UDP-N-acetylglucosamine 1-carboxyvinyltransferase (PA4450)

Identification
Name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Synonyms:
  • Enoylpyruvate transferase
  • UDP-N-acetylglucosamine enolpyruvyl transferase
  • EPT
Gene Name: murA
Enzyme Class:
Biological Properties
General Function: Involved in transferase activity, transferring alkyl or aryl (other than methyl) groups
Specific Function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine. Target for the antibiotic phosphomycin
Cellular Location: Cytoplasm (Probable)
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine ↔ Phosphate + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine ↔ UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine + Phosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb
Uridine diphosphate-N-acetylglucosamine + Phosphoenolpyruvic acid → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine ↔ Phosphate + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine
ReactionCard
Thumb+Thumb → Thumb+Thumb
Uridine diphosphate-N-acetylglucosamine + Phosphoenolpyruvic acid → UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine + Phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Inorganic phosphate + UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamine
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000111Phosphoenolpyruvic acidMetaboCard
PAMDB000647UDP-N-Acetyl-3-(1-carboxyvinyl)-D-glucosamineMetaboCard
PAMDB006354UDP-N-acetyl-α-D-glucosamine-enolpyruvateMetaboCard
PAMDB000120Uridine diphosphate-N-acetylglucosamineMetaboCard
GO Classification:
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
alcohol metabolic process
amino sugar metabolic process
metabolic process
monosaccharide metabolic process
small molecule metabolic process
UDP-N-acetylgalactosamine biosynthetic process
UDP-N-acetylgalactosamine metabolic process
Gene Properties
Locus tag: PA4450
Strand: -
Entrez Gene ID: 880969
Accession: NP_253140.1
GI: 15599646
Sequence start: 4984205
Sequence End: 4985470
Sequence Length: 1265
Gene Sequence: 
>PA4450
ATGGATAAACTGATTATTACCGGCGGTAACCGCCTCGATGGCGAAATCCGCATTTCCGGCGCGAAGAACTCGGCGCTGCCGATCCTGGCCGCGACCCTGCTGGCCGATACTCCGGTCACCGTCTGCAACCTGCCGCACCTGCACGACATTACCACCATGATCGAACTGTTCGGCCGCATGGGCGTGCAGCCGATCATCGACGAGAAGCTCAACGTCGAAGTCGATGCCAGCAGCATCAAAACCCTGGTCGCGCCGTACGAACTGGTGAAGACCATGCGTGCCTCGATCCTGGTGCTGGGCCCGATGCTGGCGCGCTTCGGCGAGGCCGAAGTGGCCCTGCCGGGCGGTTGCGCGATCGGTTCGCGTCCGGTCGACCTGCATATCCGCGGTCTCGAGGCCATGGGCGCGCAGATCGAGGTCGAAGGCGGCTACATCAAGGCCAAGGCGCCGGCCGGCGGCCTGCGTGGCGGTCACTTCTTCTTCGATACCGTCAGCGTGACCGGCACCGAGAACCTGATGATGGCCGCCGCGCTGGCCAACGGCCGTACCGTGCTGCAGAACGCCGCTCGCGAGCCGGAGGTGGTCGACCTGGCCAACTGCCTGAACGCCATGGGCGCCAACGTCCAGGGCGCTGGCTCCGATACCATCGTCATCGAAGGCGTGAAGCGCCTCGGCGGTGCTCGCTACGACGTACTGCCCGACCGTATCGAGACCGGCACCTACCTGGTGGCCGCGGCCGCGACCGGTGGCCGGGTGAAGCTGAAGGATACCGACCCGACCATCCTCGAGGCGGTCCTGCAGAAGCTGGAAGAGGCCGGTGCCCACATCAGCACCGGCAGCAACTGGATCGAGCTGGACATGAAGGGCAACCGGCCGAAGGCGGTCAACGTGCGTACCGCGCCGTACCCGGCGTTCCCCACCGACATGCAGGCCCAGTTCATCTCCATGAACGCGGTAGCCGAAGGCACCGGCGCGGTCATCGAGACGGTCTTCGAGAACCGCTTCATGCATGTTTACGAAATGAACCGCATGGGCGCGCAAATCCTCGTCGAAGGCAACACCGCCATCGTCACCGGCGTACCCAAGCTCAAGGGCGCTCCGGTCATGGCGACCGACCTGCGCGCATCCGCGAGCCTGGTGATCGCCGGCCTGGTGGCCGAAGGCGACACCCTGATCGATCGCATCTACCACATCGACCGTGGCTACGAGTGCATCGAAGAGAAACTCCAGCTGCTCGGCGCCAAGATCCGCCGCGTACCGGGCTAG
Protein Properties
Protein Residues: 421
Protein Molecular Weight: 44.6 kDa
Protein Theoretical pI: 5.49
Hydropathicity (GRAVY score): 0.152
Charge at pH 7 (predicted): -6.42
Protein Sequence: 
>PA4450
MDKLIITGGNRLDGEIRISGAKNSALPILAATLLADTPVTVCNLPHLHDITTMIELFGRMGVQPIIDEKLNVEVDASSIKTLVAPYELVKTMRASILVLGPMLARFGEAEVALPGGCAIGSRPVDLHIRGLEAMGAQIEVEGGYIKAKAPAGGLRGGHFFFDTVSVTGTENLMMAAALANGRTVLQNAAREPEVVDLANCLNAMGANVQGAGSDTIVIEGVKRLGGARYDVLPDRIETGTYLVAAAATGGRVKLKDTDPTILEAVLQKLEEAGAHISTGSNWIELDMKGNRPKAVNVRTAPYPAFPTDMQAQFISMNAVAEGTGAVIETVFENRFMHVYEMNRMGAQILVEGNTAIVTGVPKLKGAPVMATDLRASASLVIAGLVAEGDTLIDRIYHIDRGYECIEEKLQLLGAKIRRVPG
References
External Links:
Resource Link
Genome ID: PA4450
Entrez Gene ID: 880969
NCBI Protein ID: 15599646
General Reference: PaperBLAST - Find papers about PA4450 and its homologs