Guanosine diphosphate (PAMDB000296)

General function:

Involved in oxidation-reduction process

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines

Gene Name:

nrdA

Locus Tag:

PA1156

Molecular weight:

107.1 kDa

Reactions

General function:

Involved in RNA binding

Specific function:

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

Gene Name:

pnp

Locus Tag:

PA4740

Molecular weight:

75.4 kDa

Reactions

General function:

Involved in bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity

Specific function:

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP

Gene Name:

apaH

Locus Tag:

PA0590

Molecular weight:

32 kDa

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Locus Tag:

PA3807

Molecular weight:

15.6 kDa

Reactions

General function:

Involved in adenylosuccinate synthase activity

Specific function:

Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP

Gene Name:

purA

Locus Tag:

PA4938

Molecular weight:

46.8 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykF

Locus Tag:

PA1498

Molecular weight:

51.5 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ATP-dependent phosphorylation of adenosylcobinamide and adds GMP to adenosylcobinamide phosphate

Gene Name:

cobU

Locus Tag:

PA1279

Molecular weight:

36.5 kDa

Reactions

General function:

Involved in amino acid binding

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp

Gene Name:

relA

Locus Tag:

PA0934

Molecular weight:

83.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the synthesis and degradation of ppGpp. The second messengers ppGpp and c-di-GMP together control biofilm formation in response to translational stress; ppGpp represses biofilm formation while c- di-GMP induces it

Gene Name:

spoT

Locus Tag:

PA5338

Molecular weight:

78.9 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + sulfate = diphosphate + adenylyl sulfate

Gene Name:

cysD

Locus Tag:

PA4443

Molecular weight:

35.5 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + pyruvate = ADP + phosphoenolpyruvate

Gene Name:

pykA

Locus Tag:

PA4329

Molecular weight:

52.3 kDa

Reactions

General function:

Involved in GTPase activity

Specific function:

May be the GTPase, regulating ATP sulfurylase activity

Gene Name:

cysN

Locus Tag:

PA4442

Molecular weight:

69.3 kDa

Reactions

General function:

Involved in nucleotidyltransferase activity

Specific function:

Involved in the biosynthesis of the capsular polysaccharide colanic acid

Gene Name:

manC

Locus Tag:

PA3551

Molecular weight:

53.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H(2)O = ribonucleoside triphosphate + thioredoxin

Gene Name:

nrdD

Locus Tag:

PA1920

Molecular weight:

76.1 kDa

Reactions

General function:

Involved in protein binding

Specific function:

Essential for recycling GMP and indirectly, cGMP

Gene Name:

gmk

Locus Tag:

PA5336

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Locus Tag:

PA3686

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis

Gene Name:

nrdB

Locus Tag:

PA1155

Molecular weight:

47.4 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Locus Tag:

PA3533

Molecular weight:

11.8 kDa

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Locus Tag:

PA5129

Molecular weight:

9.2 kDa

General function:

Involved in electron carrier activity

Specific function:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

Gene Name:

trxA

Locus Tag:

PA5240

Molecular weight:

11.9 kDa