Branched-chain-amino-acid aminotransferase (PA5013)

Identification
Name: Branched-chain-amino-acid aminotransferase
Synonyms:
  • BCAT
  • Transaminase B
Gene Name: ilvE
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Acts on leucine, isoleucine and valine
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + L-Phenylalanine ↔ L-Glutamate + Phenylpyruvic acid
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Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + L-Isoleucine ↔ 3-Methyl-2-oxovaleric acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
alpha-Ketoglutarate + L-Valine ↔ alpha-Ketoisovaleric acid + L-Glutamate
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Thumb+Thumb ↔ 4-Methyl-2-oxopentanoate+Thumb+Thumb
L-Leucine + alpha-Ketoglutarate ↔ 4-Methyl-2-oxopentanoate + L-Glutamate + Ketoleucine
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Thumb+Thumb ↔ Thumb+Thumb
L-Valine + alpha-Ketoglutarate ↔ alpha-Ketoisovaleric acid + L-Glutamate
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Thumb+Thumb ↔ Thumb+Thumb
L-Isoleucine + alpha-Ketoglutarate ↔ 3-Methyl-2-oxovaleric acid + L-Glutamate
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SMPDB Reactions:
Thumb+L-Glutamic acid+Thumb → Thumb+L-Valine+Thumb
a-Ketoisovaleric acid + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Valine + L-Valine
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Thumb+L-Glutamic acid+Thumb → Thumb+L-Valine+Thumb
Isovaleric acid + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Valine + L-Valine
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3-Methyl-2-oxovaleric acid+L-Glutamic acid+Thumb+Thumb → Thumb+L-Valine+Thumb
3-Methyl-2-oxovaleric acid + L-Glutamic acid + 3-Methyl-2-oxovaleric acid + L-Glutamate → Oxoglutaric acid + L-Valine + L-Valine
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Thumb+L-Glutamic acid+Thumb → Thumb+Thumb
Ketoleucine + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Leucine
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Thumb+L-Glutamic acid+Thumb → Thumb+L-Phenylalanine+Thumb
Phenylpyruvic acid + L-Glutamic acid + L-Glutamate → Oxoglutaric acid + L-Phenylalanine + L-Phenylalanine
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3-Methyl-2-oxovaleric acid+L-Glutamic acid+Thumb+Thumb → Thumb+L-Isoleucine+Thumb
3-Methyl-2-oxovaleric acid + L-Glutamic acid + 3-Methyl-2-oxovaleric acid + L-Glutamate → Oxoglutaric acid + L-Isoleucine + L-Isoleucine
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PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
L-Leucine + Oxoglutaric acid ↔ Ketoleucine + L-Glutamate
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Complex Reactions:
Thumb+Thumb → Thumb+Thumb
Ketoleucine + L-Glutamate → alpha-Ketoglutarate + L-Leucine
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Thumb+Thumb → Thumb+Thumb
L-Leucine + Oxoglutaric acid → Ketoleucine + L-Glutamate
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Thumb+Thumb → Thumb+Thumb
L-Valine + Oxoglutaric acid → a-Ketoisovaleric acid + L-Glutamate
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Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0006052-Keto-3-methyl-valerateMetaboCard
PAMDB0001413-Methyl-2-oxovaleric acidMetaboCard
PAMDB000004a-Ketoisovaleric acidMetaboCard
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB000606alpha-Ketoisovaleric acidMetaboCard
PAMDB000177Isovaleric acidMetaboCard
PAMDB000174KetoleucineMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000071L-IsoleucineMetaboCard
PAMDB000170L-LeucineMetaboCard
PAMDB000061L-PhenylalanineMetaboCard
PAMDB000196L-ValineMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB000084Phenylpyruvic acidMetaboCard
GO Classification:
Function
branched-chain-amino-acid transaminase activity
catalytic activity
transaminase activity
transferase activity
transferase activity, transferring nitrogenous groups
Process
branched chain family amino acid metabolic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
cellular metabolic process
metabolic process
Gene Properties
Locus tag: PA5013
Strand: -
Entrez Gene ID: 881423
Accession: NP_253700.1
GI: 15600206
Sequence start: 5631947
Sequence End: 5632870
Sequence Length: 923
Gene Sequence: 
>PA5013
ATGTCGATGGCCGATCGTGATGGCGTGATCTGGTATGACGGTGAACTGGTGCAGTGGCGCGACGCGACCACGCACGTGCTGACCCATACCCTGCACTATGGAATGGGCGTGTTCGAGGGCGTGCGCGCCTACGACACCCCGCAGGGCACGGCGATCTTCCGCCTGCAGGCGCATACCGACCGGCTGTTCGACTCCGCGCACATCATGAACATGCAGATCCCGTACAGCCGCGACGAGATCAACGAGGCGACCCGCGCCGCCGTGCGCGAGAACAACCTGGAAAGCGCCTATATCCGCCCGATGGTGTTCTACGGAAGCGAAGGCATGGGCCTGCGCGCCAGCGGCCTGAAGGTCCATGTGATCATCGCCGCCTGGAGCTGGGGCGCCTACATGGGCGAGGAAGCCCTGCAGCAAGGCATCAAGGTGCGCACCAGTTCCTTCACCCGCCACCACGTCAACATCTCGATGACCCGCGCCAAGTCCAACGGCGCCTACATCAACTCGATGCTGGCCCTCCAGGAAGCGATCTCCGGCGGCGCCGACGAGGCCATGATGCTCGATCCGGAAGGCTACGTGGCCGAAGGCTCCGGCGAGAACATCTTCATCATCAAGGATGGCGTGATCTACACCCCGGAAGTCACCGCCTGCCTGAACGGCATCACTCGTAACACTATCCTGACCCTGGCCGCCGAACACGGTTTTAAACTGGTCGAGAAGCGCATCACCCGCGACGAGGTGTACATCGCCGACGAGGCCTTCTTCACTGGCACTGCCGCGGAAGTCACGCCGATCCGCGAAGTGGACGGTCGCAAGATCGGCGCCGGCCGCCGTGGCCCGGTCACCGAAAAGCTGCAGAAAGCCTATTTCGACCTGGTCAGCGGCAAGACCGAGGCCCACGCCGAGTGGCGTACCCTGGTCAAGTAA
Protein Properties
Protein Residues: 307
Protein Molecular Weight: 34.1 kDa
Protein Theoretical pI: 6.19
Hydropathicity (GRAVY score): -0.22
Charge at pH 7 (predicted): -4.62
Protein Sequence: 
>PA5013
MSMADRDGVIWYDGELVQWRDATTHVLTHTLHYGMGVFEGVRAYDTPQGTAIFRLQAHTDRLFDSAHIMNMQIPYSRDEINEATRAAVRENNLESAYIRPMVFYGSEGMGLRASGLKVHVIIAAWSWGAYMGEEALQQGIKVRTSSFTRHHVNISMTRAKSNGAYINSMLALQEAISGGADEAMMLDPEGYVAEGSGENIFIIKDGVIYTPEVTACLNGITRNTILTLAAEHGFKLVEKRITRDEVYIADEAFFTGTAAEVTPIREVDGRKIGAGRRGPVTEKLQKAYFDLVSGKTEAHAEWRTLVK
References
External Links:
Resource Link
Genome ID: PA5013
Entrez Gene ID: 881423
NCBI Protein ID: 15600206
General Reference: PaperBLAST - Find papers about PA5013 and its homologs