Glutathione reductase (PA2025)

Identification
Name: Glutathione reductase
Synonyms:
  • GR
  • GRase
Gene Name: gor
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Maintains high levels of reduced glutathione in the cytosol
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ 2 Thumb+Thumb
Glutathione disulfide + Hydrogen ion + NADPH ↔ 2 Glutathione + NADP
ReactionCard
2 Thumb+Thumb ↔ Thumb+Thumb+Thumb
2 Glutathione + NAD ↔ Glutathione disulfide + NADH + Hydrogen ion
ReactionCard
2 Thumb+Thumb ↔ Thumb+Thumb+Thumb
2 Glutathione + NADP ↔ Glutathione disulfide + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Oxidized glutathione+Thumb+NADPH+Thumb+Thumb → Thumb+2 Thumb
Oxidized glutathione + Hydrogen ion + NADPH + Glutathione disulfide + NADPH → NADP + 2 Glutathione
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ 2 Thumb+Thumb
Glutathione disulfide + Hydrogen ion + NADPH ↔ 2 Glutathione + NADP
ReactionCard
Complex Reactions:
2 Thumb+Thumb → Thumb+Thumb
2 Glutathione + NADP → Glutathione disulfide + NADPH
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000048GlutathioneMetaboCard
PAMDB001629Glutathione disulfideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
adenyl nucleotide binding
binding
catalytic activity
disulfide oxidoreductase activity
FAD or FADH2 binding
glutathione disulfide oxidoreductase activity
glutathione-disulfide reductase activity
NADP or NADPH binding
nucleoside binding
nucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors
peptide disulfide oxidoreductase activity
purine nucleoside binding
Process
cell redox homeostasis
cellular homeostasis
cellular metabolic process
cellular process
glutathione metabolic process
metabolic process
oxidation reduction
peptide metabolic process
Gene Properties
Locus tag: PA2025
Strand: +
Entrez Gene ID: 878570
Accession: NP_250715.1
GI: 15597221
Sequence start: 2216688
Sequence End: 2218043
Sequence Length: 1355
Gene Sequence: 
>PA2025
ATGTCTTTCGATTTCGATCTGTTCGTCATCGGCGCCGGCTCAGGGGGCGTACGCGCCGCCCGCTTCGCCGCCGGCTTCGGTGCCCGTGTCGCGGTGGCGGAGAGTCGCTACCTGGGTGGCACCTGCGTCAACGTCGGCTGCGTGCCGAAGAAGCTGCTGGTCTATGGCGCGCATTTCAGCGAGGACTTCGAGCAGGCCCGGGCCTATGGCTGGAGCGCCGGCGAGGCGCAGTTCGACTGGGCGACCCTGATCGGCAACAAGAACCGCGAGATCCAGCGGCTCAACGGGATCTACCGCAACCTGCTGGTGAACAGCGGGGTGACCTTGCTCGAAGGTCACGCCCGTCTGCTCGATGCGCACAGCGTCGAGGTGGACGGCCAGCGCTTCAGCGCCAAGCACATTCTCGTCGCCACCGGTGGCTGGCCGCAGGTGCCGGACATTCCCGGCAAGGAACACGCGATCACCTCCAACGAAGCGTTCTTCCTCGAGCGCCTGCCGCGCCGCGTGCTGGTGGTCGGCGGCGGCTACATCGCCGTCGAATTCGCCTCGATCTTCAACGGGCTCGGCGCCGAGACCACCTTGCTCTACCGTCGCGACCTGTTCCTGCGCGGCTTCGACCGCAGCGTCCGCGAGCATCTGCGCGACGAATTGGGCAAGAAGGGCCTGGACCTGCAGTTCAACAGCGACATTGCCCGTATCGACAAACAGGCCGATGGTAGCCTCGCCGCGACCCTCAAGGACGGCCGGGTGCTGGAGGCGGACTGCGTGTTCTACGCCACCGGGCGGCGGCCGATGCTGGACGACCTGGGCCTGGAAAACACAGCTGTGAAGCTGACCGACAAGGGCTTCATCGCGGTCGACGAGCACTACCAGACCAGCGAACCGTCGATACTCGCCCTCGGTGACGTGATCGGTCGCGTCCAGTTGACCCCCGTGGCGCTGGCCGAGGGTATGGCGGTGGCACGGCGATTGTTCAAGCCGGAGGAGTATCGCCCGGTGGACTACAAGTTGATTCCCACCGCGGTGTTCAGCCTGCCCAACATCGGCACCGTCGGCCTGACCGAGGAGGAGGCGCTGAGCGCCGGGCACAAGGTGAAGATCTTCGAGAGCCGCTTCCGGCCGATGAAGCTGACCCTTACCGACGACCAGGAAAAGACCCTGATGAAGCTGGTCGTGGATGCCCACGACGACAGGGTGCTGGGTTGCCACATGGTCGGCGCCGAGGCCGGCGAGATCCTCCAGGGTATTGCGGTGGCGATGAAGGCCGGGGCGACCAAGCAGGCGTTCGACGAGACCATCGGCATCCACCCGACCGCGGCGGAAGAGTTCGTCACCCTGCGCACGCCGACGCGCTGA
Protein Properties
Protein Residues: 451
Protein Molecular Weight: 49.2 kDa
Protein Theoretical pI: 6.3
Hydropathicity (GRAVY score): -0.051
Charge at pH 7 (predicted): -4.45
Protein Sequence: 
>PA2025
MSFDFDLFVIGAGSGGVRAARFAAGFGARVAVAESRYLGGTCVNVGCVPKKLLVYGAHFSEDFEQARAYGWSAGEAQFDWATLIGNKNREIQRLNGIYRNLLVNSGVTLLEGHARLLDAHSVEVDGQRFSAKHILVATGGWPQVPDIPGKEHAITSNEAFFLERLPRRVLVVGGGYIAVEFASIFNGLGAETTLLYRRDLFLRGFDRSVREHLRDELGKKGLDLQFNSDIARIDKQADGSLAATLKDGRVLEADCVFYATGRRPMLDDLGLENTAVKLTDKGFIAVDEHYQTSEPSILALGDVIGRVQLTPVALAEGMAVARRLFKPEEYRPVDYKLIPTAVFSLPNIGTVGLTEEEALSAGHKVKIFESRFRPMKLTLTDDQEKTLMKLVVDAHDDRVLGCHMVGAEAGEILQGIAVAMKAGATKQAFDETIGIHPTAAEEFVTLRTPTR
References
External Links:
Resource Link
Genome ID: PA2025
Entrez Gene ID: 878570
NCBI Protein ID: 15597221
General Reference: PaperBLAST - Find papers about PA2025 and its homologs