Bifunctional adenosylcobalamin biosynthesis protein cobU (PA1279)

Identification
Name: Bifunctional adenosylcobalamin biosynthesis protein cobU
Synonyms:
  • Adenosylcobinamide kinase
  • Adenosylcobinamide-phosphate guanylyltransferase
Gene Name: cobU
Enzyme Class:
Biological Properties
General Function: Involved in nucleotide binding
Specific Function: ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Adenosyl cobinamide + Adenosine triphosphate → Adenosyl cobinamide phosphate + ADP + Hydrogen ion
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Thumb+Thumb+Thumb → Thumb+Thumb
Adenosyl cobinamide phosphate + Guanosine triphosphate + Hydrogen ion → Adenosylcobinamide-GDP + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosyl cobinamide + Adenosine triphosphate ↔ Adenosyl cobinamide phosphate + ADP
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Thumb+Thumb ↔ Thumb+Thumb
Adenosyl cobinamide phosphate + Guanosine triphosphate ↔ Adenosylcobinamide-GDP + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosyl cobinamide + Guanosine triphosphate ↔ Adenosyl cobinamide phosphate + Guanosine diphosphate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Guanosine triphosphate + Adenosyl cobinamide ↔ Adenosyl cobinamide phosphate + ADP + Guanosine diphosphate
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SMPDB Reactions:
Adenosyl cobinamide+Thumb+Thumb → Adenosine diphosphate+Thumb+adenosylcobinamide phosphate+Thumb
Adenosyl cobinamide + Adenosine triphosphate + Adenosyl cobinamide → Adenosine diphosphate + Hydrogen ion + adenosylcobinamide phosphate + ADP
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adenosylcobinamide phosphate+Thumb+Thumb → Pyrophosphate+Adenosylcobinamide-GDP+Thumb
adenosylcobinamide phosphate + Guanosine triphosphate + Hydrogen ion → Pyrophosphate + Adenosylcobinamide-GDP + Adenosylcobinamide-GDP
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Adenosyl cobinamide + Adenosine triphosphate → Adenosyl cobinamide phosphate + ADP + Hydrogen ion
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Thumb+Thumb+Thumb → Thumb+Thumb
Adenosyl cobinamide phosphate + Guanosine triphosphate + Hydrogen ion → Adenosylcobinamide-GDP + Pyrophosphate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000706Adenosyl cobinamideMetaboCard
PAMDB000825Adenosyl cobinamide phosphateMetaboCard
PAMDB000826Adenosylcobinamide-GDPMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000296Guanosine diphosphateMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
adenosylcobinamide kinase activity
binding
catalytic activity
guanylyltransferase activity
kinase activity
nucleotide binding
nucleotidyltransferase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
biosynthetic process
cellular biosynthetic process
cofactor biosynthetic process
metabolic process
Gene Properties
Locus tag: PA1279
Strand: +
Entrez Gene ID: 881425
Accession: NP_249970.1
GI: 15596476
Sequence start: 1390225
Sequence End: 1391280
Sequence Length: 1055
Gene Sequence: 
>PA1279
ATGAGTCTGCAATGGTGGCGCGACACCTGCCGCGAGGCGGACCCGCAGATGCGCCGGCGCGCGGCCGAACGCCAGGACCGGTTGACCAAGCCGCGCGGCTCGCTGGGCCGCCTGGAGCAAGTGGCGATCGACCTGGCGGCGTTGCAGGGGCGCGAACGACCGAGCCTGGAGAGGATCTGGGTGACGGTCTTCGCCGGCGACCACGGGGTAGTCGCCGAGGGCATCTCGGCCTATCCGCAGGCGGTCACCGGCGAGATGCTGCGCAACTTCGTCCGCGGCGGCGCGGCGATCAGCGTGCTGGCGCGCGAACTCGGCGCCGGCCTGGAGGTGGTCGACCTGGGCACCGCGTTCCCCCTGGAAGCCTTGCCCGGCGTGCGTCACCTGCGCCTGGCGGCGGGCACCGCGAACTTCGTCGAGGCCCCGGCGATGGGCGCCGAAGAGTGCCTGCTGGCGCTCGAGGCCGGGCGCGAAAGCGTGCGCCGCGCCGAGCAGGCCGGCAGCCAGCTGTTCATCGGCGGCGAGATGGGCATCGGCAATACCACCGCGGCGGCGGCCATGGCCTGCGCGCTGCTGGATGCGCCGGCGAGCGCGCTGGTCGGGCCGGGAACCGGGCTGGACGCCAGCGGCGTGGCGCACAAGGCCGCGGTGATCGAGCGTGCCCTGGCCCTGCACGGCGCCCATCGCGCCGACCCCTTCGAAACCCTCCGCCGTCTCGGTGGCCTGGAGATCGCCGCGCTGGCCGGCGCCTACCTGGCCTGCGCGCAGAAAGGCATGGTCGCCCTGGTCGACGGCTACATCTGCAGCGTCGCGGCGCTCTGCGCGGTGCGCCTGAACCCGGCCTGCCGCGACTGGCTGCTGTTCGCCCACAGCGGTGCCGAGCCGGGCCATCGCCATGTGCTCGAAGCCCTGGCGGCGCAACCGCTGCTCGACCTCGGCCTGCGCCTGGGCGAGGGCAGCGGCGCGGCGCTGGCGGTGCCGCTGCTGCGCCAGGCCTGCGCGCTGCACGCGGGGATGGCGACCTTCGCCGAAGCGGCGGTCTCGGACCGCCCGGCATGA
Protein Properties
Protein Residues: 351
Protein Molecular Weight: 36.5 kDa
Protein Theoretical pI: 6.6
Hydropathicity (GRAVY score): 0.219
Charge at pH 7 (predicted): -2.07
Protein Sequence: 
>PA1279
MSLQWWRDTCREADPQMRRRAAERQDRLTKPRGSLGRLEQVAIDLAALQGRERPSLERIWVTVFAGDHGVVAEGISAYPQAVTGEMLRNFVRGGAAISVLARELGAGLEVVDLGTAFPLEALPGVRHLRLAAGTANFVEAPAMGAEECLLALEAGRESVRRAEQAGSQLFIGGEMGIGNTTAAAAMACALLDAPASALVGPGTGLDASGVAHKAAVIERALALHGAHRADPFETLRRLGGLEIAALAGAYLACAQKGMVALVDGYICSVAALCAVRLNPACRDWLLFAHSGAEPGHRHVLEALAAQPLLDLGLRLGEGSGAALAVPLLRQACALHAGMATFAEAAVSDRPA
References
External Links:
Resource Link
Genome ID: PA1279
Entrez Gene ID: 881425
NCBI Protein ID: 15596476
General Reference: PaperBLAST - Find papers about PA1279 and its homologs