L-Threonine (PAMDB000068)

General function:

Involved in catalytic activity

Specific function:

Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. To a lesser extent, is able to slowly catalyze the deamination of L-threonine into alpha-ketobutyrate and that of L- serine and 3-chloroalanine into pyruvate. Is also able to rapidly convert vinylglycine to threonine, which proves that the pyridoxal p-quinonoid of vinylglycine is an intermediate in the TS reaction

Gene Name:

thrC

Locus Tag:

PA3735

Molecular weight:

51.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia. Deaminates L-threonine, but also L-serine to a lesser extent

Gene Name:

ilvA

Locus Tag:

PA1326

Molecular weight:

55.9 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Locus Tag:

PA4602

Molecular weight:

45.2 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA

Gene Name:

thrS

Locus Tag:

PA2744

Molecular weight:

73.1 kDa

Reactions

General function:

Involved in acid phosphatase activity

Specific function:

Dephosphorylates several organic phosphomonoesters and catalyzes the transfer of low-energy phosphate groups from phosphomonoesters to hydroxyl groups of various organic compounds. Preferentially acts on aryl phosphoesters. Might function as a broad-spectrum dephosphorylating enzyme able to scavenge both 3'- and 5'-nucleotides and also additional organic phosphomonoesters

Gene Name:

aphA

Locus Tag:

PA1409

Molecular weight:

38 kDa

Reactions

General function:

Involved in lyase activity

Specific function:

Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates

Gene Name:

ltaE

Locus Tag:

PA0902

Molecular weight:

35.4 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livH

Locus Tag:

PA1073

Molecular weight:

32.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livM

Locus Tag:

PA1072

Molecular weight:

45.6 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livG

Locus Tag:

PA1071

Molecular weight:

28.3 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livF

Locus Tag:

PA1070

Molecular weight:

25.6 kDa

General function:

threonylcarbamoyladenosine biosynthetic process

Specific function:

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.

Gene Name:

tsaC

Locus Tag:

PA0022

Molecular weight:

20.4 kDa

Reactions