Gamma-glutamyltranspeptidase (PA1338)

Identification
Name: Gamma-glutamyltranspeptidase
Synonyms:
  • Gamma-glutamyltranspeptidase large chain
  • Gamma-glutamyltranspeptidase small chain
Gene Name: ggt
Enzyme Class:
Biological Properties
General Function: Involved in gamma-glutamyltransferase activity
Specific Function: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid
Cellular Location: Periplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb → Thumb+Thumb
Glutathione + Water → Cysteinylglycine + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
Glutathione + Water ↔ Cysteinylglycine + L-Glutamate
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Thumb+L-Amino acid ↔ Thumb+(5-L-Glutamyl)-L-amino acid
Glutathione + L-Amino acid ↔ Cysteinylglycine + (5-L-Glutamyl)-L-amino acid
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(5-L-Glutamyl)-peptide+Thumb ↔ Peptide+Thumb
(5-L-Glutamyl)-peptide + Taurine ↔ Peptide + 5-L-Glutamyl-taurine
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R-S-Glutathione+Thumb ↔ R-S-Cysteinylglycine+Thumb
R-S-Glutathione + Water ↔ R-S-Cysteinylglycine + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
3-Cyano-L-alanine + L-Glutamate ↔ gamma-Glutamyl-beta-cyanoalanine + Water
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Thumb+Thumb ↔ Thumb+Thumb
beta-Aminopropionitrile + L-Glutamate ↔ gamma-Glutamyl-beta-aminopropiononitrile + Water
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(5-L-Glutamyl)-peptide+Thumb ↔ Peptide+Thumb
(5-L-Glutamyl)-peptide + Se-Methylselenocysteine ↔ Peptide + gamma-Glutamyl-Se-methylselenocysteine
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(5-L-Glutamyl)-peptide+Amino acid ↔ Peptide+5-L-Glutamyl amino acid
(5-L-Glutamyl)-peptide + Amino acid ↔ Peptide + 5-L-Glutamyl amino acid
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SMPDB Reactions:
Thumb+(5-L-Glutamyl)-peptide → Thumb+Peptide
Taurine + (5-L-Glutamyl)-peptide → 5-L-Glutamyl-taurine + Peptide
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Thumb+Thumb → Thumb+Thumb
L-Glutamate + 3-Cyano-L-alanine → Water + gamma-Glutamyl-beta-cyanoalanine
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PseudoCyc/BioCyc Reactions:
R-S-Glutathione+Thumb ↔ R-S-Cysteinylglycine+Thumb
R-S-Glutathione + Water ↔ R-S-Cysteinylglycine + L-Glutamate
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Thumb+Thumb → Thumb+Thumb
Glutathione + Water → Cysteinylglycine + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
Glutathione + Water ↔ Cysteinylglycine + L-Glutamate
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Thumb+L-Amino acid ↔ Thumb+(5-L-Glutamyl)-L-amino acid
Glutathione + L-Amino acid ↔ Cysteinylglycine + (5-L-Glutamyl)-L-amino acid
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(5-L-Glutamyl)-peptide+Thumb ↔ Peptide+Thumb
(5-L-Glutamyl)-peptide + Taurine ↔ Peptide + 5-L-Glutamyl-taurine
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Thumb+Thumb ↔ Thumb+Thumb
3-Cyano-L-alanine + L-Glutamate ↔ gamma-Glutamyl-beta-cyanoalanine + Water
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Thumb+Thumb ↔ Thumb+Thumb
beta-Aminopropionitrile + L-Glutamate ↔ gamma-Glutamyl-beta-aminopropiononitrile + Water
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(5-L-Glutamyl)-peptide+Thumb ↔ Peptide+Thumb
(5-L-Glutamyl)-peptide + Se-Methylselenocysteine ↔ Peptide + gamma-Glutamyl-Se-methylselenocysteine
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Thumb+Thumb → Thumb+Thumb
Glutathione + Water → Cysteinylglycine + L-Glutamate
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Thumb
a 5-L-glutamyl-[peptide] + an amino acid = a 5-L-glutamyl-amino acid + a peptide
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S-Substituted-Glutathione+PAMDB000142 → CPD-6262+PAMDB110666
S-Substituted-Glutathione + Water → CPD-6262 + L-glutamate
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PAMDB110431+Amino-Acids-20 → PAMDB000028+5-L-GLUTAMYL-L-AMINO-ACID
glutathione + Amino-Acids-20 → Cysteinylglycine + 5-L-GLUTAMYL-L-AMINO-ACID
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PAMDB120134+PAMDB000142 → PAMDB120521+PAMDB110666
4-hydroxy-2-nonenal-glutathione conjugate + Water → 4-hydroxy-2-nonenal-[Cys-Gly] conjugate + L-glutamate
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Complex Reactions:
A (5-L-glutamyl)-peptide+an amino acid → a peptide+a 5-L-glutamyl amino acid
A (5-L-glutamyl)-peptide + an amino acid → a peptide + a 5-L-glutamyl amino acid
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Thumb+Thumb → Thumb+Thumb
Glutathione + Water → Cysteinylglycine + L-Glutamate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0009153-Cyano-L-alanineMetaboCard
PAMDB0006545-L-Glutamyl-taurineMetaboCard
PAMDB001424beta-AminopropionitrileMetaboCard
PAMDB000028CysteinylglycineMetaboCard
PAMDB000997gamma-Glutamyl-beta-aminopropiononitrileMetaboCard
PAMDB000998gamma-Glutamyl-beta-cyanoalanineMetaboCard
PAMDB000803gamma-Glutamyl-Se-methylselenocysteineMetaboCard
PAMDB000048GlutathioneMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB001427Se-MethylselenocysteineMetaboCard
PAMDB000106TaurineMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
gamma-glutamyltransferase activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring amino-acyl groups
Gene Properties
Locus tag: PA1338
Strand: -
Entrez Gene ID: 882262
Accession: NP_250029.1
GI: 15596535
Sequence start: 1451719
Sequence End: 1453392
Sequence Length: 1673
Gene Sequence: 
>PA1338
ATGCAACCTGTGCTCTTCAGAACCCTGTCCCTCGGCGTCGCCATTGCCGCCGCATCCTCCTCGGCCTTCGCCGCCACGCTCGACGGCGGCGCCGTCGCCGCGCCCGACGAGTACGGCGCCAAGGTCGCCGCGCAGATCCTCAAGGCCGGCGGCAACGCGGTGGACGCCGCGGTGGCCACCGCCTTCACCCTGGCGGTCACCTACCCCGAGGCCGGCAACATCGGCGGCGGCGGCTTCATGACCCTGTACATGGACGGCAAGCCGTACTTCCTCGACTACCGCGAGGTGGCGCCGAAGGCCGCGAGCAAGACCATGTACCTGGACGACAAGGGCGAGGTGATCGAGAACCTCAGCCTGGTCGGCGCCAAGGCCGCCGGCGTGCCGGGCACCGTGATGGGCCTCTGGGAAGCCCACAAGCGGTTCGGCAAGCTGCCCTGGAGCGAGCTGCTGACCCCGGCCATCGGCTACGCGCAAAAGGGCTTCAAGGTCGCCGACAAGCAGTTCCAGTACCGCCAGGACGCCGTCGCCCTGTTCAACGGCAAGACCAACTTCGGCGACTACTTCGGCCACATGAAGGCCGGCGAGGCGTTCCTCCAGCCGGACCTGGCGAAGACCCTGGAGCGTATCGCCGACAAGGGCCCGGACGAGTTCTACAAAGGCCATACCGCCGACCTGCTGGTGGCACAGATGCAGCAGGACAAGGGACTGATCACCCACCAGGACCTCGCCGACTACAAGGTCAGGTGGCGCGAACCGATGCGCGTCGACTGGCAGGGCAACACGCTCTATACCGCGCCGCTGCCAAGCTCCGGCGGGATCGCCCTGGCCCAGTTGCTGGGCATCAAGGAAAACCGTGCCGCCGACTTCAAGGGCGTCGAGCTGAACTCCGCGCGCTACATCCACCTGCTGGCGGAGATCGAGAAACGCGTGTTCGCCGACCGCGCCGACTACCTCGGCGACCCGGACTTCTCCAAGGTCCCGGTGGCGCGCCTGACCGATCCGGCATACCTGAAGCAGCGTGCCGCCGAGGTCAATCCGACGGCGATCTCGCCGACCGAGAAGGTCCGTCCCGGCCTGGAGCCGCACCAGACCACGCACTTCTCCATCGTCGACGCCGACGGCAACGCGGTGAGCAACACCTACACCCTCAACTGGGACTTCGGCAGCGGCGTGGTGGTCAAGGGCGCCGGCTTCCTGCTCAACGACGAGATGGACGACTTTAGCGCCAAACCGGGCGTGGCCAACGCCTTCGGCGTGGTCGGCAGCGACGCCAACGCCATCGAGCCGGGCAAGCGCATGCTCTCCTCGATGAGCCCGAGCATCGTCACCCGCGACGGCAAGGTCAGCCTGGTGGTCGGCACTCCCGGCGGCTCGCGGATCTTCACCTCGATCTTCCAGGTGCTGAACAACATCTACGACTTCCACCTGCCGCTGGAGAAGGCCGTGGCCGCGCAGCGCGTGCACCACCAGTTGCTGCCCAAGGACACGATCTACTACGACGCCTACGCGCCGCTCGCCGGCAAGGTCGCCGAGGAGCTGAAGGCGATGGGCTACACCCTGGAGGACCAGGGCTGGAACATGGGCGATATCCAGGCCATCCGCGTCGACGGCAAGGCCCTGGAGACCGCCTCCGATCCCCGTGGCCGCGGCGTCGGCCTGGTGGTGAAACCCTGA
Protein Properties
Protein Residues: 557
Protein Molecular Weight: 59.9 kDa
Protein Theoretical pI: 6.21
Hydropathicity (GRAVY score): -0.138
Charge at pH 7 (predicted): -4.58
Protein Sequence: 
>PA1338
MQPVLFRTLSLGVAIAAASSSAFAATLDGGAVAAPDEYGAKVAAQILKAGGNAVDAAVATAFTLAVTYPEAGNIGGGGFMTLYMDGKPYFLDYREVAPKAASKTMYLDDKGEVIENLSLVGAKAAGVPGTVMGLWEAHKRFGKLPWSELLTPAIGYAQKGFKVADKQFQYRQDAVALFNGKTNFGDYFGHMKAGEAFLQPDLAKTLERIADKGPDEFYKGHTADLLVAQMQQDKGLITHQDLADYKVRWREPMRVDWQGNTLYTAPLPSSGGIALAQLLGIKENRAADFKGVELNSARYIHLLAEIEKRVFADRADYLGDPDFSKVPVARLTDPAYLKQRAAEVNPTAISPTEKVRPGLEPHQTTHFSIVDADGNAVSNTYTLNWDFGSGVVVKGAGFLLNDEMDDFSAKPGVANAFGVVGSDANAIEPGKRMLSSMSPSIVTRDGKVSLVVGTPGGSRIFTSIFQVLNNIYDFHLPLEKAVAAQRVHHQLLPKDTIYYDAYAPLAGKVAEELKAMGYTLEDQGWNMGDIQAIRVDGKALETASDPRGRGVGLVVKP
References
External Links:
Resource Link
Genome ID: PA1338
Entrez Gene ID: 882262
NCBI Protein ID: 15596535
General Reference: PaperBLAST - Find papers about PA1338 and its homologs