P. aeruginosa Metabolome Database Protein PA4997

Identification

Name:

Lipid A export ATP-binding/permease protein msbA

Synonyms:

Not Available

Gene Name:

msbA

Enzyme Class:

Not Available

Biological Properties

General Function:

Involved in nucleotide binding

Specific Function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Cellular Location:

Cell inner membrane; Multi-pass membrane protein

KEGG Pathways:

Lipopolysaccharide biosynthesis PW000831
ABC transporters pae02010

KEGG Reactions:

Not Available

SMPDB Reactions:

Not Available

PseudoCyc/BioCyc Reactions:

core oligosaccharide lipid A

→

core oligosaccharide lipid A

Adenosine triphosphate + core oligosaccharide lipid A + Water → ADP + Hydrogen ion + Phosphate + core oligosaccharide lipid A
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cold adapted KDO(2)-lipid (A)

→

cold adapted KDO(2)-lipid (A)

Adenosine triphosphate + Water + cold adapted KDO(2)-lipid (A) → ADP + Hydrogen ion + Phosphate + cold adapted KDO(2)-lipid (A)
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→

Adenosine triphosphate + Water + PA(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PA(16:0/16:0)
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→

Adenosine triphosphate + Water + PA(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PA(16:0/16:0)
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→

Adenosine triphosphate + Water + PA(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PA(16:0/16:0)
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→

Adenosine triphosphate + Water + PA(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PA(16:0/16:0)
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→

Adenosine triphosphate + Water + PA(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PA(16:0/16:0)
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→

Adenosine triphosphate + Water + PA(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PA(16:0/16:0)
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→

Adenosine triphosphate + Water + PA(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PA(16:0/16:0)
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→

Adenosine triphosphate + Water + PE(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PE(14:0/14:0)
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→

Adenosine triphosphate + Water + PE(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PE(14:0/14:0)
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→

Adenosine triphosphate + Water + PE(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PE(14:0/14:0)
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→

Adenosine triphosphate + Water + PE(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PE(14:0/14:0)
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→

Adenosine triphosphate + Water + PE(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PE(14:0/14:0)
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→

Adenosine triphosphate + Water + PE(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PE(14:0/14:0)
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→

Adenosine triphosphate + Water + PE(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PE(14:0/14:0)
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→

Adenosine triphosphate + Water + PG(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PG(16:0/16:0)
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→

Adenosine triphosphate + Water + PG(16:1(9Z)/16:1(9Z)) → ADP + Hydrogen ion + Phosphate + PG(16:1(9Z)/16:1(9Z))
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→

Adenosine triphosphate + Water + PG(18:1(11Z)/18:1(11Z)) → ADP + Hydrogen ion + Phosphate + PG(18:1(11Z)/18:1(11Z))
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→

Adenosine triphosphate + Water + PG(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PG(14:0/14:0)
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→

Adenosine triphosphate + Water + KDO2-Lipid A → ADP + Hydrogen ion + Phosphate + KDO2-Lipid A
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→

Adenosine triphosphate + Water + KDO(2)-lipid IV(A) → ADP + Hydrogen ion + Phosphate + KDO(2)-lipid IV(A)
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→

Adenosine triphosphate + Water + PG(12:0/12:0) → ADP + Hydrogen ion + Phosphate + PG(12:0/12:0)
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→

Adenosine triphosphate + Water + PG(14:1(7Z)/14:1(7Z)) → ADP + Hydrogen ion + Phosphate + PG(14:1(7Z)/14:1(7Z))
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→

Adenosine triphosphate + Water + PG(18:0/18:0) → ADP + Hydrogen ion + Phosphate + PG(18:0/18:0)
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→

Adenosine triphosphate + Water + PGP(12:0/12:0) → ADP + Hydrogen ion + Phosphate + PGP(12:0/12:0)
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→

Adenosine triphosphate + Water + PGP(14:0/14:0) → ADP + Hydrogen ion + Phosphate + PGP(14:0/14:0)
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→

Adenosine triphosphate + Water + PGP(14:1(7Z)/14:1(7Z)) → ADP + Hydrogen ion + Phosphate + PGP(14:1(7Z)/14:1(7Z))
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→

Adenosine triphosphate + Water + PGP(16:0/16:0) → ADP + Hydrogen ion + Phosphate + PGP(16:0/16:0)
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→

Adenosine triphosphate + Water + PGP(16:1(9Z)/16:1(9Z)) → ADP + Hydrogen ion + Phosphate + PGP(16:1(9Z)/16:1(9Z))
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→

Adenosine triphosphate + Water + PGP(18:0/18:0) → ADP + Hydrogen ion + Phosphate + PGP(18:0/18:0)
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→

Adenosine triphosphate + Water + PGP(18:1(11Z)/18:1(11Z)) → ADP + Hydrogen ion + Phosphate + PGP(18:1(11Z)/18:1(11Z))
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→

Adenosine diphosphate

Lipid A-core + Adenosine triphosphate + Water → Adenosine diphosphate + Phosphate + Hydrogen ion + Lipid A-core + ADP
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Complex Reactions:

Not Available

Transports:

Lipid A

Metabolites:

PAMDB ID	Name	View
PAMDB000148	Adenosine triphosphate	MetaboCard
PAMDB000345	ADP	MetaboCard
PAMDB001633	Hydrogen ion	MetaboCard
PAMDB001643	KDO(2)-lipid IV(A)	MetaboCard
PAMDB001447	KDO2-Lipid A	MetaboCard
PAMDB001507	Lipid A	MetaboCard
PAMDB001343	Lipid A-core	MetaboCard
PAMDB000169	PA(16:0/16:0)	MetaboCard
PAMDB000751	PE(14:0/14:0)	MetaboCard
PAMDB004022	PG(10:0(3-OH)/10:0(3-OH))	MetaboCard
PAMDB004021	PG(10:0(3-OH)/10:0)	MetaboCard
PAMDB004024	PG(10:0(3-OH)/12:0(3-OH))	MetaboCard
PAMDB004023	PG(10:0(3-OH)/12:0)	MetaboCard
PAMDB004026	PG(10:0(3-OH)/14:0(3-OH))	MetaboCard
PAMDB004025	PG(10:0(3-OH)/14:0)	MetaboCard
PAMDB004027	PG(10:0(3-OH)/15:0)	MetaboCard
PAMDB004028	PG(10:0(3-OH)/15:0cyclo)	MetaboCard
PAMDB004029	PG(10:0(3-OH)/16:0)	MetaboCard
PAMDB004030	PG(10:0(3-OH)/16:1(9Z))	MetaboCard
PAMDB004031	PG(10:0(3-OH)/17:0cycw7c)	MetaboCard
PAMDB004032	PG(10:0(3-OH)/18:1(9Z))	MetaboCard
PAMDB004033	PG(10:0(3-OH)/19:0cycv8c)	MetaboCard
PAMDB004034	PG(10:0(3-OH)/19:iso)	MetaboCard
PAMDB004035	PG(10:0/10:0(3-OH))	MetaboCard
PAMDB004036	PG(10:0/12:0(3-OH))	MetaboCard
PAMDB004037	PG(10:0/14:0(3-OH))	MetaboCard
PAMDB004038	PG(10:0/19:iso)	MetaboCard
PAMDB004040	PG(12:0(3-OH)/10:0(3-OH))	MetaboCard
PAMDB004039	PG(12:0(3-OH)/10:0)	MetaboCard
PAMDB004042	PG(12:0(3-OH)/12:0(3-OH))	MetaboCard
PAMDB004041	PG(12:0(3-OH)/12:0)	MetaboCard
PAMDB004044	PG(12:0(3-OH)/14:0(3-OH))	MetaboCard
PAMDB004043	PG(12:0(3-OH)/14:0)	MetaboCard
PAMDB004045	PG(12:0(3-OH)/15:0)	MetaboCard
PAMDB004046	PG(12:0(3-OH)/15:0cyclo)	MetaboCard
PAMDB004047	PG(12:0(3-OH)/16:0)	MetaboCard
PAMDB004048	PG(12:0(3-OH)/16:1(9Z))	MetaboCard
PAMDB004049	PG(12:0(3-OH)/17:0cycw7c)	MetaboCard
PAMDB004050	PG(12:0(3-OH)/18:1(9Z))	MetaboCard
PAMDB004051	PG(12:0(3-OH)/19:0cycv8c)	MetaboCard
PAMDB004052	PG(12:0(3-OH)/19:iso)	MetaboCard
PAMDB004053	PG(12:0/10:0(3-OH))	MetaboCard
PAMDB004054	PG(12:0/12:0(3-OH))	MetaboCard
PAMDB001672	PG(12:0/12:0)	MetaboCard
PAMDB004055	PG(12:0/14:0(3-OH))	MetaboCard
PAMDB004056	PG(12:0/19:iso)	MetaboCard
PAMDB004058	PG(14:0(3-OH)/10:0(3-OH))	MetaboCard
PAMDB004057	PG(14:0(3-OH)/10:0)	MetaboCard
PAMDB004060	PG(14:0(3-OH)/12:0(3-OH))	MetaboCard
PAMDB004059	PG(14:0(3-OH)/12:0)	MetaboCard
PAMDB004062	PG(14:0(3-OH)/14:0(3-OH))	MetaboCard
PAMDB004061	PG(14:0(3-OH)/14:0)	MetaboCard
PAMDB004063	PG(14:0(3-OH)/15:0)	MetaboCard
PAMDB004064	PG(14:0(3-OH)/15:0cyclo)	MetaboCard
PAMDB004065	PG(14:0(3-OH)/16:0)	MetaboCard
PAMDB004066	PG(14:0(3-OH)/16:1(9Z))	MetaboCard
PAMDB004067	PG(14:0(3-OH)/17:0cycw7c)	MetaboCard
PAMDB004068	PG(14:0(3-OH)/18:1(9Z))	MetaboCard
PAMDB004069	PG(14:0(3-OH)/19:0cycv8c)	MetaboCard
PAMDB004070	PG(14:0(3-OH)/19:iso)	MetaboCard
PAMDB004071	PG(14:0/10:0(3-OH))	MetaboCard
PAMDB004072	PG(14:0/12:0(3-OH))	MetaboCard
PAMDB004073	PG(14:0/14:0(3-OH))	MetaboCard
PAMDB001429	PG(14:0/14:0)	MetaboCard
PAMDB004074	PG(14:0/19:iso)	MetaboCard
PAMDB001673	PG(14:1(7Z)/14:1(7Z))	MetaboCard
PAMDB004075	PG(15:0/10:0(3-OH))	MetaboCard
PAMDB004076	PG(15:0/12:0(3-OH))	MetaboCard
PAMDB004077	PG(15:0/14:0(3-OH))	MetaboCard
PAMDB004078	PG(15:0/19:iso)	MetaboCard
PAMDB004079	PG(15:0cyclo/10:0(3-OH))	MetaboCard
PAMDB004080	PG(15:0cyclo/12:0(3-OH))	MetaboCard
PAMDB004081	PG(15:0cyclo/14:0(3-OH))	MetaboCard
PAMDB004082	PG(15:0cyclo/19:iso)	MetaboCard
PAMDB004083	PG(16:0/10:0(3-OH))	MetaboCard
PAMDB004084	PG(16:0/12:0(3-OH))	MetaboCard
PAMDB004085	PG(16:0/14:0(3-OH))	MetaboCard
PAMDB000791	PG(16:0/16:0)	MetaboCard
PAMDB004086	PG(16:0/19:iso)	MetaboCard
PAMDB004087	PG(16:1(9Z)/10:0(3-OH))	MetaboCard
PAMDB004088	PG(16:1(9Z)/12:0(3-OH))	MetaboCard
PAMDB004089	PG(16:1(9Z)/14:0(3-OH))	MetaboCard
PAMDB000795	PG(16:1(9Z)/16:1(9Z))	MetaboCard
PAMDB004090	PG(16:1(9Z)/19:iso)	MetaboCard
PAMDB004091	PG(17:0cycw7c/10:0(3-OH))	MetaboCard
PAMDB004092	PG(17:0cycw7c/12:0(3-OH))	MetaboCard
PAMDB004093	PG(17:0cycw7c/14:0(3-OH))	MetaboCard
PAMDB004094	PG(17:0cycw7c/19:iso)	MetaboCard
PAMDB001674	PG(18:0/18:0)	MetaboCard
PAMDB000799	PG(18:1(11Z)/18:1(11Z))	MetaboCard
PAMDB004095	PG(18:1(9Z)/10:0(3-OH))	MetaboCard
PAMDB004096	PG(18:1(9Z)/12:0(3-OH))	MetaboCard
PAMDB004097	PG(18:1(9Z)/14:0(3-OH))	MetaboCard
PAMDB004098	PG(18:1(9Z)/19:iso)	MetaboCard
PAMDB004099	PG(19:0cycv8c/10:0(3-OH))	MetaboCard
PAMDB004100	PG(19:0cycv8c/12:0(3-OH))	MetaboCard
PAMDB004101	PG(19:0cycv8c/14:0(3-OH))	MetaboCard
PAMDB004102	PG(19:0cycv8c/19:iso)	MetaboCard
PAMDB004104	PG(19:iso/10:0(3-OH))	MetaboCard
PAMDB004103	PG(19:iso/10:0)	MetaboCard
PAMDB004106	PG(19:iso/12:0(3-OH))	MetaboCard
PAMDB004105	PG(19:iso/12:0)	MetaboCard
PAMDB004108	PG(19:iso/14:0(3-OH))	MetaboCard
PAMDB004107	PG(19:iso/14:0)	MetaboCard
PAMDB004109	PG(19:iso/15:0)	MetaboCard
PAMDB004110	PG(19:iso/15:0cyclo)	MetaboCard
PAMDB004111	PG(19:iso/16:0)	MetaboCard
PAMDB004112	PG(19:iso/16:1(9Z))	MetaboCard
PAMDB004113	PG(19:iso/17:0cycw7c)	MetaboCard
PAMDB004114	PG(19:iso/18:1(9Z))	MetaboCard
PAMDB004115	PG(19:iso/19:0cycv8c)	MetaboCard
PAMDB004116	PG(19:iso/19:iso)	MetaboCard
PAMDB001675	PGP(12:0/12:0)	MetaboCard
PAMDB001676	PGP(14:0/14:0)	MetaboCard
PAMDB001677	PGP(14:1(7Z)/14:1(7Z))	MetaboCard
PAMDB001678	PGP(16:0/16:0)	MetaboCard
PAMDB001679	PGP(16:1(9Z)/16:1(9Z))	MetaboCard
PAMDB001680	PGP(18:0/18:0)	MetaboCard
PAMDB001681	PGP(18:1(11Z)/18:1(11Z))	MetaboCard
PAMDB000383	Phosphate	MetaboCard
PAMDB000142	Water	MetaboCard

GO Classification:

Component
cell part
integral to membrane
intrinsic to membrane
membrane part
Function
active transmembrane transporter activity
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
binding
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside binding
nucleoside-triphosphatase activity
nucleotide binding
P-P-bond-hydrolysis-driven transmembrane transporter activity
primary active transmembrane transporter activity
purine nucleoside binding
pyrophosphatase activity
transmembrane transporter activity
transporter activity
Process
establishment of localization
lipid transport
transmembrane transport
transport

Gene Properties

Locus tag:

PA4997

Strand:

Entrez Gene ID:

881672

Accession:

NP_253684.1

GI:

15600190

Sequence start:

5613733

Sequence End:

5615544

Sequence Length:

1811

Gene Sequence:

>PA4997
ATGAGCGATAGTCCTCAGAATCCCGGACCTTCCAGTCTCAAGATCTATTTCCGCCTGTTGGGTTACGTGAAGCCCTACATCGGAATGTTCCTACTCAGCATCGTCGGTTTCCTGATCTTCGCGTCGACCCAGCCGATGCTGGCGGGCATCCTCAAGTATTTCGTCGACGGCCTCTCCAATCCTGACGCGGCATTGTTTCCGAATGTGCAGTGGCCCTGGTTGCGCGACTTGCACCTGGTCTACGCGGTGCCGTTGCTGATCATCCTGATCGCTGCCTGGCAGGGGCTGGGCTCGTTCCTCGGCAACTTCTTCCTCGCCAAGGTTTCCCTGGGGCTGGTGCATGACCTGCGGGTCGCCCTGTTCAACAAGCTGCTGGTGCTGCCGAACCGCTATTTCGACACGCACAGCTCCGGCCACCTGATCTCGCGCATCACCTTCAACGTGACCATGGTCACCGGAGCGGCCACGGATGCCATCAAGGTGGTGATCCGTGAGGGCCTGACCGTGGTCTTCCTGTTCCTCTACCTGCTGTGGATGAACTGGAAGCTGACCCTGGTGATGCTGGCGATCCTGCCGGTCATCGCGGTGATGGTGACTACCGCCAGCCGCAAGTTCCGCAAGCAGAGCAAGAAGATCCAGGTGGCCATGGGCGACGTCACCCACGTCGCCTCGGAAACCATCCAGGGCTACCGGGTGGTGCGCAGCTTCGGCGGCGAAGCCTATGAAGAGAAGCGCTTCCTCGACGCCAGCCAGAGCAATACCGACAAGCAGTTGCGGATGACCAAGACCGGCGCGGTCTACACGCCGATGCTGCAATTGGTGATCTACGTCGCCATGGCGATACTGATGTTCCTCGTGCTGTGGCTGCGCGGGGACGCCTCGGCCGGCGACCTGGTGGCCTATATCACCGCGGCGGGCCTGTTGCCCAAGCCGATCCGCCAGCTTTCCGAAGTCAGTTCCACGGTCCAGCGCGGCGTCGCCGGCGCCGAGAGCATCTTCGAGCAGCTCGACGAAGCGGCGGAGGAAGACCAGGGTACCGTCGAGAAGGAGCGGGTCAGCGGGCGCCTGGAAGTGCGCAACCTGAGCTTCCGTTATCCCGGAACCGACAAGCAGGTGCTGGATGACATCAGTTTCATCGCCGAGCCCGGGCAGATGATCGCCCTGGTCGGCCGTTCCGGTAGCGGCAAATCGACCCTGGCCAACCTGGTTCCGCGCTTTTACCAGCACAATGACGGCAAGATCCTCCTTGATGGCGTTGAAGTCGAGGATTATCGCCTGCGCAACCTGCGCCGCCACATCGCCCTGGTGACCCAGCAGGTCACGCTGTTCAACGACAGCGTGGCCAACAACATCGCCTACGGCGACCTGGCTGGCGCGCCGCGCGAGGAAATCGAGCGGGCGGCGAAGGCTGCCAACGCCAAGGAGTTCATCGACAACCTGCCGCAAGGCTTCGACACCGAGGTCGGCGAGAATGGCGTGCTGCTTTCCGGCGGCCAGCGCCAGCGTCTGGCGATCGCCCGGGCGCTGCTCAAGGACGCGCCCCTGCTGATCCTCGACGAGGCGACCTCGGCGCTGGACACCGAGTCGGAGCGGCATATCCAGGCGGCGCTGGACGAAGTGATGAAGGGGCGCACCACCCTGGTGATCGCCCACCGCCTGTCGACCATCGAGAAGGCCGACCTGATCCTGGTGATGGACCAGGGGCAGATCGTCGAGCGCGGCAGCCACGCCGAACTGCTGGCGCAGAACGGCCATTATGCGCGGCTGCACGCGATGGGACTGGATGAGCAGGCGCCGGCGCCTGTCGGCTGA

Protein Properties

Protein Residues:

603

Protein Molecular Weight:

66.4 kDa

Protein Theoretical pI:

6.98

Hydropathicity (GRAVY score):

0.153

Charge at pH 7 (predicted):

-0.09

Protein Sequence:

>PA4997
MSDSPQNPGPSSLKIYFRLLGYVKPYIGMFLLSIVGFLIFASTQPMLAGILKYFVDGLSNPDAALFPNVQWPWLRDLHLVYAVPLLIILIAAWQGLGSFLGNFFLAKVSLGLVHDLRVALFNKLLVLPNRYFDTHSSGHLISRITFNVTMVTGAATDAIKVVIREGLTVVFLFLYLLWMNWKLTLVMLAILPVIAVMVTTASRKFRKQSKKIQVAMGDVTHVASETIQGYRVVRSFGGEAYEEKRFLDASQSNTDKQLRMTKTGAVYTPMLQLVIYVAMAILMFLVLWLRGDASAGDLVAYITAAGLLPKPIRQLSEVSSTVQRGVAGAESIFEQLDEAAEEDQGTVEKERVSGRLEVRNLSFRYPGTDKQVLDDISFIAEPGQMIALVGRSGSGKSTLANLVPRFYQHNDGKILLDGVEVEDYRLRNLRRHIALVTQQVTLFNDSVANNIAYGDLAGAPREEIERAAKAANAKEFIDNLPQGFDTEVGENGVLLSGGQRQRLAIARALLKDAPLLILDEATSALDTESERHIQAALDEVMKGRTTLVIAHRLSTIEKADLILVMDQGQIVERGSHAELLAQNGHYARLHAMGLDEQAPAPVG

References

External Links:

Resource	Link
Genome ID:	PA4997
Entrez Gene ID:	881672
NCBI Protein ID:	15600190

General Reference:

PaperBLAST - Find papers about PA4997 and its homologs

Lipid A export ATP-binding/permease protein msbA (PA4997)