Glutathione (PAMDB000048)

General function:

Involved in ATP binding

Specific function:

ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione

Gene Name:

gshB

Locus Tag:

PA0407

Molecular weight:

35.7 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol

Gene Name:

gor

Locus Tag:

PA2025

Molecular weight:

49.2 kDa

Reactions

General function:

Involved in arsenate reductase (glutaredoxin) activity

Specific function:

Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance

Gene Name:

arsC

Locus Tag:

PA2279

Molecular weight:

16.6 kDa

Reactions

General function:

Involved in lactoylglutathione lyase activity

Specific function:

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione

Gene Name:

gloA

Locus Tag:

PA3524

Molecular weight:

14.3 kDa

Reactions

General function:

Involved in gamma-glutamyltransferase activity

Specific function:

(5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl amino acid

Gene Name:

ggt

Locus Tag:

PA1338

Molecular weight:

59.9 kDa

Reactions

General function:

Involved in carboxylesterase activity

Specific function:

Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate. Shows also esterase activity against alpha-naphthyl acetate, lactoylglutathione, palmitoyl-CoA and several pNP-esters of short chain fatty acids

Gene Name:

yeiG

Locus Tag:

PA3628

Molecular weight:

31.2 kDa

Reactions

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Involved in disulfide bond formation. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins such as ErfK, YbiS and YnhG. Probably also functions as a disulfide isomerase with a narrower substrate specificity than DsbC. DsbG is maintained in a reduced state by DsbD. Displays chaperone activity in both redox states in vitro

Gene Name:

dsbG

Locus Tag:

PA2476

Molecular weight:

28.1 kDa

General function:

Involved in electron carrier activity

Specific function:

Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters (Probable)

Gene Name:

grxD

Locus Tag:

PA3533

Molecular weight:

11.8 kDa

General function:

Involved in cell redox homeostasis

Specific function:

Acts as a disulfide isomerase, interacting with incorrectly folded proteins to correct non-native disulfide bonds. DsbG and DsbC are part of a periplasmic reducing system that controls the level of cysteine sulfenylation, and provides reducing equivalents to rescue oxidatively damaged secreted proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by DsbD

Gene Name:

dsbC

Locus Tag:

PA3737

Molecular weight:

26.1 kDa

General function:

Involved in electron carrier activity

Specific function:

The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione reductase

Gene Name:

grxC

Locus Tag:

PA5129

Molecular weight:

9.2 kDa

General function:

Not Available

Specific function:

Not Available

Gene Name:

yfcG

Locus Tag:

PA1033

Molecular weight:

24.5 kDa