Porphobilinogen deaminase (PA5260)

Identification
Name: Porphobilinogen deaminase
Synonyms:
  • PBG
  • Hydroxymethylbilane synthase
  • HMBS
  • Pre-uroporphyrinogen synthase
Gene Name: hemC
Enzyme Class:
Biological Properties
General Function: Involved in hydroxymethylbilane synthase activity
Specific Function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
4 Thumb+Thumb ↔ Thumb+4 Thumb
4 Porphobilinogen + Water ↔ Hydroxymethylbilane + 4 Ammonia
ReactionCard
4 Thumb+Thumb → Thumb+4 Thumb
4 Porphobilinogen + Water → Hydroxymethylbilane + 4 Ammonia
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SMPDB Reactions:
4 Thumb+Thumb → 4 Thumb+Thumb
4 Porphobilinogen + Water → 4 Ammonium + Hydroxymethylbilane
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PseudoCyc/BioCyc Reactions:
4 Thumb+Thumb ↔ Thumb+4 Thumb
4 Porphobilinogen + Water ↔ Hydroxymethylbilane + 4 Ammonia
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Thumb+Thumb ↔ Thumb+Thumb+Thumb
Water + Porphobilinogen ↔ Hydrogen ion + Ammonia + Hydroxymethylbilane
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4 Thumb+Thumb → Thumb+4 Thumb
4 Porphobilinogen + Water → Hydroxymethylbilane + 4 Ammonia
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Complex Reactions:
Thumb+4 Thumb → Thumb+4 Thumb
Water + 4 Porphobilinogen → Hydroxymethylbilane + 4 Ammonium
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB000271HydroxymethylbilaneMetaboCard
PAMDB000104PorphobilinogenMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
catalytic activity
hydroxymethylbilane synthase activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
Process
biosynthetic process
cellular biosynthetic process
heterocycle biosynthetic process
macromolecule metabolic process
macromolecule modification
metabolic process
peptidyl-pyrromethane cofactor linkage
post-translational protein modification
protein modification process
protein-cofactor linkage
tetrapyrrole biosynthetic process
Gene Properties
Locus tag: PA5260
Strand: -
Entrez Gene ID: 877673
Accession: NP_253947.1
GI: 15600453
Sequence start: 5921494
Sequence End: 5922435
Sequence Length: 941
Gene Sequence: 
>PA5260
ATGTCGTCCCGCGAAATCCGCATCGCCACTCGCCAGAGCGCCCTCGCCTTGTGGCAGGCCGAATACGTCAAGGCGCGCCTGGAACAGGCGCATCCCGGCTTGACCGTCACCCTGCTGCCGATGACCAGTCGCGGCGACAAGCTGCTCGACGCACCGCTGGCGAAGATCGGCGGCAAGGGCCTGTTCGTCAAGGAACTGGAAACCGCCCTGCTCGAAGGCGCCGCCGACATCGCGGTGCATTCGATGAAGGACGTGCCGATGGACTTTCCCGAGGGGCTCGGCCTCTACACCATCTGCGAGCGCGAAGACCCGCGTGACGCTTTCGTCTCGAACACCTACGCCAGCCTCGAGCAACTGCCAGCCGGGAGCGTGGTCGGCACCTCCAGCCTGCGCCGCCAGGCGCAGCTGCTGGCGCGCCGGCCGGACCTGCAGATCCGTTTCCTGCGGGGCAACGTCAATACCCGCCTGGCCAAGCTGGATGCCGGCGAATACGACGCGATCATCCTCGCCGCCGCCGGCCTGATCCGCCTCGGCTTCGAGTCGCGCATCCGCTCCTCGATCAGTGTCGACGACAGCCTGCCCGCCGGCGGACAAGGCGCCGTCGGCATCGAATGCCGTACGGCCGACAGCGACCTGCATGCCTTGCTGGAACCCTTGCACCATACCGACACGGCTCTGCGGGTCACTGCCGAGCGCGCGCTGAACAAGCGGCTCAACGGCGGTTGCCAGGTGCCGATCGCCTGCTACGCCATCCGCGAGGGCGACCAGCTGTGGCTGCGCGGCCTGGTCGGCCAGCCTGATGGCACCCAGTTGCTGCGCGCCGAGGGGCGGGCGCCACTGGCGGAAGCCGAGGCGCTGGGCGTGCGGGTGGCCGAGGACCTGCTGGAGCAGGGCGCCGAAGCGATTCTCGAAGCCGTCTACGGCGAGGCCGGACATCCGTGA
Protein Properties
Protein Residues: 313
Protein Molecular Weight: 33.6 kDa
Protein Theoretical pI: 5.26
Hydropathicity (GRAVY score): -0.085
Charge at pH 7 (predicted): -6.67
Protein Sequence: 
>PA5260
MSSREIRIATRQSALALWQAEYVKARLEQAHPGLTVTLLPMTSRGDKLLDAPLAKIGGKGLFVKELETALLEGAADIAVHSMKDVPMDFPEGLGLYTICEREDPRDAFVSNTYASLEQLPAGSVVGTSSLRRQAQLLARRPDLQIRFLRGNVNTRLAKLDAGEYDAIILAAAGLIRLGFESRIRSSISVDDSLPAGGQGAVGIECRTADSDLHALLEPLHHTDTALRVTAERALNKRLNGGCQVPIACYAIREGDQLWLRGLVGQPDGTQLLRAEGRAPLAEAEALGVRVAEDLLEQGAEAILEAVYGEAGHP
References
External Links:
Resource Link
Genome ID: PA5260
Entrez Gene ID: 877673
NCBI Protein ID: 15600453
General Reference: PaperBLAST - Find papers about PA5260 and its homologs