAACTGCTGGCGCAGAACGGCCATTATGCGCGGCTGCACGCGATGGGACTGGATGAGCAGGCGCCGGCGCCTGTCGGCTGA
Protein Properties
Protein Residues: 603
Protein Molecular Weight: 66.4 kDa
Protein Theoretical pI: 6.98
Hydropathicity (GRAVY score): 0.153
Charge at pH 7 (predicted): -0.09
Protein Sequence:
>PA4997
MSDSPQNPGPSSLKIYFRLLGYVKPYIGMFLLSIVGFLIFASTQPMLAGILKYFVDGLSNPDAALFPNVQWPWLRDLHLVYAVPLLIILIAAWQGLGSFLGNFFLAKVSLGLVHDLRVALFNKLLVLPNRYFDTHSSGHLISRITFNVTMVTGAATDAIKVVIREGLTVVFLFLYLLWMNWKLTLVMLAILPVIAVMVTTASRKFRKQSKKIQVAMGDVTHVASETIQGYRVVRSFGGEAYEEKRFLDASQSNTDKQLRMTKTGAVYTPMLQLVIYVAMAILMFLVLWLRGDASAGDLVAYITAAGLLPKPIRQLSEVSSTVQRGVAGAESIFEQLDEAAEEDQGTVEKERVSGRLEVRNLSFRYPGTDKQVLDDISFIAEPGQMIALVGRSGSGKSTLANLVPRFYQHNDGKILLDGVEVEDYRLRNLRRHIALVTQQVTLFNDSVANNIAYGDLAGAPREEIERAAKAANAKEFIDNLPQGFDTEVGENGVLLSGGQRQRLAIARALLKDAPLLILDEATSALDTESERHIQAALDEVMKGRTTLVIAHRLSTIEKADLILVMDQGQIVERGSHAELLAQNGHYARLHAMGLDEQAPAPVG
References
External Links:
Resource Link
Genome ID: PA4997
Entrez Gene ID: 881672
NCBI Protein ID: 15600190
General Reference: PaperBLAST - Find papers about PA4997 and its homologs