Phosphoribosylformylglycinamidine synthase (PA3763)

Identification
Name: Phosphoribosylformylglycinamidine synthase
Synonyms:
  • FGAM synthase
  • FGAMS
  • Formylglycinamide ribotide amidotransferase
  • FGARAT
  • Formylglycinamide ribotide synthetase
Gene Name: purL
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5'-Phosphoribosyl-N-formylglycineamide + L-Glutamine + Water ↔ ADP + Phosphoribosylformylglycineamidine + L-Glutamate + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5'-Phosphoribosyl-N-formylglycineamide + L-Glutamine + Water ↔ ADP + Phosphate + Phosphoribosylformylglycineamidine + L-Glutamate
ReactionCard
SMPDB Reactions:
5'-Phosphoribosyl-N-formylglycinamide+Thumb+Thumb+Thumb+Thumb → Thumb+L-Glutamic acid+Thumb+Adenosine diphosphate+Thumb+Thumb+Thumb
5'-Phosphoribosyl-N-formylglycinamide + Water + L-Glutamine + Adenosine triphosphate + 5'-Phosphoribosyl-N-formylglycineamide → 2-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidine + L-Glutamic acid + Phosphate + Adenosine diphosphate + Hydrogen ion + L-Glutamate + ADP
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5'-Phosphoribosyl-N-formylglycineamide + L-Glutamine + Water ↔ ADP + Phosphoribosylformylglycineamidine + L-Glutamate + Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5'-Phosphoribosyl-N-formylglycineamide + L-Glutamine + Water ↔ ADP + Phosphate + Phosphoribosylformylglycineamidine + L-Glutamate
ReactionCard
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + 5'-Phosphoribosyl-N-formylglycineamide + L-Glutamine + Water → Hydrogen ion + ADP + Phosphate + Phosphoribosylformylglycineamidine + L-Glutamate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0034162-(Formamido)-N(1)-(5-phospho-D-ribosyl)acetamidineMetaboCard
PAMDB0062062-(Formamido)-N1-(5-phospho-D-ribosyl)acetamidineMetaboCard
PAMDB0003325'-Phosphoribosyl-N-formylglycineamideMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000163L-GlutamineMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000220PhosphoribosylformylglycineamidineMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
phosphoribosylformylglycinamidine synthase activity
Process
'de novo' IMP biosynthetic process
cellular nitrogen compound metabolic process
IMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA3763
Strand: -
Entrez Gene ID: 879752
Accession: NP_252452.1
GI: 15598958
Sequence start: 4215544
Sequence End: 4219440
Sequence Length: 3896
Gene Sequence: 
>PA3763
ATGCTGATCCTGCGCGGCGCTCCCGCCCTTTCCGCTTTCCGCCACGGCAAACTGCTCGAGCAACTGACCCAGCACGTACCTGCCGTTACCGGGCTGTACGCTGAGTTCGCGCATTTCGCCGACGTCACCGGCGCGCTCACCGCCGACGAGGAGCAGGTGCTGGCGCGGCTGCTGAAATACGGCCCGAGCGTGCCGGTGCAGGAGCCCAGCGGACGGCTGTTCCTGGTGGTGCCGCGCTTCGGCACCATCTCGCCGTGGTCGAGCAAGGCCTCCGACATCGCCCGCAACTGCGGCCTGGCGAAGATCGACCGGCTGGAGCGCGGCATTGCCTACTATGTGCAGGGCGAACTGTCCGAGAGCGACGCCCAGCAGGTCGCCGCCCGCCTGCATGACCGCATGACCCAACTGGTGCTGGACCGCCTGGAAGGCGCCGCCGAGCTGTTCAGCCATGCGCAGCCCCGCCCGCTCACCGCCGTCGACGTGCTTGGCGGCGGTCGCGCCGCGCTGGAGAAGGCCAACGTCGAGTTGGGCCTGGCCCTGGCCGAGGACGAGATCGACTACCTGCTGAAGAGCTTCGGCGAACTGGGGCGCAACCCGCACGACGTCGAGCTGATGATGTTCGCCCAGGCCAACTCCGAGCATTGCCGGCACAAGATCTTCAATGCCAGTTGGGACATCGACGGGCAGGCCCAGGACAAGAGCCTGTTCGGCATGATCAAGAACACCTACGAGATGAACCGCGAAGGCGTGCTGTCCGCATACAAGGACAACGCCGCGGTCATCGTCGGCCATGTCGCCGGGCGTTTCTTCCCCGATCCGCAGACCCGCGAATACGCCGCCAGCCGCGAGCCGGTGCAGATCCTGATGAAGGTGGAGACCCACAACCACCCGACCGCCATCGCGCCGTTCCCCGGTGCCTCCACCGGTTCCGGCGGCGAGATCCGCGACGAGGGCGCCACCGGCCGCGGCGCCAAGCCGAAGGCCGGCCTGACCGGCTTCACCGTGTCCAACCTGCAGATCCCCGGTTTCGAACAGCCCTGGGAAGTGCCCTACGGCAAGCCCGAGCGCATCGTCACCGCGCTGGACATCATGGTCGAGGGCCCGCTGGGCGGCGCCGCGTTCAACAACGAGTTCGGCCGTCCGGCGCTGACCGGCTACTTCCGTACCTTCGAGCAGAAGATCGCTACCCCTCACGGCGAGGAAGTGCGCGGCTACCACAAGCCGATCATGCTCGCCGGCGGCATGGGCAACATTCGCGACGAACACGTGCAGAAGGGCGAGATCAGCGTCGGCGCCAAGCTCATCGTCCTTGGCGGCCCGGCCATGCTGATCGGCCTGGGCGGCGGCGCCGCCTCTTCGATGGCCACCGGCGCCAGCTCCGCCGACCTCGACTTCGCCTCGGTGCAGCGCGACAACCCGGAAATGGAGCGACGTTGCCAGGAAGTGATCGACCGCTGCTGGCAGCTCGGCGAGCGCAACCCGATCAGCTTCATCCATGACGTCGGTGCCGGCGGCCTGTCCAACGCCCTGCCGGAACTGATCAACGACGGCGGCCGCGGCGGTCGCTTCGAGCTGCGCGCGGTGCCCAACGACGAGCCGGGCATGAGCCCGCTGGAAATCTGGTGCAACGAGTCGCAGGAGCGCTACGTGCTGTCGGTGGACGCCGCCGACTTCGAGACCTTCAAGGCCATCTGCGAGCGCGAGCGCTGCCCGTTCGCGGTGGTCGGCGAGGCCATCGAGCAGCGCCAGCTGACCGTCGCCGACAGCCATTTCGACAACAAGCCGGTGGACATGCCGCTGGAAGTCCTGCTCGGCAAGGCGCCGCGCATGCACCGCGCGGTCACCCGCGAGGCCGAGCTGGGCGACGATTTCGACGCCGCCGGGCTGGAGCTGCAGGAAAGCGTCGAGCGCGTCCTGCGCCATCCCGCCGTGGCCAGCAAGAGCTTCCTGATCACCATCGGCGACCGCACCATCACCGGGCTGGTGGCCCGCGACCAGATGGTCGGGCCCTGGCAGGTGCCGGTGGCCGACTGCGCCGTCACCGCCACCAGCTTCGACGTCTACACCGGCGAGGCCATGGCGATGGGCGAGCGTACCCCGCTGGCGCTGCTGGACGCCCCGGCTTCCGGACGCATGGCCATCGGCGAGACGGTCACCAACCTGGCTGCCGCGCGTGTCGGCAAGCTGTCCGACATCAAGCTTTCCGCCAACTGGATGGCCGCCGCCGGCCACCCCGGCGAGGACGCGCGCCTGTATGACACGGTCAAGGCCGTGGGCATGGAACTGTGCCCGGAACTGGGCATCACCATCCCGGTGGGCAAGGACTCGATGTCCATGAAGACCCGCTGGCAGGACAATGGCGAGGACAAGAGCGTCACTTCTCCGGTCTCGCTGATCGTCACCGGCTTCGCCCCGGTCGCCGACGTGCGCCAGAGCCTGACCCCGCAACTGCGCCTGGACAAGGGCGAGACCGACCTGATCCTGATCGATCTCGGCCGCGGCAAGAACCGTCTCGGCGGCTCGATCCTGGCCCAGGTCCACGGCAAGCTCGGCCGCGCCGTGCCGGACGTCGACGACGCCGAGGACCTGAAAGCCTTCTTCGCGGTGATCCAGGGGCTCAATGCCGACGGCCATATCCTCGCCTACCACGACCGTTCCGACGGCGGCCTGATCACCAGCGTGCTGGAGATGGCCTTCGCCGGTCACTGCGGCGTCGAGCTGAACCTCGATGCCCTGGCCGATAGCCGCGAAGAGCTGGCGGCCGTGTTGTTCAGCGAGGAACTGGGCGCGGTGATCCAGGTTCGCGAGGGTGCCACTCCGGAAGTCCTCGCGCAGTTCAGCGCCGCCGGTCTCGACGACTGCGTGGCGGTGATCGGCCAGCCGGTCAACGGCTACGAGATCAACCTGAACTACAACGGCGAGACCGTCTACAGCGCCCAGCGCCGCATCCTGCAACGCATCTGGAGCGAGACCAGCTACCAGATCCAGCGTCTGCGCGACAACGCCGACTGCGCCGAGCAGGAGTTCGACGCGCTGCTGGACGAAGACAACCCCGGGCTGTCGATCAAGCTCAGCTACGACGTCAACGACGACATCGCCGCGCCCTACATCAAGAAGGGCGTGCGGCCGAAAGTGGCGATCCTCCGCGAGCAGGGCGTCAACGGCCAGGTGGAGATGGCCGCGGCGTTCGACCGCGCCGGCTTCGCCGCGATCGACGTGCACATGAGCGACATCCTCGCCGGGCGGGTCGACCTGGACGCCTTCAAGGGCCTGGTGGCCTGCGGTGGCTTCTCCTACGGCGACGTGCTCGGCGCCGGCGAGGGCTGGGCCAAGTCGATCCTCTTCAACGCCCGCGCCCGCGACGGCTTCCAGGCGTTCTTCGCGCGCAAGGACAGCTTCGCCCTCGGCGTCTGCAACGGCTGCCAGATGATGTCCAACCTGCACGAGCTGATTCCCGGCACCGAGTTCTGGCCGCACTTCGTGCGCAACCGTTCCGAGCAGTTCGAGGCGCGGGTGGCGATGGTCCAGGTGCAGGAGTCGTCGTCGATCTTCCTGCAGGGCATGGCCGGTTCGCGCCTGCCGATCGCCATCGCCCATGGCGAAGGCCATGCGGAGTTCGAGTCGGAGGAAGCGTTGCTCGAGGCCGACCTTTCCGGCTGCGTGTCGCTGCGTTTCGTCGACAACCACGGCAAGGTCACCGAAGCCTACCCGGCCAACCCCAACGGGTCGCCGCGCGGCATCACCGGGCTGAGCAGCCGCGACGGCCGGGTCACCATCATGATGCCGCACCCCGAGCGGGTGTTCCGCGCCGTGCAGAATTCCTGGCGTCCGGACGACTGGCAGGAAGACGGCGGCTGGCTGCGCATGTTCCGCAACGCCCGGGTCTGGGTGGACTGA
Protein Properties
Protein Residues: 1298
Protein Molecular Weight: 140.6 kDa
Protein Theoretical pI: 4.81
Hydropathicity (GRAVY score): -0.165
Charge at pH 7 (predicted): -47.15
Protein Sequence: 
>PA3763
MLILRGAPALSAFRHGKLLEQLTQHVPAVTGLYAEFAHFADVTGALTADEEQVLARLLKYGPSVPVQEPSGRLFLVVPRFGTISPWSSKASDIARNCGLAKIDRLERGIAYYVQGELSESDAQQVAARLHDRMTQLVLDRLEGAAELFSHAQPRPLTAVDVLGGGRAALEKANVELGLALAEDEIDYLLKSFGELGRNPHDVELMMFAQANSEHCRHKIFNASWDIDGQAQDKSLFGMIKNTYEMNREGVLSAYKDNAAVIVGHVAGRFFPDPQTREYAASREPVQILMKVETHNHPTAIAPFPGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLQIPGFEQPWEVPYGKPERIVTALDIMVEGPLGGAAFNNEFGRPALTGYFRTFEQKIATPHGEEVRGYHKPIMLAGGMGNIRDEHVQKGEISVGAKLIVLGGPAMLIGLGGGAASSMATGASSADLDFASVQRDNPEMERRCQEVIDRCWQLGERNPISFIHDVGAGGLSNALPELINDGGRGGRFELRAVPNDEPGMSPLEIWCNESQERYVLSVDAADFETFKAICERERCPFAVVGEAIEQRQLTVADSHFDNKPVDMPLEVLLGKAPRMHRAVTREAELGDDFDAAGLELQESVERVLRHPAVASKSFLITIGDRTITGLVARDQMVGPWQVPVADCAVTATSFDVYTGEAMAMGERTPLALLDAPASGRMAIGETVTNLAAARVGKLSDIKLSANWMAAAGHPGEDARLYDTVKAVGMELCPELGITIPVGKDSMSMKTRWQDNGEDKSVTSPVSLIVTGFAPVADVRQSLTPQLRLDKGETDLILIDLGRGKNRLGGSILAQVHGKLGRAVPDVDDAEDLKAFFAVIQGLNADGHILAYHDRSDGGLITSVLEMAFAGHCGVELNLDALADSREELAAVLFSEELGAVIQVREGATPEVLAQFSAAGLDDCVAVIGQPVNGYEINLNYNGETVYSAQRRILQRIWSETSYQIQRLRDNADCAEQEFDALLDEDNPGLSIKLSYDVNDDIAAPYIKKGVRPKVAILREQGVNGQVEMAAAFDRAGFAAIDVHMSDILAGRVDLDAFKGLVACGGFSYGDVLGAGEGWAKSILFNARARDGFQAFFARKDSFALGVCNGCQMMSNLHELIPGTEFWPHFVRNRSEQFEARVAMVQVQESSSIFLQGMAGSRLPIAIAHGEGHAEFESEEALLEADLSGCVSLRFVDNHGKVTEAYPANPNGSPRGITGLSSRDGRVTIMMPHPERVFRAVQNSWRPDDWQEDGGWLRMFRNARVWVD
References
External Links:
Resource Link
Genome ID: PA3763
Entrez Gene ID: 879752
NCBI Protein ID: 15598958
General Reference: PaperBLAST - Find papers about PA3763 and its homologs