UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (PA4020)

Identification
Name: UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase
Synonyms:
  • Murein peptide ligase
Gene Name: mpl
Enzyme Class: Not Available
Biological Properties
General Function: Involved in ATP binding
Specific Function: Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid
Cellular Location: Secreted
KEGG Pathways:
KEGG Reactions: Not Available
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
UDP-N-Acetylmuraminate + L-Ala-D-Glu-meso-A2pm + Adenosine triphosphate → Hydrogen ion + UDP-N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + ADP + Phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate + Adenosine triphosphate + UDP-N-Acetylmuraminate → ADP + Hydrogen ion + Phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001376L-Ala-D-Glu-meso-A2pmMetaboCard
PAMDB001648L-alanine-D-glutamate-meso-2,6-diaminoheptanedioateMetaboCard
PAMDB001647L-Alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanineMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000485UDP-N-AcetylmuraminateMetaboCard
PAMDB000650UDP-N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
ligase activity
nucleoside binding
purine nucleoside binding
Process
biosynthetic process
cellular cell wall organization
cellular component organization
cellular component organization or biogenesis
external encapsulating structure organization
metabolic process
Gene Properties
Locus tag: PA4020
Strand: -
Entrez Gene ID: 879000
Accession: NP_252709.1
GI: 15599215
Sequence start: 4498488
Sequence End: 4499843
Sequence Length: 1355
Gene Sequence: 
>PA4020
ATGCACATCCACGTACTCGGCATCTGCGGGACCTTCATGGGCTCGCTGGCCGTGCTGGCCAAGGAACTGGGCCACCGGGTGACCGGTTCCGACGCCAACGTCTACCCCCCCATGAGCACCCAGCTGCAAGCCCAGGGCATCGAGTTGATGCAGGGCTACGATCCGGCCCACCTGGAGCCGGCGCCGGACCTGGTAGTGATCGGCAACGCCCTGTCGCGCGGCAATCCGGCGGTGGAGCATGTCCTGAACAAGGGCCTGCCCTACGTTTCCGGCCCGCAGTGGCTGGCCGACCACGTGCTGCAAGGACGCTGGGTGCTGGCGGTGGCCGGTACCCACGGCAAGACCACCACCACCAGCATGCTCGCCTGGGTCCTGGAGCACGCCGGCATGAGCCCGGGCTTCCTGATCGGCGGGGTGCCGCAGAACTTCGGGGTTTCGGCGCGCCTGGGCGGTACGCCGTTCTTCGTGGTCGAGGCCGACGAGTACGACAGCGCCTTCTTCGACAAGCGCTCGAAGTTCGTCCATTACCGCCCGCGCACGGCGATCCTGAACAACCTGGAATTCGACCACGCGGATATCTTCCCCGACCTCGCGGCCATCGAGCGGCAGTTCCACCATCTGGTGCGCACCGTGCCGGGCGAGGGCCTGATCATTCGCCCGAGCGCCGAGAAAGCCCTGGAGCGCGTACTCGGGATGGGCTGCTGGACCCCGGTGCAGACCACCGGCGAAGGCGGCCAGTGGCAGGCGCGCCTGCTCGCCGAGGACGGCTCGCGCTTCGAGGTGCTGTTCGACGGCATCGTCCAGGGCGAGGTGGACTGGCCGCTGACCGGCCTGCACAACGTCGCCAACGCCCTCGCCAGCCTGGCGGCGGCGCGCCATGTCGGCGTGATGCCCAGCCAGGGCGCGGCGGCGCTCAGCGAGTTCCGCAACGTCAAGCGGCGCATGGAGAAGGTCGCGGAGGTCCGGGGCGTGACCCTCTACGACGACTTCGCCCACCATCCGACCGCCATCGCCACCACCCTCGACGGCCTGCGCAAGCAGGTTGGCGCCGATACCCAGGTGATCGCCATCGTCGAGCCGCGTTCCAACTCGATGAAGCTCGGCGCTCATCGCGACGGCCTGCCGGACAGCGTGCGCCAGGCCGACCAGGTGCTCTGGTACGCGCCGCCGAACCTGGGCTGGGACCTGGCCGCCACCGCCGCACAATGCGCGATACCGTCGCAGGTCTGCGATACCCTGGAGGCGATCATCGAGCAGGTGCGCCAGCAGGCCAGGCCCGGCGCGCAAGTGGTGATCATGAGCAACGGCGGCTTCGGCGGCTTGCACGGCAAGCTGGCCGCGGCGCTGGCCGAGTGA
Protein Properties
Protein Residues: 451
Protein Molecular Weight: 48.5 kDa
Protein Theoretical pI: 6.42
Hydropathicity (GRAVY score): -0.002
Charge at pH 7 (predicted): -5.78
Protein Sequence: 
>PA4020
MHIHVLGICGTFMGSLAVLAKELGHRVTGSDANVYPPMSTQLQAQGIELMQGYDPAHLEPAPDLVVIGNALSRGNPAVEHVLNKGLPYVSGPQWLADHVLQGRWVLAVAGTHGKTTTTSMLAWVLEHAGMSPGFLIGGVPQNFGVSARLGGTPFFVVEADEYDSAFFDKRSKFVHYRPRTAILNNLEFDHADIFPDLAAIERQFHHLVRTVPGEGLIIRPSAEKALERVLGMGCWTPVQTTGEGGQWQARLLAEDGSRFEVLFDGIVQGEVDWPLTGLHNVANALASLAAARHVGVMPSQGAAALSEFRNVKRRMEKVAEVRGVTLYDDFAHHPTAIATTLDGLRKQVGADTQVIAIVEPRSNSMKLGAHRDGLPDSVRQADQVLWYAPPNLGWDLAATAAQCAIPSQVCDTLEAIIEQVRQQARPGAQVVIMSNGGFGGLHGKLAAALAE
References
External Links:
Resource Link
Genome ID: PA4020
Entrez Gene ID: 879000
NCBI Protein ID: 15599215
General Reference: PaperBLAST - Find papers about PA4020 and its homologs