Carbamoyl-phosphate synthase large chain (PA4756)

Identification
Name: Carbamoyl-phosphate synthase large chain
Synonyms:
  • Carbamoyl-phosphate synthetase ammonia chain
Gene Name: carB
Enzyme Class:
Biological Properties
General Function: Involved in ATP binding
Specific Function: 2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
2 Thumb+Thumb+Thumb+Thumb → 2 Thumb+Thumb+Thumb+2 Thumb+Thumb
2 Adenosine triphosphate + L-Glutamine + Water + Hydrogen carbonate → 2 ADP + Carbamoylphosphate + L-Glutamate + 2 Hydrogen ion + Phosphate
ReactionCard
2 Thumb+Thumb+Thumb+Thumb ↔ 2 Thumb+Thumb+Thumb+Thumb
2 Adenosine triphosphate + L-Glutamine + Hydrogen carbonate + Water ↔ 2 ADP + Phosphate + L-Glutamate + Carbamoylphosphate
ReactionCard
2 Thumb+Thumb+Thumb+Thumb+Thumb+Thumb+Thumb ↔ 2 Thumb+Thumb+Thumb+Thumb
2 Adenosine triphosphate + L-Glutamine + Hydrogen carbonate + Water + Ammonia + Carbamic acid + Carboxyphosphate ↔ 2 ADP + Phosphate + L-Glutamate + Carbamoylphosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb+2 Thumb → 2 Adenosine diphosphate+Thumb+L-Glutamic acid+2 Thumb+Thumb+2 Thumb+Thumb
Hydrogen carbonate + Water + L-Glutamine + 2 Adenosine triphosphate → 2 Adenosine diphosphate + Phosphate + L-Glutamic acid + 2 Hydrogen ion + Carbamoylphosphate + 2 ADP + L-Glutamate
ReactionCard
PseudoCyc/BioCyc Reactions:
2 Thumb+Thumb+Thumb+Thumb → 2 Thumb+Thumb+Thumb+2 Thumb+Thumb
2 Adenosine triphosphate + L-Glutamine + Water + Hydrogen carbonate → 2 ADP + Carbamoylphosphate + L-Glutamate + 2 Hydrogen ion + Phosphate
ReactionCard
Complex Reactions:
2 Thumb+Thumb+Thumb+Thumb → 2 Thumb+Thumb+Thumb+Thumb
2 Adenosine triphosphate + L-Glutamine + Carbonic acid + Water → 2 ADP + Inorganic phosphate + L-Glutamate + Carbamoylphosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000253CarbamoylphosphateMetaboCard
PAMDB000510Carbonic acidMetaboCard
PAMDB000153Hydrogen carbonateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000055L-GlutamateMetaboCard
PAMDB000163L-GlutamineMetaboCard
PAMDB000383PhosphateMetaboCard
PAMDB000142WaterMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
carbamoyl-phosphate synthase activity
catalytic activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
nucleoside binding
purine nucleoside binding
Process
metabolic process
nitrogen compound metabolic process
Gene Properties
Locus tag: PA4756
Strand: -
Entrez Gene ID: 881743
Accession: NP_253444.1
GI: 15599950
Sequence start: 5339864
Sequence End: 5343085
Sequence Length: 3221
Gene Sequence: 
>PA4756
ATGCCAAAACGTACAGACATAAAGAGCATCCTGATCCTCGGTGCCGGCCCCATCGTGATTGGCCAGGCCTGCGAATTCGACTACTCCGGCGCCCAGGCCTGCAAGGCCCTGCGCGAGGAGGGCTACCGCGTCATCCTGGTGAACTCCAACCCCGCGACCATCATGACCGATCCGGCGATGGCCGACGCGACCTACATCGAGCCGATCAAGTGGGCCACCGTGGCCAAGATCATCGAGAAGGAACGCCCCGACGCGCTGCTGCCGACCATGGGCGGCCAGACTGCGTTGAACTGCGCCCTGGACCTGGAGCGCCACGGCGTGCTGGAGAAGTTCGGCGTGGAGATGATCGGCGCCAATGCCGATACCATCGACAAGGCCGAGGACCGCTCGCGCTTCGACAAGGCGATGAAGGATATCGGCCTGGCCTGTCCGCGCTCGGGCATCGCCCACAGCATGGAGGAGGCCTACGGCGTGCTCGAGCAGGTCGGCTTCCCCTGCATCATCCGTCCGTCCTTCACCATGGGCGGCACCGGCGGCGGTATCGCCTACAACCGTGAAGAGTTCGAAGAGATCTGCGCCCGTGGCCTCGACCTGTCGCCGACCAACGAGCTGCTGATCGACGAGTCGCTGATCGGCTGGAAGGAATACGAGATGGAGGTGGTCCGCGACAAGAAGGACAACTGCATCATCGTCTGCTCCATCGAGAACTTCGACCCGATGGGCGTGCACACCGGTGACTCGATCACCGTGGCGCCGGCGCAGACCCTGACCGACAAGGAATACCAGATCATGCGCAACGCCTCGCTGGCGGTATTGCGCGAGATCGGCGTGGAAACCGGCGGTTCCAACGTGCAGTTCGGCATCTGCCCGAACACCGGGCGCATGGTGGTGATCGAGATGAACCCGCGGGTTTCCCGCTCCTCGGCCCTGGCCTCCAAGGCCACCGGTTTCCCGATCGCCAAGATCGCCGCCAAGCTGGCGGTCGGCTACACCCTCGACGAACTGCAGAACGACATCACCGGCGGTCGCACCCCGGCGTCGTTCGAGCCGGCCATCGACTACGTGGTGACCAAGATCCCGCGCTTCGCCTTCGAGAAATTCCCGAAAGCCGATGCCCGCCTGACCACCCAGATGAAGTCGGTCGGCGAAGTCATGGCCATCGGCCGGACCTTCCAGGAGTCGGTGCAGAAAGCCTTGCGTGGCCTGGAAGTCGGCGCCACCGGCTTCGATCCGAAGCTCGACCTGAACGACCCGGAGGCCGACAGCATCCTCAAGCGCGAGCTGACCGTGCCCAGCGCCGAGCGTGTCTGGTACGTCGCCGACGCCTTCCGCGCCGGCAAGAGCGTCGAGGAAGTGTTCGAGCTGACCCGCATCGACGAATGGTTCCTGGTGCAGATCGAGGACCTGGTCAAGGACGAGGAGAAGGTCAAGACCCTCGGCCTGTCCTCCATCGATCGCGAGCTGATGTACAAGCTCAAGCGCAAGGGCTTCTCCGACGCGCGCCTGGCCAAGCTGCTCGGCGTCACCGAGAAGAACCTGCGCAGCCATCGCCACAAGCTGAAGGTACTGCCGGTCTACAAGCGTGTCGATACCTGCGCCGCCGAGTTCGCCACCGACACCGCCTACATGTATTCGACCTACGAGGAAGAGTGCGAGGCCAACCCGTCGAGCCGCGAGAAGATCATGATCCTCGGCGGCGGTCCGAACCGCATCGGCCAGGGCATCGAGTTCGACTACTGCTGCGTGCACGCGGCGCTGGCGATGCGCGAAGACGGCTACGAGACCATCATGGTCAACTGCAACCCGGAAACCGTCTCCACCGACTATGACACCTCCGACCGCCTGTACTTCGAGCCGGTGACCCTCGAGGACGTCCTTGAGATCGTCCGCGTCGAGCAGCCCAAGGGCGTGATCGTCCAGTACGGCGGCCAGACCCCGCTGAAGCTCTGCCGCGCCCTCGAAGAGGCCGGCGTGCCGATCATCGGCACCAGTCCGGACGCCATCGACCGTGCCGAAGACCGCGAGCGCTTCCAGCAGATGGTCCAGCGCCTGAACCTGCGCCAGCCGGCCAACGCCACCGCGCGCAGCGAAGACGAGGCCCTGGCCGCGTCCAAGGCCATCGGTTATCCGCTGGTGGTACGCCCGTCCTACGTGCTGGGCGGGCGGGCGATGGAAATCGTCTACCAGGAAGAAGAACTCAAGCGCTACATGCGTGAGGCGGTTCAGGTTTCCAACGACAGCCCGGTGCTGCTCGACCACTTCCTCAACTGCGCCATCGAAGTCGACATCGACGCGGTATGCGACGGCGAGATCGTGGTGATCGGCGCGATCATGCAGCATATCGAGCAGGCTGGCGTTCACTCCGGCGACTCCGCCTGTTCGCTGCCGCCGTACTCGCTGCCGCAGCACATCCAGGACGAGATCCGCGAGCAGGTCAAGAAAATGGCCCTGGAGCTTGGCGTGGTCGGCCTGATGAACGTGCAGATGGCGGTGCAGGGCGAGGATATCTTCGTCATCGAGGTCAATCCGCGCGCCTCGCGTACCGTGCCGTTCGTCTCCAAGTGCGTCGGCGAGTCGCTGGCCAAGGTCGCCGCCCGCGTCATGGCCGGCAAGACCCTGGCCGAGGTCGGCTTCACCCAGGAAATCATCCCGCCGTTCTTCAGCGTCAAGGAAGCGGTGTTCCCGTTCGCCAAGTTCCCCGGCGTCGATCCGATCCTCGGCCCGGAAATGAAGTCCACTGGTGAAGTGATGGGCGTCGGTGATAGCTTTGCCGAAGCCTTTGCCAAGGCTCAGTTGGGGGCCAGCGAGATTCTCCCGACCGCCGGTTGCGCCTTCATCAGCGTCCGCGAAGACGACAAGCCGTTCGCCGCCCAGGTGGCTGGCGACCTGGTCGCGCTGGGCTTCGAAGTGGTAGCCACCGCCGGTACCGCGCGTGTCATCGAGGCCGCGGGCCTGCCGGTGCGTCGCGTGAACAAGGTGACCGAAGGTCGCCCGCACGTGGTGGACATGATCAAGAACGACGAGGTCACCCTGATCATCAACACCACCGAGGGCCGGCAGTCCATCGCTGACTCCTACTCCATTCGTCGAAACGCCCTGCAGCACAAGATCTGCTGCACCACCACCATTGCGGGTGGGCAGGCGATCTGTGAGGCGCTCAAGTTCGGTCCCGAGAAGACCGTTCGGCGTCTGCAGGATCTCCACGCAGGAATCAAGGCATGA
Protein Properties
Protein Residues: 1073
Protein Molecular Weight: 117.3 kDa
Protein Theoretical pI: 4.78
Hydropathicity (GRAVY score): -0.096
Charge at pH 7 (predicted): -33.47
Protein Sequence: 
>PA4756
MPKRTDIKSILILGAGPIVIGQACEFDYSGAQACKALREEGYRVILVNSNPATIMTDPAMADATYIEPIKWATVAKIIEKERPDALLPTMGGQTALNCALDLERHGVLEKFGVEMIGANADTIDKAEDRSRFDKAMKDIGLACPRSGIAHSMEEAYGVLEQVGFPCIIRPSFTMGGTGGGIAYNREEFEEICARGLDLSPTNELLIDESLIGWKEYEMEVVRDKKDNCIIVCSIENFDPMGVHTGDSITVAPAQTLTDKEYQIMRNASLAVLREIGVETGGSNVQFGICPNTGRMVVIEMNPRVSRSSALASKATGFPIAKIAAKLAVGYTLDELQNDITGGRTPASFEPAIDYVVTKIPRFAFEKFPKADARLTTQMKSVGEVMAIGRTFQESVQKALRGLEVGATGFDPKLDLNDPEADSILKRELTVPSAERVWYVADAFRAGKSVEEVFELTRIDEWFLVQIEDLVKDEEKVKTLGLSSIDRELMYKLKRKGFSDARLAKLLGVTEKNLRSHRHKLKVLPVYKRVDTCAAEFATDTAYMYSTYEEECEANPSSREKIMILGGGPNRIGQGIEFDYCCVHAALAMREDGYETIMVNCNPETVSTDYDTSDRLYFEPVTLEDVLEIVRVEQPKGVIVQYGGQTPLKLCRALEEAGVPIIGTSPDAIDRAEDRERFQQMVQRLNLRQPANATARSEDEALAASKAIGYPLVVRPSYVLGGRAMEIVYQEEELKRYMREAVQVSNDSPVLLDHFLNCAIEVDIDAVCDGEIVVIGAIMQHIEQAGVHSGDSACSLPPYSLPQHIQDEIREQVKKMALELGVVGLMNVQMAVQGEDIFVIEVNPRASRTVPFVSKCVGESLAKVAARVMAGKTLAEVGFTQEIIPPFFSVKEAVFPFAKFPGVDPILGPEMKSTGEVMGVGDSFAEAFAKAQLGASEILPTAGCAFISVREDDKPFAAQVAGDLVALGFEVVATAGTARVIEAAGLPVRRVNKVTEGRPHVVDMIKNDEVTLIINTTEGRQSIADSYSIRRNALQHKICCTTTIAGGQAICEALKFGPEKTVRRLQDLHAGIKA
References
External Links:
Resource Link
Genome ID: PA4756
Entrez Gene ID: 881743
NCBI Protein ID: 15599950
General Reference: PaperBLAST - Find papers about PA4756 and its homologs