L-Alanine (PAMDB000063)

General function:

Involved in nucleotide binding

Specific function:

Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr)

Gene Name:

alaS

Locus Tag:

PA0903

Molecular weight:

94.7 kDa

Reactions

General function:

Involved in alanine racemase activity

Specific function:

Provides the D-alanine required for cell wall biosynthesis

Gene Name:

alr

Locus Tag:

PA4930

Molecular weight:

38.3 kDa

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Locus Tag:

PA3814

Molecular weight:

44.7 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Interconversion of serine and glycine

Gene Name:

glyA

Locus Tag:

PA4602

Molecular weight:

45.2 kDa

Reactions

General function:

Involved in 8-amino-7-oxononanoate synthase activity

Specific function:

Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

Gene Name:

bioF

Locus Tag:

PA0501

Molecular weight:

42.2 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

Cell wall formation

Gene Name:

murC

Locus Tag:

PA4411

Molecular weight:

51.9 kDa

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling

Gene Name:

amiB

Locus Tag:

PA4947

Molecular weight:

50.7 kDa

Reactions

General function:

Involved in alanine racemase activity

Specific function:

Isomerizes L-alanine to D-alanine which is then oxidized to pyruvate by dadA

Gene Name:

dadX

Locus Tag:

PA5302

Molecular weight:

38.9 kDa

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides

Gene Name:

amiA

Locus Tag:

PA5538

Molecular weight:

42.9 kDa

Reactions

General function:

Involved in N-acetylmuramoyl-L-alanine amidase activity

Specific function:

Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling

Gene Name:

amiC

Locus Tag:

PA3364

Molecular weight:

42.8 kDa

Reactions

General function:

Involved in lyase activity

Specific function:

Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde. L-threo-phenylserine and L- erythro-phenylserine are also good substrates

Gene Name:

ltaE

Locus Tag:

PA0902

Molecular weight:

35.4 kDa

Reactions

General function:

Defense mechanisms

Specific function:

Releases the terminal D-alanine residue from the cytoplasmic tetrapeptide recycling product L-Ala-gamma-D-Glu-meso- Dap-D-Ala. To a lesser extent, can also cleave D-Ala from murein derivatives containing the tetrapeptide, i.e. MurNAc-tetrapeptide, UDP-MurNAc-tetrapeptide, GlcNAc-MurNAc-tetrapeptide, and GlcNAc- anhMurNAc-tetrapeptide. Does not act on murein sacculi or cross- linked muropeptides. The tripeptides produced by the lcdA reaction can then be reused as peptidoglycan building blocks; lcdA is thereby involved in murein recycling. Is also essential for viability during stationary phase

Gene Name:

ldcA

Locus Tag:

PA1818

Molecular weight:

82.8 kDa

Reactions

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livH

Locus Tag:

PA1073

Molecular weight:

32.5 kDa

General function:

Involved in transporter activity

Specific function:

Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane

Gene Name:

livM

Locus Tag:

PA1072

Molecular weight:

45.6 kDa

General function:

Involved in 1-aminocyclopropane-1-carboxylate synthase activity

Specific function:

Specific function unknown

Gene Name:

yfbQ

Locus Tag:

PA2828

Molecular weight:

44.8 kDa

Reactions

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livG

Locus Tag:

PA1071

Molecular weight:

28.3 kDa

General function:

Involved in nucleotide binding

Specific function:

Component of the leucine-specific transport system

Gene Name:

livF

Locus Tag:

PA1070

Molecular weight:

25.6 kDa

General function:

Amino acid transport and metabolism

Specific function:

Specific function unknown

Gene Name:

yfdZ

Locus Tag:

PA4715

Molecular weight:

46.1 kDa

Reactions