N-acetylmuramoyl-L-alanine amidase AmiC (PA3364)

Identification
Name: N-acetylmuramoyl-L-alanine amidase AmiC
Synonyms: Not Available
Gene Name: amiC
Enzyme Class:
Biological Properties
General Function: Involved in N-acetylmuramoyl-L-alanine amidase activity
Specific Function: Cell-wall hydrolase probably involved in cell-wall hydrolysis, septation or recycling
Cellular Location: Secreted (Potential)
KEGG Pathways:
  • Cationic antimicrobial peptide (CAMP) resistance pae01503
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
N-Acetylmuramoyl-Ala + Water ↔ N-Acetyl-D-muramoate + L-Alanine
ReactionCard
SMPDB Reactions: Not Available
PseudoCyc/BioCyc Reactions:
Thumb+Thumb → Thumb+Thumb
N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide + Water → L-Alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine + N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid
ReactionCard
Thumb+Thumb → Thumb+Thumb
N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide + Water → L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate + N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
N-Acetylmuramoyl-Ala + Water ↔ N-Acetyl-D-muramoate + L-Alanine
ReactionCard
Complex Reactions:
Thumb+Thumb → Thumb+Thumb
N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptide + Water → L-Alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanine + N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid
ReactionCard
Thumb+Thumb → Thumb+Thumb
N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptide + Water → L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate + N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acid
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000063L-AlanineMetaboCard
PAMDB001648L-alanine-D-glutamate-meso-2,6-diaminoheptanedioateMetaboCard
PAMDB001647L-Alanine-D-glutamate-meso-2,6-diaminoheptanedioate-D-alanineMetaboCard
PAMDB001656N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramic acidMetaboCard
PAMDB001657N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tetrapeptideMetaboCard
PAMDB001658N-Acetyl-D-glucosamine(anhydrous)N-Acetylmuramyl-tripeptideMetaboCard
PAMDB001023N-Acetyl-D-muramoateMetaboCard
PAMDB001025N-Acetylmuramoyl-AlaMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
N-acetylmuramoyl-L-alanine amidase activity
Process
aminoglycan metabolic process
carbohydrate metabolic process
glycosaminoglycan metabolic process
metabolic process
peptidoglycan catabolic process
peptidoglycan metabolic process
polysaccharide metabolic process
primary metabolic process
Gene Properties
Locus tag: PA3364
Strand: -
Entrez Gene ID: 877798
Accession: NP_252054.1
GI: 15598560
Sequence start: 3774578
Sequence End: 3775735
Sequence Length: 1157
Gene Sequence: 
>PA3364
ATGGGATCGCACCAGGAGCGGCCGCTGATCGGCCTGCTGTTCTCCGAAACCGGCGTCACCGCCGATATCGAGCGCTCGCAGCGCTATGGCGCATTGCTTGCGGTCGAGCAACTGAACCGCGAGGGCGGCGTCGGCGGTCGCCCGATCGAAACGCTGTCCCAGGACCCCGGCGGCGATCCGGACCGCTATCGGCTGTGCGCCGAGGACTTCATTCGCAACCGGGGGGTACGGTTCCTCGTGGGCTGCTACATGTCGCACACGCGCAAGGCGGTGATGCCGGTGGTCGAGCGCGCCGACGCGCTGCTCTGCTACCCGACTCCCTACGAGGGCTTCGAGTATTCGCCGAACATCGTCTACGGCGGTCCGGCGCCGAACCAGAACAGTGCGCCGCTGGCGGCGTACCTGATTCGCCACTACGGCGAGCGGGTGGTGTTCATCGGCTCGGACTACATCTATCCGCGGGAAAGCAACCATGTGATGCGCCACCTGTACCGCCAGCACGGCGGCACGGTGCTCGAGGAAATCTACATTCCGCTGTATCCCTCCGACGACGACGTGCAGCGCGCCGTCGAGCGCATCTACCAGGCGCGCGCCGACGTGGTCTTCTCCACCGTGGTGGGCACCGGCACCGCCGAGCTGTATCGCGCCATCGCCCGTCGCTACGGCGATGGCAGGCGGCCGCCGATCGCCAGCCTGACCACCAGCGAGGCGGAGGTGGCGAAGATGGAGAGCGACGTGGCGGAGGGGCAGGTGGTGGTCGCGCCGTACTTCTCCAGCATCGATACGGCCGCCAGCCGCGCCTTCGTCCAGGCCTGCCATGGCTTCTTCCCGGAAAACGCGACCATCACCGCCTGGGCCGAGGCGGCCTACTGGCAGACCTTGCTGCTTGGCCGCGCCGCGCAGGCCGCAGGCAGTTGGCGAGTGGAAGACGTGCAGCGGCACCTGTACGACATTTGCATCGACGCGCCCCAGGGGCCGGTCCGGGTGGAGCGCCAGAACAACCACAGCCGCCTGTCTTCGCGCATCGCGGAAATCGATGCGCGCGGCGTGTTCCAGGTCCGCTGGCAGTCGCCCGAACCGATTCGCCCCGATCCTTATGTCGTCGTGCATAACCTCGACGACTGGTCCGCCAGCATGGGCGGGGGAGCGCTCCCATGA
Protein Properties
Protein Residues: 385
Protein Molecular Weight: 42.8 kDa
Protein Theoretical pI: 5.82
Hydropathicity (GRAVY score): -0.313
Charge at pH 7 (predicted): -6.74
Protein Sequence: 
>PA3364
MGSHQERPLIGLLFSETGVTADIERSQRYGALLAVEQLNREGGVGGRPIETLSQDPGGDPDRYRLCAEDFIRNRGVRFLVGCYMSHTRKAVMPVVERADALLCYPTPYEGFEYSPNIVYGGPAPNQNSAPLAAYLIRHYGERVVFIGSDYIYPRESNHVMRHLYRQHGGTVLEEIYIPLYPSDDDVQRAVERIYQARADVVFSTVVGTGTAELYRAIARRYGDGRRPPIASLTTSEAEVAKMESDVAEGQVVVAPYFSSIDTAASRAFVQACHGFFPENATITAWAEAAYWQTLLLGRAAQAAGSWRVEDVQRHLYDICIDAPQGPVRVERQNNHSRLSSRIAEIDARGVFQVRWQSPEPIRPDPYVVVHNLDDWSASMGGGALP
References
External Links:
Resource Link
Genome ID: PA3364
Entrez Gene ID: 877798
NCBI Protein ID: 15598560
General Reference: PaperBLAST - Find papers about PA3364 and its homologs