Hydrogen carbonate (PAMDB000153)

General function:

Involved in cyanate hydratase activity

Specific function:

Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide

Gene Name:

cynS

Locus Tag:

PA2052

Molecular weight:

16.8 kDa

Reactions

General function:

Involved in ATP binding

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carB

Locus Tag:

PA4756

Molecular weight:

117.3 kDa

Reactions

General function:

Involved in phosphoribosylaminoimidazole carboxylase activity

Specific function:

Possesses an ATPase activity that is dependent on the presence of AIR (aminoimidazole ribonucleotide). The association of purK and purE produces an enzyme complex capable of converting AIR to CAIR efficiently under physiological condition

Gene Name:

purK

Locus Tag:

PA5425

Molecular weight:

38.5 kDa

Reactions

General function:

Involved in glutamine catabolic process

Specific function:

2 ATP + L-glutamine + HCO(3)(-) + H(2)O = 2 ADP + phosphate + L-glutamate + carbamoyl phosphate

Gene Name:

carA

Locus Tag:

PA4758

Molecular weight:

40.8 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Controls translation of mRNA for both itself and the alpha-subunit (accA) by binding to a probable hairpin in the 5' of the mRNA. Binding to mRNA inhibits translation; this is partially relieved by acetyl-CoA. Increasing amounts of mRNA also inhibit enzyme activity

Gene Name:

accD

Locus Tag:

PA3112

Molecular weight:

31.8 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA

Gene Name:

accA

Locus Tag:

PA3639

Molecular weight:

34.9 kDa

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accB

Locus Tag:

PA4847

Molecular weight:

16.5 kDa

General function:

Involved in carbonate dehydratase activity

Specific function:

Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (cynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate

Gene Name:

cynT

Locus Tag:

PA2053

Molecular weight:

23.4 kDa

Reactions

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Locus Tag:

PA4848

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in carbonate dehydratase activity

Specific function:

H(2)CO(3) = CO(2) + H(2)O

Gene Name:

can

Locus Tag:

PA4676

Molecular weight:

24.2 kDa

Reactions

General function:

threonylcarbamoyladenosine biosynthetic process

Specific function:

Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, bicarbonate/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of pyrophosphate. Is also able to catalyze the reverse reaction in vitro, i.e. the formation of ATP from TC-AMP and PPi. Shows higher affinity for the full-length tRNA(Thr) lacking only the t(6)A37 modification than for its fully modified counterpart. Could also be required for the maturation of 16S rRNA. Binds to double-stranded RNA but does not interact tightly with either of the ribosomal subunits, or the 70S particles.

Gene Name:

tsaC

Locus Tag:

PA0022

Molecular weight:

20.4 kDa

Reactions