Lactoylglutathione lyase (PA3524)

Identification
Name: Lactoylglutathione lyase
Synonyms:
  • Aldoketomutase
  • Glyoxalase I
  • Glx I
  • Ketone-aldehyde mutase
  • Methylglyoxalase
  • S-D-lactoylglutathione methylglyoxal lyase
Gene Name: gloA
Enzyme Class:
Biological Properties
General Function: Involved in lactoylglutathione lyase activity
Specific Function: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb
Glutathione + Pyruvaldehyde ↔ S-Lactoylglutathione
ReactionCard
SMPDB Reactions:
Thumb+Thumb → Thumb
Pyruvaldehyde + Glutathione → S-Lactoylglutathione
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb
Glutathione + Pyruvaldehyde ↔ S-Lactoylglutathione
ReactionCard
Complex Reactions:
Thumb → Thumb+Thumb
S-Lactoylglutathione → Glutathione + Pyruvaldehyde
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000048GlutathioneMetaboCard
PAMDB000281PyruvaldehydeMetaboCard
PAMDB000239S-LactoylglutathioneMetaboCard
GO Classification:
Function
binding
carbon-sulfur lyase activity
catalytic activity
cation binding
ion binding
lactoylglutathione lyase activity
lyase activity
metal ion binding
Gene Properties
Locus tag: PA3524
Strand: +
Entrez Gene ID: 879791
Accession: NP_252214.1
GI: 15598720
Sequence start: 3944184
Sequence End: 3944570
Sequence Length: 386
Gene Sequence: 
>PA3524
ATGCGCATTCTCCATACCATGATCCGGGTCGGAAACATCGATCGCTCGATCGATTTCTATACCCGGGTGCTAGGCATGACCCTGCTCAGGAAGAACGACTATCCCGACGGCCAGTTCACCCTCGCCTTCGTCGGCTATGGCAACGAAGCGGATTCCGCGGTGATCGAGCTTACCCACAACTGGGGCGTGGATGCCTACGAGATCGGCACCGGCTACGGCCATATCGCCATCGAGGTCGACGACGCCTACCAGGCCTGCGACGACATCCGCTACAACGGCGGCCAGGTCACCCGCGAAGCCGGGCCGATGAAGCACGGTACCACCGTGATCGCCTTCGTGACCGACCCGGACGGCTACAAGATCGAACTGATCCAGAAGTCTTCCTGA
Protein Properties
Protein Residues: 128
Protein Molecular Weight: 14.3 kDa
Protein Theoretical pI: 4.68
Hydropathicity (GRAVY score): -0.238
Charge at pH 7 (predicted): -6.08
Protein Sequence: 
>PA3524
MRILHTMIRVGNIDRSIDFYTRVLGMTLLRKNDYPDGQFTLAFVGYGNEADSAVIELTHNWGVDAYEIGTGYGHIAIEVDDAYQACDDIRYNGGQVTREAGPMKHGTTVIAFVTDPDGYKIELIQKSS
References
External Links:
Resource Link
Genome ID: PA3524
Entrez Gene ID: 879791
NCBI Protein ID: 15598720
General Reference: PaperBLAST - Find papers about PA3524 and its homologs