Tetraacyldisaccharide 4'-kinase (PA2981)

Identification
Name: Tetraacyldisaccharide 4'-kinase
Synonyms:
  • Lipid A 4'-kinase
Gene Name: lpxK
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + 2,3,2',3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate ↔ ADP + 2,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
ReactionCard
SMPDB Reactions:
(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate)+Thumb → Adenosine diphosphate+Thumb+Thumb+Thumb
(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) + Adenosine triphosphate → Adenosine diphosphate + Hydrogen ion + (2-N,3-O-bis(3-Hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate) + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+lipid IVA+Thumb
2,3,2',3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate + Adenosine triphosphate ↔ Hydrogen ion + lipid IVA + ADP
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + 2,3,2',3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphate → ADP + Hydrogen ion + 2,3,2'3'-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB003481(2-N,3-O-bis(3-Hydroxytetradecanoyl)-4-O-phosphono-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl phosphate)MetaboCard
PAMDB0009052,3,2',3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1-phosphateMetaboCard
PAMDB0009062,3,2'3'-Tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphateMetaboCard
PAMDB0015452,3,2'3'-Tetrakis(beta-hydroxymyristoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
catalytic activity
kinase activity
nucleoside binding
purine nucleoside binding
tetraacyldisaccharide 4'-kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
lipid A biosynthetic process
metabolic process
organophosphate metabolic process
phospholipid biosynthetic process
phospholipid metabolic process
Gene Properties
Locus tag: PA2981
Strand: -
Entrez Gene ID: 880503
Accession: NP_251671.1
GI: 15598177
Sequence start: 3338679
Sequence End: 3339677
Sequence Length: 998
Gene Sequence: 
>PA2981
ATGTCGTTCTCCGAGCGACTGCTCGCCGCCTGGTACCAGGGGCATCCGGCGCTGGCGCTGCTGCGTCCGCTGGAGGCTCTCTATCGTCGGGTGGCGAACGGCCGCCGGGCGGACTTCCTGTCCGGGCGCAAGCCCGCCTACCGGGCACCGCTGCCGGTGCTGGTGGTAGGCAACATCACCGTCGGCGGAACCGGCAAGACGCCGATGATCCTCTGGATGATCGAGCACTGCAGGGCTCGCGGCTTGCGGGTTGGCGTGATCAGCCGCGGCTATGGTGCCCGGCCGCCCACCACGCCGTGGCGGGTGCGGGCCGAGCAGGACGCCGCGGAGGCCGGCGACGAACCGCTGATGATCGTCCGGCGCAGCGGCGTGCCGCTGATGATCGACCCGGATCGTCCGCGCGCCCTGCAGGCGCTGCTCGCCGAAGAGCAGTTGGACCTGGTCCTCTGCGACGATGGCTTGCAGCACTATCGCCTGGCACGCGATCTGGAGCTGGTGCTGATCGATGCCGCGCGCGGTCTCGGCAATGGTCGTTGCCTGCCGGCCGGTCCGTTGCGCGAACCGGCGGAGCGTCTGGAAAGCGTCGACGCGCTGCTTTACAACGGCGCCGACGAGGATCCTGACGGCGGTTACGCATTCCGCTTGCAGCCTACTGCGCTGATCAACCTGCAGAGCGGCGAGCGCCGACCGCTGGAGCATTTTCCCGCGGGCCAGGAGGTCCATGCCCTGGCCGGGATCGGCAATCCGCAGCGTTTCTTCAGGACGCTCGAGGCGCTACACTGGCGGGCGATTCCGCATGCCTTCCCGGATCACGCGACCTACACGGCGGCCGAACTGGCGTTCAGCCCGCCGCTGCCGCTGCTGATGACCGAGAAGGATGCCGTTAAATGCCGGGCTTTCGCAGCGGCCGACTGGTGGTACCTGGCGGTCGATGCGGTGCCTTCCCCAGCATTCGTCGCCTGGTTCGACGCCCGACTCGAGCATCTCCTGGCGCGCTGA
Protein Properties
Protein Residues: 332
Protein Molecular Weight: 36.7 kDa
Protein Theoretical pI: 7.29
Hydropathicity (GRAVY score): -0.119
Charge at pH 7 (predicted): 1.05
Protein Sequence: 
>PA2981
MSFSERLLAAWYQGHPALALLRPLEALYRRVANGRRADFLSGRKPAYRAPLPVLVVGNITVGGTGKTPMILWMIEHCRARGLRVGVISRGYGARPPTTPWRVRAEQDAAEAGDEPLMIVRRSGVPLMIDPDRPRALQALLAEEQLDLVLCDDGLQHYRLARDLELVLIDAARGLGNGRCLPAGPLREPAERLESVDALLYNGADEDPDGGYAFRLQPTALINLQSGERRPLEHFPAGQEVHALAGIGNPQRFFRTLEALHWRAIPHAFPDHATYTAAELAFSPPLPLLMTEKDAVKCRAFAAADWWYLAVDAVPSPAFVAWFDARLEHLLAR
References
External Links:
Resource Link
Genome ID: PA2981
Entrez Gene ID: 880503
NCBI Protein ID: 15598177
General Reference: PaperBLAST - Find papers about PA2981 and its homologs