CTP synthase (PA3637)

Identification
Name: CTP synthase
Synonyms:
  • CTP synthetase
  • UTP--ammonia ligase
Gene Name: pyrG
Enzyme Class:
Biological Properties
General Function: Involved in CTP synthase activity
Specific Function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+2 Thumb+Thumb
Adenosine triphosphate + L-Glutamine + Water + Uridine triphosphate → ADP + Cytidine triphosphate + L-Glutamate + 2 Hydrogen ion + Phosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Uridine triphosphate + Ammonia ↔ ADP + Phosphate + Cytidine triphosphate
ReactionCard
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Uridine triphosphate + L-Glutamine + Water ↔ ADP + Phosphate + Cytidine triphosphate + L-Glutamate
ReactionCard
Thumb+Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Uridine triphosphate + L-Glutamine + Water + Ammonia ↔ ADP + Phosphate + Cytidine triphosphate + L-Glutamate
ReactionCard
SMPDB Reactions:
Uridine triphosphate+Thumb+Thumb+Thumb+Thumb → Adenosine diphosphate+Thumb+Thumb+L-Glutamic acid+Thumb+Thumb+Thumb
Uridine triphosphate + L-Glutamine + Water + Adenosine triphosphate + Uridine triphosphate → Adenosine diphosphate + Hydrogen ion + Phosphate + L-Glutamic acid + Cytidine triphosphate + ADP + L-Glutamate
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+2 Thumb+Thumb
Adenosine triphosphate + L-Glutamine + Water + Uridine triphosphate → ADP + Cytidine triphosphate + L-Glutamate + 2 Hydrogen ion + Phosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Adenosine triphosphate + Uridine triphosphate + Ammonia → ADP + Inorganic phosphate + Cytidine triphosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB000030Cytidine triphosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000163L-GlutamineMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000117Uridine triphosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
CTP synthase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
Process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
pyrimidine nucleotide biosynthetic process
pyrimidine nucleotide metabolic process
Gene Properties
Locus tag: PA3637
Strand: -
Entrez Gene ID: 880546
Accession: NP_252327.1
GI: 15598833
Sequence start: 4070860
Sequence End: 4072488
Sequence Length: 1628
Gene Sequence: 
>PA3637
ATGACGCGCTACATCTTCGTCACGGGTGGTGTTGTTTCTTCATTGGGGAAAGGCATCGCTTCGGCTTCTCTGGCTGCGATCTTGGAAGCGCGTGGCCTGAAGATCACGATGCTCAAGCTGGACCCTTACATCAACGTGGACCCGGGCACCATGAGCCCGTTCCAGCACGGTGAGGTCTTCGTGACCCAGGACGGCGCCGAGACCGACCTGGACCTGGGCCATTACGAGCGCTTCGTTCGTACCACCATGACCCAGAACAACAACTTCACCACCGGCCGCGTCTACATGGACGTGTTGCGCAAGGAACGCCGCGGCGACTACCTGGGCGCCACCGTGCAGGTGATCCCGCACATCACCGACGAGATCAAGCGGCGCATCATCAAGGGCGCCGGCGATGCCGACGTCGCCCTGGTGGAGATCGGTGGCACCGTCGGCGACATCGAGTCGCAGCCGTTCCTCGAGGCGATCCGCCAACTGCGCGTCGAGATCGGCGCCAAGCGCGCGATGCTGATGCACCTGACCCTGGTCCCGTACATCGCCACCGCCGGCGAGACCAAGACCAAGCCGACCCAGCACTCGGTCAAGGAGCTGCGCTCCATCGGCCTGCAACCGGACGTGCTGGTCTGCCGTTCCGACCACCCGATCGACGTCTCCTCGCGGCGCAAGATCGCGCTCTTCACCAACGTCGAGGAGCGCGCGGTGATCGCCCTGGAAGACGTCGACACCATCTACCGCATCCCGTCGGTGCTGCATGCCCAGGGCCTAGACGACATCGTCGTCGAGCGCTTCGGCCTGGAGTGCGGGCAGGCCGACCTGTCCGAATGGGACCGGGTGGTCGATGCCAAGCTCAACCCCGAGCGTGAAGTCACCATCGCCATGGTCGGCAAGTACATGGAACTGCTGGACGCGTACAAGTCGCTGATCGAGGCGATGACCCACGCCGGCATCCAGAGCCGCACCAAGGTCAACCTGCGCTACATCGACTCCGAAGACATCGAGCAGCAGGGCACCAGCCTGCTGGAAGGCGTCGACGCCATCCTGGTCCCGGGCGGCTTCGGCCTGCGCGGCGTGGAAGGCAAGATCAGCACCGTGCAGTACGCCCGCGAGAACAAGATTCCCTACCTGGGCATCTGCCTGGGCATGCAGGTCGCGGTCATCGAATACGCCCGCAACGTGCTCGGCTGGAGCGACGCCAACTCCACCGAGTTCGACAAGTCCAGCGGCCATCCGGTGGTCGGCCTGATCACCGAATGGCAGGACGCGACCGGCGCCACCGAGATCCGCACCGAAGCTTCCGACCTGGGCGGCACCATGCGCCTGGGCGCCCAGGAGTGCCAGCTGCAGACCGGCACCTTGGTGCACGACTGCTATGCCAAGGACGTGATCGTCGAGCGCCATCGCCATCGCTACGAAGTGAACAACAACCTGCTGCCGCAACTGGAACAGGCCGGCCTGAAGATTTCCGGCCGCTCCGGCGACGGCGCCCTGGTGGAAGTGGTCGAGGCCCCGGAGCATCCGTGGTTCGTCGCCTGCCAGTTCCACCCGGAGTTCACCTCCACACCGCGTGATGGCCACCCGCTGTTCAGCGGTTTCGTCAACGCCGCGCTGAAATATTCCGGGAAGGCCTGA
Protein Properties
Protein Residues: 542
Protein Molecular Weight: 59.6 kDa
Protein Theoretical pI: 5.38
Hydropathicity (GRAVY score): -0.152
Charge at pH 7 (predicted): -13.54
Protein Sequence: 
>PA3637
MTRYIFVTGGVVSSLGKGIASASLAAILEARGLKITMLKLDPYINVDPGTMSPFQHGEVFVTQDGAETDLDLGHYERFVRTTMTQNNNFTTGRVYMDVLRKERRGDYLGATVQVIPHITDEIKRRIIKGAGDADVALVEIGGTVGDIESQPFLEAIRQLRVEIGAKRAMLMHLTLVPYIATAGETKTKPTQHSVKELRSIGLQPDVLVCRSDHPIDVSSRRKIALFTNVEERAVIALEDVDTIYRIPSVLHAQGLDDIVVERFGLECGQADLSEWDRVVDAKLNPEREVTIAMVGKYMELLDAYKSLIEAMTHAGIQSRTKVNLRYIDSEDIEQQGTSLLEGVDAILVPGGFGLRGVEGKISTVQYARENKIPYLGICLGMQVAVIEYARNVLGWSDANSTEFDKSSGHPVVGLITEWQDATGATEIRTEASDLGGTMRLGAQECQLQTGTLVHDCYAKDVIVERHRHRYEVNNNLLPQLEQAGLKISGRSGDGALVEVVEAPEHPWFVACQFHPEFTSTPRDGHPLFSGFVNAALKYSGKA
References
External Links:
Resource Link
Genome ID: PA3637
Entrez Gene ID: 880546
NCBI Protein ID: 15598833
General Reference: PaperBLAST - Find papers about PA3637 and its homologs