Phosphate (PAMDB000383)

General function:

Involved in catalytic activity

Specific function:

A phosphate monoester + H(2)O = an alcohol + phosphate

Gene Name:

phoA

Locus Tag:

PA3296

Molecular weight:

50.4 kDa

Reactions

General function:

Involved in phosphoenolpyruvate carboxylase activity

Specific function:

Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle

Gene Name:

ppc

Locus Tag:

PA3687

Molecular weight:

97.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)

Gene Name:

aroF

Locus Tag:

PA1750

Molecular weight:

39.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction

Gene Name:

thrC

Locus Tag:

PA3735

Molecular weight:

51.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Locus Tag:

PA4756

Molecular weight:

117.3 kDa

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpA

Locus Tag:

PA1633

Molecular weight:

59.9 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpB

Locus Tag:

PA1634

Molecular weight:

73 kDa

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex

Gene Name:

kdpC

Locus Tag:

PA1635

Molecular weight:

19.3 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Locus Tag:

PA0407

Molecular weight:

35.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system

Gene Name:

rbsA

Locus Tag:

PA1947

Molecular weight:

55.8 kDa

Reactions

General function:

Involved in RNA binding

Specific function:

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

Gene Name:

pnp

Locus Tag:

PA4740

Molecular weight:

75.4 kDa

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline

Gene Name:

argF

Locus Tag:

PA3537

Molecular weight:

33.9 kDa

Reactions

General function:

Involved in hydrolase activity

Specific function:

This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA

Gene Name:

dut

Locus Tag:

PA5321

Molecular weight:

15.9 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

D-erythro-1-(imidazol-4-yl)glycerol 3- phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O

Gene Name:

hisB

Locus Tag:

PA5143

Molecular weight:

21.9 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate

Gene Name:

proA

Locus Tag:

PA4007

Molecular weight:

45 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system

Gene Name:

hisP

Locus Tag:

PA2926

Molecular weight:

28.5 kDa

General function:

Involved in 3-dehydroquinate synthase activity

Specific function:

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate

Gene Name:

aroB

Locus Tag:

PA5038

Molecular weight:

40.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlB

Locus Tag:

PA4410

Molecular weight:

34.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole

Gene Name:

purM

Locus Tag:

PA0945

Molecular weight:

37.1 kDa

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Locus Tag:

PA3111

Molecular weight:

46.5 kDa

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Gene Name:

purK

Locus Tag:

PA5425

Molecular weight:

38.5 kDa

Reactions

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane

Gene Name:

atpC

Locus Tag:

PA5553

Molecular weight:

14.7 kDa

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Locus Tag:

PA4758

Molecular weight:

40.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlA

Locus Tag:

PA4201

Molecular weight:

36.5 kDa

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Locus Tag:

PA5203

Molecular weight:

59.2 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth

Gene Name:

kdsA

Locus Tag:

PA3636

Molecular weight:

31.1 kDa

Reactions

General function:

Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups

Specific function:

Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin

Gene Name:

murA

Locus Tag:

PA4450

Molecular weight:

44.6 kDa

Reactions

General function:

Involved in carboxyl- or carbamoyltransferase activity

Specific function:

Carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate

Gene Name:

pyrB

Locus Tag:

PA0402

Molecular weight:

36.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate

Gene Name:

pdxJ

Locus Tag:

PA0773

Molecular weight:

27.2 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Diphosphate + H(2)O = 2 phosphate

Gene Name:

ppa

Locus Tag:

PA4031

Molecular weight:

19.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can also act in the reverse direction to form ATP in the presence of excess ADP. Can also use GTP instead of ATP; but the efficiency of GTP is 5% that of ATP

Gene Name:

ppk

Locus Tag:

PA5242

Molecular weight:

83.2 kDa

Reactions

General function:

Involved in adenylosuccinate synthase activity

Specific function:

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

Gene Name:

purA

Locus Tag:

PA4938

Molecular weight:

46.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

Gene Name:

purC

Locus Tag:

PA1013

Molecular weight:

26.8 kDa

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Locus Tag:

PA3637

Molecular weight:

59.6 kDa

Reactions

General function:

Involved in methionine adenosyltransferase activity

Specific function:

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth

Gene Name:

metK

Locus Tag:

PA0546

Molecular weight:

42.7 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. Requires selenophosphate as the selenium-donor molecule

Gene Name:

selA

Locus Tag:

PA4808

Molecular weight:

50.3 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Locus Tag:

PA1588

Molecular weight:

41.5 kDa

Reactions

General function:

Involved in hydrolase activity

Specific function:

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'- monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain- length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. Also plays a significant physiological role in stress-response and is required for the survival of Pseudomonas aeruginosa in stationary growth phase

Gene Name:

surE

Locus Tag:

PA3625

Molecular weight:

26.4 kDa

Reactions

General function:

Involved in phosphoric ester hydrolase activity

Specific function:

D-fructose 1,6-bisphosphate + H(2)O = D- fructose 6-phosphate + phosphate

Gene Name:

fbp

Locus Tag:

PA5110

Molecular weight:

37.2 kDa

Reactions

General function:

Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Specific function:

D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH

Gene Name:

gapA

Locus Tag:

PA3195

Molecular weight:

36.2 kDa

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Locus Tag:

PA5119

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in phosphate acetyltransferase activity

Specific function:

Acetyl-CoA + phosphate = CoA + acetyl phosphate

Gene Name:

pta

Locus Tag:

PA0835

Molecular weight:

75.7 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity

Gene Name:

accD

Locus Tag:

PA3112

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in aspartate-semialdehyde dehydrogenase activity

Specific function:

L-aspartate 4-semialdehyde + phosphate + NADP(+) = L-4-aspartyl phosphate + NADPH

Gene Name:

asd

Locus Tag:

PA3117

Molecular weight:

40.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system

Gene Name:

pstB

Locus Tag:

PA5366

Molecular weight:

31 kDa

Reactions

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

Gene Name:

atpB

Locus Tag:

PA5560

Molecular weight:

31.9 kDa

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)

Gene Name:

atpF

Locus Tag:

PA5558

Molecular weight:

16.9 kDa

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction

Gene Name:

atpH

Locus Tag:

PA5557

Molecular weight:

19.3 kDa

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex

Gene Name:

atpG

Locus Tag:

PA5555

Molecular weight:

31.6 kDa

General function:

Involved in ATP binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

Gene Name:

atpA

Locus Tag:

PA5556

Molecular weight:

55.4 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits

Gene Name:

atpD

Locus Tag:

PA5554

Molecular weight:

49.5 kDa

Reactions

General function:

Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Specific function:

Mediates magnesium influx to the cytosol

Gene Name:

mgtA

Locus Tag:

PA4825

Molecular weight:

100.1 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

Gene Name:

accA

Locus Tag:

PA3639

Molecular weight:

34.9 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accB

Locus Tag:

PA4847

Molecular weight:

16.5 kDa

General function:

Involved in phosphorylase activity

Specific function:

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties

Gene Name:

glgP

Locus Tag:

PA2144

Molecular weight:

92 kDa

Reactions

General function:

Involved in phosphatidylinositol phosphorylation

Specific function:

Myo-inositol phosphate + H(2)O = myo-inositol + phosphate

Gene Name:

suhB

Locus Tag:

PA3818

Molecular weight:

29.5 kDa

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Locus Tag:

PA1409

Molecular weight:

38 kDa

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Locus Tag:

PA0935

Molecular weight:

31.2 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate of circa 500 residues long, while chains of circa 15 residues compete poorly with polyphosphate as substrate

Gene Name:

ppx

Locus Tag:

PA5241

Molecular weight:

56.4 kDa

Reactions

General function:

Involved in riboflavin synthase activity

Specific function:

Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The alpha subunit catalyzes the dismutation of 6,7-dimethyl-8-lumazine to riboflavin and 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)- pyrimidinedione

Gene Name:

ribE

Locus Tag:

PA4053

Molecular weight:

16.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Locus Tag:

PA1589

Molecular weight:

30.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters

Gene Name:

ugpC

Locus Tag:

PA3187

Molecular weight:

42.2 kDa

Reactions

General function:

Involved in N-acetyl-gamma-glutamyl-phosphate reductase activity

Specific function:

N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5-glutamyl phosphate + NADPH

Gene Name:

argC

Locus Tag:

PA0662

Molecular weight:

36.7 kDa

Reactions

General function:

Involved in quinolinate synthetase A activity

Specific function:

Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

Gene Name:

nadA

Locus Tag:

PA1004

Molecular weight:

38.4 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

Gene Name:

murF

Locus Tag:

PA4416

Molecular weight:

47.4 kDa

Reactions

General function:

Involved in chorismate synthase activity

Specific function:

5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate

Gene Name:

aroC

Locus Tag:

PA1681

Molecular weight:

39 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

bioD

Locus Tag:

PA0504

Molecular weight:

23.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline

Gene Name:

proV

Locus Tag:

PA5094

Molecular weight:

30.7 kDa

General function:

Involved in ATP binding

Specific function:

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

Gene Name:

murD

Locus Tag:

PA4414

Molecular weight:

48.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

purL

Locus Tag:

PA3763

Molecular weight:

140.6 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide

Gene Name:

purD

Locus Tag:

PA4855

Molecular weight:

45.2 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Synthesizes selenophosphate from selenide and ATP

Gene Name:

selD

Locus Tag:

PA1642

Molecular weight:

36.4 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system

Gene Name:

cysA

Locus Tag:

PA0280

Molecular weight:

36.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

murC

Locus Tag:

PA4411

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in nicotinate phosphoribosyltransferase activity

Specific function:

Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate

Gene Name:

pncB

Locus Tag:

PA4919

Molecular weight:

46.1 kDa

Reactions

General function:

Involved in phosphatidylglycerophosphatase activity

Specific function:

One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate

Gene Name:

pgpA

Locus Tag:

PA4050

Molecular weight:

19.6 kDa

Reactions

General function:

Involved in 4-hydroxythreonine-4-phosphate dehydrogenase activity

Specific function:

Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

Gene Name:

pdxA

Locus Tag:

PA0593

Molecular weight:

34.9 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + sulfate = diphosphate + adenylyl sulfate

Gene Name:

cysD

Locus Tag:

PA4443

Molecular weight:

35.5 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine

Gene Name:

murE

Locus Tag:

PA4417

Molecular weight:

51.3 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Converts 3'(2')-phosphoadenosine 5'-phosphate (PAP) to AMP. May also convert adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS). Has 10000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2)

Gene Name:

cysQ

Locus Tag:

PA5175

Molecular weight:

29.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate

Gene Name:

ppsA

Locus Tag:

PA1770

Molecular weight:

85.8 kDa

Reactions

General function:

Involved in GTPase activity

Specific function:

May be the GTPase, regulating ATP sulfurylase activity

Gene Name:

cysN

Locus Tag:

PA4442

Molecular weight:

69.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system

Gene Name:

fepC

Locus Tag:

PA4158

Molecular weight:

28.6 kDa

General function:

Involved in nucleotidyltransferase activity

Specific function:

Involved in the biosynthesis of the capsular polysaccharide colanic acid

Gene Name:

manC

Locus Tag:

PA3551

Molecular weight:

53.1 kDa

Reactions

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Locus Tag:

PA4848

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

Gene Name:

acs

Locus Tag:

PA0887

Molecular weight:

71.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP

Gene Name:

purT

Locus Tag:

PA3751

Molecular weight:

42.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

Gene Name:

ccmA

Locus Tag:

PA1475

Molecular weight:

25 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Converts N1-(5-phospho-alpha-D-ribosyl)-5,6- dimethylbenzimidazole into N1-alpha-D-ribosyl-5,6- dimethylbenzimidazole; involved in the assembly of the nucleotide loop of cobalamin

Gene Name:

cobC

Locus Tag:

PA1276

Molecular weight:

36.7 kDa

Reactions

General function:

Involved in undecaprenyl-diphosphatase activity

Specific function:

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin

Gene Name:

uppP

Locus Tag:

PA1959

Molecular weight:

30.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system

Gene Name:

malK

Locus Tag:

PA2341

Molecular weight:

40.2 kDa

Reactions

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 10 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits

Gene Name:

atpE

Locus Tag:

PA5559

Molecular weight:

8.6 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system

Gene Name:

potA

Locus Tag:

PA3607

Molecular weight:

40 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

pstA

Locus Tag:

PA5367

Molecular weight:

61.2 kDa

General function:

Involved in lipopolysaccharide transport

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptG

Locus Tag:

PA3827

Molecular weight:

39.2 kDa

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

cysW

Locus Tag:

PA0281

Molecular weight:

31.3 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

dppB

Locus Tag:

PA4503

Molecular weight:

37 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

dppC

Locus Tag:

PA4504

Molecular weight:

32.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltJ

Locus Tag:

PA1341

Molecular weight:

27.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltK

Locus Tag:

PA1340

Molecular weight:

24.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane

Gene Name:

hisM

Locus Tag:

PA2925

Molecular weight:

26.7 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livH

Locus Tag:

PA1073

Molecular weight:

32.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane

Gene Name:

modB

Locus Tag:

PA1862

Molecular weight:

24.4 kDa

General function:

Involved in lipopolysaccharide-transporting ATPase acti

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptF

Locus Tag:

PA3828

Molecular weight:

41.3 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine

Gene Name:

potB

Locus Tag:

PA3608

Molecular weight:

32.7 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine

Gene Name:

potC

Locus Tag:

PA3609

Molecular weight:

27.7 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine

Gene Name:

potI

Locus Tag:

PA0304

Molecular weight:

31.9 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

pstC

Locus Tag:

PA5368

Molecular weight:

73.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

rbsC

Locus Tag:

PA1948

Molecular weight:

34 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livM

Locus Tag:

PA1072

Molecular weight:

45.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

fepD

Locus Tag:

PA4160

Molecular weight:

34.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

fepG

Locus Tag:

PA4161

Molecular weight:

34.8 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine

Gene Name:

potH

Locus Tag:

PA0303

Molecular weight:

32.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane

Gene Name:

hisQ

Locus Tag:

PA2924

Molecular weight:

24.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Gene Name:

msbA

Locus Tag:

PA4997

Molecular weight:

66.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

ssuC

Locus Tag:

PA3443

Molecular weight:

28.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for taurine. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

tauC

Locus Tag:

PA3936

Molecular weight:

29.4 kDa

General function:

Involved in transporter activity

Specific function:

This protein specifically binds sulfate and is involved in its transmembrane transport

Gene Name:

sbp

Locus Tag:

PA0283

Molecular weight:

36.4 kDa

General function:

Involved in GTP binding

Specific function:

GTP-driven Fe(2+) uptake system

Gene Name:

feoB

Locus Tag:

PA4358

Molecular weight:

82.5 kDa

General function:

Involved in binding

Specific function:

Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin

Gene Name:

fepB

Locus Tag:

PA4159

Molecular weight:

32.1 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system

Gene Name:

znuC

Locus Tag:

PA5500

Molecular weight:

29.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system

Gene Name:

dppD

Locus Tag:

PA4505

Molecular weight:

35.4 kDa

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA

Gene Name:

plsX

Locus Tag:

PA2969

Molecular weight:

34.6 kDa

Reactions

General function:

Involved in protein complex assembly

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmC

Locus Tag:

PA1477

Molecular weight:

28.3 kDa

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport

Gene Name:

cysP

Locus Tag:

PA1493

Molecular weight:

36.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system

Gene Name:

lptB

Locus Tag:

PA4461

Molecular weight:

26.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system

Gene Name:

dppF

Locus Tag:

PA4506

Molecular weight:

36.3 kDa

General function:

Involved in phosphate ion binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import

Gene Name:

pstS

Locus Tag:

PA5369

Molecular weight:

34.5 kDa

General function:

Involved in heme transporter activity

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmB

Locus Tag:

PA1476

Molecular weight:

23.4 kDa

General function:

Involved in lipopolysaccharide transmembrane transporter activity

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptC

Locus Tag:

PA4459

Molecular weight:

21.4 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system

Gene Name:

gltL

Locus Tag:

PA1339

Molecular weight:

26.9 kDa

General function:

Involved in lipopolysaccharide binding

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain of LPS

Gene Name:

lptA

Locus Tag:

PA0005

Molecular weight:

28.7 kDa

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the high-affinity D-ribose membrane transport system and also serves as the primary chemoreceptor for chemotaxis

Gene Name:

rbsB

Locus Tag:

PA1946

Molecular weight:

33.9 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livG

Locus Tag:

PA1071

Molecular weight:

28.3 kDa

General function:

Involved in transporter activity

Specific function:

Component of the high-affinity histidine permease, a binding-protein-dependent transport system. The other components are proteins hisQ, hisM, and hisP

Gene Name:

hisJ

Locus Tag:

PA2923

Molecular weight:

28.2 kDa

General function:

Energy production and conversion

Specific function:

A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex

Gene Name:

atpI

Locus Tag:

PA5561

Molecular weight:

13.7 kDa

General function:

Involved in arsenite transmembrane transporter activity

Specific function:

Involved in arsenical resistance. Thought to form the channel of an arsenite pump

Gene Name:

arsB

Locus Tag:

PA2278

Molecular weight:

45.1 kDa

General function:

Involved in ATP binding

Specific function:

Involved in the high-affinity zinc uptake transport system

Gene Name:

znuB

Locus Tag:

PA5501

Molecular weight:

27.3 kDa

General function:

Involved in protein-heme linkage

Specific function:

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

Gene Name:

ccmE

Locus Tag:

PA1479

Molecular weight:

17.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livF

Locus Tag:

PA1070

Molecular weight:

25.6 kDa

General function:

Involved in transporter activity

Specific function:

Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis

Gene Name:

dppA

Locus Tag:

PA4496

Molecular weight:

60.1 kDa

General function:

Not Available

Specific function:

Specific function unknown

Gene Name:

kdpF

Locus Tag:

PA1632

Molecular weight:

3.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system

Gene Name:

tauB

Locus Tag:

PA3937

Molecular weight:

28.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system

Gene Name:

modC

Locus Tag:

PA1861

Molecular weight:

39.8 kDa

Reactions

General function:

Involved in metal ion binding

Specific function:

Involved in the high-affinity zinc uptake transport system

Gene Name:

znuA

Locus Tag:

PA5498

Molecular weight:

33.6 kDa

General function:

Amino acid transport and metabolism

Specific function:

Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system

Gene Name:

potG

Locus Tag:

PA0302

Molecular weight:

42.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for taurine

Gene Name:

tauA

Locus Tag:

PA3938

Molecular weight:

35.9 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable)

Gene Name:

ssuB

Locus Tag:

PA3442

Molecular weight:

29.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate

Gene Name:

gltI

Locus Tag:

PA1342

Molecular weight:

33.1 kDa

General function:

Involved in amino acid transport

Specific function:

This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in Pseudomonas aeruginosa

Gene Name:

livK

Locus Tag:

PA1074

Molecular weight:

39.8 kDa

General function:

Involved in fatty acid biosynthetic process

Specific function:

Carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Name:

acpP

Locus Tag:

PA2966

Molecular weight:

8.7 kDa

General function:

Involved in ATP binding

Specific function:

Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid

Gene Name:

mpl

Locus Tag:

PA4020

Molecular weight:

48.5 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein

Gene Name:

potF

Locus Tag:

PA1410

Molecular weight:

40.5 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein

Gene Name:

potD

Locus Tag:

PA3610

Molecular weight:

39.3 kDa

General function:

Involved in molybdate transmembrane-transporting ATPase activity

Specific function:

Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity

Gene Name:

modA

Locus Tag:

PA1863

Molecular weight:

26.4 kDa

General function:

Not Available

Specific function:

Not Available

Gene Name:

yjdM

Locus Tag:

PA0128

Molecular weight:

12.1 kDa

General function:

Inorganic ion transport and metabolism

Specific function:

Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system

Gene Name:

phnC

Locus Tag:

PA3384

Molecular weight:

30.3 kDa

Reactions