Deoxyuridine 5'-triphosphate nucleotidohydrolase (PA5321)

Identification
Name: Deoxyuridine 5'-triphosphate nucleotidohydrolase
Synonyms:
  • dUTPase
  • dUTP pyrophosphatase
Gene Name: dut
Enzyme Class:
Biological Properties
General Function: Involved in hydrolase activity
Specific Function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Deoxyuridine triphosphate + Water ↔ dUMP + Hydrogen ion + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Deoxyuridine triphosphate + Water ↔ dUMP + Pyrophosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Deoxyuridine triphosphate + Water → Phosphate + Hydrogen ion + dUMP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb+Thumb
Deoxyuridine triphosphate + Water ↔ dUMP + Hydrogen ion + Pyrophosphate
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Deoxyuridine triphosphate + Water → dUMP + Pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000290Deoxyuridine triphosphateMetaboCard
PAMDB000375dUMPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
dUTP diphosphatase activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside-triphosphate diphosphatase activity
pyrophosphatase activity
Process
cellular nitrogen compound metabolic process
dUTP metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine deoxyribonucleoside triphosphate metabolic process
pyrimidine nucleoside triphosphate metabolic process
pyrimidine nucleotide metabolic process
Gene Properties
Locus tag: PA5321
Strand: +
Entrez Gene ID: 879405
Accession: NP_254008.1
GI: 15600514
Sequence start: 5990676
Sequence End: 5991131
Sequence Length: 455
Gene Sequence: 
>PA5321
ATGCACTCTCTCCAAGCCAAGATCCTCGACCCCCGCCTGGGCTCCGACTTCCCGCTCCCGCAGTACGCCACGCCGGGCTCGGCCGGCCTGGACCTGCGCGCCATGCTCAAGGAAGACAGCGTCCTCGGCCCGGGCCAGACCCTGCTGATTCCCACCGGCCTGTCCATCTACATCGCCGATCCCGGCCTCGCCGCCCTGGTCCTGCCGCGCTCCGGCCTGGGGCACAAGCACGGCATCGTGCTGGGCAACCTGGTCGGCCTGATCGACTCGGACTACCAGGGCGAGCTGATGGTGTCGTGCTGGAACCGCGGCGAGTCGCCGTTCACCATCGCCGTCGGCGAGCGCATCGCGCAGTTGGTACTGGTGCCGGTGGTGCAGGCGCATTTCGAGCTGGTCGAAGCGTTCGACGAAAGCCAGCGCGGCGCCGGCGGCTTCGGCCATTCCGGCAGCCACTGA
Protein Properties
Protein Residues: 151
Protein Molecular Weight: 15.9 kDa
Protein Theoretical pI: 5.47
Hydropathicity (GRAVY score): 0.175
Charge at pH 7 (predicted): -4.6
Protein Sequence: 
>PA5321
MHSLQAKILDPRLGSDFPLPQYATPGSAGLDLRAMLKEDSVLGPGQTLLIPTGLSIYIADPGLAALVLPRSGLGHKHGIVLGNLVGLIDSDYQGELMVSCWNRGESPFTIAVGERIAQLVLVPVVQAHFELVEAFDESQRGAGGFGHSGSH
References
External Links:
Resource Link
Genome ID: PA5321
Entrez Gene ID: 879405
NCBI Protein ID: 15600514
General Reference: PaperBLAST - Find papers about PA5321 and its homologs