NADP-specific glutamate dehydrogenase (PA4588)

Identification
Name: NADP-specific glutamate dehydrogenase
Synonyms:
  • NADP-GDH
Gene Name: gdhA
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate + NH(3) + NADPH
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Glutamate + NAD + Water ↔ alpha-Ketoglutarate + Ammonia + NADH + Hydrogen ion
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Glutamate + NADP + Water ↔ alpha-Ketoglutarate + Ammonia + NADPH + Hydrogen ion
ReactionCard
SMPDB Reactions:
Thumb+NADPH+Thumb+Thumb ↔ Thumb+Thumb+L-Glutamic acid+Thumb
Hydrogen ion + NADPH + Ammonia + NADPH ↔ Water + NADP + L-Glutamic acid + L-Glutamate
ReactionCard
Thumb+NADPH+Thumb+Thumb+Thumb → L-Glutamic acid+Thumb+Thumb+Thumb
Oxoglutaric acid + NADPH + Ammonium + Hydrogen ion + NADPH → L-Glutamic acid + Water + NADP + L-Glutamate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
L-Glutamate + Water + NADP → Oxoglutaric acid + Ammonia + NADPH
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
L-Glutamate + Water + NADP ↔ alpha-Ketoglutarate + Hydrogen ion + NADPH + Ammonium
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB000017AmmoniaMetaboCard
PAMDB001595AmmoniumMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000089NADPMetaboCard
PAMDB000615NADPHMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
binding
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on the CH-NH2 group of donors
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
Process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA4588
Strand: -
Entrez Gene ID: 881027
Accession: NP_253278.1
GI: 15599784
Sequence start: 5137417
Sequence End: 5138754
Sequence Length: 1337
Gene Sequence: 
>PA4588
ATGACGCAATCCGTCGACGCTTTCCTCGAGCGCCTGAAGCGGCGCGATCCCGATCAGCCCGAATTCCACCAGGCGGTGGAAGAGGTGCTGCGTTCCCTCTGGCCGTTCCTCGAGGCCAACCCACACTACCTGGAAGCCGGCATCATCGAACGCATCGTCGAACCCGAGCGGGCGATCCTGTTCCGCGTACCCTGGGTCGACGACCAGGGCCGGGTACGGGTCAACCGTGGCTACCGGGTGCAGATGAGCAGCGCCATCGGCCCCTACAAGGGCGGCCTGCGCTTCCATCCCTCGGTCAACCTCGGGGTGCTGAAGTTCCTCGCCTTCGAGCAGGTCTTCAAGAACTCCCTGACCACTCTGCCCATGGGCGGCGGCAAGGGCGGCTCCGACTTCGATCCGAAGGGCAAGAGCGACGCCGAGGTGATGCGTTTCTGCCAGTCGTTCATGAGCGAGCTGTACCGCCACGTCGGCGCCGACCTGGACGTGCCGGCCGGCGACATCGGCGTCGGCGCGCGTGAGATCGGCTACCTGTTCGGCCAGTACAAGCGCCTGTCCAACCAGTTCACCTCGGTGCTGACCGGCAAGGGCCTGAGCTATGGCGGCAGCCTGATCCGCCCGGAGGCGACCGGCTTCGGCTGCGTCTACTTCGCCCAGGAAATGCTCAAGGATCGTGGCCGCGGCTTCGACGGCCAGCGGGTGGCGATCTCCGGCTCGGGCAACGTCGCCCAGTACGCGGCGCGCAAGGTCATGGAAATGGGCGGCAAGGTGATCTCGCTGTCCGATTCCGAAGGCACCCTGTATGCCGAGGCGGGGCTCTCCGACGAGCAGTGGGAATACCTGATGGAGCTGAAGAACGTGCGCCGCGGGCGCATCCGCGAGATGGCGGAGCAGTTTTCCCTGCAGTTTCTCGAAGGGCGCCGGCCCTGGGGCCTGGCCTGCGATATCGCGCTGCCCTGCGCGACCCAGAACGAACTGGATGCCGAGGATGCGCGGCGCCTGCTGGCCAACGGCTGCGTCTGTGTCGCCGAAGGCGCCAACATGCCCTCGACCCTGGAAGCCGTCGACCTGTTCCTCGAGGCCGGCATCCTCTACGCGCCGGGCAAGGCGTCGAACGCCGGCGGGGTGGCGGTGAGCGGCCTGGAGATGTCGCAGAACGCCATGCGCCTGCGTTGGAGCGAGGGCGAGGTGGATACCAAGCTGCACGGCATCATGCAGTCGATCCACCATGCCTGCCTGCTGTACGGCGAGGAGCAGGGGCGGGTCAACTACGTGAAGGGGGCGAACATCGCCGGCTTCGTCAAGGTCGCCGATGCGATGCTGGCGCAGGGCGTGGTCTGA
Protein Properties
Protein Residues: 445
Protein Molecular Weight: 48.9 kDa
Protein Theoretical pI: 5.97
Hydropathicity (GRAVY score): -0.187
Charge at pH 7 (predicted): -4.51
Protein Sequence: 
>PA4588
MTQSVDAFLERLKRRDPDQPEFHQAVEEVLRSLWPFLEANPHYLEAGIIERIVEPERAILFRVPWVDDQGRVRVNRGYRVQMSSAIGPYKGGLRFHPSVNLGVLKFLAFEQVFKNSLTTLPMGGGKGGSDFDPKGKSDAEVMRFCQSFMSELYRHVGADLDVPAGDIGVGAREIGYLFGQYKRLSNQFTSVLTGKGLSYGGSLIRPEATGFGCVYFAQEMLKDRGRGFDGQRVAISGSGNVAQYAARKVMEMGGKVISLSDSEGTLYAEAGLSDEQWEYLMELKNVRRGRIREMAEQFSLQFLEGRRPWGLACDIALPCATQNELDAEDARRLLANGCVCVAEGANMPSTLEAVDLFLEAGILYAPGKASNAGGVAVSGLEMSQNAMRLRWSEGEVDTKLHGIMQSIHHACLLYGEEQGRVNYVKGANIAGFVKVADAMLAQGVV
References
External Links:
Resource Link
Genome ID: PA4588
Entrez Gene ID: 881027
NCBI Protein ID: 15599784
General Reference: PaperBLAST - Find papers about PA4588 and its homologs