CDP (PAMDB000415)

General function:

Involved in oxidation-reduction process

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox- active cysteines

Gene Name:

nrdA

Locus Tag:

PA1156

Molecular weight:

107.1 kDa

Reactions

General function:

Involved in RNA binding

Specific function:

Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction

Gene Name:

pnp

Locus Tag:

PA4740

Molecular weight:

75.4 kDa

Reactions

General function:

Involved in cytidylate kinase activity

Specific function:

ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors

Gene Name:

cmk

Locus Tag:

PA3163

Molecular weight:

24.6 kDa

Reactions

General function:

Involved in nucleoside diphosphate kinase activity

Specific function:

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

Gene Name:

ndk

Locus Tag:

PA3807

Molecular weight:

15.6 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

Gene Name:

adk

Locus Tag:

PA3686

Molecular weight:

23.1 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis

Gene Name:

nrdB

Locus Tag:

PA1155

Molecular weight:

47.4 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Locus Tag:

PA3533

Molecular weight:

11.8 kDa

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Locus Tag:

PA5129

Molecular weight:

9.2 kDa

General function:

Involved in electron carrier activity

Specific function:

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

Gene Name:

trxA

Locus Tag:

PA5240

Molecular weight:

11.9 kDa