Nicotinate-nucleotide pyrophosphorylase [carboxylating] (PA4524)

Identification
Name: Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Synonyms:
  • Quinolinate phosphoribosyltransferase [decarboxylating]
  • QAPRTase
Gene Name: nadC
Enzyme Class:
Biological Properties
General Function: Involved in catalytic activity
Specific Function: Involved in the catabolism of quinolinic acid (QA)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
2 Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
2 Hydrogen ion + Phosphoribosyl pyrophosphate + Quinolinic acid ↔ Carbon dioxide + Nicotinamide ribotide + Pyrophosphate
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb
Nicotinamide ribotide + Pyrophosphate + Carbon dioxide ↔ Quinolinic acid + Phosphoribosyl pyrophosphate
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Thumb+Pyrophosphate+nicotinate beta-D-ribonucleotide+Thumb
Quinolinic acid + Hydrogen ion + Phosphoribosyl pyrophosphate → Carbon dioxide + Pyrophosphate + nicotinate beta-D-ribonucleotide + Nicotinamide ribotide
ReactionCard
PseudoCyc/BioCyc Reactions:
2 Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb
2 Hydrogen ion + Phosphoribosyl pyrophosphate + Quinolinic acid ↔ Carbon dioxide + Nicotinamide ribotide + Pyrophosphate
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb
Nicotinamide ribotide + Pyrophosphate + Carbon dioxide → Quinolinic acid + Phosphoribosyl pyrophosphate
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000568Carbon dioxideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000095Nicotinamide ribotideMetaboCard
PAMDB000115Phosphoribosyl pyrophosphateMetaboCard
PAMDB000633PyrophosphateMetaboCard
PAMDB000096Quinolinic acidMetaboCard
GO Classification:
Function
catalytic activity
nicotinate-nucleotide diphosphorylase (carboxylating) activity
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring pentosyl groups
Process
cellular metabolic process
coenzyme biosynthetic process
coenzyme metabolic process
cofactor metabolic process
metabolic process
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
Gene Properties
Locus tag: PA4524
Strand: +
Entrez Gene ID: 878422
Accession: NP_253214.1
GI: 15599720
Sequence start: 5068032
Sequence End: 5068880
Sequence Length: 848
Gene Sequence: 
>PA4524
ATGCCTAACCTCACCCTTGCCGACCTCCAAGGCGAAATCCAGGCCAACGTCCGCACCGCCCTGGCGGAAGACGTCGGCGGCGGCGACCTTACCGCTCAGTTGATCGATCCACAACGCGAGGCCGAGGCCCGGGTGATTACCCGCGAGCACGCGACGATCGCGGGCCGCGCCTGGGTCGACGAGGTCTTCCGCCAGGTCGATCCGCGAGTGCTGGTGACCTGGCAGGTGGAGGACGGCCAGCGAGTCGAGCCGAACCAGATGCTGTTCCAGCTAAAAGGTCCGGCCCGCGCGCTGCTCACCGGCGAGCGCAGCGCGCTGAACTTCCTCCAGCTGCTTTCCGGTACCGCTACCCGCAGCCAGCACTACGCCGACCTGGTCGCCGGCACCGCGGTGAAGCTCCTCGACACCCGCAAGACCCTGCCAGGCCTGCGCCTCGCGCAGAAGTACGCGGTCACCTGCGGCGGTTGCCACAACCATCGCATCGGCCTCTACGATGCCTTCCTGATCAAGGAAAACCACATCGCCGCCTGCGGCGGTATCGACCGGGCAATTGCCGAGGCCCGGCGCATAGCACCCGGCAAGCCGGTGGAAGTGGAAGTGGAGAACCTCGATGAACTGCGCCAGGCGCTGGAGGCCGGCGCCGATATCGTCATGCTCGACGAACTCAGCCTGGACGACATGCGCACCGCCGTCGCCCTCACCGCCGGCCGTGCCAAGCTGGAAGCTTCCGGCGGAATCAACGAGGGCACCCTGCGCAACATCGCCGAGACCGGCGTCGACTACATCTCCATCGGCACCCTGACCAAGGATGTCAGGGCCGTCGACCTGTCCATGCGCCTCACCCTCTGA
Protein Properties
Protein Residues: 282
Protein Molecular Weight: 30.6 kDa
Protein Theoretical pI: 5.07
Hydropathicity (GRAVY score): -0.098
Charge at pH 7 (predicted): -6.88
Protein Sequence: 
>PA4524
MPNLTLADLQGEIQANVRTALAEDVGGGDLTAQLIDPQREAEARVITREHATIAGRAWVDEVFRQVDPRVLVTWQVEDGQRVEPNQMLFQLKGPARALLTGERSALNFLQLLSGTATRSQHYADLVAGTAVKLLDTRKTLPGLRLAQKYAVTCGGCHNHRIGLYDAFLIKENHIAACGGIDRAIAEARRIAPGKPVEVEVENLDELRQALEAGADIVMLDELSLDDMRTAVALTAGRAKLEASGGINEGTLRNIAETGVDYISIGTLTKDVRAVDLSMRLTL
References
External Links:
Resource Link
Genome ID: PA4524
Entrez Gene ID: 878422
NCBI Protein ID: 15599720
General Reference: PaperBLAST - Find papers about PA4524 and its homologs