| Identification |
| Name: |
S-adenosylmethionine synthase |
| Synonyms: |
- AdoMet synthase
- MAT
- Methionine adenosyltransferase
|
| Gene Name: |
metK |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in methionine adenosyltransferase activity |
| Specific Function: |
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. Is essential for growth |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
| SMPDB Reactions: |
| | |
 | + |  | + |  | → |  | + | Pyrophosphate | + | S-adenosyl-L-methionine |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
Not Available |
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | ATP binding | | binding | | catalytic activity | | methionine adenosyltransferase activity | | nucleoside binding | | purine nucleoside binding | | transferase activity | | transferase activity, transferring alkyl or aryl (other than methyl) groups | | Process |
|---|
| cellular metabolic process | | metabolic process | | one-carbon metabolic process |
|
| Gene Properties |
| Locus tag: |
PA0546 |
| Strand: |
- |
| Entrez Gene ID: |
878379 |
| Accession: |
NP_249237.1 |
| GI: |
15595743 |
| Sequence start: |
603706 |
| Sequence End: |
604896 |
| Sequence Length: |
1190 |
| Gene Sequence: |
>PA0546
ATGAGCGAATATTCCGTTTTCACCTCCGAGTCCGTGTCCGAAGGCCATCCGGACAAGATCGCGGACCAGATCTCCGACGCGGTGCTGGACGCCATCATCGCCAAGGACAAGTACGCTCGCGTGGCATGCGAAACCCTGGTCAAGACCGGCGTGGCGATCATCGCCGGTGAAGTCACCACCTCCGCCTGGGTCGACCTGGAAGAGCTGGTGCGCAAGGTCATCATCGACATCGGCTACGACAGCTCCGACGTCGGCTTCGATGGTGCCACCTGCGGCGTGCTGAACATCATCGGCAAGCAGTCGGTGGACATCAACCAGGGCGTCGACCGGGCCAAGCCGGAAGACCAGGGCGCCGGCGACCAGGGCCTGATGTTCGGCTACGCCAGCAACGAGACCGACGTGCTGATGCCGGCGCCGATCTGTTTCTCCCACCGCCTGGTCGAGCGCCAGGCCGAGGCGCGCAAGTCCGGCCTGCTGCCATGGCTGCGCCCGGACGCCAAGTCCCAGGTGACCTGCCGCTACGAAGGCGGCAAGGTGGTCGGCATCGATGCGGTGGTGCTGTCCACCCAGCACAACCCGGAAGTCTCCTATAACGACCTGCGCGACGGCGTGATGGAGCTGATCATCAAGCAGGTGCTGCCGGCCGAGCTGCTGCACAAGGACACCCAGTTCCACATCAACCCGACCGGCAACTTCGTGATCGGCGGCCCGGTCGGCGACTGCGGCCTGACCGGACGCAAGATCATCGTCGACTCCTACGGCGGCATGGCCCGCCACGGCGGCGGCGCGTTCTCCGGCAAGGACCCGTCCAAGGTCGACCGCTCCGCCGCCTACGCCGGCCGCTACGTGGCGAAGAACATCGTCGCCGCCGGCCTCGCCGAGCGTTGCGAGATCCAGGTTTCCTACGCCATCGGCGTGGCCCAGCCGACCTCGATCTCGATCAACACCTTCGGCACCGGCAAGGTCAGCGACGAGAAGATCGTGCAACTGGTCCGCGAGCACTTCGACCTGCGCCCGTACGCGATCACCAAGATGCTCGACCTGCTCCACCCGATGTACCAGCCGACCGCGGCCTACGGCCACTTCGGTCGTCATCCGTTCGAGCTGACCGTGGACGGCGATACCTTCACCGCGTTCACCTGGGAGAAGACCGACAAGGCCGCTCTCCTGCGCGACGCCGCCGGCCTCTGA |
| Protein Properties |
| Protein Residues: |
396 |
| Protein Molecular Weight: |
42.7 kDa |
| Protein Theoretical pI: |
5.15 |
| Hydropathicity (GRAVY score): |
-0.103 |
| Charge at pH 7 (predicted): |
-10.77 |
| Protein Sequence: |
>PA0546
MSEYSVFTSESVSEGHPDKIADQISDAVLDAIIAKDKYARVACETLVKTGVAIIAGEVTTSAWVDLEELVRKVIIDIGYDSSDVGFDGATCGVLNIIGKQSVDINQGVDRAKPEDQGAGDQGLMFGYASNETDVLMPAPICFSHRLVERQAEARKSGLLPWLRPDAKSQVTCRYEGGKVVGIDAVVLSTQHNPEVSYNDLRDGVMELIIKQVLPAELLHKDTQFHINPTGNFVIGGPVGDCGLTGRKIIVDSYGGMARHGGGAFSGKDPSKVDRSAAYAGRYVAKNIVAAGLAERCEIQVSYAIGVAQPTSISINTFGTGKVSDEKIVQLVREHFDLRPYAITKMLDLLHPMYQPTAAYGHFGRHPFELTVDGDTFTAFTWEKTDKAALLRDAAGL |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA0546 and its homologs
|
