Adenylosuccinate synthetase (PA4938)

Identification
Name: Adenylosuccinate synthetase
Synonyms:
  • AMPSase
  • AdSS
  • IMP--aspartate ligase
Gene Name: purA
Enzyme Class:
Biological Properties
General Function: Involved in adenylosuccinate synthase activity
Specific Function: Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+2 Thumb+Thumb
L-Aspartic acid + Guanosine triphosphate + Inosinic acid ↔ Adenylsuccinic acid + Guanosine diphosphate + 2 Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Guanosine triphosphate + Inosinic acid + L-Aspartic acid ↔ Guanosine diphosphate + Phosphate + Adenylsuccinic acid
ReactionCard
SMPDB Reactions:
Thumb+Thumb+L-Aspartic acid+Thumb → Thumb+Thumb+N(6)-(1,2-dicarboxyethyl)AMP
Guanosine triphosphate + Inosinic acid + L-Aspartic acid + L-Aspartic acid → Guanosine diphosphate + Phosphate + N(6)-(1,2-dicarboxyethyl)AMP
ReactionCard
Thumb+L-Aspartic acid+Thumb+Thumb → Thumb+Thumb+2 Thumb+N(6)-(1,2-dicarboxyethyl)AMP+Thumb
Inosinic acid + L-Aspartic acid + Guanosine triphosphate + L-Aspartic acid → Guanosine diphosphate + Phosphate + 2 Hydrogen ion + N(6)-(1,2-dicarboxyethyl)AMP + Adenylsuccinic acid
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+2 Thumb+Thumb
L-Aspartic acid + Guanosine triphosphate + Inosinic acid ↔ Adenylsuccinic acid + Guanosine diphosphate + 2 Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Guanosine triphosphate + Inosinic acid + L-Aspartic acid ↔ Guanosine diphosphate + Phosphate + Adenylsuccinic acid
ReactionCard
Thumb+Thumb+L-Aspartic acid+Thumb → Thumb+Thumb+N(6)-(1,2-dicarboxyethyl)AMP
Guanosine triphosphate + Inosinic acid + L-Aspartic acid + L-Aspartic acid → Guanosine diphosphate + Phosphate + N(6)-(1,2-dicarboxyethyl)AMP
ReactionCard
Thumb+L-Aspartic acid+Thumb+Thumb → Thumb+Thumb+2 Thumb+N(6)-(1,2-dicarboxyethyl)AMP+Thumb
Inosinic acid + L-Aspartic acid + Guanosine triphosphate + L-Aspartic acid → Guanosine diphosphate + Phosphate + 2 Hydrogen ion + N(6)-(1,2-dicarboxyethyl)AMP + Adenylsuccinic acid
ReactionCard
Thumb
L-aspartate + IMP + GTP → adenylo-succinate + GDP + phosphate + 2 H+
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000340Adenylsuccinic acidMetaboCard
PAMDB000296Guanosine diphosphateMetaboCard
PAMDB000319Guanosine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000601Inosinic acidMetaboCard
PAMDB000080L-Aspartic acidMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenylosuccinate synthase activity
binding
catalytic activity
cation binding
GTP binding
guanyl nucleotide binding
guanyl ribonucleotide binding
ion binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
magnesium ion binding
metal ion binding
nucleotide binding
purine nucleotide binding
Process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
Gene Properties
Locus tag: PA4938
Strand: -
Entrez Gene ID: 877657
Accession: NP_253625.1
GI: 15600131
Sequence start: 5542073
Sequence End: 5543365
Sequence Length: 1292
Gene Sequence: 
>PA4938
ATGGGTAAGAATGTCGTAGTCCTGGGCACCCAATGGGGTGATGAGGGCAAGGGCAAGATCGTCGACCTGCTCACCGAGCAGGCGGCTGCCGTAGTTCGCTACCAGGGTGGTCACAACGCTGGCCACACCCTGGTGATCGATGGCGAGAAAACCGTCCTGCACCTGATTCCATCGGGCATCCTGCGCGAAGGCGTGCAGTGCCTGATCGGCAATGGCGTGGTGCTGGCGCCGGATGCGCTGCTGCGCGAAATCACCAAGCTGGAAGAGAAGGGCGTGCCGGTGCGCGAGCGCCTGCGCATCAGTCCTTCCTGTCCGCTGATCCTGTCCTATCACGTCGCCCTCGACCAGGCGCGCGAGAAGGCCCGCGGCGAAGCCAAGATCGGCACCACCGGTCGTGGCATCGGCCCGGCATACGAGGACAAGGTGGCACGTCGCGGCCTGCGCGTCGGCGACCTGTTCCACCGCGAGCGCTTCGCCGCCAAGCTGGGCGAGCTGCTGGACTACCATAACTTCGTCCTGCAGCACTACTACAAGGAGCCGGCCATCGACTTCCAGAAGACCCTGGACGAGGCGATGGAGTATGCCGAGCTGCTCAAGCCGATGATGGCCGATGTCGCTGCGACCCTGCACGACCTGCGCAAGCACGGCAAGGACATCATGTTCGAAGGCGCCCAGGGATCGCTGCTGGACATCGACCATGGCACCTACCCCTACGTGACCAGTTCCAACACCACCGCTGGCGGTACCGCCACCGGTTCCGGCTTCGGCCCGCTGTACCTGGACTACGTACTGGGTATCACCAAGGCCTATACCACTCGCGTCGGCTCCGGTCCGTTCCCGACCGAGCTGTTCGACGACGTCGGCGCCTACCTGGCCAAGCGCGGCCACGAGTTCGGTGCCACCACCGGTCGCGCTCGTCGCTGCGGCTGGTTCGATGCCGTGATCCTGCGCCGCGCCATCGAGATCAACAGCATCTCCGGCCTGTGCCTGACCAAGCTCGACGTGCTCGATGGCCTGGATGTGGTGCGCCTGTGCGTCGGCTACAAGAATGCCGATGGCGATGTGCTGGAAGCGCCGACCGATGCCGACAGCTACATCGGCCTGCAGCCGGTCTACGAGGAAATGCCCGGCTGGAGCGAGTCGACCGTGGGTGCGAAGACCCTGGAAGAGTTGCCGGCCAACGCCCGCGCCTACATCAAGCGCGTGGAAGAGCTGGTGGGTGCGCCGATCGATATCATCTCCACCGGTCCGGACCGCAACGAGACCATCATCCTGCGCCATCCATTCGCCTGA
Protein Properties
Protein Residues: 430
Protein Molecular Weight: 46.8 kDa
Protein Theoretical pI: 5.95
Hydropathicity (GRAVY score): -0.146
Charge at pH 7 (predicted): -7.25
Protein Sequence: 
>PA4938
MGKNVVVLGTQWGDEGKGKIVDLLTEQAAAVVRYQGGHNAGHTLVIDGEKTVLHLIPSGILREGVQCLIGNGVVLAPDALLREITKLEEKGVPVRERLRISPSCPLILSYHVALDQAREKARGEAKIGTTGRGIGPAYEDKVARRGLRVGDLFHRERFAAKLGELLDYHNFVLQHYYKEPAIDFQKTLDEAMEYAELLKPMMADVAATLHDLRKHGKDIMFEGAQGSLLDIDHGTYPYVTSSNTTAGGTATGSGFGPLYLDYVLGITKAYTTRVGSGPFPTELFDDVGAYLAKRGHEFGATTGRARRCGWFDAVILRRAIEINSISGLCLTKLDVLDGLDVVRLCVGYKNADGDVLEAPTDADSYIGLQPVYEEMPGWSESTVGAKTLEELPANARAYIKRVEELVGAPIDIISTGPDRNETIILRHPFA
References
External Links:
Resource Link
Genome ID: PA4938
Entrez Gene ID: 877657
NCBI Protein ID: 15600131
General Reference: PaperBLAST - Find papers about PA4938 and its homologs