Guanosine triphosphate (PAMDB000319)

General function:

Involved in adenylate cyclase activity

Specific function:

ATP = 3',5'-cyclic AMP + diphosphate

Gene Name:

cyaA

Locus Tag:

PA5272

Molecular weight:

108.7 kDa

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Locus Tag:

PA3807

Molecular weight:

15.6 kDa

Reactions

General function:

Involved in adenylosuccinate synthase activity

Specific function:

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

Gene Name:

purA

Locus Tag:

PA4938

Molecular weight:

46.8 kDa

Reactions

General function:

Involved in GTP cyclohydrolase II activity

Specific function:

Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate

Gene Name:

ribA

Locus Tag:

PA4047

Molecular weight:

22.1 kDa

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme

Gene Name:

rpoA

Locus Tag:

PA4238

Molecular weight:

36.6 kDa

Reactions

General function:

Involved in DNA-directed RNA polymerase activity

Specific function:

Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits

Gene Name:

rpoZ

Locus Tag:

PA5337

Molecular weight:

9.8 kDa

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoC

Locus Tag:

PA4269

Molecular weight:

154.4 kDa

Reactions

General function:

Involved in DNA binding

Specific function:

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates

Gene Name:

rpoB

Locus Tag:

PA4270

Molecular weight:

150.8 kDa

Reactions

General function:

Involved in [formate-C-acetyltransferase]-activating enzyme activity

Specific function:

Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine

Gene Name:

nrdG

Locus Tag:

PA1919

Molecular weight:

25.7 kDa

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Locus Tag:

PA1498

Molecular weight:

51.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate

Gene Name:

cobU

Locus Tag:

PA1279

Molecular weight:

36.5 kDa

Reactions

General function:

Involved in nucleoside-triphosphate diphosphatase activity

Specific function:

Specific function unknown

Gene Name:

mazG

Locus Tag:

PA0935

Molecular weight:

31.2 kDa

Reactions

General function:

Involved in amino acid binding

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp

Gene Name:

relA

Locus Tag:

PA0934

Molecular weight:

83.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it

Gene Name:

spoT

Locus Tag:

PA5338

Molecular weight:

78.9 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs

Gene Name:

dgt

Locus Tag:

PA1124

Molecular weight:

56.7 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + sulfate = diphosphate + adenylyl sulfate

Gene Name:

cysD

Locus Tag:

PA4443

Molecular weight:

35.5 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Locus Tag:

PA4329

Molecular weight:

52.3 kDa

Reactions

General function:

Involved in GTPase activity

Specific function:

May be the GTPase, regulating ATP sulfurylase activity

Gene Name:

cysN

Locus Tag:

PA4442

Molecular weight:

69.3 kDa

Reactions

General function:

Involved in nucleotidyltransferase activity

Specific function:

Involved in the biosynthesis of the capsular polysaccharide colanic acid

Gene Name:

manC

Locus Tag:

PA3551

Molecular weight:

53.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Locus Tag:

PA1920

Molecular weight:

76.1 kDa

Reactions

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

Gene Name:

rdgB

Locus Tag:

PA0387

Molecular weight:

21.2 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Locus Tag:

PA3686

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Links a guanosine 5'-phosphate to molydopterin (MPT) forming molybdopterin guanine dinucleotide (MGD)

Gene Name:

mobA

Locus Tag:

PA3030

Molecular weight:

21.9 kDa

Reactions

General function:

Involved in Mo-molybdopterin cofactor biosynthetic process

Specific function:

Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

Gene Name:

moaC

Locus Tag:

PA3918

Molecular weight:

17.3 kDa

General function:

Replication, recombination and repair

Specific function:

Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate

Gene Name:

mutT

Locus Tag:

PA4400

Molecular weight:

34 kDa

Reactions