Identification
Name: Threonine dehydratase biosynthetic
Synonyms:
  • Threonine deaminase
Gene Name: ilvA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
ThumbThumb+Thumb
ThumbThumb+Thumb
ThumbThumb+Thumb+Thumb
Thumb+Thumb+Thumb+ThumbThumb+Thumb
SMPDB Reactions:
L-Threonine+ThumbThumb+Thumb+Thumb
PseudoCyc/BioCyc Reactions:
ThumbThumb+Thumb
ThumbThumb+Thumb+Thumb
ThumbThumb+Thumb
Complex Reactions:
ThumbThumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB006321 (2Z)-2-aminobut-2-enoateMetaboCard
PAMDB0041382-Aminobut-2-enoateMetaboCard
PAMDB0000012-Ketobutyric acidMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000077L-SerineMetaboCard
PAMDB000068L-ThreonineMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
ammonia-lyase activity
binding
carbon-nitrogen lyase activity
catalytic activity
cofactor binding
L-threonine ammonia-lyase activity
lyase activity
pyridoxal phosphate binding
Process
branched chain family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
isoleucine biosynthetic process
isoleucine metabolic process
metabolic process
Gene Properties
Locus tag: PA1326
Strand: +
Entrez Gene ID: 878607
Accession: NP_250017.1
GI: 15596523
Sequence start: 1437067
Sequence End: 1438614
Sequence Length: 1547
Gene Sequence:
>PA1326
ATGAGCGCCTCGACCCTCAGCGCAAGCAAACCCCTGCTGGCCGGCTACGTGGAAAGCATCCTGGCCGCGCCGGTGTACGACGTCGCCGTGGAAACCCCCTTGCAGGTCGCGCCGCAGTTGTCCCAGCGCCTGGGCAACCGGGTGCTGCTCAAGCGCGAGGACCTGCAGCCGGTGTTCTCCTTCAAGATCCGCGGCGCCTACACCCGTGTCGCGCGCCTGAGCGACGAGCAGAAGGCCCGCGGGGTGATCACCGCCTCCGCCGGCAACCATGCCCAGGGCCTGGCCCTGGCGGCGCAGCGCCTGGGCGTGCGGGCGGTGATCGTGATGCCGCGCACCACTCCCGAACTCAAGGTCAAGGGCGTGCTGGCACGCGGCGGCGAGGCGTTGCTGCACGGCGACGCCTTCCCCGATGCGCTGGCCCATGCCCTGCAACTGGCCGAGCGCGAAGGCATGACCTTCGTCCCACCCTACGACGATCCGGACGTGATCGCCGGACAGGGCACGGTGGCGATGGAGATCCTCCGCCAGCACAGCGGCCGCCTCGACGCGATCTTCGTGCCGGTCGGCGGCGGCAGCCTGATCGCCGGGATCGCCGCCTACGTCAAGCACCTGCGTCCGGATATTCGCGTGATCGGCGTCGAGCCGGAGGATTCCAACTGCCTGCAGGCGGCGCTGGCCGCCGGCGAACGGGTGGTGCTGGGCCAGGTCGGGCTGTTCGCCGACGGGGTGGCGGTGGCGCAGATCGGCGCTTGCAACTTCGAGGTCTGCAAGGACCATGTCGACGAGGTGATCACCGTCGGCAGCGACGAAATCTGCGCGGCGATCAAGGACATCTACGACGACACCCGTTCGATCACCGAGCCGGCCGGCGCCCTGGCCGTAGCGGGGATCAAGAAGTACGTGGCCCGCGAACGCACCGAGGGGCAGACCCTGGTGGCCATCGACTCCGGTGCCAACATCAACTTCGACCGCCTGCGCCACGTTGCCGAGCGCGCCGAACTGGGCGAACAGCGCGAAGCGATCATCGCCGTCACCGTGGCCGAGCGGCCGGGCAGCTTCAAGGCCTTCTGCGCGGCGCTGGGCCGGCGCCAGATCACCGAGTTCAACTACCGCTACCACAGCGACCGCCAGGCCCACCTGTTCGTCGGCGTGCAGACCCATCCGCTCACCGACAGCCGCGCCGACCTGCTCGCCGGCCTGCGCGAGCAGGGCTTCCCGGTACTCGACCTGACCGACAACGAGATGGCCAAGCTGCACATCCGCCACATGGTCGGCGGCCACGGTACCGAGGTGCGCCGCGAGCGGCTGTTCCGCTTCGAGTTTCCCGAACGCCCCGGGGCCTTGCTGAACTTCCTCGACAAGCTCGGCTCGCGCTGGAACATCAGCCTGTTCCACTACCGCAACCACGGCGCCGCCGACGGTCGGGTGCTGGCCGGATTGCAGGTGCCGGACGAGGAGCGCGGCGAGCTGGAGGCGGCGTTGCAAGCCATCGGCTATCCGTACTGGGAGGAAACCCACAACCCGGCCTACCGGCTGTTCGCCGGTTGA
Protein Properties
Protein Residues: 515
Protein Molecular Weight: 55.9 kDa
Protein Theoretical pI: 6.52
Hydropathicity (GRAVY score): -0.07
Charge at pH 7 (predicted): -4.28
Protein Sequence:
>PA1326
MSASTLSASKPLLAGYVESILAAPVYDVAVETPLQVAPQLSQRLGNRVLLKREDLQPVFSFKIRGAYTRVARLSDEQKARGVITASAGNHAQGLALAAQRLGVRAVIVMPRTTPELKVKGVLARGGEALLHGDAFPDALAHALQLAEREGMTFVPPYDDPDVIAGQGTVAMEILRQHSGRLDAIFVPVGGGSLIAGIAAYVKHLRPDIRVIGVEPEDSNCLQAALAAGERVVLGQVGLFADGVAVAQIGACNFEVCKDHVDEVITVGSDEICAAIKDIYDDTRSITEPAGALAVAGIKKYVARERTEGQTLVAIDSGANINFDRLRHVAERAELGEQREAIIAVTVAERPGSFKAFCAALGRRQITEFNYRYHSDRQAHLFVGVQTHPLTDSRADLLAGLREQGFPVLDLTDNEMAKLHIRHMVGGHGTEVRRERLFRFEFPERPGALLNFLDKLGSRWNISLFHYRNHGAADGRVLAGLQVPDEERGELEAALQAIGYPYWEETHNPAYRLFAG
References
External Links:
Resource Link
Genome ID: PA1326
Entrez Gene ID: 878607
NCBI Protein ID: 15596523
General Reference: PaperBLAST - Find papers about PA1326 and its homologs