GMP synthase [glutamine-hydrolyzing] (PA3769)

Identification
Name: GMP synthase [glutamine-hydrolyzing]
Synonyms:
  • GMP synthetase
  • GMPS
  • Glutamine amidotransferase
Gene Name: guaA
Enzyme Class:
Biological Properties
General Function: Involved in GMP synthase (glutamine-hydrolyzing) activity
Specific Function: Catalyzes the synthesis of GMP from XMP
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+2 Thumb+Thumb
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid → Adenosine monophosphate + L-Glutamate + Guanosine monophosphate + 2 Hydrogen ion + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
Adenosine triphosphate + Xanthylic acid + Ammonia ↔ Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate
ReactionCard
Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Xanthylic acid + L-Glutamine + Water ↔ Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate + L-Glutamate
ReactionCard
6-Thioxanthine 5'-monophosphate+Thumb+Thumb+Thumb ↔ 6-Thioguanosine monophosphate+Thumb+Thumb+Thumb
6-Thioxanthine 5'-monophosphate + Adenosine triphosphate + L-Glutamine + Water ↔ 6-Thioguanosine monophosphate + Adenosine monophosphate + Pyrophosphate + L-Glutamate
ReactionCard
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb+Thumb
Water + L-Glutamine + Xanthylic acid + Adenosine triphosphate → Hydrogen ion + L-Glutamate + Guanosine monophosphate + Pyrophosphate + Adenosine monophosphate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Xanthylic acid + Ammonia → Hydrogen ion + Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate
ReactionCard
Thumb+Thumb+Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Xanthylic acid + L-Glutamine + Water + Ammonia ↔ Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate + L-Glutamate
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Pyrophosphate+L-Glutamic acid+2 Thumb+Thumb+Thumb
Xanthylic acid + Adenosine triphosphate + L-Glutamine + Water → Adenosine monophosphate + Pyrophosphate + L-Glutamic acid + 2 Hydrogen ion + Guanosine monophosphate + L-Glutamate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+2 Thumb+Thumb
Adenosine triphosphate + L-Glutamine + Water + Xanthylic acid → Adenosine monophosphate + L-Glutamate + Guanosine monophosphate + 2 Hydrogen ion + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb+Thumb
Water + L-Glutamine + Xanthylic acid + Adenosine triphosphate → Hydrogen ion + L-Glutamate + Guanosine monophosphate + Pyrophosphate + Adenosine monophosphate
ReactionCard
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Xanthylic acid + Ammonia → Hydrogen ion + Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Adenosine triphosphate + Xanthylic acid + L-Glutamine + Water → Adenosine monophosphate + Pyrophosphate + Guanosine monophosphate + L-Glutamate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000014Adenosine monophosphateMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB000369Guanosine monophosphateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000163L-GlutamineMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
PAMDB000419Xanthylic acidMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
carbon-nitrogen ligase activity, with glutamine as amido-N-donor
catalytic activity
GMP synthase (glutamine-hydrolyzing) activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
purine nucleoside binding
Process
biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
cellular nitrogen compound metabolic process
glutamine family amino acid metabolic process
glutamine metabolic process
GMP biosynthetic process
metabolic process
nitrogen compound metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
purine nucleoside monophosphate biosynthetic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
purine ribonucleoside monophosphate biosynthetic process
Gene Properties
Locus tag: PA3769
Strand: -
Entrez Gene ID: 880552
Accession: NP_252458.1
GI: 15598964
Sequence start: 4225660
Sequence End: 4227237
Sequence Length: 1577
Gene Sequence: 
>PA3769
ATGTCCCAAGACATTCACGCCCACCGTATCCTGATCCTCGATTTCGGCTCCCAGTACACCCAACTGATCGCTCGCCGCGTGCGCGAGATCGGCGTGTATTGCGAAATCCATCCCTTCGACATGAGCAACGAGGCGATCATCGCCTTCGCGCCGCGCGGCATCATCCTCGCCGGTGGCCCCGAGTCGGTACACGAAGCCGACAGCCCGCGCGCGCCGCAGGCGGTGTTCGACCTGAAGGTGCCGCTGTTCGGCATCTGCTACGGCATGCAGACCATGGCCGAGCAGATGGGCGGCAAGGTGCAGGGCTCCGACCTGCGCGAGTTCGGCTACGCCCGCGTCGACGTGGTCGGCAAGGCGCGCCTGCTGGACGGCATCGAGGACCACGTGGACGACGACGGCGTGCTCGGCCTCGACGTGTGGATGAGCCACGGCGACAAGGTCACCGAGATGCCGGCCGGCTTCCACATCCTGGCCAGCACCCCGAGCTGCCCGATCGCCGCCATGGCCGACGATGCCCGCGCCTACTACGGCGTGCAATTCCACCCGGAAGTCACCCACACCAAGCAGGGCCTGCGCATTCTCTCGCGCTTCGTCCTCGACATCTGCGGTTGCGCCGCGCTGTGGACCCCCTCGAACATCGTCGACGACGCCATCGCCACCGTGCGCGCCCAGGTCGGTTCCTCCAAGGTCCTGCTCGGCCTCTCCGGCGGCGTGGACTCCTCGGTGGTCGCCGCGCTGCTGCACAAGGCCATCGGCGACCAACTGACCTGCGTGTTCGTCGACAACGGCCTGCTGCGCCTGCACGAAGGCGACCAGGTGATGGCCATGTTCGCCGAGAACATGGGCGTGAAGGTGATCCGCGCCAACGCCGAGGACAAGTTCCTCGGCCGCCTGGCCGGCGTCGCCGACCCGGAAGAGAAGCGCAAGATCATCGGCCGCACCTTCATCGAAGTCTTCGACGAAGAAGCCACCAAGCTGCAGGACGTGAAGTTCCTCGCCCAGGGCACCATCTACCCCGACGTGATCGAGTCGGCCGGCGCCAAGACCGGCAAGGCCCACGTGATCAAGTCGCACCACAACGTCGGCGGCCTGCCGGAGGACATGCAGTTCGAACTGGTCGAGCCGCTGCGCGAACTGTTCAAGGACGAAGTGCGCAAGATCGGCCTGGAGCTGGGCCTGCCCTACGACATGGTCTACCGCCACCCGTTCCCCGGCCCGGGCCTGGGCGTGCGCATCCTCGGCGAGGTGAAGAAGGAGTACGCCGACCTGCTGCGCCAGGCCGACCACATCTTCATCGAGGAACTGCGCGCCTTCGACTGGTACCACAAGACCAGCCAGGCGTTCGTGGTGTTCCAGCCAGTGAAATCGGTCGGCGTGGTCGGCGACGGCCGTCGCTACGCCTGGGTCGTCGCCCTGCGCGCGGTGGAGACCATCGACTTCATGACCGCGCGCTGGGCGCACCTGCCCTACGAACTGCTGGAGAAGGTCTCGAACCGCATCATCAACGAGATTGCCGGTATCTCCCGGGTCACCTACGACGTGTCGAGCAAGCCGCCGGCGACTATCGAGTGGGAATGA
Protein Properties
Protein Residues: 525
Protein Molecular Weight: 58 kDa
Protein Theoretical pI: 5.57
Hydropathicity (GRAVY score): 0.003
Charge at pH 7 (predicted): -13.83
Protein Sequence: 
>PA3769
MSQDIHAHRILILDFGSQYTQLIARRVREIGVYCEIHPFDMSNEAIIAFAPRGIILAGGPESVHEADSPRAPQAVFDLKVPLFGICYGMQTMAEQMGGKVQGSDLREFGYARVDVVGKARLLDGIEDHVDDDGVLGLDVWMSHGDKVTEMPAGFHILASTPSCPIAAMADDARAYYGVQFHPEVTHTKQGLRILSRFVLDICGCAALWTPSNIVDDAIATVRAQVGSSKVLLGLSGGVDSSVVAALLHKAIGDQLTCVFVDNGLLRLHEGDQVMAMFAENMGVKVIRANAEDKFLGRLAGVADPEEKRKIIGRTFIEVFDEEATKLQDVKFLAQGTIYPDVIESAGAKTGKAHVIKSHHNVGGLPEDMQFELVEPLRELFKDEVRKIGLELGLPYDMVYRHPFPGPGLGVRILGEVKKEYADLLRQADHIFIEELRAFDWYHKTSQAFVVFQPVKSVGVVGDGRRYAWVVALRAVETIDFMTARWAHLPYELLEKVSNRIINEIAGISRVTYDVSSKPPATIEWE
References
External Links:
Resource Link
Genome ID: PA3769
Entrez Gene ID: 880552
NCBI Protein ID: 15598964
General Reference: PaperBLAST - Find papers about PA3769 and its homologs