Adenylate cyclase (PA5272)

Identification
Name: Adenylate cyclase
Synonyms:
  • ATP pyrophosphate-lyase
  • Adenylyl cyclase
Gene Name: cyaA
Enzyme Class:
Biological Properties
General Function: Involved in adenylate cyclase activity
Specific Function: ATP = 3',5'-cyclic AMP + diphosphate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
Adenosine triphosphate ↔ Cyclic AMP + Pyrophosphate
ReactionCard
Thumb ↔ Thumb+Thumb
Guanosine triphosphate ↔ Cyclic GMP + Pyrophosphate
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
Adenosine triphosphate ↔ Cyclic AMP + Pyrophosphate
ReactionCard
Thumb ↔ Thumb+Thumb
Guanosine triphosphate ↔ Cyclic GMP + Pyrophosphate
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
Adenosine triphosphate → Cyclic AMP + Pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000020Cyclic AMPMetaboCard
PAMDB000570Cyclic GMPMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
GO Classification:
Function
adenylate cyclase activity
catalytic activity
cyclase activity
Process
cAMP biosynthetic process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
Gene Properties
Locus tag: PA5272
Strand: +
Entrez Gene ID: 877744
Accession: NP_253959.1
GI: 15600465
Sequence start: 5936370
Sequence End: 5939222
Sequence Length: 2852
Gene Sequence: 
>PA5272
ATGAACCGACACCCCGCACTCAGCCTCGATCTCGACGATGGCATCGACCGCAAGGTCCTCGGCCAGTTGCGCCAACGCTTCCTGGCGGTCAATGCCGGTCGCCTGCAACGCGCCCGGCAGGCGTTGTCCAGCCGCCAGGAGCGGGTCCTGCGCCTGCTACCGCTGCTGTTCCACATCAACCATCCGCTGCTGCCGGGCTACCTGTCGGCCAGCACGCCAGCGGGCCTGAGCGGTTTCGAAGCGGACGACGAAGTACTCGCCGAAGCCCAGCGCCTGGCCCGCTCGTTTGTCTACAAGCCACGCAGGCAAGAACCCGCACAGCAGCCGATCCACGGCCTGTTCCTGATGGGCAGCCTGGGGAGCCTGGCCCAGGAGGAACAGAGCGATCTCGACCTCTGGGTCTGCCATGCCCCAGAACTGGAGCCCGGCGCGCGCCAGGAGCTGCGCCGCAAGTGCGCGTTGATCGAGGACTGGGCGCGCAGCCAGGGCAGCGAGGTGCACTGTTTCCTGATCGACGTCGCCCGCTTCGGCCAGGACGAACGCGAAGACCGGAAGGAGCCCGGCGGCGACGGCAATACCCAGCACTTCCTGCTGCTCGACGAGTTCTACCGCAGCGCGATCTGGCTCGGCGGACGCACCCCTCTGTGGTGGCTGGTGCCGCCGGCCCATGAACGGCGCTACGACGAATACTGCCGGACCCTGCTCGGCAAACGCTTCATCCGCGCCGAAGAGGTGCTCGACCTCGGCCACCTGGCGCACATCCCCGCCCGGGAGTTCATCGGCGCCGGCCTCTGGCAGTTGTCCAAGGCCATCGATTCGCCCTACAAGTCGCTGCTCAAGCTGCTGCTCACCGAGGCCTACGCCAGCGAGCACCCGCGGGTCCGCTGCGTCGCCCTGCGCTTCAAGGAGCAGGTATTCGCCGGCCAGCTCGATCTCGACGAACTGGACCCCTACGTCCTGGTCTATCGCCATCTCGAACGCTACCTGCGGGAACAGCAGGCGCCGGAACGCCTGGAACTCGTGCGGCGCTGCCTGTACCTCAAGGTCGGGCGCAAGCTCGGCGGTCGCCAGCGCCAGGCGCAGAAGGGCTGGCAGCACCTGTCGATGGAGCGGCTCGTCGCGGAATGGCAATGGGAGCCTCGCCGCTTGGCCCTGCTCGACAGCCGCAGCCAGTGGAAGATGCGCCAGGTGATGGAAGAGCGTCGCACGGTGGTCAACGAACTGACCTACAGCTACCGCCTGCTGTTCCAGATCGCCCGCCAGCAAGGCGCTGACAGCGGCATCGACAGCCGCGACCTGGGCCTGCTCGGCCGCCGCCTGTATGCAGCCTTCGAGCGCAAGGCAGGCAAGGTGGAAAACATCAACCCGGGGATCGCCCCGGATCTCGGCGAAGACGTCCTGACCCTGGTCCAGCTGCCCGCCGACGACGGCCGCGAGCAGGCGCAGTGGGCGATCTTCCCCGGTGCCCTGGGCGCTCACCAGTGGCCTGACTACGCGCCGCTGAAACGCAGCCTCAGGCTGGTCGAGCTGCTCGCCTGGTGCCATCGCAACGGCGTCATCGACAGCGCCACCCGGCTGTCCCTGCATCCCGGCCAGAGCGACCTCGGCGATGCCGAACTGGACAATCTCCTGGGCAGCCTGCGGCAGTTCCTGCCGGTCCCCCTGGCGACCGTGGACGACGCCGACCTGCTGCAACCGCGTCGGCTCAAGAGCGTCCTGCTGCTGGTCAACGTCGGTGTCGACCCGCTGCGCCACCACAGCCAGATGAACCTGCACATGGCTACCGGGCGTACCGACGTGCTTGGTTATGCCGGGGTGCGCGACAACCTGGTGCTGACCCTCGACCAGCTCAGCCTCAACAGCTGGAACGAACTGACGGTGCGCCATTACGCAGGCCCCCAGGCGCTGCCCGAGTGCCTTGCCGAGTTCCTCGACGCCGTCCGCGAAAAGCCCGGAAGCCCGCCGCAGCCGCCTGAACTGATGGTGCGCTGCTTCTGTCGCAACCGGGCCGCCGCCATCGCCGTGCGGGTCGAAGAGCTGTTCCGCGAGACCTACGGGCAACTGCTTGGCGGCCAGCCAAGCCGCTACCTGCTGCAGATCCGCCAGCAGTACCACCTGCTGGAAATGTCGCCGGAAGCGGTCAGCCACGAGAGCCTGCCCGACCTGCCGAGCCTGCTCCAGCACCTGGGCCGCGAGCGAGATGGCTACAGCGCCCTGAAGCTGGATCGCCACGCCCTGGAGGGCGAGGACCTCGGGCTGATCCTGTCCATGGGGCGGCCGGACTGCATCCAGGTGTTCTACCGGCGCGACTTCGACAGCGCCGAGATCAGCCTGCTCGACGAACGCAACGCCCTCTGGCGCCAGCGCCAGGCATTGCGTGACGAACGCAGCCTGCTCGCACCGCTGCAGCGCTTCCTGCAATCGCTGCTGTACCGGCGCAACGCCCTGTCGCTGGCGGAACAGGTGCCGGCCGCGCTGGATATCCGCTACTACGAGTTGCTCTCCAACGACGGCAGAGTGCATGTCGAGCCTCGCGAGGCGCCGGAGGCCCTGGCCGGGCCCGCGCTGTACGAGCTACAGGCGCTACTCGAGCGCGGCGAACGCAAGCGCGTGCAGGTCACCCTGTACTGCGACCACCAGGAGTTTTCCGAACTGGAGTACGGCGCCGGCCTGTTCAAGGCGGTCGCCCGGCATATCCTGGCGCATCGCGCAGAAAGCGAACCCTACCCCTGCTACCTGACCGACCTCGACCTGTCGCGGCTGTTCGCCGACGAACAGCCGCAAACGCTGCACTATCTGCGTTATAAAAGCGTCCTGGAAACGGCGCTGAACCAGGCGCTGCTGGAACAATGA
Protein Properties
Protein Residues: 950
Protein Molecular Weight: 108.7 kDa
Protein Theoretical pI: 6.78
Hydropathicity (GRAVY score): -0.387
Charge at pH 7 (predicted): -3.35
Protein Sequence: 
>PA5272
MNRHPALSLDLDDGIDRKVLGQLRQRFLAVNAGRLQRARQALSSRQERVLRLLPLLFHINHPLLPGYLSASTPAGLSGFEADDEVLAEAQRLARSFVYKPRRQEPAQQPIHGLFLMGSLGSLAQEEQSDLDLWVCHAPELEPGARQELRRKCALIEDWARSQGSEVHCFLIDVARFGQDEREDRKEPGGDGNTQHFLLLDEFYRSAIWLGGRTPLWWLVPPAHERRYDEYCRTLLGKRFIRAEEVLDLGHLAHIPAREFIGAGLWQLSKAIDSPYKSLLKLLLTEAYASEHPRVRCVALRFKEQVFAGQLDLDELDPYVLVYRHLERYLREQQAPERLELVRRCLYLKVGRKLGGRQRQAQKGWQHLSMERLVAEWQWEPRRLALLDSRSQWKMRQVMEERRTVVNELTYSYRLLFQIARQQGADSGIDSRDLGLLGRRLYAAFERKAGKVENINPGIAPDLGEDVLTLVQLPADDGREQAQWAIFPGALGAHQWPDYAPLKRSLRLVELLAWCHRNGVIDSATRLSLHPGQSDLGDAELDNLLGSLRQFLPVPLATVDDADLLQPRRLKSVLLLVNVGVDPLRHHSQMNLHMATGRTDVLGYAGVRDNLVLTLDQLSLNSWNELTVRHYAGPQALPECLAEFLDAVREKPGSPPQPPELMVRCFCRNRAAAIAVRVEELFRETYGQLLGGQPSRYLLQIRQQYHLLEMSPEAVSHESLPDLPSLLQHLGRERDGYSALKLDRHALEGEDLGLILSMGRPDCIQVFYRRDFDSAEISLLDERNALWRQRQALRDERSLLAPLQRFLQSLLYRRNALSLAEQVPAALDIRYYELLSNDGRVHVEPREAPEALAGPALYELQALLERGERKRVQVTLYCDHQEFSELEYGAGLFKAVARHILAHRAESEPYPCYLTDLDLSRLFADEQPQTLHYLRYKSVLETALNQALLEQ
References
External Links:
Resource Link
Genome ID: PA5272
Entrez Gene ID: 877744
NCBI Protein ID: 15600465
General Reference: PaperBLAST - Find papers about PA5272 and its homologs