S-adenosylmethionine decarboxylase proenzyme (PA0654)

Identification
Name: S-adenosylmethionine decarboxylase proenzyme
Synonyms:
  • AdoMetDC
  • SAMDC
  • S-adenosylmethionine decarboxylase beta chain
  • S-adenosylmethionine decarboxylase alpha chain
Gene Name: speD
Enzyme Class:
Biological Properties
General Function: Involved in adenosylmethionine decarboxylase activity
Specific Function: Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethionine + Hydrogen ion ↔ S-Adenosylmethioninamine + Carbon dioxide
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethionine + Hydrogen ion ↔ S-Adenosylmethioninamine + Carbon dioxide
ReactionCard
SMPDB Reactions:
S-adenosyl-L-methionine+Thumb → Thumb+Thumb
S-adenosyl-L-methionine + Hydrogen ion → Carbon dioxide + S-Adenosylmethioninamine
ReactionCard
S-adenosyl-L-methionine+Thumb → Thumb+Thumb
S-adenosyl-L-methionine + Hydrogen ion → Decarboxy-SAM + Carbon dioxide
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethionine + Hydrogen ion ↔ S-Adenosylmethioninamine + Carbon dioxide
ReactionCard
Thumb+Thumb ↔ Thumb+Thumb
S-Adenosylmethionine + Hydrogen ion ↔ S-Adenosylmethioninamine + Carbon dioxide
ReactionCard
Complex Reactions: Not Available
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000568Carbon dioxideMetaboCard
PAMDB001159Decarboxy-SAMMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000216S-AdenosylmethioninamineMetaboCard
PAMDB000289S-AdenosylmethionineMetaboCard
GO Classification:
Function
adenosylmethionine decarboxylase activity
carbon-carbon lyase activity
carboxy-lyase activity
catalytic activity
lyase activity
Process
cellular amino acid and derivative metabolic process
cellular amino acid derivative metabolic process
cellular biogenic amine metabolic process
cellular metabolic process
metabolic process
polyamine biosynthetic process
polyamine metabolic process
spermidine biosynthetic process
Gene Properties
Locus tag: PA0654
Strand: +
Entrez Gene ID: 878446
Accession: NP_249345.1
GI: 15595851
Sequence start: 707686
Sequence End: 708480
Sequence Length: 794
Gene Sequence: 
>PA0654
GTGAAAAGCAAACTCAAGCTCCACGGGTTCAACAACCTGACGAAGACCTTGAGCTTCAACATCTACGACATCTGCTACGCCGAGACGCCCGAAGACCTCCAGGCCTACGTGCAGTACATCGACGAAGAGTATGACGCGGAGCGTCTGACGCAGATTCTTACCGATGTTGTCGACATCATCGGCGCCAATATCCTGAACATCGCGCGTCAGGACTACGACCCCCAGGGCGCCAGCGTGACCATCCTGATCTCCGAGCAGCCGGTCACTCCGACCGACAGCCAGATCGAAGAGTCCCCGGGCCCGCTGCCGGACACCATCCTGGCGCACCTGGACAAGAGCCACATCACCGTGCATACCTACCCGGAAATCCATCCGGTGGACGGCATCGCGACCTTCCGCGTGGACATCGATGTGTCCACCTGCGGAGTGATCTCCCCGCTGAAGGCCCTGAACTACCTGATCCACCAGTTCGACTCGGACATCGTCACGGTCGACTATCGGGTCCGCGGCTTCACCCGCGACATCGAGGGGCGCAAGCATTTCATCGACCACGAGATCAACTCGATCCAGAACTATCTCTCCGACGACACGCGCGAGGCCTACCAGATGACCGACGTGAACGTGTACCAGGAGAACCTGTTCCACACCAAGATGCTGCTCAAGGACTTCGAACTGGAGAACTACCTGTTCGGCGACGCTACCCGGACGCTCTCGGCGGAACAGCGTGAGCAGGTCACGGAACGGCTCAAGCACGAAATGCTGGAGATCTTCTACGCGCGCAACATGCCGCGCTGA
Protein Properties
Protein Residues: 264
Protein Molecular Weight: 30.4 kDa
Protein Theoretical pI: 4.48
Hydropathicity (GRAVY score): -0.382
Charge at pH 7 (predicted): -18.65
Protein Sequence: 
>PA0654
MKSKLKLHGFNNLTKTLSFNIYDICYAETPEDLQAYVQYIDEEYDAERLTQILTDVVDIIGANILNIARQDYDPQGASVTILISEQPVTPTDSQIEESPGPLPDTILAHLDKSHITVHTYPEIHPVDGIATFRVDIDVSTCGVISPLKALNYLIHQFDSDIVTVDYRVRGFTRDIEGRKHFIDHEINSIQNYLSDDTREAYQMTDVNVYQENLFHTKMLLKDFELENYLFGDATRTLSAEQREQVTERLKHEMLEIFYARNMPR
References
External Links:
Resource Link
Genome ID: PA0654
Entrez Gene ID: 878446
NCBI Protein ID: 15595851
General Reference: PaperBLAST - Find papers about PA0654 and its homologs