Reaction Details
Reaction: Thumb
a 2'-deoxyribonucleoside 5'-diphosphate + an oxidized thioredoxin + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = a ribonucleoside diphosphate + a reduced thioredoxin + a ribonucleoside diphosphate
External Links:
  • Larsson A, Reichard P (1966). "Enzymatic synthesis of deoxyribonucleotides. IX. Allosteric effects in the reduction of pyrimidine ribonucleotides by the ribonucleoside diphosphate reductase system of Escherichia coli." J Biol Chem 241(11);2533-9. PMID: 5330119
  • Larsson A, Reichard P (1966). "Enzymatic synthesis of deoxyribonucleotides. X. Reduction of purine ribonucleotides; allosteric behavior and substrate specificity of the enzyme system from Escherichia coli B." J Biol Chem 241(11);2540-9. PMID: 5330120
  • Larsson A (1973). "Ribonucleotide reductase from regenerating rat liver. II. Substrate phosphorylation level and effect of deoxyadenosine triphosphate." Biochim Biophys Acta 324(4);447-51. PMID: 4543472
  • Moore EC, Hurlbert RB (1966). "Regulation of mammalian deoxyribonucleotide biosynthesis by nucleotides as activators and inhibitors." J Biol Chem 241(20);4802-9. PMID: 5926184
  • Qiu W, Zhou B, Darwish D, Shao J, Yen Y (2006). "Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits." Biochem Biophys Res Commun 340(2);428-34. PMID: 16376858