Ammonia (PAMDB000017)

General function:

Involved in oxidoreductase activity

Specific function:

L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH

Gene Name:

gdhA

Locus Tag:

PA4588

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansB

Locus Tag:

PA1337

Molecular weight:

38.6 kDa

Reactions

General function:

Involved in cyanate hydratase activity

Specific function:

Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide

Gene Name:

cynS

Locus Tag:

PA2052

Molecular weight:

16.8 kDa

Reactions

General function:

Involved in biosynthetic process

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpE

Locus Tag:

PA0609

Molecular weight:

54.6 kDa

Reactions

General function:

Involved in anthranilate phosphoribosyltransferase activity

Specific function:

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate

Gene Name:

trpD

Locus Tag:

PA0650

Molecular weight:

37.4 kDa

Reactions

General function:

Involved in D-serine ammonia-lyase activity

Specific function:

D-serine = pyruvate + NH(3)

Gene Name:

dsdA

Locus Tag:

PA3357

Molecular weight:

48.2 kDa

Reactions

General function:

Involved in GMP synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes the synthesis of GMP from XMP

Gene Name:

guaA

Locus Tag:

PA3769

Molecular weight:

58 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent

Gene Name:

ilvA

Locus Tag:

PA1326

Molecular weight:

55.9 kDa

Reactions

General function:

Involved in hydroxymethylbilane synthase activity

Specific function:

Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

Gene Name:

hemC

Locus Tag:

PA5260

Molecular weight:

33.6 kDa

Reactions

General function:

Involved in oxidation-reduction process

Specific function:

Ammonium hydroxide + 3 NAD(P)(+) + H(2)O = nitrite + 3 NAD(P)H

Gene Name:

nirB

Locus Tag:

PA1781

Molecular weight:

89.7 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltB

Locus Tag:

PA5036

Molecular weight:

161.6 kDa

Reactions

General function:

Involved in iron-sulfur cluster binding

Specific function:

2 L-glutamate + NADP(+) = L-glutamine + 2- oxoglutarate + NADPH

Gene Name:

gltD

Locus Tag:

PA5035

Molecular weight:

52.6 kDa

Reactions

General function:

Involved in D-amino-acid dehydrogenase activity

Specific function:

Oxidative deamination of D-amino acids

Gene Name:

dadA

Locus Tag:

PA5304

Molecular weight:

47.1 kDa

Reactions

General function:

Involved in glutaminase activity

Specific function:

L-glutamine + H(2)O = L-glutamate + NH(3)

Gene Name:

glsA2

Locus Tag:

PA1638

Molecular weight:

33 kDa

Reactions

General function:

Involved in CTP synthase activity

Specific function:

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

Gene Name:

pyrG

Locus Tag:

PA3637

Molecular weight:

59.6 kDa

Reactions

General function:

Involved in asparaginase activity

Specific function:

L-asparagine + H(2)O = L-aspartate + NH(3)

Gene Name:

ansA

Locus Tag:

PA2253

Molecular weight:

34.8 kDa

Reactions

General function:

Involved in glutamate-ammonia ligase activity

Specific function:

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine

Gene Name:

glnA

Locus Tag:

PA5119

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in nitrite reductase [NAD(P)H] activity

Specific function:

Required for activity of the reductase

Gene Name:

nirD

Locus Tag:

PA1780

Molecular weight:

11.6 kDa

Reactions

General function:

Involved in aspartate ammonia-lyase activity

Specific function:

L-aspartate = fumarate + NH(3)

Gene Name:

aspA

Locus Tag:

PA5429

Molecular weight:

51.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Ethanolamine = acetaldehyde + NH(3)

Gene Name:

eutB

Locus Tag:

PA4024

Molecular weight:

50.2 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Catalyzes the oxidation of L-aspartate to iminoaspartate

Gene Name:

nadB

Locus Tag:

PA0761

Molecular weight:

60 kDa

Reactions

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

Deaminates also threonine, particularly when it is present in high concentration

Gene Name:

sdaA

Locus Tag:

PA2443

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in NAD+ synthase (glutamine-hydrolyzing) activity

Specific function:

Catalyzes a key step in NAD biosynthesis, transforming deamido-NAD into NAD by a two-step reaction

Gene Name:

nadE

Locus Tag:

PA4920

Molecular weight:

29.7 kDa

Reactions

General function:

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Specific function:

Cytosine + H(2)O = uracil + NH(3)

Gene Name:

codA

Locus Tag:

PA0437

Molecular weight:

47.1 kDa

Reactions

General function:

Involved in zinc ion binding

Specific function:

Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate

Gene Name:

ribD

Locus Tag:

PA4056

Molecular weight:

39.8 kDa

Reactions

General function:

Involved in aminomethyltransferase activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine

Gene Name:

gcvT

Locus Tag:

PA5215

Molecular weight:

38.9 kDa

Reactions

General function:

Involved in L-serine ammonia-lyase activity

Specific function:

Deaminates also threonine, particularly when it is present in high concentration

Gene Name:

sdaB

Locus Tag:

PA5379

Molecular weight:

49.2 kDa

Reactions

General function:

Involved in glycine dehydrogenase (decarboxylating) activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

Gene Name:

gcvP

Locus Tag:

PA5213

Molecular weight:

104.7 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate

Gene Name:

arcC

Locus Tag:

PA5173

Molecular weight:

33.1 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Involved in the breakdown of putrescine via the oxidation of L-glutamylputrescine

Gene Name:

puuB

Locus Tag:

PA2776

Molecular weight:

46.7 kDa

Reactions

General function:

Involved in N-succinylarginine dihydrolase activity

Specific function:

Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)

Gene Name:

astB

Locus Tag:

PA0899

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in hydrolase activity

Specific function:

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia

Gene Name:

guaD

Locus Tag:

PA1521

Molecular weight:

48.3 kDa

Reactions

General function:

Involved in ureidoglycolate hydrolase activity

Specific function:

Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate

Gene Name:

allA

Locus Tag:

PA1514

Molecular weight:

19 kDa

Reactions

General function:

Amino acid transport and metabolism

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein

Gene Name:

gcvH

Locus Tag:

PA5214

Molecular weight:

13.6 kDa

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

Gene Name:

pdxH

Locus Tag:

PA1049

Molecular weight:

24.9 kDa

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

cobB

Locus Tag:

PA1273

Molecular weight:

46.5 kDa

General function:

Energy production and conversion

Specific function:

Deaminates adenosine-34 to inosine in tRNA-Arg2. Mutation in this protein makes Pseudomonas aeruginosa resistant to the toxic proteins encoded by the gef gene family. Essential for cell viability

Gene Name:

tadA

Locus Tag:

PA4302

Molecular weight:

46.8 kDa

Reactions

General function:

pyridine nucleotide biosynthetic process

Specific function:

Has nicotinamidemononucleotide (NMN) aminohydrolase activity, not active on other substrates.

Gene Name:

pncC

Locus Tag:

PA3618

Molecular weight:

17.7 kDa

Reactions