| Identification |
| Name: |
Ribonucleoside-diphosphate reductase 1 subunit alpha |
| Synonyms: |
- Protein B1
- Ribonucleoside-diphosphate reductase 1 R1 subunit
- Ribonucleotide reductase 1
|
| Gene Name: |
nrdA |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in oxidation-reduction process |
| Specific Function: |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
 | + | Thioredoxin disulfide | + |  | ↔ | Thioredoxin | + |  |
| | |
dUDP | + | Thioredoxin disulfide | + | | ↔ | Thioredoxin | + |  |
| | |
dGDP | + | Thioredoxin disulfide | + | | ↔ |  | + | Thioredoxin |
| | |
 | + | Thioredoxin disulfide | + | | ↔ | Thioredoxin | + |  |
| | |
2'-Deoxyribonucleoside diphosphate | + | Thioredoxin disulfide | + | | ↔ | Ribonucleoside diphosphate | + |  |
| |
|
| SMPDB Reactions: |
|
| + | reduced thioredoxin | → | | + | oxidized thioredoxin | + | |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| macromolecular complex | | protein complex | | ribonucleoside-diphosphate reductase complex | | Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | ATP binding | | binding | | catalytic activity | | nucleoside binding | | oxidoreductase activity | | oxidoreductase activity, acting on CH or CH2 groups | | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | | protein binding | | purine nucleoside binding | | ribonucleoside-diphosphate reductase activity | | Process |
|---|
| cellular macromolecule metabolic process | | DNA metabolic process | | DNA replication | | macromolecule metabolic process | | metabolic process | | oxidation reduction |
|
| Gene Properties |
| Locus tag: |
PA1156 |
| Strand: |
- |
| Entrez Gene ID: |
877716 |
| Accession: |
NP_249847.1 |
| GI: |
15596353 |
| Sequence start: |
1251418 |
| Sequence End: |
1254309 |
| Sequence Length: |
2891 |
| Gene Sequence: |
>PA1156
ATGCATACCGACACCACACGCGAGAACCCGCAGGCCAGCGCGCCGCAGGCCGCCGATTCGTCGCAGGATCTGGCCGCCACCGCGCCGGGCCAGCTACGCGTGATCAAGCGCAACGGCACCGTAGTCCCCTACACCGATGACAAGATCACCGTCGCCATCACCAAGGCGTTCCTCGCCGTGGAAGGCGGCACCGCCGCCGCCTCGTCGCGTATCCATGACACCGTGCGCCGCCTGACCGAGCAGGTCACCGCCACCTTCAAGCGCCGCATGCCGTCCGGCGGCACCATCCACATCGAAGAGATCCAGGACCAGGTCGAACTGGCCCTGATGCGCGCCGGCGAGCAGAAGGTCGCCCGCGACTACGTGATCTACCGCGAAGCCCGCGCCGCCGAGCGCAAGAACGCCGGCGCCGCCAGCGACGTCGCCCAGCCGCACCCGAGCATCCGCATCACCCGCGCCGACGGCAGCCTGTCGCCGCTGGACATGGGCCGCCTGAACACCATCATCAGCGAAGCCTGCGAAGGCCTGGCCGAGGTGGACGGCGCGCTGATCGAGCGCGAGACCCTGAAGAACCTCTACGACGGCGTCGCCGAGAAGGACGTCAACACCGCCCTGGTGATGACCGCGCGCACCCTGGTCGAGCGCGAGCCGAACTACTCCTACGTCACCGCCCGCCTGCTGATGGACACCCTGCGCGCCGAAGCCCTGGGCTTCCTCGGCGTGGCCGAGAGCGCCACCCATCACGAGATGGCCGAGCTGTACGCCAAGGCCCTGCCGGCCTACATCGAGAAAGGCGCCGAGTTCGAGCTGGTCGATGCCAAGCTGAAGGAATTCGACCTGGAGAAACTGGGCAAGGCCATCGATCACGAGCGCGACCAGCAGTTCACCTACCTCGGCCTGCAGACCCTGTACGACCGCTACTTCATCCACAAGGACGGCATCCGCTTCGAACTGCCGCAGATCTTCTTCATGCGCGTGGCCATGGGCCTGGCCATCGAGGAGAAGGACCGCGAGGCACGTGCCATCGAGTTCTACAACCTGCTGTCGTCCTTCGACTACATGAGTTCCACCCCCACCCTGTTCAACGCCGGCACCCTGCGTCCGCAGCTCTCCAGCTGCTACCTGACCACCGTGCCGGACGACCTGTCGGGCATCTACGGCGCCATCCACGACAACGCCATGCTGTCGAAATTCGCCGGCGGCCTGGGCAACGACTGGACCCCGGTGCGCGCGCTGGGCTCCTACATCAAGGGCACCAACGGCAAGTCCCAGGGCGTCGTGCCCTTCCTGAAAGTGGTCAATGACACCGCGGTCGCGGTCAACCAGGGCGGCAAGCGCAAGGGCGCGGTCTGCGCCTACCTGGAAACCTGGCACCTGGACATCGAGGAATTCCTCGAGCTGCGCAAGAACACCGGTGACGACCGTCGTCGTACCCACGACATGAACACCGCCAACTGGATCCCCGACCTGTTCATGAAGCGCGTCTTCGACGACGGCTCCTGGACCCTCTTCTCGCCGTCCGACGTCCCCGACCTGCACGACCTCTACGGCAAGGCCTTCGAGGAGCGCTACGAGTACTACGAGGCCCTGGCCAGCTACGGCAAGCTGAAGCTGCACAAGGTCGTCCAGGCCAAGGACCTGTGGCGCAAGATGCTCTCCATGCTGTTCGAGACCGGCCACCCATGGCTGACCTTCAAGGACCCGTGCAACCTGCGCAGCCCGCAGCAGCACGTGGGCGTGGTGCACAGCTCGAACCTCTGCACCGAGATCACCCTGAACACCAACAAGGACGAGATCGCCGTCTGCAACCTGGGCTCGATCAACCTGGTCAACCACATCGTCGACGGCAAGCTGGACACCGCCAAGCTGGAGAAGACCGTCAAGACCGCGGTACGCATGCTCGATAACGTCATCGACATCAACTACTACTCGGTCCCGCAGGCGCAGAACTCCAACTTCAAGCACCGTCCGGTCGGCCTGGGCATCATGGGCTTCCAGGACGCCCTGTACCTGCAGCACATCCCCTACGGTTCGGACGCGGCCATCGCCTTCGCCGACCAGTCCATGGAAGCCATCAGCTACTACGCGATCCAGGCTTCCTGCGACCTGGCCGACGAGCGCGGCGCCTACCAAACCTTCCAGGGCTCGCTGTGGTCGCAAGGCATCCTGCCGATCGACTCGGAGAAGAAGCTGATCGAAGAGCGCGGCGCCAAGTACATCGAAGTCGACCTGTCGGAAACCCTCGACTGGGCGCCGCTGCGCGAGCGCGTACAGAAAGGCATCCGCAACTCGAACATCATGGCCATCGCGCCGACCGCGACCATCGCCAACATCACCGGCGTCTCGCAGTCGATCGAGCCGACCTACCAGAACCTGTACGTGAAGTCGAACCTCTCCGGCGAGTTCACCGTGATCAACCCCTACCTGGTGCGCGACCTCAAGGCCCGCGGCCTGTGGGACCCGGTCATGGTCAACGACCTGAAGTACTACGACGGTTCCGTGCAGCAGATCGAGCGCATCCCGCAGGACCTCAAGGACCTCTACGCCACCGCGTTCGAAGTCGAGACCCGCTGGATCGTCGAAGCCGCCAGCCGTCGCCAGAAGTGGATCGACCAGGCCCAGTCGCTGAACCTGTACATCGCCGGCGCCTCGGGCAAGAAGCTCGACGTGACCTACCGCATGGCCTGGTTCCGCGGCCTGAAGACCACCTACTACCTCCGTGCCCTGGCCGCCACCAGCACCGAGAAGTCCACCATCAACACCGGCAAGCTCAACGCCGTGTCGGCCGGTGGCAACGACGGCCTGCAAGCCGCCCCGGCCGCCGAGCCGAAGCCGGCGCCGGTGCCGCAGGCGTGCAGCATCGATAACCCCGACTGCGAAGCCTGCCAGTGA |
| Protein Properties |
| Protein Residues: |
963 |
| Protein Molecular Weight: |
107.1 kDa |
| Protein Theoretical pI: |
5.69 |
| Hydropathicity (GRAVY score): |
-0.309 |
| Charge at pH 7 (predicted): |
-14.68 |
| Protein Sequence: |
>PA1156
MHTDTTRENPQASAPQAADSSQDLAATAPGQLRVIKRNGTVVPYTDDKITVAITKAFLAVEGGTAAASSRIHDTVRRLTEQVTATFKRRMPSGGTIHIEEIQDQVELALMRAGEQKVARDYVIYREARAAERKNAGAASDVAQPHPSIRITRADGSLSPLDMGRLNTIISEACEGLAEVDGALIERETLKNLYDGVAEKDVNTALVMTARTLVEREPNYSYVTARLLMDTLRAEALGFLGVAESATHHEMAELYAKALPAYIEKGAEFELVDAKLKEFDLEKLGKAIDHERDQQFTYLGLQTLYDRYFIHKDGIRFELPQIFFMRVAMGLAIEEKDREARAIEFYNLLSSFDYMSSTPTLFNAGTLRPQLSSCYLTTVPDDLSGIYGAIHDNAMLSKFAGGLGNDWTPVRALGSYIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVFDDGSWTLFSPSDVPDLHDLYGKAFEERYEYYEALASYGKLKLHKVVQAKDLWRKMLSMLFETGHPWLTFKDPCNLRSPQQHVGVVHSSNLCTEITLNTNKDEIAVCNLGSINLVNHIVDGKLDTAKLEKTVKTAVRMLDNVIDINYYSVPQAQNSNFKHRPVGLGIMGFQDALYLQHIPYGSDAAIAFADQSMEAISYYAIQASCDLADERGAYQTFQGSLWSQGILPIDSEKKLIEERGAKYIEVDLSETLDWAPLRERVQKGIRNSNIMAIAPTATIANITGVSQSIEPTYQNLYVKSNLSGEFTVINPYLVRDLKARGLWDPVMVNDLKYYDGSVQQIERIPQDLKDLYATAFEVETRWIVEAASRRQKWIDQAQSLNLYIAGASGKKLDVTYRMAWFRGLKTTYYLRALAATSTEKSTINTGKLNAVSAGGNDGLQAAPAAEPKPAPVPQACSIDNPDCEACQ |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA1156 and its homologs
|
