L-Glutamate (PAMDB000055)

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

gdhA

Locus Tag:

PA4588

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansB

Locus Tag:

PA1337

Molecular weight:

38.6 kDa

Reactions

General function:

Involved in biosynthetic process

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpE

Locus Tag:

PA0609

Molecular weight:

54.6 kDa

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

Gene Name:

pabA

Locus Tag:

PA0649

Molecular weight:

22 kDa

Reactions

General function:

Involved in anthranilate phosphoribosyltransferase activity

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpD

Locus Tag:

PA0650

Molecular weight:

37.4 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Locus Tag:

PA4756

Molecular weight:

117.3 kDa

Reactions

General function:

Involved in GMP synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes the synthesis of GMP from XMP

Gene Name:

guaA

Locus Tag:

PA3769

Molecular weight:

58 kDa

Reactions

General function:

Involved in transferase activity

Specific function:

An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate

Gene Name:

tyrB

Locus Tag:

PA3139

Molecular weight:

43.3 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction:glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)

Gene Name:

gltX

Locus Tag:

PA3134

Molecular weight:

56.7 kDa

Reactions

General function:

Involved in biosynthetic process

Specific function:

Catalyzes the biosynthesis of 4-amino-4-deoxychorismate (ADC) from chorismate and glutamine

Gene Name:

pabB

Locus Tag:

PA1758

Molecular weight:

49.6 kDa

Reactions

General function:

Involved in tetrahydrofolylpolyglutamate synthase activity

Specific function:

Conversion of folates to polyglutamate derivatives

Gene Name:

folC

Locus Tag:

PA3111

Molecular weight:

46.5 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Oxidizes proline to glutamate for use as a carbon and nitrogen source and also function as a transcriptional repressor of the put operon

Gene Name:

putA

Locus Tag:

PA0782

Molecular weight:

115.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltB

Locus Tag:

PA5036

Molecular weight:

161.6 kDa

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltD

Locus Tag:

PA5035

Molecular weight:

52.6 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L- glutamate

Gene Name:

argA

Locus Tag:

PA5204

Molecular weight:

47.9 kDa

Reactions

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Locus Tag:

PA4758

Molecular weight:

40.8 kDa

Reactions

General function:

Involved in glutaminase activity

Specific function:

L-glutamine + H(2)O = L-glutamate + NH(3)

Gene Name:

glsA2

Locus Tag:

PA1638

Molecular weight:

33 kDa

Reactions

General function:

Involved in glutamate-cysteine ligase activity

Specific function:

ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine

Gene Name:

gshA

Locus Tag:

PA5203

Molecular weight:

59.2 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline

Gene Name:

proB

Locus Tag:

PA4565

Molecular weight:

39.8 kDa

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Locus Tag:

PA3637

Molecular weight:

59.6 kDa

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Locus Tag:

PA5119

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in amidophosphoribosyltransferase activity

Specific function:

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O

Gene Name:

purF

Locus Tag:

PA3108

Molecular weight:

55.4 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

ATP + N(2)-formyl-N(1)-(5-phospho-D- ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2- (formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate

Gene Name:

purL

Locus Tag:

PA3763

Molecular weight:

140.6 kDa

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

Gene Name:

glmS

Locus Tag:

PA5549

Molecular weight:

66.3 kDa

Reactions

General function:

Involved in transaminase activity

Specific function:

Involved in both the arginine and lysine biosynthetic pathways

Gene Name:

argD

Locus Tag:

PA0895

Molecular weight:

43.7 kDa

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Gene Name:

nadE

Locus Tag:

PA4920

Molecular weight:

29.7 kDa

Reactions

General function:

Involved in gamma-glutamyltransferase activity

Specific function:

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

Gene Name:

ggt

Locus Tag:

PA1338

Molecular weight:

59.9 kDa

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

Gene Name:

gabT

Locus Tag:

PA0266

Molecular weight:

45.2 kDa

Reactions

General function:

Involved in racemase and epimerase activity, acting on amino acids and derivatives

Specific function:

Provides the (R)-glutamate required for cell wall biosynthesis

Gene Name:

murI

Locus Tag:

PA4662

Molecular weight:

28.3 kDa

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. Is involved in both pyridoxine and serine biosynthesis

Gene Name:

serC

Locus Tag:

PA3167

Molecular weight:

39.9 kDa

Reactions

General function:

Involved in zinc ion binding

Specific function:

Displays a broad specificity and can also deacylate substrates such as acetylarginine, acetylhistidine or acetylglutamate semialdehyde

Gene Name:

argE

Locus Tag:

PA5206

Molecular weight:

42.2 kDa

Reactions

General function:

Involved in transaminase activity

Specific function:

Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnB

Locus Tag:

PA3552

Molecular weight:

41.9 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltJ

Locus Tag:

PA1341

Molecular weight:

27.6 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for aspartate/glutamate; probably responsible for the translocation of the substrate across the membrane

Gene Name:

gltK

Locus Tag:

PA1340

Molecular weight:

24.6 kDa

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Specific function unknown

Gene Name:

yfbQ

Locus Tag:

PA2828

Molecular weight:

44.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Acts on leucine, isoleucine and valine

Gene Name:

ilvE

Locus Tag:

PA5013

Molecular weight:

34.1 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Probably responsible for energy coupling to the transport system

Gene Name:

gltL

Locus Tag:

PA1339

Molecular weight:

26.9 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for glutamate and aspartate. Binds to both aspartate and glutamate

Gene Name:

gltI

Locus Tag:

PA1342

Molecular weight:

33.1 kDa

General function:

Amino acid transport and metabolism

Specific function:

Specific function unknown

Gene Name:

yfdZ

Locus Tag:

PA4715

Molecular weight:

46.1 kDa

Reactions