GSH-dependent disulfide bond oxidoreductase (PA1033)

Identification
Name: GSH-dependent disulfide bond oxidoreductase
Synonyms: Not Available
Gene Name: yfcG
Enzyme Class:
Biological Properties
General Function: Not Available
Specific Function: protein binding
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
RX+Thumb ↔ Halide+R-S-Glutathione
RX + Glutathione ↔ Halide + R-S-Glutathione
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-7,8-oxide + Glutathione ↔ 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-7,8-oxide + Glutathione ↔ 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-5,6-oxide + Glutathione ↔ 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-5,6-oxide + Glutathione ↔ 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
Bromobenzene-3,4-oxide + Glutathione ↔ 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
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Thumb+Thumb ↔ Thumb
Bromobenzene-2,3-oxide + Glutathione ↔ 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
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Thumb+Thumb ↔ Thumb
Benzo[a]pyrene-4,5-oxide + Glutathione ↔ 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
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Thumb+Thumb ↔ Thumb+Thumb
Benzo[a]pyrene-7,8-diol + Glutathione ↔ 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + Water
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Thumb+Thumb ↔ Thumb
2,2-Dichloroacetaldehyde + Glutathione ↔ S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
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Thumb+Thumb ↔ Thumb+Hydrochloric acid
2,2-Dichloroacetaldehyde + Glutathione ↔ S-(2-Chloroacetyl)glutathione + Hydrochloric acid
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Thumb+Thumb ↔ Thumb+Hydrochloric acid
2-(S-Glutathionyl)acetyl chloride + Glutathione ↔ 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid
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Trichloroethene+Thumb ↔ Thumb+Hydrochloric acid
Trichloroethene + Glutathione ↔ S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid
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1,2-Dibromoethane+Thumb+Thumb ↔ Thumb+2 Hydrobromic acid
1,2-Dibromoethane + Glutathione + Hydrogen ion ↔ Glutathione episulfonium ion + 2 Hydrobromic acid
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Aflatoxin B1-exo-8,9-epoxide+Thumb ↔ Aflatoxin B1exo-8,9-epoxide-GSH
Aflatoxin B1-exo-8,9-epoxide + Glutathione ↔ Aflatoxin B1exo-8,9-epoxide-GSH
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RX+Thumb ↔ Thumb+R-S-Glutathione
RX + Glutathione ↔ Halide + R-S-Glutathione
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SMPDB Reactions:
Thumb+Thumb → Thumb+Hydrochloric acid
Glutathione + 2-(S-Glutathionyl)acetyl chloride → 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid
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PseudoCyc/BioCyc Reactions:
RX+Thumb ↔ Halide+R-S-Glutathione
RX + Glutathione ↔ Halide + R-S-Glutathione
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-7,8-oxide + Glutathione ↔ 1-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-7,8-oxide + Glutathione ↔ 1-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-5,6-oxide + Glutathione ↔ 1-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
1-Nitronaphthalene-5,6-oxide + Glutathione ↔ 1-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthalene
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Thumb+Thumb ↔ Thumb
Bromobenzene-3,4-oxide + Glutathione ↔ 3,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzene
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Thumb+Thumb ↔ Thumb
Bromobenzene-2,3-oxide + Glutathione ↔ 2,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzene
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Thumb+Thumb ↔ Thumb
Benzo[a]pyrene-4,5-oxide + Glutathione ↔ 4,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyrene
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Thumb+Thumb ↔ Thumb+Thumb
Benzo[a]pyrene-7,8-diol + Glutathione ↔ 7,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyrene + Water
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Thumb+Thumb ↔ Thumb
2,2-Dichloroacetaldehyde + Glutathione ↔ S-(2,2-Dichloro-1-hydroxy)ethyl glutathione
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Thumb+Thumb ↔ Thumb+Hydrochloric acid
2,2-Dichloroacetaldehyde + Glutathione ↔ S-(2-Chloroacetyl)glutathione + Hydrochloric acid
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Thumb+Thumb ↔ Thumb+Hydrochloric acid
2-(S-Glutathionyl)acetyl chloride + Glutathione ↔ 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid
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Trichloroethene+Thumb ↔ Thumb+Hydrochloric acid
Trichloroethene + Glutathione ↔ S-(1,2-Dichlorovinyl)glutathione + Hydrochloric acid
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1,2-Dibromoethane+Thumb+Thumb ↔ Thumb+2 Hydrobromic acid
1,2-Dibromoethane + Glutathione + Hydrogen ion ↔ Glutathione episulfonium ion + 2 Hydrobromic acid
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Aflatoxin B1-exo-8,9-epoxide+Thumb ↔ Aflatoxin B1exo-8,9-epoxide-GSH
Aflatoxin B1-exo-8,9-epoxide + Glutathione ↔ Aflatoxin B1exo-8,9-epoxide-GSH
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RX+Thumb ↔ Thumb+R-S-Glutathione
RX + Glutathione ↔ Halide + R-S-Glutathione
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Thumb
glutathione + RX = a glutathione-toxin conjugate + HX
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PAMDB110431+PAMDB120148 → PAMDB120134
glutathione + 4-hydroxy-2-nonenal → 4-hydroxy-2-nonenal-glutathione conjugate
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PAMDB120194+PAMDB110431 → PAMDB001633+PAMDB120184+PAMDB000573
1-chloro-2,4-dinitrobenzene + glutathione → Hydrogen ion + 2,4-dinitrophenyl-S-glutathione + Chloride
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Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000852(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthaleneMetaboCard
PAMDB000853(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthaleneMetaboCard
PAMDB000850(1R,2S)-Naphthalene 1,2-oxideMetaboCard
PAMDB000855(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthaleneMetaboCard
PAMDB0008731-Nitro-5-glutathionyl-6-hydroxy-5,6-dihydronaphthaleneMetaboCard
PAMDB0008741-Nitro-5-hydroxy-6-glutathionyl-5,6-dihydronaphthaleneMetaboCard
PAMDB0008751-Nitro-7-glutathionyl-8-hydroxy-7,8-dihydronaphthaleneMetaboCard
PAMDB0008761-Nitro-7-hydroxy-8-glutathionyl-7,8-dihydronaphthaleneMetaboCard
PAMDB0008771-Nitronaphthalene-5,6-oxideMetaboCard
PAMDB0008781-Nitronaphthalene-7,8-oxideMetaboCard
PAMDB0009022,2-DichloroacetaldehydeMetaboCard
PAMDB0009042,3-Dihydro-2-S-glutathionyl-3-hydroxy bromobenzeneMetaboCard
PAMDB0008832-(S-Glutathionyl)acetyl chlorideMetaboCard
PAMDB0008842-(S-Glutathionyl)acetyl glutathioneMetaboCard
PAMDB0009273,4-Dihydro-3-hydroxy-4-S-glutathionyl bromobenzeneMetaboCard
PAMDB0009444,5-Dihydro-4-hydroxy-5-S-glutathionyl-benzo[a]pyreneMetaboCard
PAMDB0009364-Glutathionyl cyclophosphamideMetaboCard
PAMDB0009587,8-Dihydro-7-hydroxy-8-S-glutathionyl-benzo[a]pyreneMetaboCard
PAMDB000966Benzo[a]pyrene-4,5-oxideMetaboCard
PAMDB000967Benzo[a]pyrene-7,8-diolMetaboCard
PAMDB000973Bromobenzene-2,3-oxideMetaboCard
PAMDB000974Bromobenzene-3,4-oxideMetaboCard
PAMDB000048GlutathioneMetaboCard
PAMDB001001Glutathione episulfonium ionMetaboCard
PAMDB004133HalideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001032S-(1,2-Dichlorovinyl)glutathioneMetaboCard
PAMDB001034S-(2,2-Dichloro-1-hydroxy)ethyl glutathioneMetaboCard
PAMDB001033S-(2-Chloroacetyl)glutathioneMetaboCard
PAMDB001035S-(Formylmethyl)glutathioneMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
protein binding
Gene Properties
Locus tag: PA1033
Strand: -
Entrez Gene ID: 880186
Accession: NP_249724.1
GI: 15596230
Sequence start: 1122340
Sequence End: 1122981
Sequence Length: 641
Gene Sequence: 
>PA1033
ATGATCGACCTGTACTACTGGACCACCCCGAACGGCCACAAGATTACTCTTTTCCTGGAAGAAACCGGCCTGCCCTACGCCATCCATCCGATCAACATCAGCCAGGGCGACCAGTTCCAGGCGGATTTCCTGAAGGTGTCGCCGAACAACAAGATTCCCGCCATCGTCGATCGCCAACCGGCCGACGGCGGCGCTCCCCTGTCGCTGTTCGAGTCCGGCGCCATCCTGCTCTATCTCGCGGAAAAGACTGGACGCTTCCTCGCCAAGGACCTGCGCGCGCGCCAGGAAACCCTGCAGTGGCTGTTCTGGCAGATGGGCGGGCTGGGGCCGATGGCCGGGCAGAACCACCATTTCAACCGCTTCGCCCCGGAGAAGATTCCCTACGCCATCGACCGGTACGTCAAGGAAACCGCGCGCCTGTACGGCGTTCTCGACCAGCGCCTGGCGGACCGCGCCTTCGTCGCCGGCGACGACTACAGCATCGCCGACATGGCCATCTATCCGTGGATCGTCCCGCACCAGTGGCAGGAGCAGGATCTCGCCGACTTCCCGCACCTGCAGCGCTGGTTCGAGAGCATTCGCCAGCGTCCGGCGACGCAACGCGCCTATGCTTTGGTGGAGCGCATCAATCCGCCGAAGTAG
Protein Properties
Protein Residues: 213
Protein Molecular Weight: 24.5 kDa
Protein Theoretical pI: 6.81
Hydropathicity (GRAVY score): -0.372
Charge at pH 7 (predicted): -0.57
Protein Sequence: 
>PA1033
MIDLYYWTTPNGHKITLFLEETGLPYAIHPINISQGDQFQADFLKVSPNNKIPAIVDRQPADGGAPLSLFESGAILLYLAEKTGRFLAKDLRARQETLQWLFWQMGGLGPMAGQNHHFNRFAPEKIPYAIDRYVKETARLYGVLDQRLADRAFVAGDDYSIADMAIYPWIVPHQWQEQDLADFPHLQRWFESIRQRPATQRAYALVERINPPK
References
External Links:
Resource Link
Genome ID: PA1033
Entrez Gene ID: 880186
NCBI Protein ID: 15596230
General Reference: PaperBLAST - Find papers about PA1033 and its homologs