Identification |
Name: |
Alanyl-tRNA synthetase |
Synonyms: |
- Alanine--tRNA ligase
- AlaRS
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Gene Name: |
alaS |
Enzyme Class: |
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Biological Properties |
General Function: |
Involved in nucleotide binding |
Specific Function: |
Edits incorrectly charged Ser-tRNA(Ala) and Gly- tRNA(Ala) but not incorrectly charged Ser-tRNA(Thr) |
Cellular Location: |
Cytoplasm |
KEGG Pathways: |
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KEGG Reactions: |
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![Thumb](/molecules/PAMDB000148thumb.png) | + | ![Thumb](/molecules/PAMDB000063thumb.png) | + | tRNA(Ala) | + | ![Thumb](/molecules/PAMDB005597thumb.png) | ↔ | ![Thumb](/molecules/PAMDB000014thumb.png) | + | ![Thumb](/molecules/PAMDB000633thumb.png) | + | L-Alanyl-tRNA | + | ![Thumb](/molecules/PAMDB004326thumb.png) |
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SMPDB Reactions: |
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L-Alanine | + | ![Thumb](/molecules/PAMDB000148thumb.png) | + | ![Thumb](/molecules/PAMDB001633thumb.png) | + | tRNA(Ala) | + | ![Thumb](/molecules/PAMDB000063thumb.png) | → | Pyrophosphate | + | ![Thumb](/molecules/PAMDB000014thumb.png) | + | L-alanyl-tRNA(Ala) |
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PseudoCyc/BioCyc Reactions: |
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Complex Reactions: |
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![Thumb](/molecules/PAMDB000063thumb.png) | + | ![Thumb](/molecules/PAMDB000148thumb.png) | + | tRNA(Ala) | → | L-Alanyl-tRNA(Ala) | + | ![Thumb](/molecules/PAMDB000014thumb.png) | + | ![Thumb](/molecules/PAMDB000633thumb.png) |
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![Thumb](/molecules/PAMDB000148thumb.png) | + | ![Thumb](/molecules/PAMDB000063thumb.png) | + | tRNA(Ala) | → | ![Thumb](/molecules/PAMDB000014thumb.png) | + | ![Thumb](/molecules/PAMDB000633thumb.png) | + | L-alanyl-tRNA(Ala) |
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Transports: |
Not Available |
Metabolites: |
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GO Classification: |
Component |
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cell part | cytoplasm | intracellular part | Function |
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adenyl nucleotide binding | adenyl ribonucleotide binding | alanine-tRNA ligase activity | aminoacyl-tRNA ligase activity | ATP binding | binding | catalytic activity | ligase activity | ligase activity, forming aminoacyl-tRNA and related compounds | ligase activity, forming carbon-oxygen bonds | nucleic acid binding | nucleoside binding | nucleotide binding | purine nucleoside binding | Process |
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alanyl-tRNA aminoacylation | biosynthetic process | cellular macromolecule biosynthetic process | cellular macromolecule metabolic process | macromolecule biosynthetic process | macromolecule metabolic process | metabolic process | ncRNA metabolic process | RNA metabolic process | translation | tRNA aminoacylation | tRNA aminoacylation for protein translation | tRNA metabolic process |
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Gene Properties |
Locus tag: |
PA0903 |
Strand: |
+ |
Entrez Gene ID: |
878299 |
Accession: |
NP_249594.1 |
GI: |
15596100 |
Sequence start: |
986818 |
Sequence End: |
989442 |
Sequence Length: |
2624 |
Gene Sequence: |
>PA0903
ATGAAAAGCGCTGAAATCCGTGAAGCCTTCCTCCGCTTCTTCGAAGAGAAGGGACACACCCGTGTCGCTTCCAGTTCGCTGATCCCGGCGAACGATCCGACCCTGCTGTTCACCAACGCGGGCATGAACCAGTTCAAGGACTGCTTCCTCGGCCTGGAAAAGCGCGCCTACACCCGTGCGACCACCAGCCAGAAATGCGTGCGCGCCGGCGGCAAGCACAACGACCTGGAAAACGTCGGCTACACCGCGCGGCACCACACCTTCTTCGAAATGCTGGGTAACTTCAGCTTCGGCGACTATTTCAAGCGCGACGCCATCCATTACGCCTGGGAGTTCCTCACCGGCGAGAAATGGCTGAACCTGCCCAAGGAAAAGCTCTGGGTCACCGTCTACGCCACCGACGACGAGGCCTACGACATCTGGACCAAGGAAGTTGGCGTGCCCGCCGAGCGTATGGTGCGGATCGGCGACAACAAGGGCGCGCCCTATGCGTCCGACAACTTCTGGGCGATGGGCGATACCGGACCCTGCGGTCCCTGCACCGAGATCTTCTTCGACCATGGGCCGGAGATCTGGGGCGGCCCGCCCGGTTCGCCGGAAGAGGACGGCGACCGCTACATCGAGATCTGGAACAACGTGTTCATGCAGTTCAACCGCACCGCGGACGGCGTCATGCACCCGCTGCCGGCGCCGAGCGTGGACACCGGCATGGGCCTGGAGCGCGTCAGCGCGGTACTCCAGCACGTGCACTCGAACTATGAGATCGACCTGTTCCAGAACCTGCTGAAAGCCTCCGCCGAGGCCATCGGCTGCGCCAACGACGACGCGCCGTCGCTGAAGGTGGTAGCCGACCACATCCGTTCCTGCAGCTTCCTGATCGCCGACGGCGTGCTGCCGTCCAACGAAGGTCGCGGCTACGTCTTGCGGCGGATCATCCGCCGCGCCTGCCGCCACGGCAACAAGCTGGGCGCCAGGGGCACCTTCTTCCACAAGATCGTCGCAGCGCTGGTCGCCGAGATGGGCGATGCCTTCCCCGAGCTGAAGCAACAGCAGGCACACATCGAGCGCGTGCTGAAGACCGAGGAAGAACAGTTCGCCAAGACCCTGGAGCAAGGCCTGAAGATCCTCGAACAGGACCTCGCCGAACTGCAGGGCAGCGTGATTCCCGGCAACGTGGTGTTCAAGCTGTACGACACCTATGGCTTCCCGGTCGACCTGACCAATGACATCGCCCGCGAGCGCGAGCTGACCATCGACGAGGACGGCTTCGAGCGCGAGATGGAGGCCCAGCGCGAGCGCGCCCGCGCTTCCAGCGCCTTCGGCATGGACTACAACAGCCTGGTCAAGGTCGACGGCGAGACCCGCTTCCTCGGCTATCAGGGCGTCTCCGGCGCCGGGCAGATCGTCGCGCTGTTCAGGGACGGCCAGGCCGTCGAGCGCCTGGAGGAGGGCGAGGAGGGCGTCGTGGTCCTCGACCAGACGCCGTTCTACGCCGAGTCCGGCGGCCAGGTCGGCGACAGTGGCTACCTCGAGGCGGCTGGCGTGCGCTTCGACGTGCGCGATACCACCAAGGCTGGCGGCGCGCACCTGCACCATGGCGTGGTCGCCCGGGGCAACCTGAGCGTCGGCGGCGCGGTCAAGGCCGAGGTCGACGCCTCGGTACGCCAGGCCACCGCGCTCAACCACTCCGCGACCCACCTGCTGCATGCCGCGCTGCGCCAGGTACTGGGCGACCACGTACAACAGAAGGGCTCGCTGGTGGACAGCCAGCGCCTGCGTTTCGACTTCAGCCACTTCGAGGCGATCAAGGCGGAACAACTGAAGGCCCTGGAGGATATCGTCAACGCCGAAATCCGTCGCAACACCGAGGTCGAGACCGAGGAAACCGATATCGACACCGCCAAGGCCAAGGGCGCCATGGCGCTGTTCGGCGAGAAGTACGGCGACCAGGTGCGCGTACTGAGCATGGGCGGCGATTTCTCCGTCGAGCTGTGCGGTGGCACCCACGTATCCCGCACCGGCGACATCGGCCTGTTCAAGATCACCAGCGAGGGTGGCGTGGCTGCTGGCGTACGCCGTATCGAGGCGGTCACCGGCGCGGCGGCGCTGGCCTACCTGAACGGTGCCGAGGAGCAGCTCAAGGAAGCCGCCAGCCTGGTCAAGGGCAGCCGCGACAACCTGCTGGACAAGCTCGGCGCCCTGCTGGAGCGCAACCGCTCGCTGGAGAAGGAGCTGGAACAGCTCAAGGCCAAGGCTGCCAGCGCGGCCGGCGACGACCTTTCGGCGGCGGCGGTGGAAATCAAGGGCGCGAAGGTACTCGCCGCGCGCCTCGATGGTCTGGACGGCAAGGCGCTGCTGGCGCTGGTCGACCAGTTGAAGAACAAGCTCGGCCGCGCAGTGATCCTGCTCGGCGGCGAGCTGGACGGGAAGGTCGTACTGGTCGCAGGCGTGACCCAGGACCTGACCGGCCAACTGAAGGCCGGCGAGCTTATGAAGCAAGCCGCGGCGGCAGTTGGTGGCAAAGGTGGCGGACGCCCGGATATGGCCCAGGGCGGCGGCACCGATGCAGCGAAATTGGACGAGGCCCTGGCCCTGGCCCAGCGCTTCGTCGAGCAAGGGCTCTGA |
Protein Properties |
Protein Residues: |
874 |
Protein Molecular Weight: |
94.7 kDa |
Protein Theoretical pI: |
5.15 |
Hydropathicity (GRAVY score): |
-0.256 |
Charge at pH 7 (predicted): |
-24.87 |
Protein Sequence: |
>PA0903
MKSAEIREAFLRFFEEKGHTRVASSSLIPANDPTLLFTNAGMNQFKDCFLGLEKRAYTRATTSQKCVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWEFLTGEKWLNLPKEKLWVTVYATDDEAYDIWTKEVGVPAERMVRIGDNKGAPYASDNFWAMGDTGPCGPCTEIFFDHGPEIWGGPPGSPEEDGDRYIEIWNNVFMQFNRTADGVMHPLPAPSVDTGMGLERVSAVLQHVHSNYEIDLFQNLLKASAEAIGCANDDAPSLKVVADHIRSCSFLIADGVLPSNEGRGYVLRRIIRRACRHGNKLGARGTFFHKIVAALVAEMGDAFPELKQQQAHIERVLKTEEEQFAKTLEQGLKILEQDLAELQGSVIPGNVVFKLYDTYGFPVDLTNDIARERELTIDEDGFEREMEAQRERARASSAFGMDYNSLVKVDGETRFLGYQGVSGAGQIVALFRDGQAVERLEEGEEGVVVLDQTPFYAESGGQVGDSGYLEAAGVRFDVRDTTKAGGAHLHHGVVARGNLSVGGAVKAEVDASVRQATALNHSATHLLHAALRQVLGDHVQQKGSLVDSQRLRFDFSHFEAIKAEQLKALEDIVNAEIRRNTEVETEETDIDTAKAKGAMALFGEKYGDQVRVLSMGGDFSVELCGGTHVSRTGDIGLFKITSEGGVAAGVRRIEAVTGAAALAYLNGAEEQLKEAASLVKGSRDNLLDKLGALLERNRSLEKELEQLKAKAASAAGDDLSAAAVEIKGAKVLAARLDGLDGKALLALVDQLKNKLGRAVILLGGELDGKVVLVAGVTQDLTGQLKAGELMKQAAAAVGGKGGGRPDMAQGGGTDAAKLDEALALAQRFVEQGL |
References |
External Links: |
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General Reference: |
PaperBLAST - Find papers about PA0903 and its homologs
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