ADP (PAMDB000345)

General function:

Involved in oxidation-reduction process

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines

Gene Name:

nrdA

Locus Tag:

PA1156

Molecular weight:

107.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate. Is also able to phosphorylate the hydroxy group on gamma-carbon of L-homoserine analogs when the functional group at the alpha-position is a carboxyl, an ester, or even a hydroxymethyl group. Neither L- threonine nor L-serine are substrates of the enzyme

Gene Name:

thrB

Locus Tag:

PA5495

Molecular weight:

35.4 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)

Gene Name:

glnS

Locus Tag:

PA1794

Molecular weight:

62.9 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Locus Tag:

PA4756

Molecular weight:

117.3 kDa

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpA

Locus Tag:

PA1633

Molecular weight:

59.9 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions

Gene Name:

kdpB

Locus Tag:

PA1634

Molecular weight:

73 kDa

Reactions

General function:

Involved in potassium-transporting ATPase activity

Specific function:

One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex

Gene Name:

kdpC

Locus Tag:

PA1635

Molecular weight:

19.3 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Locus Tag:

PA0407

Molecular weight:

35.7 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex RbsABCD involved in ribose import. Responsible for energy coupling to the transport system

Gene Name:

rbsA

Locus Tag:

PA1947

Molecular weight:

55.8 kDa

Reactions

General function:

Involved in RNA binding

Specific function:

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

Gene Name:

pnp

Locus Tag:

PA4740

Molecular weight:

75.4 kDa

Reactions

General function:

Involved in bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Specific function:

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

Gene Name:

apaH

Locus Tag:

PA0590

Molecular weight:

32 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for histidine. Probably responsible for energy coupling to the transport system

Gene Name:

hisP

Locus Tag:

PA2926

Molecular weight:

28.5 kDa

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlB

Locus Tag:

PA4410

Molecular weight:

34.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D- ribosyl)imidazole

Gene Name:

purM

Locus Tag:

PA0945

Molecular weight:

37.1 kDa

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Locus Tag:

PA3111

Molecular weight:

46.5 kDa

Reactions

General function:

Involved in amino acid binding

Specific function:

ATP + L-aspartate = ADP + 4-phospho-L- aspartate

Gene Name:

lysC

Locus Tag:

PA0904

Molecular weight:

44.4 kDa

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Gene Name:

purK

Locus Tag:

PA5425

Molecular weight:

38.5 kDa

Reactions

General function:

Involved in kinase activity

Specific function:

Involved in the activation of acetate to acetyl CoA and the secretion of acetate. During anaerobic growth of the organism, this enzyme is also involved in the synthesis of most of the ATP formed catabolically

Gene Name:

ackA

Locus Tag:

PA0836

Molecular weight:

42.4 kDa

Reactions

General function:

Involved in acetylglutamate kinase activity

Specific function:

ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L- glutamate 5-phosphate

Gene Name:

argB

Locus Tag:

PA5323

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in shikimate kinase activity

Specific function:

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

Gene Name:

aroK

Locus Tag:

PA5039

Molecular weight:

19.2 kDa

Reactions

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane

Gene Name:

atpC

Locus Tag:

PA5553

Molecular weight:

14.7 kDa

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Locus Tag:

PA4758

Molecular weight:

40.8 kDa

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Key enzyme in the regulation of glycerol uptake and metabolism

Gene Name:

glpK

Locus Tag:

PA3582

Molecular weight:

56 kDa

Reactions

General function:

Involved in cytidylate kinase activity

Specific function:

ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors

Gene Name:

cmk

Locus Tag:

PA3163

Molecular weight:

24.6 kDa

Reactions

General function:

Involved in dephospho-CoA kinase activity

Specific function:

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A

Gene Name:

coaE

Locus Tag:

PA4529

Molecular weight:

22.8 kDa

Reactions

General function:

Involved in adenylylsulfate kinase activity

Specific function:

Catalyzes the synthesis of activated sulfate

Gene Name:

cysC

Locus Tag:

PA1393

Molecular weight:

22.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

ddlA

Locus Tag:

PA4201

Molecular weight:

36.5 kDa

Reactions

General function:

Involved in glucokinase activity

Specific function:

Not highly important in Pseudomonas aeruginosa as glucose is transported into the cell by the PTS system already as glucose 6-phosphate

Gene Name:

glk

Locus Tag:

PA3193

Molecular weight:

34.6 kDa

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Locus Tag:

PA5203

Molecular weight:

59.2 kDa

Reactions

General function:

Involved in thymidylate kinase activity

Specific function:

Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate (dTTP) synthesis, is essential for DNA synthesis and cellular growth

Gene Name:

tmk

Locus Tag:

PA2962

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Locus Tag:

PA3807

Molecular weight:

15.6 kDa

Reactions

General function:

Involved in phosphoglycerate kinase activity

Specific function:

ATP + 3-phospho-D-glycerate = ADP + 3-phospho- D-glyceroyl phosphate

Gene Name:

pgk

Locus Tag:

PA0552

Molecular weight:

40.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can also act in the reverse direction to form ATP in the presence of excess ADP. Can also use GTP instead of ATP; but the efficiency of GTP is 5% that of ATP

Gene Name:

ppk

Locus Tag:

PA5242

Molecular weight:

83.2 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline

Gene Name:

proB

Locus Tag:

PA4565

Molecular weight:

39.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate

Gene Name:

purC

Locus Tag:

PA1013

Molecular weight:

26.8 kDa

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Locus Tag:

PA3637

Molecular weight:

59.6 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor

Gene Name:

pyrH

Locus Tag:

PA3654

Molecular weight:

26.3 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucC

Locus Tag:

PA1588

Molecular weight:

41.5 kDa

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Locus Tag:

PA5119

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

ATP + D-ribose = ADP + D-ribose 5-phosphate

Gene Name:

rbsK

Locus Tag:

PA1950

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity

Gene Name:

accD

Locus Tag:

PA3112

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import. Responsible for energy coupling to the transport system

Gene Name:

pstB

Locus Tag:

PA5366

Molecular weight:

31 kDa

Reactions

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane

Gene Name:

atpB

Locus Tag:

PA5560

Molecular weight:

31.9 kDa

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)

Gene Name:

atpF

Locus Tag:

PA5558

Molecular weight:

16.9 kDa

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction

Gene Name:

atpH

Locus Tag:

PA5557

Molecular weight:

19.3 kDa

General function:

Involved in hydrogen ion transporting ATP synthase activity, rotational mechanism

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex

Gene Name:

atpG

Locus Tag:

PA5555

Molecular weight:

31.6 kDa

General function:

Involved in ATP binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

Gene Name:

atpA

Locus Tag:

PA5556

Molecular weight:

55.4 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits

Gene Name:

atpD

Locus Tag:

PA5554

Molecular weight:

49.5 kDa

Reactions

General function:

Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances

Specific function:

Mediates magnesium influx to the cytosol

Gene Name:

mgtA

Locus Tag:

PA4825

Molecular weight:

100.1 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

Gene Name:

accA

Locus Tag:

PA3639

Molecular weight:

34.9 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accB

Locus Tag:

PA4847

Molecular weight:

16.5 kDa

General function:

Involved in diacylglycerol kinase activity

Specific function:

Recycling of diacylglycerol produced during the turnover of membrane phospholipid

Gene Name:

dgkA

Locus Tag:

PA3603

Molecular weight:

13.1 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Locus Tag:

PA1498

Molecular weight:

51.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate

Gene Name:

cobU

Locus Tag:

PA1279

Molecular weight:

36.5 kDa

Reactions

General function:

Involved in 1-phosphofructokinase activity

Specific function:

ATP + D-fructose 1-phosphate = ADP + D- fructose 1,6-bisphosphate

Gene Name:

fruK

Locus Tag:

PA3561

Molecular weight:

33.4 kDa

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Locus Tag:

PA0935

Molecular weight:

31.2 kDa

Reactions

General function:

Involved in FMN adenylyltransferase activity

Specific function:

ATP + riboflavin = ADP + FMN

Gene Name:

ribF

Locus Tag:

PA4561

Molecular weight:

34.3 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + succinate + CoA = ADP + phosphate + succinyl-CoA

Gene Name:

sucD

Locus Tag:

PA1589

Molecular weight:

30.3 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + thiamine phosphate = ADP + thiamine diphosphate

Gene Name:

thiL

Locus Tag:

PA4051

Molecular weight:

32.9 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system (Probable). Can also transport glycerophosphoryl diesters

Gene Name:

ugpC

Locus Tag:

PA3187

Molecular weight:

42.2 kDa

Reactions

General function:

Involved in [isocitrate dehydrogenase (NADP+)] kinase activity

Specific function:

Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation

Gene Name:

aceK

Locus Tag:

PA1376

Molecular weight:

66.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein

Gene Name:

murF

Locus Tag:

PA4416

Molecular weight:

47.4 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

bioD

Locus Tag:

PA0504

Molecular weight:

23.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Involved in a multicomponent binding-protein-dependent transport system for glycine betaine/L-proline

Gene Name:

proV

Locus Tag:

PA5094

Molecular weight:

30.7 kDa

General function:

Involved in ATP binding

Specific function:

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

Gene Name:

murD

Locus Tag:

PA4414

Molecular weight:

48.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

purL

Locus Tag:

PA3763

Molecular weight:

140.6 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide

Gene Name:

purD

Locus Tag:

PA4855

Molecular weight:

45.2 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system

Gene Name:

cysA

Locus Tag:

PA0280

Molecular weight:

36.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

murC

Locus Tag:

PA4411

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in nicotinate phosphoribosyltransferase activity

Specific function:

Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate

Gene Name:

pncB

Locus Tag:

PA4919

Molecular weight:

46.1 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Locus Tag:

PA4329

Molecular weight:

52.3 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use many meso-diaminopimelate analogs as substrates, although much less efficiently, but not L-lysine

Gene Name:

murE

Locus Tag:

PA4417

Molecular weight:

51.3 kDa

Reactions

General function:

Involved in phosphoenolpyruvate carboxykinase (ATP) activity

Specific function:

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)

Gene Name:

pckA

Locus Tag:

PA5192

Molecular weight:

55.7 kDa

Reactions

General function:

Involved in glycerate kinase activity

Specific function:

ATP + (R)-glycerate = ADP + 3-phospho-(R)- glycerate

Gene Name:

garK

Locus Tag:

PA1052

Molecular weight:

38.6 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Member of the two-component regulatory system phoQ/phoP involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to phoP, which results in the expression of phoP-activated genes (PAG) and repression of phoP-repressed genes (PRG). In presence of high periplasmic Mg(2+) concentrations, acts as a protein phosphatase that dephosphorylates phospho-phoP, which results in the repression of phoP-activated genes and may lead to expression of some phoP- repressed genes. Mediates magnesium influx to the cytosol by activation of mgtA. Promotes expression of the two- component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes

Gene Name:

phoQ

Locus Tag:

PA1180

Molecular weight:

50.2 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for energy coupling to the transport system

Gene Name:

fepC

Locus Tag:

PA4158

Molecular weight:

28.6 kDa

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Locus Tag:

PA4848

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

Gene Name:

lpxK

Locus Tag:

PA2981

Molecular weight:

36.7 kDa

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. Acetylates CheY, the response regulator involved in flagellar movement and chemotaxis

Gene Name:

acs

Locus Tag:

PA0887

Molecular weight:

71.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Locus Tag:

PA1920

Molecular weight:

76.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes two reactions:the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR; the second, a side reaction, is the production of acetyl phosphate and ADP from acetate and ATP

Gene Name:

purT

Locus Tag:

PA3751

Molecular weight:

42.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

Gene Name:

ccmA

Locus Tag:

PA1475

Molecular weight:

25 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate

Gene Name:

arcC

Locus Tag:

PA5173

Molecular weight:

33.1 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage

Gene Name:

fliI

Locus Tag:

PA1104

Molecular weight:

48.6 kDa

Reactions

General function:

Involved in protein binding

Specific function:

Essential for recycling GMP and indirectly, cGMP

Gene Name:

gmk

Locus Tag:

PA5336

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. Phosphorylates isopentenyl phosphate at low rates. Also acts on isopentenol, and, much less efficiently, dimethylallyl alcohol. Dimethylallyl monophosphate does not serve as a substrate

Gene Name:

ispE

Locus Tag:

PA4669

Molecular weight:

30.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system

Gene Name:

malK

Locus Tag:

PA2341

Molecular weight:

40.2 kDa

Reactions

General function:

Involved in hydrogen ion transmembrane transporter activity

Specific function:

Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of 10 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits

Gene Name:

atpE

Locus Tag:

PA5559

Molecular weight:

8.6 kDa

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Locus Tag:

PA3686

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system

Gene Name:

potA

Locus Tag:

PA3607

Molecular weight:

40 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis

Gene Name:

nrdB

Locus Tag:

PA1155

Molecular weight:

47.4 kDa

Reactions

General function:

Involved in phosphomethylpyrimidine kinase activity

Specific function:

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine

Gene Name:

thiD

Locus Tag:

PA3975

Molecular weight:

28 kDa

Reactions

General function:

Involved in pyridoxal kinase activity

Specific function:

Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine, but has negligible activity toward pyridoxal and pyridoxine as substrates

Gene Name:

pdxY

Locus Tag:

PA5516

Molecular weight:

31.3 kDa

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core

Gene Name:

rfaP

Locus Tag:

PA5009

Molecular weight:

31.3 kDa

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

Heptose transfer to the lipopolysaccharide core. It transfers the innnermost heptose to [4'-P](3-deoxy-D-manno- octulosonic acid)2-IVA

Gene Name:

rfaC

Locus Tag:

PA5011

Molecular weight:

39.7 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

pstA

Locus Tag:

PA5367

Molecular weight:

61.2 kDa

General function:

Involved in lipopolysaccharide transport

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptG

Locus Tag:

PA3827

Molecular weight:

39.2 kDa

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

cysW

Locus Tag:

PA0281

Molecular weight:

31.3 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

dppB

Locus Tag:

PA4503

Molecular weight:

37 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for dipeptides; probably responsible for the translocation of the substrate across the membrane

Gene Name:

dppC

Locus Tag:

PA4504

Molecular weight:

32.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltJ

Locus Tag:

PA1341

Molecular weight:

27.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltK

Locus Tag:

PA1340

Molecular weight:

24.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane

Gene Name:

hisM

Locus Tag:

PA2925

Molecular weight:

26.7 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livH

Locus Tag:

PA1073

Molecular weight:

32.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane

Gene Name:

modB

Locus Tag:

PA1862

Molecular weight:

24.4 kDa

General function:

Involved in lipopolysaccharide-transporting ATPase acti

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptF

Locus Tag:

PA3828

Molecular weight:

41.3 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine

Gene Name:

potB

Locus Tag:

PA3608

Molecular weight:

32.7 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine

Gene Name:

potC

Locus Tag:

PA3609

Molecular weight:

27.7 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine

Gene Name:

potI

Locus Tag:

PA0304

Molecular weight:

31.9 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

pstC

Locus Tag:

PA5368

Molecular weight:

73.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ribose. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

rbsC

Locus Tag:

PA1948

Molecular weight:

34 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livM

Locus Tag:

PA1072

Molecular weight:

45.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

fepD

Locus Tag:

PA4160

Molecular weight:

34.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for ferric enterobactin. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

fepG

Locus Tag:

PA4161

Molecular weight:

34.8 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine

Gene Name:

potH

Locus Tag:

PA0303

Molecular weight:

32.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane

Gene Name:

hisQ

Locus Tag:

PA2924

Molecular weight:

24.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation

Gene Name:

msbA

Locus Tag:

PA4997

Molecular weight:

66.4 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for aliphatic sulfonates. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

ssuC

Locus Tag:

PA3443

Molecular weight:

28.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for taurine. Probably responsible for the translocation of the substrate across the membrane

Gene Name:

tauC

Locus Tag:

PA3936

Molecular weight:

29.4 kDa

General function:

Involved in phosphotransferase activity, alcohol group as acceptor

Specific function:

Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose

Gene Name:

hldE

Locus Tag:

PA4996

Molecular weight:

50.3 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

This protein specifically binds sulfate and is involved in its transmembrane transport

Gene Name:

sbp

Locus Tag:

PA0283

Molecular weight:

36.4 kDa

General function:

Involved in GTP binding

Specific function:

GTP-driven Fe(2+) uptake system

Gene Name:

feoB

Locus Tag:

PA4358

Molecular weight:

82.5 kDa

General function:

Involved in binding

Specific function:

Binds ferrienterobactin; part of the binding-protein- dependent transport system for uptake of ferrienterobactin

Gene Name:

fepB

Locus Tag:

PA4159

Molecular weight:

32.1 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system

Gene Name:

znuC

Locus Tag:

PA5500

Molecular weight:

29.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system

Gene Name:

dppD

Locus Tag:

PA4505

Molecular weight:

35.4 kDa

General function:

Involved in protein complex assembly

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmC

Locus Tag:

PA1477

Molecular weight:

28.3 kDa

General function:

Involved in transporter activity

Specific function:

Part of the ABC transporter complex cysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. This protein specifically binds thiosulfate and is involved in its transmembrane transport

Gene Name:

cysP

Locus Tag:

PA1493

Molecular weight:

36.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex lptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system

Gene Name:

lptB

Locus Tag:

PA4461

Molecular weight:

26.5 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system

Gene Name:

dppF

Locus Tag:

PA4506

Molecular weight:

36.3 kDa

General function:

Involved in phosphate ion binding

Specific function:

Part of the ABC transporter complex pstSACB involved in phosphate import

Gene Name:

pstS

Locus Tag:

PA5369

Molecular weight:

34.5 kDa

General function:

Involved in heme transporter activity

Specific function:

Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes

Gene Name:

ccmB

Locus Tag:

PA1476

Molecular weight:

23.4 kDa

General function:

Involved in lipopolysaccharide transmembrane transporter activity

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane

Gene Name:

lptC

Locus Tag:

PA4459

Molecular weight:

21.4 kDa

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Locus Tag:

PA3533

Molecular weight:

11.8 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system

Gene Name:

gltL

Locus Tag:

PA1339

Molecular weight:

26.9 kDa

General function:

Involved in lipopolysaccharide binding

Specific function:

Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. May act as a chaperone that facilitates LPS transfer across the aquaeous environment of the periplasm. Interacts specifically with the lipid A domain of LPS

Gene Name:

lptA

Locus Tag:

PA0005

Molecular weight:

28.7 kDa

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the high-affinity D-ribose membrane transport system and also serves as the primary chemoreceptor for chemotaxis

Gene Name:

rbsB

Locus Tag:

PA1946

Molecular weight:

33.9 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livG

Locus Tag:

PA1071

Molecular weight:

28.3 kDa

General function:

Involved in transporter activity

Specific function:

Component of the high-affinity histidine permease, a binding-protein-dependent transport system. The other components are proteins hisQ, hisM, and hisP

Gene Name:

hisJ

Locus Tag:

PA2923

Molecular weight:

28.2 kDa

General function:

Energy production and conversion

Specific function:

A possible function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex

Gene Name:

atpI

Locus Tag:

PA5561

Molecular weight:

13.7 kDa

General function:

Involved in arsenite transmembrane transporter activity

Specific function:

Involved in arsenical resistance. Thought to form the channel of an arsenite pump

Gene Name:

arsB

Locus Tag:

PA2278

Molecular weight:

45.1 kDa

General function:

Involved in ATP binding

Specific function:

Involved in the high-affinity zinc uptake transport system

Gene Name:

znuB

Locus Tag:

PA5501

Molecular weight:

27.3 kDa

General function:

Involved in protein-heme linkage

Specific function:

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

Gene Name:

ccmE

Locus Tag:

PA1479

Molecular weight:

17.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livF

Locus Tag:

PA1070

Molecular weight:

25.6 kDa

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Locus Tag:

PA5129

Molecular weight:

9.2 kDa

General function:

Involved in transporter activity

Specific function:

Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis

Gene Name:

dppA

Locus Tag:

PA4496

Molecular weight:

60.1 kDa

General function:

Not Available

Specific function:

Specific function unknown

Gene Name:

kdpF

Locus Tag:

PA1632

Molecular weight:

3.2 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system

Gene Name:

tauB

Locus Tag:

PA3937

Molecular weight:

28.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system

Gene Name:

modC

Locus Tag:

PA1861

Molecular weight:

39.8 kDa

Reactions

General function:

Involved in metal ion binding

Specific function:

Involved in the high-affinity zinc uptake transport system

Gene Name:

znuA

Locus Tag:

PA5498

Molecular weight:

33.6 kDa

General function:

Amino acid transport and metabolism

Specific function:

Part of the binding-protein-dependent transport system for putrescine. Probably responsible for energy coupling to the transport system

Gene Name:

potG

Locus Tag:

PA0302

Molecular weight:

42.8 kDa

General function:

Involved in transporter activity

Specific function:

Part of a binding-protein-dependent transport system for taurine

Gene Name:

tauA

Locus Tag:

PA3938

Molecular weight:

35.9 kDa

General function:

Involved in nucleotide binding

Specific function:

Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system (Probable)

Gene Name:

ssuB

Locus Tag:

PA3442

Molecular weight:

29.8 kDa

General function:

Involved in electron carrier activity

Specific function:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

Gene Name:

trxA

Locus Tag:

PA5240

Molecular weight:

11.9 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate

Gene Name:

gltI

Locus Tag:

PA1342

Molecular weight:

33.1 kDa

General function:

Involved in amino acid transport

Specific function:

This protein is a component of the leucine-specific transport system, which is one of the two periplasmic binding protein-dependent transport systems of the high-affinity transport of the branched-chain amino acids in Pseudomonas aeruginosa

Gene Name:

livK

Locus Tag:

PA1074

Molecular weight:

39.8 kDa

General function:

Involved in ATP binding

Specific function:

Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N-acetylmuramic acid

Gene Name:

mpl

Locus Tag:

PA4020

Molecular weight:

48.5 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine. Polyamine binding protein

Gene Name:

potF

Locus Tag:

PA1410

Molecular weight:

40.5 kDa

General function:

Involved in transporter activity

Specific function:

Required for the activity of the bacterial periplasmic transport system of putrescine and spermidine. Polyamine binding protein

Gene Name:

potD

Locus Tag:

PA3610

Molecular weight:

39.3 kDa

General function:

Involved in molybdate transmembrane-transporting ATPase activity

Specific function:

Involved in the transport of molybdenum into the cell. Binds molybdate with high specificity and affinity

Gene Name:

modA

Locus Tag:

PA1863

Molecular weight:

26.4 kDa

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system ArcB/ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576

Gene Name:

arcB

Locus Tag:

PA5172

Molecular weight:

38.1 kDa

Reactions

General function:

Cell motility

Specific function:

Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY

Gene Name:

cheA

Locus Tag:

PA0178

Molecular weight:

68.9 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system creC/creB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates creB in response to environmental signals. CreC can also phosphorylate phoB

Gene Name:

creC

Locus Tag:

PA0464

Molecular weight:

52.3 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Has a helix-destabilizing activity, which is not coupled to the ATPase activity. Can unwind the 23S rRNA as well as 16S rRNA. Exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA. Could play a major role in ribosome assembly, specifically in the assembly process of the active center of 50S ribosomal subunits

Gene Name:

dbpA

Locus Tag:

PA0455

Molecular weight:

49.8 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with dnaC protein, primase, and other prepriming proteins

Gene Name:

dnaB

Locus Tag:

PA4931

Molecular weight:

51.6 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals

Gene Name:

kdpD

Locus Tag:

PA1636

Molecular weight:

97 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Acts as a sensor for nitrate/nitrite and transduces signal of nitrate availability to the narL protein and of both nitrate/nitrite to the narP protein. NarX probably activates narL and narP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling narL activity, probably through dephosphorylation in the absence of nitrate

Gene Name:

narX

Locus Tag:

PA3878

Molecular weight:

69.3 kDa

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Part of the ABC transporter complex PhnCDE involved in phosphonates, phosphate esters, phosphite and phosphate import. Responsible for energy coupling to the transport system

Gene Name:

phnC

Locus Tag:

PA3384

Molecular weight:

30.3 kDa

Reactions

General function:

Signal transduction mechanisms

Specific function:

Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals

Gene Name:

phoR

Locus Tag:

PA5361

Molecular weight:

50.1 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Critical role in recombination and DNA repair. Help process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3' to 5' polarity. recG unwind branched duplex DNA (Y-DNA). Has a role in constitutive stable DNA replication (csdR) and R-loop formation

Gene Name:

recG

Locus Tag:

PA5345

Molecular weight:

76.2 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase

Gene Name:

recQ

Locus Tag:

PA3344

Molecular weight:

79.4 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction

Gene Name:

rep

Locus Tag:

PA5296

Molecular weight:

77 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Can carry out ATP-dependent unwinding of double stranded RNA. Has a role in RNA decay. Involved in the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation

Gene Name:

rhlB

Locus Tag:

PA3478

Molecular weight:

47.1 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Acts as an ATP-dependent RNA helicase, able to unwind ds-RNA

Gene Name:

rhlE

Locus Tag:

PA0428

Molecular weight:

70.1 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of ruvB. Binds both single- and double-stranded DNA (dsDNA). Binds preferentially to supercoiled rather than to relaxed dsDNA

Gene Name:

ruvA

Locus Tag:

PA0966

Molecular weight:

21.9 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

The ruvA-ruvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing

Gene Name:

ruvB

Locus Tag:

PA0967

Molecular weight:

38.9 kDa

Reactions

General function:

Replication, recombination and repair

Specific function:

Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair

Gene Name:

uvrD

Locus Tag:

PA5443

Molecular weight:

81.5 kDa

Reactions