Amidophosphoribosyltransferase (PA3108)

Identification
Name: Amidophosphoribosyltransferase
Synonyms:
  • ATase
  • Glutamine phosphoribosylpyrophosphate amidotransferase
  • GPATase
Gene Name: purF
Enzyme Class:
Biological Properties
General Function: Involved in amidophosphoribosyltransferase activity
Specific Function: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Glutamine + Water + Phosphoribosyl pyrophosphate ↔ L-Glutamate + Pyrophosphate + 5-Phosphoribosylamine
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
5-Phosphoribosylamine + Pyrophosphate + L-Glutamate ↔ L-Glutamine + Phosphoribosyl pyrophosphate + Water
ReactionCard
Thumb+Thumb+Thumb ← Thumb+Thumb+Thumb
5-Phosphoribosylamine + Pyrophosphate + L-Glutamate ← Phosphoribosyl pyrophosphate + L-Glutamine + Water
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → 5-Phosphoribosylamine+L-Glutamic acid+Pyrophosphate+Thumb+Thumb
Phosphoribosyl pyrophosphate + Water + L-Glutamine → 5-Phosphoribosylamine + L-Glutamic acid + Pyrophosphate + 5-Phosphoribosylamine + L-Glutamate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
L-Glutamine + Water + Phosphoribosyl pyrophosphate ↔ L-Glutamate + Pyrophosphate + 5-Phosphoribosylamine
ReactionCard
Thumb+Thumb+Thumb ← Thumb+Thumb+Thumb
5-Phosphoribosylamine + Pyrophosphate + L-Glutamate ← Phosphoribosyl pyrophosphate + L-Glutamine + Water
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
5-Phosphoribosylamine + Pyrophosphate + L-Glutamate → L-Glutamine + Phosphoribosyl pyrophosphate + Water
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB0002655-PhosphoribosylamineMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000163L-GlutamineMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
amidophosphoribosyltransferase activity
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
Process
cellular aromatic compound metabolic process
cellular metabolic process
cellular nitrogen compound metabolic process
metabolic process
nitrogen compound metabolic process
nucleobase metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside metabolic process
purine base biosynthetic process
purine base metabolic process
Gene Properties
Locus tag: PA3108
Strand: -
Entrez Gene ID: 880477
Accession: NP_251798.1
GI: 15598304
Sequence start: 3488409
Sequence End: 3489914
Sequence Length: 1505
Gene Sequence: 
>PA3108
ATGTGTGGCATCGTCGGTATCGTGGGCAAGTCGAACGTCAATCAGGCGCTGTATGACGCGCTCACCGTCCTCCAACATCGCGGCCAGGACGCTGCCGGTATCGTCACCTGCCATGACGATAAGCTGTACCTGCGCAAGGACAACGGCCTGGTCCGCGACGTCTTCCAGCAGCGCCACATGCAGCGCCTGATCGGCAGCGTCGGCATCGGCCATGTGCGTTACCCGACCGCCGGCAGCTCCAGCTCGGCGGAAGCGCAGCCGTTCTACGTCAACTCGCCCTACGGCATCACCCTGGCGCACAACGGCAACCTGACCAATGTCGAGCAGTTGGCCAAGGAAATCTACGAATCCGACCTGCGCCACGTGAACACCAACTCCGATTCGGAAGTGCTGCTCAACGTGTTCGCCCACGAGCTGGCGGTGCGCAACAAGCTGCAGCCCACCGAGGAGGACATCTTCGCCGCGGTTTCCTGCGTGCACGACCGTTGCGTCGGCGGCTACGCGGTGGTGGCGATGATCACCGGCCATGGCATCGTCGGTTTCCGCGACCCCAATGCGATCCGTCCGATCGTCTTCGGCCAGCGGCATACCGAGAACGGCGTCGAATACATGATCGCCTCCGAGAGCGTGGCCCTGGACGTACTCGGCTTCACCCTGATCCGCGACCTGGCGCCGGGCGAGGCGGTGTACATCACCGAGGAAGGCAAGCTCTATACCCGCCAGTGCGCCAAGGCACCGAAGTACGCGCCGTGCATCTTCGAGCACGTCTACCTGGCGCGTCCGGATTCGATCATGGACGGCATCTCGGTGTACAAGGCGCGCCTGCGCATGGGCGAGAAGCTTGCCGACAAGATCCTCCGCGAGCGTCCCGACCACGACATCGACGTGGTCATCCCGATCCCGGACACCAGCCGCACCGCGGCGCTGGAACTGGCCAACCGGCTCGGCGTGAAGTTCCGCGAGGGCTTCGTCAAGAACCGCTACATCGGCCGCACCTTCATCATGCCCGGCCAGGCGGCGCGGAAGAAATCCGTGCGGCAGAAGCTCAACGCCATCGAGCTGGAGTTCCGCGGCAAGAACGTGATGCTGGTGGATGACTCCATCGTCCGCGGCACCACCTGCAAGCAGATCATCCAGATGGCCCGCGAGGCCGGGGCGAAGAACGTCTACTTCTGCTCCGCCGCGCCGGCCGTGCGCTACCCCAACGTCTACGGCATCGACATGCCGAGTGCGCACGAGCTGATCGCGCACAATCGCAGCACCGAGGACGTCAGCAAGCTGATCGGCGCCGACTGGCTGGTCTACCAGGACCTGCCCGACCTGATCGACGCGGTCGGCGGCGGCAAGATCAAGATCGATCACTTCGACTGCGCCGTGTTCGACGGCGAGTACGTGACCGGCGACGTCAACGAGGCCTACCTGAACCGGATCGAACAGGCGCGCAACGATGCGACCAAGGCCAAGAGCCAGGCGGTCAGCGCGATCATCGATCTGTACAACGACTGA
Protein Properties
Protein Residues: 501
Protein Molecular Weight: 55.4 kDa
Protein Theoretical pI: 6.79
Hydropathicity (GRAVY score): -0.175
Charge at pH 7 (predicted): -1.66
Protein Sequence: 
>PA3108
MCGIVGIVGKSNVNQALYDALTVLQHRGQDAAGIVTCHDDKLYLRKDNGLVRDVFQQRHMQRLIGSVGIGHVRYPTAGSSSSAEAQPFYVNSPYGITLAHNGNLTNVEQLAKEIYESDLRHVNTNSDSEVLLNVFAHELAVRNKLQPTEEDIFAAVSCVHDRCVGGYAVVAMITGHGIVGFRDPNAIRPIVFGQRHTENGVEYMIASESVALDVLGFTLIRDLAPGEAVYITEEGKLYTRQCAKAPKYAPCIFEHVYLARPDSIMDGISVYKARLRMGEKLADKILRERPDHDIDVVIPIPDTSRTAALELANRLGVKFREGFVKNRYIGRTFIMPGQAARKKSVRQKLNAIELEFRGKNVMLVDDSIVRGTTCKQIIQMAREAGAKNVYFCSAAPAVRYPNVYGIDMPSAHELIAHNRSTEDVSKLIGADWLVYQDLPDLIDAVGGGKIKIDHFDCAVFDGEYVTGDVNEAYLNRIEQARNDATKAKSQAVSAIIDLYND
References
External Links:
Resource Link
Genome ID: PA3108
Entrez Gene ID: 880477
NCBI Protein ID: 15598304
General Reference: PaperBLAST - Find papers about PA3108 and its homologs