Pyruvate dehydrogenase E1 component (PA5015)

Identification
Name: Pyruvate dehydrogenase E1 component
Synonyms: Not Available
Gene Name: aceE
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Enzyme N6-(lipoyl)lysine ↔ [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine+Thumb+[Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Pyruvic acid + Enzyme N6-(lipoyl)lysine ↔ [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Carbon dioxide + [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
ReactionCard
SMPDB Reactions:
Thumb+a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine+Thumb → a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine+Thumb
Pyruvic acid + a [pyruvate dehydrogenase E2 protein] N6-lipoyl-L-lysine + Hydrogen ion → a [pyruvate dehydrogenase E2 protein] N6-S-acetyldihydrolipoyl-L-lysine + Carbon dioxide
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb
Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH
ReactionCard
Complex Reactions:
Thumb+[dihydrolipoyllysine-residue acetyltransferase] lipoyllysine → [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine+Thumb
Pyruvic acid + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine → [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Carbon dioxide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000298Acetyl-CoAMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB000381Coenzyme AMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000197NADMetaboCard
PAMDB000398NADHMetaboCard
PAMDB000102Pyruvic acidMetaboCard
PAMDB000361Thiamine pyrophosphateMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA5015
Strand: +
Entrez Gene ID: 881326
Accession: NP_253702.1
GI: 15600208
Sequence start: 5636156
Sequence End: 5638804
Sequence Length: 2648
Gene Sequence: 
>PA5015
ATGCAAGACCTCGATCCCGTCGAAACCCAGGAATGGCTGGACGCCCTGGAGTCCGTACTCGACCGCGAAGGTGAAGACCGCGCTCATTACCTGATGACCCGCATGGGCGAGCTGGCCAGCCGTAGCGGCACCCAACTGCCCTACGCGATCACCACGCCCTATCGCAACACCATTCCGGTAACCCACGAAGCACGCATGCCCGGCGACCTGTTCATGGAACGCCGGATCCGCTCCCTGGTGCGCTGGAACGCCCTGGCGATGGTGATGCGGGCGAACAAGCACGACCCGGACCTGGGCGGCCACATCTCCACCTTCGCCTCCTCGGCGACCCTCTACGACATCGGCTTCAACTATTTCTTCCAGGCTCCCACCGACGAACACGGCGGCGACCTGGTGTTCTTCCAGGGCCACGCGTCCCCCGGCGTCTACGCCCGGGCCTTCCTCGAAGGCCGCATCAGCGAGGAACAACTGGAGAACTTCCGCCAGGAAGTGGACGGCAACGGCCTGTCCTCCTATCCGCACCCCTGGCTGATGCCAGACTTCTGGCAGTTCCCCACCGTATCCATGGGCCTTGGCCCGATCCAGGCGATCTACCAGGCACGCTTCATGAAGTACCTGGAAAGCCGCGGCTTCATCCCCGCCGGCAAGCAGAAGGTCTGGTGCTTCATGGGCGACGGCGAGTGCGACGAGCCGGAATCCCTCGGCGCGATCTCCCTGGCCGGCCGCGAGAAACTCGACAACCTGATCTTCGTCATCAACTGCAACCTGCAGCGCCTCGACGGCCCGGTCCGCGGCAACGCCAAGATCATCCAGGAACTGGAAGGCGTGTTCCGCGGCGCCGAGTGGAACGTCAACAAGGTCATCTGGGGTCGCTTCTGGGACCCGCTGTTCGCCAAGGACACCGCCGGCCTGCTGCAGCAGCGCATGGACGAGGTCATCGACGGCGAATACCAGAACTACAAGGCGAAAGACGGCGCCTACGTGCGCGAGCACTTCTTCGGCGCGCGTCCGGAACTGCTGGAAATGGTCAAGGACCTTTCCGACGAGGAAATCTGGAAGCTCAACCGCGGCGGCCACGACCCCTACAAGGTCTATGCGGCCTACCACCAGGCGGTCAACCACAAGGGCCAGCCGACCGTCATCCTGGCCAAGACCATCAAGGGCTACGGCACCGGCAGCGGCGAAGCGAAGAACATCGCGCACAACGTGAAGAAGGTCGACGTCGACAGCCTGCGCGCGTTCCGCGACAAGTTCGACATCCCGGTCAAGGACGCCGACCTGGAGAAGCTGCCGTTCTACAAGCCTGAAGAAGGCAGCGCCGAGGCCAAGTACCTGGCCGAGCGCCGCGCCGCGCTGGGCGGCTTCATGCCGGTGCGCCGGCAGAAGAGCATGAGCGTGCCGGTTCCGCCGCTGGAAACCCTGAAGGCCATGCTCGACGGCTCCGGCGATCGCGAGATCTCCACCACCATGGCCTTCGTGCGGATCATCTCGCAGCTGGTCAAGGACAAGGAACTCGGCCCGCGCATCGTCCCGATCGTCCCGGACGAGGCCCGTACCTTCGGCATGGAAGGCATGTTCCGCCAGCTCGGCATCTACTCCTCGGTCGGCCAGCTCTACGAGCCGGTGGACAAGGACCAGGTGATGTTCTACCGCGAGGACAAGAAGGGCCAGATCCTCGAGGAAGGCATCAACGAGGCCGGCGCCATGTCCAGCTGGATTGCCGCCGGTACCTCCTACAGCACCCACAACCAGCCGATGCTGCCGTTCTACATCTTCTATTCGATGTTCGGCTTCCAGCGCATCGGCGACCTGGCCTGGGCCGCCGGCGACAGCCGCGCGCACGGCTTCCTGATCGGCGGCACCGCCGGTCGCACCACGCTGAACGGCGAAGGCCTGCAGCACGAGGACGGCCACAGCCACCTGCTGGCCTCGACCATCCCGAACTGCCGCACCTACGATCCGACCTACGCCTACGAACTGGCGGTGATCATCCGCGAAGGCTCGCGGCAGATGATCGAAGAGCAGCAGGACATCTTCTACTACATCACCGTGATGAACGAGAACTACGTCCAGCCGGCCATGCCGAAGGGCGCAGAGGAAGGCATCATCAAGGGCATGTACCTCCTCGAGGAGGACAAGAAGGAAGCCGCTCACCACGTGCAACTGCTGGGCTCCGGCACCATCCTGCGCGAAGTCGAGGAAGCGGCCAAGCTGCTGCGCAACGACTTCGGCATCGGCGCCGACGTCTGGAGCGTGCCGAGCTTCAACGAGCTGCGTCGCGACGGCCTTGCCGTCGAGCGCTGGAACCGCCTGCATCCGGGCCAGAAGCCGAAGCAGAGCTACGTCGAGGAGTGCCTGGGCGGCCGTCGCGGCCCGGTGATCGCCTCCACCGACTACATGAAGCTCTACGCCGAGCAGATCCGCCAGTGGGTTCCCTCCAAGGAGTACAAGGTGCTCGGCACCGACGGCTTCGGCCGCAGCGACAGCCGCAAGAAGCTGCGCAACTTCTTCGAAGTGGATCGTCACTGGGTGGTGCTGGCCGCGCTCGAAGCGCTGGCCGATCGCGGCGATATCGAGCCGAAAGTGGTGGCCGAGGCCATCGCCAAGTACGGTATCGATCCGGAGAAGCGCAACCCGCTGGATTGCTAA
Protein Properties
Protein Residues: 882
Protein Molecular Weight: 99.6 kDa
Protein Theoretical pI: 5.59
Hydropathicity (GRAVY score): -0.426
Charge at pH 7 (predicted): -17.07
Protein Sequence: 
>PA5015
MQDLDPVETQEWLDALESVLDREGEDRAHYLMTRMGELASRSGTQLPYAITTPYRNTIPVTHEARMPGDLFMERRIRSLVRWNALAMVMRANKHDPDLGGHISTFASSATLYDIGFNYFFQAPTDEHGGDLVFFQGHASPGVYARAFLEGRISEEQLENFRQEVDGNGLSSYPHPWLMPDFWQFPTVSMGLGPIQAIYQARFMKYLESRGFIPAGKQKVWCFMGDGECDEPESLGAISLAGREKLDNLIFVINCNLQRLDGPVRGNAKIIQELEGVFRGAEWNVNKVIWGRFWDPLFAKDTAGLLQQRMDEVIDGEYQNYKAKDGAYVREHFFGARPELLEMVKDLSDEEIWKLNRGGHDPYKVYAAYHQAVNHKGQPTVILAKTIKGYGTGSGEAKNIAHNVKKVDVDSLRAFRDKFDIPVKDADLEKLPFYKPEEGSAEAKYLAERRAALGGFMPVRRQKSMSVPVPPLETLKAMLDGSGDREISTTMAFVRIISQLVKDKELGPRIVPIVPDEARTFGMEGMFRQLGIYSSVGQLYEPVDKDQVMFYREDKKGQILEEGINEAGAMSSWIAAGTSYSTHNQPMLPFYIFYSMFGFQRIGDLAWAAGDSRAHGFLIGGTAGRTTLNGEGLQHEDGHSHLLASTIPNCRTYDPTYAYELAVIIREGSRQMIEEQQDIFYYITVMNENYVQPAMPKGAEEGIIKGMYLLEEDKKEAAHHVQLLGSGTILREVEEAAKLLRNDFGIGADVWSVPSFNELRRDGLAVERWNRLHPGQKPKQSYVEECLGGRRGPVIASTDYMKLYAEQIRQWVPSKEYKVLGTDGFGRSDSRKKLRNFFEVDRHWVVLAALEALADRGDIEPKVVAEAIAKYGIDPEKRNPLDC
References
External Links:
Resource Link
Genome ID: PA5015
Entrez Gene ID: 881326
NCBI Protein ID: 15600208
General Reference: PaperBLAST - Find papers about PA5015 and its homologs