P. aeruginosa Metabolome Database Protein PA0934

Identification

Name:

GTP pyrophosphokinase

Synonyms:

(p)ppGpp synthase
ATP:GTP 3'-pyrophosphotransferase
ppGpp synthase I

Gene Name:

relA

Enzyme Class:

2.7.6.5

Biological Properties

General Function:

Involved in amino acid binding

Specific Function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp

Cellular Location:

Not Available

KEGG Pathways:

Purine metabolism pae00230

KEGG Reactions:

SMPDB Reactions:

Not Available

PseudoCyc/BioCyc Reactions:

Complex Reactions:

→

Adenosine triphosphate + Guanosine triphosphate → Adenosine monophosphate + Guanosine 3'-diphosphate 5'-triphosphate
ReactionCard

Transports:

Not Available

Metabolites:

PAMDB ID	Name	View
PAMDB000014	Adenosine monophosphate	MetaboCard
PAMDB000148	Adenosine triphosphate	MetaboCard
PAMDB001005	Guanosine 3',5'-bis(diphosphate)	MetaboCard
PAMDB001003	Guanosine 3'-diphosphate 5'-triphosphate	MetaboCard
PAMDB000296	Guanosine diphosphate	MetaboCard
PAMDB000319	Guanosine triphosphate	MetaboCard
PAMDB001633	Hydrogen ion	MetaboCard

GO Classification:

Function
amino acid binding
binding
carboxylic acid binding
Process
cellular nitrogen compound metabolic process
guanosine metabolic process
guanosine tetraphosphate metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside metabolic process
purine ribonucleoside metabolic process
ribonucleoside metabolic process

Gene Properties

Locus tag:

PA0934

Strand:

Entrez Gene ID:

881299

Accession:

NP_249625.1

GI:

15596131

Sequence start:

1023053

Sequence End:

1025296

Sequence Length:

2243

Gene Sequence:

>PA0934
ATGGTACAGGTGAGAGCGCACCAGCCGGTCAACACCGACGGCAGTATCAACCTCGAGGCCTGGCTGGACCACGTCCAGAACCTCGTCCCCGGGCTCGATCGTCAGGGCTTGCTGGAGGCTTGCGAGTTCGCTCGCGAATCCGAGCAGCGAGCGATCGCCGCACAGAACTCCTGGGCGGAAGGCACGTCCAGCTTCCAGACCGGACTGGAAATCGCCGAGATCCTCGCGGATCTCAAGCTGGATCAGGAGTCCCTGGTCGCCGCGGTCATCTATCGAGGCGTGCGGGAAGGCAAGATCACCCTGGAAGCGGTCAACAAGCATTTCGGGCCGGTGGTGGCCAAGCTGATCGAGGGCGTGCTGCGCATGGCCGCGATCAGCGCCAGCCTCAATCCGCGCCATTCCATGGTGCTGGGTACCCAGGCGCAGGTGGAGAACCTGCGCAAGATGCTGGTGGCGATGGTCGACGACGTTCGCGTCGCCCTGATCAAGCTGGCCGAGCGCACCTGCGCCATTCGCGCGGTGAAGAACGCCGACGAGGAAAAGCGCCACCGCGTCGCCCGGGAAGTCTTCGATATCTACGCGCCGCTGGCCCACCGCCTGGGCATCGGGCATATCAAGTGGGAGCTGGAGGACCTGTCCTTCCGTTACCTCGAGCCCGACCAGTACAAGCAGATCGCCAAGCTGCTGCACGAGCGCCGGCTGGATCGTGAGCAGTACATCGCCAACGTGATGAGCCAGTTGAAGGAAGCTCTCGCGGCCACCGGCGTACAGGCCGATCTCAGCGGACGGGCGAAACACATCTATTCGATCTGGCGCAAGATGCAGCGCAAGGGCCTGGACTTCAGCCAGATCTACGACGTTCGCGCCGTGCGCGTGCTCGTTCCGGAGATGCGCGACTGCTACACCGCGCTGGGCATCGTGCATACCCTCTGGCGGCACATTCCCAAGGAGTTCGACGACTACATCGCCAACCCCAAGGAAAACGGCTATCGCTCGCTGCATACCGCAGTGATCGGCCCCGAGGGGAAGGTGCTGGAAGTACAGATCCGTACCCACTCCATGCACGAAGAGGCGGAGCTCGGAGTCTGCGCGCACTGGCGCTACAAGGGGACCGACGTCAAGGCCAGCTCCAACCATTACGAGGAAAAGATCTCCTGGCTGCGCCAGGTGCTCGAATGGCACGAGGAACTGGGCGACATCGGTGGCCTGGCGGAGCAACTGCGGGTCGATATCGAGCCGGACAGGGTCTACGTCTTCACTCCCGACGGCCATGCCATCGACCTGCCCAAGGGCGCGACCCCGCTGGATTTCGCCTATCGGGTCCACACTGAAGTCGGGCACAACTGCCGCGGGGCGAAGATCAACGGACGCATCGTGCCGCTGAACTACAGCCTGCAGACCGGCGAGCAGGTCGAGATCATAACCGGCAAGCACAGCGGTCCGAGCCGCGACTGGCTGAACAGCAACCTGGGCTACGTCACCACCTCCCGGGCGCGGGCGAAGATCGTCCACTGGTTCAAGCTGCAGGCGCGGGACCAGAACGTCGCTGCCGGCAAGGCCCTGATCGAACGCGAGCTGTCGCGCCTGGCGCTGCCGCCGGTGGATTTCGACCGGCTGGCGGAGAAGGCCAACGTGCGTACCGCCGAGGATATGTTCGCCGCTCTCGGCGCCGGCGACCTGCGCTTGGCGCACCTGGTCAACTATGCCCAGCAACTGGTCGAGCCGGACCGCGACAGCGAGCAACTCGAACTGATCCCGCGCAAGCCGAGCAAGATCGGCCACGGCAAGCGCGGCGACGTGCAGATCCAGGGTGTCGGCAACCTCCTGACGCAGATGGCCGGCTGCTGCCAGCCGCTGCCGGGAGATCCCATCGTCGGCTACATCACGCTGGGCCGTGGGGTCACCATCCACCGCCAGGATTGCGCCACCGCGCTGCAACTGGCGGGACGCGAACCGGAGCGGATGATCCAGGTCAGCTGGGGGCCGGAGCCGGTTCGCACCTATCCGGTGGATATCGCGATCCGTGCCTATGATCGTTCCGGCCTGTTGCGCGACGTGTCCCAGGTGCTGCTCAACGAGCGGATCAACGTTCTGGCGGTGAATACCCGTTCGAACAAGGAAGACAACACCGCGACCATGCAACTGACCATCGAGATTCCCGGTCTGGACGCTCTTGGACGCCTGCTGGCGCGCGTCTCGCAACTGCCCAACATCATCGAGGCGCGGCGCAACCGTACGCCTTGA

Protein Properties

Protein Residues:

747

Protein Molecular Weight:

83.8 kDa

Protein Theoretical pI:

7.57

Hydropathicity (GRAVY score):

-0.312

Charge at pH 7 (predicted):

4.82

Protein Sequence:

>PA0934
MVQVRAHQPVNTDGSINLEAWLDHVQNLVPGLDRQGLLEACEFARESEQRAIAAQNSWAEGTSSFQTGLEIAEILADLKLDQESLVAAVIYRGVREGKITLEAVNKHFGPVVAKLIEGVLRMAAISASLNPRHSMVLGTQAQVENLRKMLVAMVDDVRVALIKLAERTCAIRAVKNADEEKRHRVAREVFDIYAPLAHRLGIGHIKWELEDLSFRYLEPDQYKQIAKLLHERRLDREQYIANVMSQLKEALAATGVQADLSGRAKHIYSIWRKMQRKGLDFSQIYDVRAVRVLVPEMRDCYTALGIVHTLWRHIPKEFDDYIANPKENGYRSLHTAVIGPEGKVLEVQIRTHSMHEEAELGVCAHWRYKGTDVKASSNHYEEKISWLRQVLEWHEELGDIGGLAEQLRVDIEPDRVYVFTPDGHAIDLPKGATPLDFAYRVHTEVGHNCRGAKINGRIVPLNYSLQTGEQVEIITGKHSGPSRDWLNSNLGYVTTSRARAKIVHWFKLQARDQNVAAGKALIERELSRLALPPVDFDRLAEKANVRTAEDMFAALGAGDLRLAHLVNYAQQLVEPDRDSEQLELIPRKPSKIGHGKRGDVQIQGVGNLLTQMAGCCQPLPGDPIVGYITLGRGVTIHRQDCATALQLAGREPERMIQVSWGPEPVRTYPVDIAIRAYDRSGLLRDVSQVLLNERINVLAVNTRSNKEDNTATMQLTIEIPGLDALGRLLARVSQLPNIIEARRNRTP

References

External Links:

Resource	Link
Genome ID:	PA0934
Entrez Gene ID:	881299
NCBI Protein ID:	15596131

General Reference:

PaperBLAST - Find papers about PA0934 and its homologs

GTP pyrophosphokinase (PA0934)