Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (PA5549)

Identification
Name: Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]
Synonyms:
  • D-fructose-6-phosphate amidotransferase
  • GFAT
  • Glucosamine-6-phosphate synthase
  • Hexosephosphate aminotransferase
  • L-glutamine-D-fructose-6-phosphate amidotransferase
Gene Name: glmS
Enzyme Class:
Biological Properties
General Function: Involved in metabolic process
Specific Function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
Cellular Location: Cytoplasm
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Fructose 6-phosphate + L-Glutamine ↔ Glucosamine 6-phosphate + L-Glutamate
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
L-Glutamine + Fructose 6-phosphate ↔ L-Glutamate + Glucosamine 6-phosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb ↔ Thumb+L-Glutamic acid+Thumb
D-tagatofuranose 6-phosphate + L-Glutamine ↔ Glucosamine 6-phosphate + L-Glutamic acid + L-Glutamate
ReactionCard
Fructose 6-phosphate+Thumb+Thumb → L-Glutamic acid+Thumb+Thumb
Fructose 6-phosphate + L-Glutamine + Fructose 6-phosphate → L-Glutamic acid + Glucosamine 6-phosphate + L-Glutamate
ReactionCard
Thumb+Thumb ↔ D-glucosamine 6-phosphate+Thumb
D-tagatofuranose 6-phosphate + L-Glutamine ↔ D-glucosamine 6-phosphate + L-Glutamate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
Fructose 6-phosphate + L-Glutamine ↔ Glucosamine 6-phosphate + L-Glutamate
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB006322D-tagatofuranose 6-phosphateMetaboCard
PAMDB000047Fructose 6-phosphateMetaboCard
PAMDB000310Glucosamine 6-phosphateMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000163L-GlutamineMetaboCard
GO Classification:
Component
cell part
cytoplasm
intracellular part
Function
binding
carbohydrate binding
catalytic activity
glutamine-fructose-6-phosphate transaminase (isomerizing) activity
sugar binding
transaminase activity
transferase activity
transferase activity, transferring nitrogenous groups
Process
carbohydrate biosynthetic process
carbohydrate metabolic process
metabolic process
primary metabolic process
Gene Properties
Locus tag: PA5549
Strand: -
Entrez Gene ID: 877797
Accession: NP_254236.1
GI: 15600742
Sequence start: 6243111
Sequence End: 6244946
Sequence Length: 1835
Gene Sequence: 
>PA5549
ATGTGTGGAATCGTAGGCGCGATCGCCGAGCGCAACATCACCCCCATCCTTATCGAAGGCCTCAAGCGCCTCGAGTATCGCGGCTACGACAGCGCCGGCGTGGCGGTCTTCGATAACGAAGGCAGGCTGCAGCGCTGCCGCCGGGTCGGCAAGGTCGCCAGCCTGGAGGAAGGCCTGGCCGGTACGCCGCTGCTCGGCCGCCTGGGCATCGCCCATACCCGCTGGGCGACCCACGGCGCGCCAACCGAAGGCAACGCCCACCCGCATTTCTCCAGCGACGAAGTGGCGGTGGTGCACAACGGCATCATCGAGAACCACGAACCTCTCCGTGAGCGGCTCAAGGGCCTGGGCTACGTGTTCACCTCGCAGACCGACACCGAGGTCATCGTCCACCTGCTGCACCACAAGCTGCAGTCCATCGGCGACCTGACCCTGGCGCTGAAGGACGCGGTCAAGGAATTGCACGGGGCCTATGGCCTGGCAGTGATCAGCGCGGCGCAGCCGGACCGCATCGTCGCCGCTCGCAGCGGCAGCCCGCTGGTGATCGGCCTCGGGCTTGGCGAGAACTTCCTCGCTTCCGACCAACTGGCGCTGCGCCAGGTGACCGACCGCTTCATCTACCTGGAAGAAGGCGATATCGCCGAGATCCGTCGCGACAGCGTGCGCCTGTGGGATGTCCAGGGCAACGACGTGCAGCGCGAGACCGTGCAGTACCACGAAGGCGCCGAAGCCGCCGACAAGGGCGAGTACCGGCACTTCATGCTCAAGGAAATCCACGAGCAGCCCAGCGTCGTGCAGCGCACCCTGGAAGGCCGCCTCGGGCAGAACCAGGTACTGGTGGAAAGCTTCGGTCCGCAGGCGGCGGAGCTGTTCGCCAAGGTCCGCAACGTGCAGATCGTCGCCTGCGGCACCAGTTACCACGCCGGCATGGTCGCCCGTTACTGGCTGGAAAGCCTGACCGGGATTCCCTGCCAGGTGGAGGTCGCCAGCGAGTTCCGCTACCGCAAGGTCGCGGTGCAGCCGGATTGCCTGTTCGTCACCATCTCCCAGTCCGGTGAGACCGCCGACACCCTGGCTGCCCTGCGCAACGCCAAGGAGCTGGGCTTCCTCTCCAGCGTGGCGATCTGCAACGTTGCCACCAGTTCGCTGGTGCGCGAATCCGACCTGACCCTGCTGACCCAGGCCGGCCCGGAAATCGGCGTGGCCTCGACCAAGGCCTTCACCACCCAGTTGGTCGCCCTGCTGCTGCTGACCCTGGGCATCGGCCAGGTGCAGAAGCGCCTGGCCGATGGCGTCGAAGCCGAGCTGGTGGACGAACTGCGTCGCCTGCCGACCCGGCTGGGCGAGGCGCTGGCGATGAACCGGACGGTGGAGAAGGTTTCCGAGCTGTTCGCCGAGAAGCACCACACCCTGTTCCTCGGCCGTGGCGCGCAGTTCCCGGTGGCCCTGGAAGGCGCGCTGAAGCTCAAGGAAATTTCCTATATCCATGCCGAAGCCTACCCGGCCGGCGAACTCAAGCATGGCCCGCTGGCGCTGGTGGACAGCGACATGCCGGTGGTTACCGTGGCGCCGAACAACGAGCTGGTGGAGAAGCTCAAGTCGAACCTGCAGGAAGTCCGCGCCCGCGGCGGCGAACTGGTGGTGTTCGCCGACGAAGGCGCGGGCATCGAGGCTGGCGAGGGCACCCATGTGGTGGGCATGCCGCACATCGGCGACGTGCTCTCGCCGATCCTCTACACCATCCCGTTGCAATTGCTCTCGTACCATGTCGCCGTGCTCAAGGGCACCGACGTCGACCAGCCGCGCAACCTGGCCAAGTCGGTCACCGTCGAGTAA
Protein Properties
Protein Residues: 611
Protein Molecular Weight: 66.3 kDa
Protein Theoretical pI: 5.88
Hydropathicity (GRAVY score): -0.012
Charge at pH 7 (predicted): -13.09
Protein Sequence: 
>PA5549
MCGIVGAIAERNITPILIEGLKRLEYRGYDSAGVAVFDNEGRLQRCRRVGKVASLEEGLAGTPLLGRLGIAHTRWATHGAPTEGNAHPHFSSDEVAVVHNGIIENHEPLRERLKGLGYVFTSQTDTEVIVHLLHHKLQSIGDLTLALKDAVKELHGAYGLAVISAAQPDRIVAARSGSPLVIGLGLGENFLASDQLALRQVTDRFIYLEEGDIAEIRRDSVRLWDVQGNDVQRETVQYHEGAEAADKGEYRHFMLKEIHEQPSVVQRTLEGRLGQNQVLVESFGPQAAELFAKVRNVQIVACGTSYHAGMVARYWLESLTGIPCQVEVASEFRYRKVAVQPDCLFVTISQSGETADTLAALRNAKELGFLSSVAICNVATSSLVRESDLTLLTQAGPEIGVASTKAFTTQLVALLLLTLGIGQVQKRLADGVEAELVDELRRLPTRLGEALAMNRTVEKVSELFAEKHHTLFLGRGAQFPVALEGALKLKEISYIHAEAYPAGELKHGPLALVDSDMPVVTVAPNNELVEKLKSNLQEVRARGGELVVFADEGAGIEAGEGTHVVGMPHIGDVLSPILYTIPLQLLSYHVAVLKGTDVDQPRNLAKSVTVE
References
External Links:
Resource Link
Genome ID: PA5549
Entrez Gene ID: 877797
NCBI Protein ID: 15600742
General Reference: PaperBLAST - Find papers about PA5549 and its homologs