Serine hydroxymethyltransferase (PA4602)

Identification
Name: Serine hydroxymethyltransferase
Synonyms:
  • SHMT
  • Serine methylase
Gene Name: glyA
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Interconversion of serine and glycine
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb ↔ Thumb+Thumb
L-Threonine ↔ Acetaldehyde + Glycine
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Thumb → Thumb+Thumb
L-Allothreonine → Acetaldehyde + Glycine
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Serine + Tetrahydrofolic acid ↔ Glycine + Water + 5,10-Methylene-THF
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Thumb+Thumb → Thumb+Thumb
N5-Formyl-H4F + Hydrogen ion → Water + 5,10-Methenyltetrahydrofolate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb
5,10-Methylene-THF + Glycine + Water ↔ Tetrahydrofolic acid + L-Serine
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Thumb+5,6,7,8-Tetrahydromethanopterin ↔ 5,10-Methylenetetrahydromethanopterin+Thumb+Thumb
L-Serine + 5,6,7,8-Tetrahydromethanopterin ↔ 5,10-Methylenetetrahydromethanopterin + Glycine + Water
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SMPDB Reactions:
Tetrahydrofolic acid+L-Serine+Thumb+Thumb ↔ 5,10-Methylene-THF+Thumb+Thumb+Thumb
Tetrahydrofolic acid + L-Serine + Tetrahydrofolic acid + L-Serine ↔ 5,10-Methylene-THF + Glycine + Water + 5,10-Methylene-THF
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PseudoCyc/BioCyc Reactions:
Thumb ↔ Thumb+Thumb
L-Threonine ↔ Acetaldehyde + Glycine
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Thumb+Thumb → Thumb+Thumb
D-Alanine + Pyridoxal 5'-phosphate → Pyridoxamine 5'-phosphate + Pyruvic acid
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Thumb → Thumb+Thumb
L-Allothreonine → Acetaldehyde + Glycine
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Serine + Tetrahydrofolic acid ↔ Glycine + Water + 5,10-Methylene-THF
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Thumb+Thumb → Thumb+Thumb
N5-Formyl-H4F + Hydrogen ion → Water + 5,10-Methenyltetrahydrofolate
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Thumb+Thumb+Thumb ↔ Thumb+Thumb
5,10-Methylene-THF + Glycine + Water ↔ Tetrahydrofolic acid + L-Serine
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
L-Alanine + Pyridoxal 5'-phosphate → Pyridoxamine 5'-phosphate + Pyruvic acid
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Thumb+Thumb → Thumb+Thumb
Water + 5,10-Methenyltetrahydrofolate → N5-Formyl-H4F + Hydrogen ion
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Thumb+Thumb+Thumb → Thumb+Thumb
5,10-Methylene-THF + Glycine + Water → Tetrahydrofolic acid + L-Serine
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0015855,10-MethenyltetrahydrofolateMetaboCard
PAMDB0003535,10-Methylene-THFMetaboCard
PAMDB000217AcetaldehydeMetaboCard
PAMDB000333D-AlanineMetaboCard
PAMDB000046GlycineMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000063L-AlanineMetaboCard
PAMDB001426L-AllothreonineMetaboCard
PAMDB000077L-SerineMetaboCard
PAMDB000068L-ThreonineMetaboCard
PAMDB000421N5-Formyl-H4FMetaboCard
PAMDB000400Pyridoxal 5'-phosphateMetaboCard
PAMDB000420Pyridoxamine 5'-phosphateMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000424Tetrahydrofolic acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
cofactor binding
glycine hydroxymethyltransferase activity
methyltransferase activity
pyridoxal phosphate binding
transferase activity
transferase activity, transferring one-carbon groups
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
glycine metabolic process
L-serine metabolic process
metabolic process
serine family amino acid metabolic process
Gene Properties
Locus tag: PA4602
Strand: +
Entrez Gene ID: 881085
Accession: NP_253292.1
GI: 15599798
Sequence start: 5160738
Sequence End: 5161991
Sequence Length: 1253
Gene Sequence: 
>PA4602
ATGTTCAGCCGTGATTTGACCCTCGCCCGCTACGATGCCGAACTCTTTGCCGCGATGGAGCAGGAAGCCCAGCGCCAGGAAGAGCACATCGAGCTGATCGCCTCCGAGAACTACACCAGCCCGGCGGTGATGGAAGCCCAGGGTTCGGTGCTGACCAACAAGTACGCCGAAGGTTATCCGCACAAGCGCTACTACGGCGGCTGCGAGTACGTCGATATCGTCGAGCAACTGGCCATCGACCGCGCCAAGCAACTGTTCGGCGCCGATTACGCCAACGTCCAGCCGCACGCCGGCTCCCAGGCCAACGCCGCGGTCTACCTGGCCCTGCTGTCGGCCGGCGACACCATCCTCGGCATGAGCCTGGCCCATGGCGGCCACCTGACCCACGGCGCCAGCGTCTCCTCCTCCGGCAAGCTGTACAACGCCGTGCAGTACGGCATCGACGCCAATGGCCTGATCGACTACGACGAAGTCGAGCGCCTGGCCGTGGAGCACAAGCCGAAGATGATCGTCGCCGGCTTCTCCGCCTATTCCCAGGTCCTCGATTTCGCCCGCTTCCGCGCCATCGCCGACAAGGTCGGCGCCTACCTGTTCGTCGACATGGCCCACGTCGCCGGCCTGGTCGCCGCTGGCGTCTACCCGAACCCGGTGCCGTTCGCCGACGTGGTCACCACCACCACCCACAAGACCCTGCGCGGTCCGCGCGGTGGCCTGATCCTGGCGCGCGCCAACGAGGAGATCGAGAAGAAGCTCAACTCCGCGGTATTCCCCAGCGCCCAGGGCGGTCCGCTGGAGCACGTGATCGCGGCCAAGGCGGTGTGCTTCAAGGAAGCCCTGCAGCCGGAGTTCAAGACCTACCAGCAGCAGGTCCTGAAGAACGCCCAGAGCATGGCCCAGGTCTTCCTGGACCGCGGTTTCGACGTGGTTTCCGGCGGCACCCAGAACCACCTGTTCCTGCTCTCCCTGATCAAGCAGGACATCACCGGCAAAGACGCCGACGCCGCCCTCGGCCGCGCGTTCATCACCGTGAACAAGAACTCGGTCCCGAACGACCCGCGCTCGCCGTTCGTCACCTCCGGCCTGCGCATCGGTACCCCGGCCGTGACCACCCGCGGCTTCAAGGAAGCCGAGTGCCGCGAGCTGGCCGGCTGGATCTGCGACATCCTCGAGAACATGGGCGACGAGTCCGTGGTCGACGGCGTACGCGAGAAGGTCAAGGCGATCTGCGCCAAGTTCCCGGTCTACGGCAACTAA
Protein Properties
Protein Residues: 417
Protein Molecular Weight: 45.2 kDa
Protein Theoretical pI: 5.97
Hydropathicity (GRAVY score): -0.087
Charge at pH 7 (predicted): -6.5
Protein Sequence: 
>PA4602
MFSRDLTLARYDAELFAAMEQEAQRQEEHIELIASENYTSPAVMEAQGSVLTNKYAEGYPHKRYYGGCEYVDIVEQLAIDRAKQLFGADYANVQPHAGSQANAAVYLALLSAGDTILGMSLAHGGHLTHGASVSSSGKLYNAVQYGIDANGLIDYDEVERLAVEHKPKMIVAGFSAYSQVLDFARFRAIADKVGAYLFVDMAHVAGLVAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILARANEEIEKKLNSAVFPSAQGGPLEHVIAAKAVCFKEALQPEFKTYQQQVLKNAQSMAQVFLDRGFDVVSGGTQNHLFLLSLIKQDITGKDADAALGRAFITVNKNSVPNDPRSPFVTSGLRIGTPAVTTRGFKEAECRELAGWICDILENMGDESVVDGVREKVKAICAKFPVYGN
References
External Links:
Resource Link
Genome ID: PA4602
Entrez Gene ID: 881085
NCBI Protein ID: 15599798
General Reference: PaperBLAST - Find papers about PA4602 and its homologs