| Identification |
| Name: |
Biotin carboxylase |
| Synonyms: |
- Acetyl-CoA carboxylase subunit A
- ACC
|
| Gene Name: |
accC |
| Enzyme Class: |
|
| Biological Properties |
| General Function: |
Involved in ligase activity |
| Specific Function: |
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA |
| Cellular Location: |
Not Available |
| KEGG Pathways: |
|
| KEGG Reactions: |
| | | | |
 | + | Holo-[carboxylase] | + |  | + | Holo-[carboxylase] | ↔ |  | + |  | + | Carboxybiotin-carboxyl-carrier protein | + | Carboxybiotin-carboxyl-carrier protein |
| | |
 | + | Carboxybiotin-carboxyl-carrier protein | ↔ |  | + | Holo-[carboxylase] |
| |
|
| SMPDB Reactions: |
|
| + | | + | | → | Adenosine diphosphate | + | | + |  | + | Malonyl-CoA | + | | + | |
| | |
a biotinylated [BCCP dimer] | + | | + | | → | carboxylated-biotinylated [BCCP dimer] | + | | + | | + | |
| |
|
| PseudoCyc/BioCyc Reactions: |
|
| Complex Reactions: |
|
| + | biotin-[carboxyl-carrier-protein] | + |  | → | | + |  | + | carboxy-biotin-[carboxyl-carrier-protein] |
| | | | | |
|
| Transports: |
Not Available |
| Metabolites: |
|
| GO Classification: |
| Function |
|---|
| adenyl nucleotide binding | | adenyl ribonucleotide binding | | ATP binding | | binding | | biotin binding | | catalytic activity | | ligase activity | | nucleoside binding | | purine nucleoside binding | | vitamin binding | | Process |
|---|
| metabolic process |
|
| Gene Properties |
| Locus tag: |
PA4848 |
| Strand: |
+ |
| Entrez Gene ID: |
879558 |
| Accession: |
NP_253535.1 |
| GI: |
15600041 |
| Sequence start: |
5442792 |
| Sequence End: |
5444141 |
| Sequence Length: |
1349 |
| Gene Sequence: |
>PA4848
ATGTTGGAAAAAGTGCTGATCGCCAACCGCGGCGAAATCGCCTTGCGCATCCTTCGCGCATGCAAGGAGCTGGGGATCAAGACGGTGGCGGTACACTCCACCGCCGACCGCGAGTTGATGCACCTGTCGCTCGCCGACGAATCGGTGTGCATCGGTCCGGCCCCGGCCACCCAGTCGTACCTGCAGATCCCGGCGATCATCGCCGCGGCCGAGGTCACCGGCGCCACCGCGATCCACCCCGGCTACGGCTTCCTCGCCGAGAACGCCGACTTCGCCGAGCAGATCGAACGCTCCGGCTTCACCTTCGTCGGCCCGACCGCCGAGGTGATCCGCCTGATGGGCGACAAGGTTTCGGCCAAGGACGCCATGAAGCGCGCCGGCGTCCCCACCGTGCCGGGCTCCGACGGCCCGCTGCCGGAAGATGAAGAGACCGCCCTGGCGATCGCCCGCGAGGTCGGCTACCCGGTGATCATCAAGGCCGCCGGCGGCGGCGGTGGGCGCGGCATGCGCGTGGTCTACGACGAGTCCGAGCTGATCAAGTCGGCCAAGCTGACCCGCACCGAGGCCGGCGCGGCGTTCGGCAACCCGATGGTCTACCTGGAGAAGTTCCTGACCAACCCGCGCCACGTGGAAGTCCAGGTGCTTTCCGACGGCCAGGGCAACGCCATCCACCTCGGCGACCGCGACTGCTCCCTGCAGCGCCGCCACCAGAAGGTGATCGAAGAGGCGCCGGCCCCCGGCATCGACGAGAAGGCTCGCCAGGAAGTCTTCGCCCGCTGCGTCCAGGCCTGCATCGAGATCGGCTACCGCGGCGCCGGCACCTTCGAGTTCCTCTACGAGAACGGCCGCTTCTACTTCATCGAGATGAACACTCGCGTGCAGGTGGAGCACCCGGTATCTGAGATGGTCACCGGTGTCGACATCGTCAAGGAGATGCTGCGCATCGCCTCCGGCGAGAAGCTCTCGATCCGCCAGGAGGACGTGGTCATCCGCGGCCATGCGCTGGAATGCCGGATCAACGCCGAAGACCCGAAGACCTTCATGCCCAGCCCGGGCAAGGTCAAGCACTTCCACGCCCCCGGCGGCAACGGCGTGCGCGTCGACTCGCACCTCTACAGCGGCTACAGCGTGCCGCCGAACTACGACTCGCTGGTCGGCAAGGTCATCACCTACGGTGCCGACCGCGACGAGGCGCTGGCGCGGATGCGCAATGCCCTGGACGAGTTGATCGTCGACGGTATCAAGACCAATACCGAACTGCACAAGGACCTGGTGCGCGACGCCGCCTTCTGCAAGGGCGGGGTGAACATCCATTACCTGGAGAAGAAACTGGGTATGGACAAGCACTGA |
| Protein Properties |
| Protein Residues: |
449 |
| Protein Molecular Weight: |
48.9 kDa |
| Protein Theoretical pI: |
6.28 |
| Hydropathicity (GRAVY score): |
-0.183 |
| Charge at pH 7 (predicted): |
-5.82 |
| Protein Sequence: |
>PA4848
MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLSLADESVCIGPAPATQSYLQIPAIIAAAEVTGATAIHPGYGFLAENADFAEQIERSGFTFVGPTAEVIRLMGDKVSAKDAMKRAGVPTVPGSDGPLPEDEETALAIAREVGYPVIIKAAGGGGGRGMRVVYDESELIKSAKLTRTEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQKVIEEAPAPGIDEKARQEVFARCVQACIEIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGVDIVKEMLRIASGEKLSIRQEDVVIRGHALECRINAEDPKTFMPSPGKVKHFHAPGGNGVRVDSHLYSGYSVPPNYDSLVGKVITYGADRDEALARMRNALDELIVDGIKTNTELHKDLVRDAAFCKGGVNIHYLEKKLGMDKH |
| References |
| External Links: |
|
| General Reference: |
PaperBLAST - Find papers about PA4848 and its homologs
|
