Carbon dioxide (PAMDB000568)

General function:

Involved in cyanate hydratase activity

Specific function:

Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide

Gene Name:

cynS

Locus Tag:

PA2052

Molecular weight:

16.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Meso-2,6-diaminoheptanedioate = L-lysine + CO(2)

Gene Name:

lysA

Locus Tag:

PA5277

Molecular weight:

45.5 kDa

Reactions

General function:

Involved in phosphoenolpyruvate carboxylase activity

Specific function:

Through the carboxylation of phosphoenolpyruvate (PEP) it forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle

Gene Name:

ppc

Locus Tag:

PA3687

Molecular weight:

97.8 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

2 pyruvate = 2-acetolactate + CO(2)

Gene Name:

ilvI

Locus Tag:

PA4696

Molecular weight:

63 kDa

Reactions

General function:

Involved in acetolactate synthase activity

Specific function:

2 pyruvate = 2-acetolactate + CO(2)

Gene Name:

ilvH

Locus Tag:

PA4695

Molecular weight:

17.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain

Gene Name:

trpC

Locus Tag:

PA0651

Molecular weight:

30.3 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceF

Locus Tag:

PA5016

Molecular weight:

56.7 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Pyruvate + ferricytochrome b1 + H(2)O = acetate + CO(2) + ferrocytochrome b1

Gene Name:

poxB

Locus Tag:

PA5297

Molecular weight:

62.3 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH

Gene Name:

icd

Locus Tag:

PA2623

Molecular weight:

45.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)

Gene Name:

pyrF

Locus Tag:

PA2876

Molecular weight:

24.4 kDa

Reactions

General function:

Involved in metabolic process

Specific function:

Catalyzes the removal of elemental sulfur and selenium atoms from cysteine and selenocysteine to produce alanine. Functions as a sulfur delivery protein for NAD, biotin and Fe-S cluster synthesis. Transfers sulfur on 'Cys-456' of thiI in a transpersulfidation reaction. Transfers sulfur on 'Cys-19' of tusA in a transpersulfidation reaction. Functions also as a selenium delivery protein in the pathway for the biosynthesis of selenophosphate

Gene Name:

iscS

Locus Tag:

PA3814

Molecular weight:

44.7 kDa

Reactions

General function:

Involved in aspartate 1-decarboxylase activity

Specific function:

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine

Gene Name:

panD

Locus Tag:

PA4731

Molecular weight:

13.9 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate

Gene Name:

pdxJ

Locus Tag:

PA0773

Molecular weight:

27.2 kDa

Reactions

General function:

Involved in adenosylmethionine decarboxylase activity

Specific function:

Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine

Gene Name:

speD

Locus Tag:

PA0654

Molecular weight:

30.4 kDa

Reactions

General function:

Involved in phosphatidylserine decarboxylase activity

Specific function:

Phosphatidyl-L-serine = phosphatidylethanolamine + CO(2)

Gene Name:

psd

Locus Tag:

PA4957

Molecular weight:

32 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids

Gene Name:

fabB

Locus Tag:

PA1609

Molecular weight:

42.8 kDa

Reactions

General function:

Involved in chorismate mutase activity

Specific function:

Chorismate = prephenate

Gene Name:

pheA

Locus Tag:

PA3166

Molecular weight:

40.6 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups other than amino-acyl groups

Specific function:

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis

Gene Name:

fabF

Locus Tag:

PA2965

Molecular weight:

43.5 kDa

Reactions

General function:

Involved in electron carrier activity

Specific function:

Formate dehydrogenase allows Pseudomonas aeruginosa to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit

Gene Name:

fdnH

Locus Tag:

PA4811

Molecular weight:

33.8 kDa

General function:

Involved in carbonate dehydratase activity

Specific function:

Reversible hydration of carbon dioxide. Carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (cynS) diffuses out of the cell faster than it would be hydrated to bicarbonate, so the apparent function of this enzyme is to catalyze the hydration of carbon dioxide and thus prevent depletion of cellular bicarbonate

Gene Name:

cynT

Locus Tag:

PA2053

Molecular weight:

23.4 kDa

Reactions

General function:

Involved in transferase activity, transferring phosphorus-containing groups

Specific function:

CTP + phosphatidate = diphosphate + CDP- diacylglycerol

Gene Name:

cdsA

Locus Tag:

PA3651

Molecular weight:

28.9 kDa

Reactions

General function:

Involved in phosphopantothenate--cysteine ligase activity

Specific function:

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

Gene Name:

coaBC

Locus Tag:

PA5320

Molecular weight:

43.1 kDa

Reactions

General function:

Involved in respiratory electron transport chain

Specific function:

Formate dehydrogenase allows Pseudomonas aeruginosa to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. Subunit gamma is the cytochrome b556(FDN) component of the formate dehydrogenase

Gene Name:

fdnI

Locus Tag:

PA4810

Molecular weight:

23.9 kDa

General function:

Involved in tartronate-semialdehyde synthase activity

Specific function:

Catalyzes the condensation of two molecules of glyoxylate to give 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde)

Gene Name:

gcl

Locus Tag:

PA1502

Molecular weight:

64.4 kDa

Reactions

General function:

Involved in oxoglutarate dehydrogenase (succinyl-transferring) activity

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucA

Locus Tag:

PA1585

Molecular weight:

105.9 kDa

Reactions

General function:

Involved in transferase activity, transferring acyl groups

Specific function:

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components:2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

sucB

Locus Tag:

PA1586

Molecular weight:

42.9 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Gene Name:

aceE

Locus Tag:

PA5015

Molecular weight:

99.6 kDa

Reactions

General function:

Involved in 8-amino-7-oxononanoate synthase activity

Specific function:

Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

Gene Name:

bioF

Locus Tag:

PA0501

Molecular weight:

42.2 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

ATP + 7,8-diaminononanoate + CO(2) = ADP + phosphate + dethiobiotin

Gene Name:

bioD

Locus Tag:

PA0504

Molecular weight:

23.3 kDa

Reactions

General function:

Involved in phosphatidylglycerophosphatase activity

Specific function:

One of the three phospholipid phosphatases, specifically hydrolyzes phosphatidylglycerophosphate

Gene Name:

pgpA

Locus Tag:

PA4050

Molecular weight:

19.6 kDa

Reactions

General function:

Involved in 4-hydroxythreonine-4-phosphate dehydrogenase activity

Specific function:

Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

Gene Name:

pdxA

Locus Tag:

PA0593

Molecular weight:

34.9 kDa

Reactions

General function:

Involved in carboxy-lyase activity

Specific function:

L-ornithine = putrescine + CO(2)

Gene Name:

speC

Locus Tag:

PA4519

Molecular weight:

43.6 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the biosynthesis of agmatine from arginine

Gene Name:

speA

Locus Tag:

PA4839

Molecular weight:

70.7 kDa

Reactions

General function:

Involved in phosphoenolpyruvate carboxykinase (ATP) activity

Specific function:

ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO(2)

Gene Name:

pckA

Locus Tag:

PA5192

Molecular weight:

55.7 kDa

Reactions

General function:

Involved in ligase activity

Specific function:

This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

Gene Name:

accC

Locus Tag:

PA4848

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in formate dehydrogenase (NAD+) activity

Specific function:

Formate dehydrogenase allows Pseudomonas aeruginosa to use formate as major electron donor during anaerobic respiration, when nitrate is used as electron acceptor. The alpha subunit forms the active site

Gene Name:

fdnG

Locus Tag:

PA4812

Molecular weight:

104.7 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(S)-malate + NAD(+) = pyruvate + CO(2) + NADH

Gene Name:

sfcA

Locus Tag:

PA3471

Molecular weight:

62.4 kDa

Reactions

General function:

Involved in aminomethyltransferase activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine

Gene Name:

gcvT

Locus Tag:

PA5215

Molecular weight:

38.9 kDa

Reactions

General function:

Involved in uroporphyrinogen decarboxylase activity

Specific function:

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

Gene Name:

hemE

Locus Tag:

PA5034

Molecular weight:

38.8 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Involved in the catabolism of quinolinic acid (QA)

Gene Name:

nadC

Locus Tag:

PA4524

Molecular weight:

30.6 kDa

Reactions

General function:

Involved in magnesium ion binding

Specific function:

Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate

Gene Name:

leuB

Locus Tag:

PA3118

Molecular weight:

39.1 kDa

Reactions

General function:

Involved in catalytic activity

Specific function:

Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)

Gene Name:

thiE

Locus Tag:

PA3976

Molecular weight:

22.1 kDa

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX

Gene Name:

hemN

Locus Tag:

PA1546

Molecular weight:

52.5 kDa

Reactions

General function:

Involved in glycine dehydrogenase (decarboxylating) activity

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein

Gene Name:

gcvP

Locus Tag:

PA5213

Molecular weight:

104.7 kDa

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III

Gene Name:

hemF

Locus Tag:

PA0024

Molecular weight:

34.8 kDa

Reactions

General function:

Involved in cellular amino acid biosynthetic process

Specific function:

ATP + NH(3) + CO(2) = ADP + carbamoyl phosphate

Gene Name:

arcC

Locus Tag:

PA5173

Molecular weight:

33.1 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme

Gene Name:

tauD

Locus Tag:

PA3935

Molecular weight:

31 kDa

Reactions

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Not Available

Gene Name:

yggW

Locus Tag:

PA0386

Molecular weight:

42.5 kDa

General function:

Involved in carbonate dehydratase activity

Specific function:

H(2)CO(3) = CO(2) + H(2)O

Gene Name:

can

Locus Tag:

PA4676

Molecular weight:

24.2 kDa

Reactions

General function:

Involved in N-succinylarginine dihydrolase activity

Specific function:

Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)

Gene Name:

astB

Locus Tag:

PA0899

Molecular weight:

48.9 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

(S)-malate + NADP(+) = pyruvate + CO(2) + NADPH

Gene Name:

maeB

Locus Tag:

PA5046

Molecular weight:

45.4 kDa

Reactions

General function:

Involved in hydroxymethyl-, formyl- and related transferase activity

Specific function:

Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides

Gene Name:

arnA

Locus Tag:

PA3554

Molecular weight:

74.4 kDa

Reactions

General function:

Involved in 1-deoxy-D-xylulose-5-phosphate synthase activity

Specific function:

Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

Gene Name:

dxs

Locus Tag:

PA4044

Molecular weight:

68 kDa

Reactions

General function:

Involved in ureidoglycolate hydrolase activity

Specific function:

Involved in the anaerobic utilization of allantoin. Reinforces the induction of genes involved in the degradation of allantoin and glyoxylate by producing glyoxylate

Gene Name:

allA

Locus Tag:

PA1514

Molecular weight:

19 kDa

Reactions

General function:

Involved in carboxy-lyase activity

Specific function:

Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol

Gene Name:

ubiD

Locus Tag:

PA5237

Molecular weight:

54.6 kDa

General function:

Involved in RNA binding

Specific function:

Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by iscS

Gene Name:

thiI

Locus Tag:

PA5118

Molecular weight:

54.8 kDa

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADP-dependent oxidation of L-allo- threonine to L-2-amino-3-keto-butyrate, which is spontaneously decarboxylated into aminoacetone. Also acts on L-serine, D-serine, D-threonine, D-3-hydroxyisobutyrate, L-3-hydroxyisobutyrate, D- glycerate and L-glycerate

Gene Name:

ydfG

Locus Tag:

PA4907

Molecular weight:

27.4 kDa

Reactions

General function:

Involved in phosphotransferase activity, for other substituted phosphate groups

Specific function:

CDP-diacylglycerol + L-serine = CMP + (3-sn- phosphatidyl)-L-serine

Gene Name:

pssA

Locus Tag:

PA4693

Molecular weight:

29.3 kDa

Reactions

General function:

Amino acid transport and metabolism

Specific function:

The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein

Gene Name:

gcvH

Locus Tag:

PA5214

Molecular weight:

13.6 kDa