Identification
Name: Biotin carboxylase
Synonyms:
  • Acetyl-CoA carboxylase subunit A
  • ACC
Gene Name: accC
Enzyme Class:
Biological Properties
General Function: Involved in ligase activity
Specific Function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Thumb+Holo-[carboxylase]+Thumb+Holo-[carboxylase]Thumb+Thumb+Carboxybiotin-carboxyl-carrier protein+Carboxybiotin-carboxyl-carrier protein
Adenosine triphosphate + Holo-[carboxylase] + Hydrogen carbonate + Holo-[carboxylase] ↔ ADP + Phosphate + Carboxybiotin-carboxyl-carrier protein + Carboxybiotin-carboxyl-carrier protein
ReactionCard
Thumb+Carboxybiotin-carboxyl-carrier proteinThumb+Holo-[carboxylase]
Acetyl-CoA + Carboxybiotin-carboxyl-carrier protein ↔ Malonyl-CoA + Holo-[carboxylase]
ReactionCard
SMPDB Reactions:
Thumb+Thumb+ThumbAdenosine diphosphate+Thumb+Thumb+Malonyl-CoA+Thumb+Thumb
a biotinylated [BCCP dimer]+Thumb+Thumbcarboxylated-biotinylated [BCCP dimer]+Thumb+Thumb+Thumb
a biotinylated [BCCP dimer] + Adenosine triphosphate + Hydrogen carbonate → carboxylated-biotinylated [BCCP dimer] + Hydrogen ion + ADP + Phosphate
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+ThumbThumb+Thumb+Thumb+Thumb
Complex Reactions:
Thumb+biotin-[carboxyl-carrier-protein]+ThumbThumb+Thumb+carboxy-biotin-[carboxyl-carrier-protein]
Adenosine triphosphate + biotin-[carboxyl-carrier-protein] + Carbon dioxideADP + Inorganic phosphate + carboxy-biotin-[carboxyl-carrier-protein]
ReactionCard
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Thumb+Thumb+ThumbThumb+Thumb+Thumb
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000148Adenosine triphosphateMetaboCard
PAMDB000345ADPMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB000510Carbonic acidMetaboCard
PAMDB000153Hydrogen carbonateMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB001776Inorganic phosphateMetaboCard
PAMDB000284Malonyl-CoAMetaboCard
PAMDB000383PhosphateMetaboCard
GO Classification:
Function
adenyl nucleotide binding
adenyl ribonucleotide binding
ATP binding
binding
biotin binding
catalytic activity
ligase activity
nucleoside binding
purine nucleoside binding
vitamin binding
Process
metabolic process
Gene Properties
Locus tag: PA4848
Strand: +
Entrez Gene ID: 879558
Accession: NP_253535.1
GI: 15600041
Sequence start: 5442792
Sequence End: 5444141
Sequence Length: 1349
Gene Sequence:
>PA4848
ATGTTGGAAAAAGTGCTGATCGCCAACCGCGGCGAAATCGCCTTGCGCATCCTTCGCGCATGCAAGGAGCTGGGGATCAAGACGGTGGCGGTACACTCCACCGCCGACCGCGAGTTGATGCACCTGTCGCTCGCCGACGAATCGGTGTGCATCGGTCCGGCCCCGGCCACCCAGTCGTACCTGCAGATCCCGGCGATCATCGCCGCGGCCGAGGTCACCGGCGCCACCGCGATCCACCCCGGCTACGGCTTCCTCGCCGAGAACGCCGACTTCGCCGAGCAGATCGAACGCTCCGGCTTCACCTTCGTCGGCCCGACCGCCGAGGTGATCCGCCTGATGGGCGACAAGGTTTCGGCCAAGGACGCCATGAAGCGCGCCGGCGTCCCCACCGTGCCGGGCTCCGACGGCCCGCTGCCGGAAGATGAAGAGACCGCCCTGGCGATCGCCCGCGAGGTCGGCTACCCGGTGATCATCAAGGCCGCCGGCGGCGGCGGTGGGCGCGGCATGCGCGTGGTCTACGACGAGTCCGAGCTGATCAAGTCGGCCAAGCTGACCCGCACCGAGGCCGGCGCGGCGTTCGGCAACCCGATGGTCTACCTGGAGAAGTTCCTGACCAACCCGCGCCACGTGGAAGTCCAGGTGCTTTCCGACGGCCAGGGCAACGCCATCCACCTCGGCGACCGCGACTGCTCCCTGCAGCGCCGCCACCAGAAGGTGATCGAAGAGGCGCCGGCCCCCGGCATCGACGAGAAGGCTCGCCAGGAAGTCTTCGCCCGCTGCGTCCAGGCCTGCATCGAGATCGGCTACCGCGGCGCCGGCACCTTCGAGTTCCTCTACGAGAACGGCCGCTTCTACTTCATCGAGATGAACACTCGCGTGCAGGTGGAGCACCCGGTATCTGAGATGGTCACCGGTGTCGACATCGTCAAGGAGATGCTGCGCATCGCCTCCGGCGAGAAGCTCTCGATCCGCCAGGAGGACGTGGTCATCCGCGGCCATGCGCTGGAATGCCGGATCAACGCCGAAGACCCGAAGACCTTCATGCCCAGCCCGGGCAAGGTCAAGCACTTCCACGCCCCCGGCGGCAACGGCGTGCGCGTCGACTCGCACCTCTACAGCGGCTACAGCGTGCCGCCGAACTACGACTCGCTGGTCGGCAAGGTCATCACCTACGGTGCCGACCGCGACGAGGCGCTGGCGCGGATGCGCAATGCCCTGGACGAGTTGATCGTCGACGGTATCAAGACCAATACCGAACTGCACAAGGACCTGGTGCGCGACGCCGCCTTCTGCAAGGGCGGGGTGAACATCCATTACCTGGAGAAGAAACTGGGTATGGACAAGCACTGA
Protein Properties
Protein Residues: 449
Protein Molecular Weight: 48.9 kDa
Protein Theoretical pI: 6.28
Hydropathicity (GRAVY score): -0.183
Charge at pH 7 (predicted): -5.82
Protein Sequence:
>PA4848
MLEKVLIANRGEIALRILRACKELGIKTVAVHSTADRELMHLSLADESVCIGPAPATQSYLQIPAIIAAAEVTGATAIHPGYGFLAENADFAEQIERSGFTFVGPTAEVIRLMGDKVSAKDAMKRAGVPTVPGSDGPLPEDEETALAIAREVGYPVIIKAAGGGGGRGMRVVYDESELIKSAKLTRTEAGAAFGNPMVYLEKFLTNPRHVEVQVLSDGQGNAIHLGDRDCSLQRRHQKVIEEAPAPGIDEKARQEVFARCVQACIEIGYRGAGTFEFLYENGRFYFIEMNTRVQVEHPVSEMVTGVDIVKEMLRIASGEKLSIRQEDVVIRGHALECRINAEDPKTFMPSPGKVKHFHAPGGNGVRVDSHLYSGYSVPPNYDSLVGKVITYGADRDEALARMRNALDELIVDGIKTNTELHKDLVRDAAFCKGGVNIHYLEKKLGMDKH
References
External Links:
Resource Link
Genome ID: PA4848
Entrez Gene ID: 879558
NCBI Protein ID: 15600041
General Reference: PaperBLAST - Find papers about PA4848 and its homologs