| Identification |
| Name: |
Ribonucleoside-diphosphate reductase 1 subunit beta |
| Synonyms: |
- Protein B2
- Protein R2
- Ribonucleotide reductase 1
|
| Gene Name: |
nrdB |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in oxidoreductase activity |
| Specific Function: |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R2 contains the tyrosyl radical required for catalysis |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
 | + | Thioredoxin disulfide | + |  | ↔ | Thioredoxin | + |  |
| | |
dUDP | + | Thioredoxin disulfide | + | | ↔ | Thioredoxin | + |  |
| | |
dGDP | + | Thioredoxin disulfide | + | | ↔ |  | + | Thioredoxin |
| | |
 | + | Thioredoxin disulfide | + | | ↔ | Thioredoxin | + |  |
| | |
2'-Deoxyribonucleoside diphosphate | + | Thioredoxin disulfide | + | | ↔ | Ribonucleoside diphosphate | + |  |
| |
|
| SMPDB Reactions: |
|
| + | reduced thioredoxin | → | oxidized thioredoxin | + | | + | dGDP | + |  |
| | |
Adenosine diphosphate | + | reduced thioredoxin | + | | ↔ | | + | oxidized thioredoxin | + | dADP | + | |
| | |
Uridine 5'-diphosphate | + | reduced thioredoxin | + | | ? | oxidized thioredoxin | + | | + | dUDP | + |  |
| | |
| + | reduced thioredoxin | → | | + | oxidized thioredoxin | + | |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| binding | | catalytic activity | | cation binding | | ion binding | | metal ion binding | | oxidoreductase activity | | oxidoreductase activity, acting on CH or CH2 groups | | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | | ribonucleoside-diphosphate reductase activity | | transition metal ion binding | | Process |
|---|
| cellular nitrogen compound metabolic process | | deoxyribonucleoside diphosphate metabolic process | | metabolic process | | nitrogen compound metabolic process | | nucleobase, nucleoside and nucleotide metabolic process | | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | | nucleoside diphosphate metabolic process | | nucleoside phosphate metabolic process | | nucleotide metabolic process | | oxidation reduction |
|
| Gene Properties |
| Locus tag: |
PA1155 |
| Strand: |
- |
| Entrez Gene ID: |
877692 |
| Accession: |
NP_249846.1 |
| GI: |
15596352 |
| Sequence start: |
1249907 |
| Sequence End: |
1251154 |
| Sequence Length: |
1247 |
| Gene Sequence: |
>PA1155
ATGCTGAGCTGGGACGAATTCGACAAAGAAGACCCGACCGAAGCCAAGGCCGCGCCCGCCGCCGCCCAGGCCGTTGCCCAGGGCCATGACAAGCTGGACGACGAAGCCGCCGGCTCGGTGGAAGAAGCGCGCGCCGTTTCCGCCGACGACTCCGACGCTGTCGCCCGCGCCAAGAAGGCCCTGAACGACCTCGACATCCAGGAAGGCTTGGACGACCTCGAAGGCTCCGCCGCGCGCGTGCAGGTCGGCGACAAGCAGATGATCAACGCCCGTGCCGACCTCAACCAGCTCGTTCCCTTCAAGTACGACTGGGCCTGGCAGAAGTATCTGGATGGTTGCGCCAACCACTGGATGCCGCAGGAAGTCAACATGAACGCCGACATCGCCCTGTGGAAGAGCAAGGACGGCCTCAGCGAAGACGAGCGGCGCATCGTCATGCGCAACCTCGGCTTCTTCTCCACCGCCGACTCGCTGGTCGCCAACAACCTGGTGCTGGCCGTGTACCGCCTGATCACCAACCCCGAGTGCCGCCAGTACATCCTGCGCCAGGCCTTCGAAGAGGCGATCCACACCCACGCCTACCAGTACTGCATCGAGTCGCTGGGCATGGACGAGGGCGAGATCTTCAACATGTACCACGAGATCCCCAGCGTGGCGAAGAAGGCCTCCTGGGGCCTGAAGTACACCCGCTCGATCTCCGACCCGATGTTCCAGACCGGCACCCCGGAAACCGACCGCCAGTTCCTGCGCAACCTGATCGCCTACTACTGCGTGCTGGAAGGCATCTTCTTCTACTGCGGCTTCACCCAGATCCTCTCCATGGGCCGCCGCAACAAGATGACCGGCACCGCCGAGCAGTTCCAGTACATCCTCCGCGACGAGTCGATGCACCTGAACTTCGGTATCGACGTGATCAACCAGATCAAGATCGAGAACCCGCACCTGTGGGACGCCCAGATGAAGGACGAGGCGACCCAGATGATCCTCCAGGGCACCCAGCTGGAGATCGAATACGCGCGCGACACCATGCCGCGCGGGGTGCTGGGCATGAACGCGGCGATGATGGAGGACTACCTGAAGTTCATCGCCAACCGGCGCCTGACCCAGATCGGCCTGAAGGAAGAGTATCCGGGGACCACCAACCCGTTCCCGTGGATGTCGGAGATCATGGACCTGAAGAAGGAGAAGAACTTCTTCGAGACGCGGGTTATCGAGTACCAGACGGGCGGAGCACTGAGCTGGGATTGA |
| Protein Properties |
| Protein Residues: |
415 |
| Protein Molecular Weight: |
47.4 kDa |
| Protein Theoretical pI: |
4.5 |
| Hydropathicity (GRAVY score): |
-0.431 |
| Charge at pH 7 (predicted): |
-21.44 |
| Protein Sequence: |
>PA1155
MLSWDEFDKEDPTEAKAAPAAAQAVAQGHDKLDDEAAGSVEEARAVSADDSDAVARAKKALNDLDIQEGLDDLEGSAARVQVGDKQMINARADLNQLVPFKYDWAWQKYLDGCANHWMPQEVNMNADIALWKSKDGLSEDERRIVMRNLGFFSTADSLVANNLVLAVYRLITNPECRQYILRQAFEEAIHTHAYQYCIESLGMDEGEIFNMYHEIPSVAKKASWGLKYTRSISDPMFQTGTPETDRQFLRNLIAYYCVLEGIFFYCGFTQILSMGRRNKMTGTAEQFQYILRDESMHLNFGIDVINQIKIENPHLWDAQMKDEATQMILQGTQLEIEYARDTMPRGVLGMNAAMMEDYLKFIANRRLTQIGLKEEYPGTTNPFPWMSEIMDLKKEKNFFETRVIEYQTGGALSWD |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA1155 and its homologs
|
