Polyphosphate kinase (PA5242)

Identification
Name: Polyphosphate kinase
Synonyms:
  • ATP-polyphosphate phosphotransferase
  • Polyphosphoric acid kinase
Gene Name: ppk
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Can form linear polymers of orthophosphate with chain lengths up to 1000 or more. Can also act in the reverse direction to form ATP in the presence of excess ADP. Can also use GTP instead of ATP; but the efficiency of GTP is 5% that of ATP
Cellular Location: Cell inner membrane; Peripheral membrane protein
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb
Adenosine triphosphate + Polyphosphate ↔ ADP
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Phosphate ↔ ADP + Pyrophosphate
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Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Pyrophosphate ↔ ADP + Triphosphate
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Thumb+(phosphate)(n) → Thumb+(phosphate)(n+1)
Adenosine triphosphate + (phosphate)(n) → ADP + (phosphate)(n+1)
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Thumb+Thumb ↔ Thumb
Adenosine triphosphate + Polyphosphate ↔ ADP
ReactionCard
Thumb
ATP + (polyphosphate)(n) = ADP + (polyphosphate)(n+1)
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Complex Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Phosphate ↔ ADP + Pyrophosphate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
Adenosine triphosphate + Pyrophosphate ↔ ADP + Triphosphate
ReactionCard
Thumb+(phosphate)(n) → Thumb+(phosphate)(n+1)
Adenosine triphosphate + (phosphate)(n) → ADP + (phosphate)(n+1)
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000496TriphosphateMetaboCard
GO Classification:
Component
macromolecular complex
polyphosphate kinase complex
protein complex
Function
catalytic activity
kinase activity
polyphosphate kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
Process
cellular metabolic process
metabolic process
phosphate metabolic process
phosphorus metabolic process
polyphosphate biosynthetic process
polyphosphate metabolic process
Gene Properties
Locus tag: PA5242
Strand: -
Entrez Gene ID: 879700
Accession: NP_253929.1
GI: 15600435
Sequence start: 5902386
Sequence End: 5904596
Sequence Length: 2210
Gene Sequence: 
>PA5242
ATGAATACGCAGCAAGGACTTGATGAGATCGAACGTATCGCCGCCGACGAAACCGTAGTGGCGAACGTGGAAAGCGAAGCAGAAGTGAAGATGGCCGAAACGATCCCGGTGGAAACGCCACCTGCGGTGGTTCCCAGCGTGGATGACAGCAGCCTGTACATTCATCGCGAGCTCTCCCAGTTGCAGTTCAACATCCGCGTGCTCGAACAGGCGCTGGACGAGTCCTACCCGCTCCTGGAGCGGCTGAAGTTCCTCCTCATCTTCTCGAGCAACCTCGACGAATTCTTCGAGATCCGCATCGCCGGCCTGAAGAAGCAGATCACCTTCGCCCGCGAGCAGGCCGGCGCCGACGGCCTGCTGCCGCACCAGGCCCTGGCGCGGATCAGCGAGCTGGTCCACGAGCAGGTATCGCGGCAGTACCGGATCCTCAACGAGACCCTGTTGCCGGAGCTGGCCAAGCACCAGATCCGCTTCATCCGCCGGCGTCACTGGACGCTGAAGATCAAGACCTGGGTGCGGCGCTTCTTCCGCGACGAGATCGCGCCGATCATCACCCCGATCGGCCTCGACCCGACCCATCCGTTCCCGCTGCTGGTGAACAAGAGCCTCAACTTCATCGTCGAGCTGGAGGGGATGGATGCCTTCGGCCGCGACTCCGGCCTGGCGATCATCCCGGCGCCGCGCCTGCTGCCACGGATCATCAGGCTGCCGGAAGACGTTGGCGGCGAGGGTGACAACTACGTGTTCCTGTCGTCGATGATCCACGCCCACGCCGACGACCTGTTCCCCGGCATGAAGGTGAAGGGCTGCTACCAGTTCCGCCTGACCCGCAACGCCGACCTGTCGGTGGACACCGAGGATGTCGAGGACCTGGCCCGCGCGCTGCGCGGCGAGCTGTTCTCGCGTCGCTACGGGGATGCGGTACGCCTGGAGGTGGTGGATACCTGCCCGCAGAACCTGACCAACTACCTGCTCAAGCAGTTCGGCCTGTCCGAAAGCGAGTTGTACAAGGTCAGCGGCCCGGTCAACCTGACCCGCCTGTTCAGCGTCACCGGCCTGGAAAGCCATCCGGAGCTGCAGTACCCGCCCTTCACCCCGGCGATCCCGCGTCTTTTGCAGAAGAAGGAAAACCTCTTCAACGTCCTCAGCAAGCTCGACGTGTTGCTGATGCACCCGTTCGAATCCTTCACCCCGGTGATCGACCTGCTGCGCCAGGCCGCCAAGGATCCGAACGTGCTGGCGATCAAGCAGACCCTGTACCGCAGCGGCGCCAACTCTGAGATCGTCGACGCCCTGGTCGAGGCGGCACGCAACGGCAAGGAGGTCACCGCGGTGATCGAGCTGCGCGCCCGCTTCGACGAAGAGTCCAACCTGCAACTGGCCAGCCGCCTGCAACAGGCCGGCGCGGTGGTGATCTACGGCGTGGTCGGCTTCAAGACCCACGCCAAGATGATGCTGATCCTCCGTCGCGAGGACGGCGAACTGCGCCGCTACGCGCACCTGGGCACCGGCAACTACCATGCCGGCAACGCTCGCCTGTACACCGACTACAGCCTGCTGACCGCCGACGTGGCGCTCTGCGAGGACCTGCACAAGCTGTTCAACCAACTGATCGGGATGGGCAAGACGCTGCGCATGAAGAAGCTGTTGCATGCGCCGTTCACCCTGAAGAAGAACCTGCTGGAAATGATCAACCGCGAGGCGGCCCAGGCGGCGCTCGGCCAGCCTGCGCACATCATGGCCAAGGTCAACTCGCTGACCGATCCGAAGGTCATCCGCGCCCTGTACAAGGCCAGCCAGGCCGGGGTCAGGATCGACCTGGTGGTGCGTGGCATGTGCTGCCTGCGGCCGGGCATCCCGGGGGTCTCGCACAATATCCACGTGCGCTCGATCATCGGGCGCTTCCTCGAGCACAGCCGCATCTACTACTTCCTCAACGGCGGCGACGAGAAGCTCTATCTCTCCAGCGCCGACTGGATGGAGCGCAACCTCGACATGCGCGTCGAGACCTGCTTCCCGGTGGAAGGCAAGAAGCTGGTGCAGCGGGTCAAGAAGGAACTGGAAACGTACCTGACCGACAACACCCAGGCCTGGGTGTTGCAGGCCGACGGTAGCTACCAGCGGCTCAGTCCCACCGGTAACCAGAACCCCCGCAATACCCAGGCGACCCTGCTGGAGAAGCTGGCCGCGCCGGTGCTTACCGCACGTTGA
Protein Properties
Protein Residues: 736
Protein Molecular Weight: 83.2 kDa
Protein Theoretical pI: 7.72
Hydropathicity (GRAVY score): -0.168
Charge at pH 7 (predicted): 4.43
Protein Sequence: 
>PA5242
MNTQQGLDEIERIAADETVVANVESEAEVKMAETIPVETPPAVVPSVDDSSLYIHRELSQLQFNIRVLEQALDESYPLLERLKFLLIFSSNLDEFFEIRIAGLKKQITFAREQAGADGLLPHQALARISELVHEQVSRQYRILNETLLPELAKHQIRFIRRRHWTLKIKTWVRRFFRDEIAPIITPIGLDPTHPFPLLVNKSLNFIVELEGMDAFGRDSGLAIIPAPRLLPRIIRLPEDVGGEGDNYVFLSSMIHAHADDLFPGMKVKGCYQFRLTRNADLSVDTEDVEDLARALRGELFSRRYGDAVRLEVVDTCPQNLTNYLLKQFGLSESELYKVSGPVNLTRLFSVTGLESHPELQYPPFTPAIPRLLQKKENLFNVLSKLDVLLMHPFESFTPVIDLLRQAAKDPNVLAIKQTLYRSGANSEIVDALVEAARNGKEVTAVIELRARFDEESNLQLASRLQQAGAVVIYGVVGFKTHAKMMLILRREDGELRRYAHLGTGNYHAGNARLYTDYSLLTADVALCEDLHKLFNQLIGMGKTLRMKKLLHAPFTLKKNLLEMINREAAQAALGQPAHIMAKVNSLTDPKVIRALYKASQAGVRIDLVVRGMCCLRPGIPGVSHNIHVRSIIGRFLEHSRIYYFLNGGDEKLYLSSADWMERNLDMRVETCFPVEGKKLVQRVKKELETYLTDNTQAWVLQADGSYQRLSPTGNQNPRNTQATLLEKLAAPVLTAR
References
External Links:
Resource Link
Genome ID: PA5242
Entrez Gene ID: 879700
NCBI Protein ID: 15600435
General Reference: PaperBLAST - Find papers about PA5242 and its homologs