Nucleoside-triphosphatase rdgB (PA0387)

Identification
Name: Nucleoside-triphosphatase rdgB
Synonyms:
  • Nucleoside triphosphate phosphohydrolase
  • NTPase
Gene Name: rdgB
Enzyme Class:
Biological Properties
General Function: Involved in hydrolase activity
Specific Function: Hydrolyzes O6 atom-containing purine bases deoxyinosine triphosphate (dITP) and xanthosine triphosphate (XTP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) to nucleotide monophosphate and pyrophosphate. Probably excludes non- standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions
Cellular Location: Cytoplasmic
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Guanosine triphosphate + Water → Guanosine monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
dGTP + Water → 2'-Deoxyguanosine 5'-monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Deoxyuridine triphosphate + Water ↔ dUMP + Hydrogen ion + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Uridine triphosphate → Hydrogen ion + Pyrophosphate + Uridine 5'-monophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Inosine triphosphate → Hydrogen ion + Inosinic acid + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Xanthosine 5-triphosphate → Hydrogen ion + Pyrophosphate + Xanthylic acid
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Thumb+Thumb → Thumb+Thumb+Thumb
2'-Deoxyinosine triphosphate + Water → DIMP + Hydrogen ion + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Guanosine triphosphate + Water ↔ Guanosine monophosphate + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Uridine triphosphate + Water ↔ Uridine 5'-monophosphate + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Inosine triphosphate + Water ↔ Inosinic acid + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
dGTP + Water ↔ 2'-Deoxyguanosine 5'-monophosphate + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Deoxyuridine triphosphate + Water ↔ dUMP + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Xanthosine 5-triphosphate + Water ↔ Xanthylic acid + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
2'-Deoxyinosine triphosphate + Water ↔ DIMP + Pyrophosphate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Xanthosine 5-triphosphate + Water + 2'-Deoxyinosine triphosphate ↔ Xanthylic acid + Pyrophosphate + DIMP
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Nucleoside triphosphate+Thumb ↔ NDP+Thumb
Nucleoside triphosphate + Water ↔ NDP + Phosphate
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SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
dGTP + Water → 2'-Deoxyguanosine 5'-monophosphate + Hydrogen ion + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Deoxyuridine triphosphate + Water ↔ dUMP + Hydrogen ion + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Inosine triphosphate → Hydrogen ion + Inosinic acid + Pyrophosphate
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Thumb+Thumb → Thumb+Thumb+Thumb
Water + Xanthosine 5-triphosphate → Hydrogen ion + Pyrophosphate + Xanthylic acid
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Thumb+Thumb → Thumb+Thumb+Thumb
2'-Deoxyinosine triphosphate + Water → DIMP + Hydrogen ion + Pyrophosphate
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Complex Reactions:
A nucleoside triphosphate+Thumb → a nucleotide+Thumb
A nucleoside triphosphate + Water → a nucleotide + Pyrophosphate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002312'-Deoxyguanosine 5'-monophosphateMetaboCard
PAMDB0005932'-Deoxyinosine triphosphateMetaboCard
PAMDB000290Deoxyuridine triphosphateMetaboCard
PAMDB000389dGTPMetaboCard
PAMDB000681DIMPMetaboCard
PAMDB000375dUMPMetaboCard
PAMDB000369Guanosine monophosphateMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000078Inosine triphosphateMetaboCard
PAMDB000601Inosinic acidMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000118Uridine 5'-monophosphateMetaboCard
PAMDB000117Uridine triphosphateMetaboCard
PAMDB000142WaterMetaboCard
PAMDB000122Xanthosine 5-triphosphateMetaboCard
PAMDB000419Xanthylic acidMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
nucleoside-triphosphatase activity
pyrophosphatase activity
Gene Properties
Locus tag: PA0387
Strand: -
Entrez Gene ID: 878675
Accession: NP_249078.1
GI: 15595584
Sequence start: 428861
Sequence End: 429454
Sequence Length: 593
Gene Sequence: 
>PA0387
ATGATCAAGCTCGAACAGCTGGTGCTGGCCAGCCACAATGCCGGCAAACTCAAGGAACTCCAGGCCATGCTCGGCGCCAGCGTGAAGGTGCGCTCGATCGGCGAGTTCAGCCAGGTGGAACCGGAGGAAACCGGTCTTTCCTTCGTCGAGAACGCCATCCTCAAGGCACGCAACGCCGCACGCCTCTCCGGCCTGCCGGCGCTGGCCGACGACTCCGGGCTGGCGGTGGACTTCCTCGGCGGCGCGCCGGGCATCTACTCGGCGCGCTATGCCGACGGCCGGGGCGACGCGGCGAACAACGCCAAGCTGCTGGAGGCCATGAAGGATGTCCCGGACGCCGAGCGCGGCGCACAGTTCGTCAGCGTGCTGGCGCTGGTGCGCCACGCCGACGACCCGCTGCCGATCCTCTGCGAGGGCATCTGGGAAGGCCGCATCCTCCGCGAAGCCCGCGGCGCCCACGGCTTCGGCTACGACCCGCTGTTCTGGGTGCCGGAACGCGACTGCTCCAGCGCCGAGCTGGCGCCCGAGGAGAAGAACCGCCTCAGCCACCGAGCCCGCGCCATGGCCCTGCTCAAGCAGCGCCTGGGTCTCTGA
Protein Properties
Protein Residues: 197
Protein Molecular Weight: 21.2 kDa
Protein Theoretical pI: 6.13
Hydropathicity (GRAVY score): -0.122
Charge at pH 7 (predicted): -2.1
Protein Sequence: 
>PA0387
MIKLEQLVLASHNAGKLKELQAMLGASVKVRSIGEFSQVEPEETGLSFVENAILKARNAARLSGLPALADDSGLAVDFLGGAPGIYSARYADGRGDAANNAKLLEAMKDVPDAERGAQFVSVLALVRHADDPLPILCEGIWEGRILREARGAHGFGYDPLFWVPERDCSSAELAPEEKNRLSHRARAMALLKQRLGL
References
External Links:
Resource Link
Genome ID: PA0387
Entrez Gene ID: 878675
NCBI Protein ID: 15595584
General Reference: PaperBLAST - Find papers about PA0387 and its homologs