| Identification |
| Name: |
Alanyl-tRNA synthetase |
| Synonyms: |
- Alanine--tRNA ligase
- AlaRS
|
| Gene Name: |
alaS |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in nucleotide binding |
| Specific Function: |
Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr) |
| Cellular Location: |
Cytoplasm |
| KEGG Pathways: |
|
| KEGG Reactions: |
|
 | + |  | + | tRNA(Ala) | + |  | ↔ |  | + |  | + | L-Alanyl-tRNA | + |  |
| |
|
| SMPDB Reactions: |
|
L-Alanine | + | | + |  | + | tRNA(Ala) | + | | → | Pyrophosphate | + | | + | L-alanyl-tRNA(Ala) |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | | + | tRNA(Ala) | → | L-Alanyl-tRNA(Ala) | + | | + | |
| | |
| + | | + | tRNA(Ala) | → | | + | | + | L-alanyl-tRNA(Ala) |
| |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Component |
|---|
| cell part | | cytoplasm | | intracellular part | | Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | alanine-tRNA ligase activity | | aminoacyl-tRNA ligase activity | | ATP binding | | binding | | catalytic activity | | ligase activity | | ligase activity, forming aminoacyl-tRNA and related compounds | | ligase activity, forming carbon-oxygen bonds | | nucleic acid binding | | nucleoside binding | | nucleotide binding | | purine nucleoside binding | | Process |
|---|
| alanyl-tRNA aminoacylation | | biosynthetic process | | cellular macromolecule biosynthetic process | | cellular macromolecule metabolic process | | macromolecule biosynthetic process | | macromolecule metabolic process | | metabolic process | | ncRNA metabolic process | | RNA metabolic process | | translation | | tRNA aminoacylation | | tRNA aminoacylation for protein translation | | tRNA metabolic process |
|
| Gene Properties |
| Locus tag: |
PA0903 |
| Strand: |
+ |
| Entrez Gene ID: |
878299 |
| Accession: |
NP_249594.1 |
| GI: |
15596100 |
| Sequence start: |
986818 |
| Sequence End: |
989442 |
| Sequence Length: |
2624 |
| Gene Sequence: |
>PA0903
ATGAAAAGCGCTGAAATCCGTGAAGCCTTCCTCCGCTTCTTCGAAGAGAAGGGACACACCCGTGTCGCTTCCAGTTCGCTGATCCCGGCGAACGATCCGACCCTGCTGTTCACCAACGCGGGCATGAACCAGTTCAAGGACTGCTTCCTCGGCCTGGAAAAGCGCGCCTACACCCGTGCGACCACCAGCCAGAAATGCGTGCGCGCCGGCGGCAAGCACAACGACCTGGAAAACGTCGGCTACACCGCGCGGCACCACACCTTCTTCGAAATGCTGGGTAACTTCAGCTTCGGCGACTATTTCAAGCGCGACGCCATCCATTACGCCTGGGAGTTCCTCACCGGCGAGAAATGGCTGAACCTGCCCAAGGAAAAGCTCTGGGTCACCGTCTACGCCACCGACGACGAGGCCTACGACATCTGGACCAAGGAAGTTGGCGTGCCCGCCGAGCGTATGGTGCGGATCGGCGACAACAAGGGCGCGCCCTATGCGTCCGACAACTTCTGGGCGATGGGCGATACCGGACCCTGCGGTCCCTGCACCGAGATCTTCTTCGACCATGGGCCGGAGATCTGGGGCGGCCCGCCCGGTTCGCCGGAAGAGGACGGCGACCGCTACATCGAGATCTGGAACAACGTGTTCATGCAGTTCAACCGCACCGCGGACGGCGTCATGCACCCGCTGCCGGCGCCGAGCGTGGACACCGGCATGGGCCTGGAGCGCGTCAGCGCGGTACTCCAGCACGTGCACTCGAACTATGAGATCGACCTGTTCCAGAACCTGCTGAAAGCCTCCGCCGAGGCCATCGGCTGCGCCAACGACGACGCGCCGTCGCTGAAGGTGGTAGCCGACCACATCCGTTCCTGCAGCTTCCTGATCGCCGACGGCGTGCTGCCGTCCAACGAAGGTCGCGGCTACGTCTTGCGGCGGATCATCCGCCGCGCCTGCCGCCACGGCAACAAGCTGGGCGCCAGGGGCACCTTCTTCCACAAGATCGTCGCAGCGCTGGTCGCCGAGATGGGCGATGCCTTCCCCGAGCTGAAGCAACAGCAGGCACACATCGAGCGCGTGCTGAAGACCGAGGAAGAACAGTTCGCCAAGACCCTGGAGCAAGGCCTGAAGATCCTCGAACAGGACCTCGCCGAACTGCAGGGCAGCGTGATTCCCGGCAACGTGGTGTTCAAGCTGTACGACACCTATGGCTTCCCGGTCGACCTGACCAATGACATCGCCCGCGAGCGCGAGCTGACCATCGACGAGGACGGCTTCGAGCGCGAGATGGAGGCCCAGCGCGAGCGCGCCCGCGCTTCCAGCGCCTTCGGCATGGACTACAACAGCCTGGTCAAGGTCGACGGCGAGACCCGCTTCCTCGGCTATCAGGGCGTCTCCGGCGCCGGGCAGATCGTCGCGCTGTTCAGGGACGGCCAGGCCGTCGAGCGCCTGGAGGAGGGCGAGGAGGGCGTCGTGGTCCTCGACCAGACGCCGTTCTACGCCGAGTCCGGCGGCCAGGTCGGCGACAGTGGCTACCTCGAGGCGGCTGGCGTGCGCTTCGACGTGCGCGATACCACCAAGGCTGGCGGCGCGCACCTGCACCATGGCGTGGTCGCCCGGGGCAACCTGAGCGTCGGCGGCGCGGTCAAGGCCGAGGTCGACGCCTCGGTACGCCAGGCCACCGCGCTCAACCACTCCGCGACCCACCTGCTGCATGCCGCGCTGCGCCAGGTACTGGGCGACCACGTACAACAGAAGGGCTCGCTGGTGGACAGCCAGCGCCTGCGTTTCGACTTCAGCCACTTCGAGGCGATCAAGGCGGAACAACTGAAGGCCCTGGAGGATATCGTCAACGCCGAAATCCGTCGCAACACCGAGGTCGAGACCGAGGAAACCGATATCGACACCGCCAAGGCCAAGGGCGCCATGGCGCTGTTCGGCGAGAAGTACGGCGACCAGGTGCGCGTACTGAGCATGGGCGGCGATTTCTCCGTCGAGCTGTGCGGTGGCACCCACGTATCCCGCACCGGCGACATCGGCCTGTTCAAGATCACCAGCGAGGGTGGCGTGGCTGCTGGCGTACGCCGTATCGAGGCGGTCACCGGCGCGGCGGCGCTGGCCTACCTGAACGGTGCCGAGGAGCAGCTCAAGGAAGCCGCCAGCCTGGTCAAGGGCAGCCGCGACAACCTGCTGGACAAGCTCGGCGCCCTGCTGGAGCGCAACCGCTCGCTGGAGAAGGAGCTGGAACAGCTCAAGGCCAAGGCTGCCAGCGCGGCCGGCGACGACCTTTCGGCGGCGGCGGTGGAAATCAAGGGCGCGAAGGTACTCGCCGCGCGCCTCGATGGTCTGGACGGCAAGGCGCTGCTGGCGCTGGTCGACCAGTTGAAGAACAAGCTCGGCCGCGCAGTGATCCTGCTCGGCGGCGAGCTGGACGGGAAGGTCGTACTGGTCGCAGGCGTGACCCAGGACCTGACCGGCCAACTGAAGGCCGGCGAGCTTATGAAGCAAGCCGCGGCGGCAGTTGGTGGCAAAGGTGGCGGACGCCCGGATATGGCCCAGGGCGGCGGCACCGATGCAGCGAAATTGGACGAGGCCCTGGCCCTGGCCCAGCGCTTCGTCGAGCAAGGGCTCTGA |
| Protein Properties |
| Protein Residues: |
874 |
| Protein Molecular Weight: |
94.7 kDa |
| Protein Theoretical pI: |
5.15 |
| Hydropathicity (GRAVY score): |
-0.256 |
| Charge at pH 7 (predicted): |
-24.87 |
| Protein Sequence: |
>PA0903
MKSAEIREAFLRFFEEKGHTRVASSSLIPANDPTLLFTNAGMNQFKDCFLGLEKRAYTRATTSQKCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWEFLTGEKWLNLPKEKLWVTVYATDDEAYDIWTKEVGVPAERMVRIGDNKGAPYASDNFWAMGDTGPCGPCTEIFFDHGPEIWGGPPGSPEEDGDRYIEIWNNVFMQFNRTADGVMHPLPAPSVDTGMGLERVSAVLQHVHSNYEIDLFQNLLKASAEAIGCANDDAPSLKVVADHIRSCSFLIADGVLPSNEGRGYVLRRIIRRACRHGNKLGARGTFFHKIVAALVAEMGDAFPELKQQQAHIERVLKTEEEQFAKTLEQGLKILEQDLAELQGSVIPGNVVFKLYDTYGFPVDLTNDIARERELTIDEDGFEREMEAQRERARASSAFGMDYNSLVKVDGETRFLGYQGVSGAGQIVALFRDGQAVERLEEGEEGVVVLDQTPFYAESGGQVGDSGYLEAAGVRFDVRDTTKAGGAHLHHGVVARGNLSVGGAVKAEVDASVRQATALNHSATHLLHAALRQVLGDHVQQKGSLVDSQRLRFDFSHFEAIKAEQLKALEDIVNAEIRRNTEVETEETDIDTAKAKGAMALFGEKYGDQVRVLSMGGDFSVELCGGTHVSRTGDIGLFKITSEGGVAAGVRRIEAVTGAAALAYLNGAEEQLKEAASLVKGSRDNLLDKLGALLERNRSLEKELEQLKAKAASAAGDDLSAAAVEIKGAKVLAARLDGLDGKALLALVDQLKNKLGRAVILLGGELDGKVVLVAGVTQDLTGQLKAGELMKQAAAAVGGKGGGRPDMAQGGGTDAAKLDEALALAQRFVEQGL |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA0903 and its homologs
|
