Alpha-ketoglutarate-dependent taurine dioxygenase (PA3935)

Identification
Name: Alpha-ketoglutarate-dependent taurine dioxygenase
Synonyms:
  • 2-aminoethanesulfonate dioxygenase
  • Sulfate starvation-induced protein 3
  • SSI3
Gene Name: tauD
Enzyme Class:
Biological Properties
General Function: Involved in oxidoreductase activity
Specific Function: Catalyzes the conversion of taurine and alpha ketoglutarate to sulfite, aminoacetaldehyde and succinate. Required for the utilization of taurine (2-aminoethanesulfonic acid) as an alternative sulfur source. Pentane-sulfonic acid, 3- (N-morpholino)propanesulfonic acid and 1,3-dioxo-2- isoindolineethanesulfonic acid are also substrates for this enzyme
Cellular Location: Not Available
KEGG Pathways:
KEGG Reactions:
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb+Thumb
alpha-Ketoglutarate + Oxygen + Taurine ↔ Aminoacetaldehyde + Carbon dioxide + Hydrogen ion + Sulfite + Succinic acid
ReactionCard
Thumb+Thumb+Thumb ↔ Thumb+Thumb+Thumb+Thumb
Taurine + alpha-Ketoglutarate + Oxygen ↔ Sulfite + Aminoacetaldehyde + Succinic acid + Carbon dioxide
ReactionCard
SMPDB Reactions:
Thumb+Thumb+Thumb → Sulfite+Thumb+Thumb+Thumb+Thumb
Taurine + Oxoglutaric acid + Oxygen → Sulfite + Succinic acid + Aminoacetaldehyde + Carbon dioxide + Sulfite
ReactionCard
Thumb+Thumb+Thumb → Sulfite+Thumb+Thumb+Thumb+Thumb+Thumb
Taurine + Oxoglutaric acid + Oxygen → Sulfite + Succinic acid + Carbon dioxide + Hydrogen ion + Aminoacetaldehyde + Sulfite
ReactionCard
PseudoCyc/BioCyc Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb+Thumb
Taurine + Oxoglutaric acid + Oxygen → Hydrogen ion + Aminoacetaldehyde + Sulfite + Succinic acid + Carbon dioxide
ReactionCard
Complex Reactions:
Thumb+Thumb+Thumb → Thumb+Thumb+Thumb+Thumb
Taurine + Oxoglutaric acid + Oxygen → Sulfite + Aminoacetaldehyde + Succinic acid + Carbon dioxide
ReactionCard
Transports: Not Available
Metabolites:
PAMDB IDNameView
PAMDB000466alpha-KetoglutarateMetaboCard
PAMDB000964AminoacetaldehydeMetaboCard
PAMDB000568Carbon dioxideMetaboCard
PAMDB001633Hydrogen ionMetaboCard
PAMDB000623Oxoglutaric acidMetaboCard
PAMDB000624OxygenMetaboCard
PAMDB000107Succinic acidMetaboCard
PAMDB000100SulfiteMetaboCard
PAMDB000106TaurineMetaboCard
GO Classification:
Function
catalytic activity
oxidoreductase activity
Process
metabolic process
oxidation reduction
Gene Properties
Locus tag: PA3935
Strand: -
Entrez Gene ID: 878589
Accession: NP_252624.1
GI: 15599130
Sequence start: 4413192
Sequence End: 4414025
Sequence Length: 833
Gene Sequence: 
>PA3935
ATGAGCCTGACCATCCAACCCATCAGCCCGGCCCTGGGCGCCATCGTTTCCGGCATCGACCTCGGCGCGCCGCTGGACGACACCGGCCAGCGGGCCATCGAGCAGGCCCTGCTCGAACACCAGGTGCTGTTCTTCCGCGACCAGTCGCTGGAACCCAGGAGCCAGGCGCGCTTCGCCGCCCGCTTCGGCGACCTGCACATCCATCCTATCTACCCCAGCGTGCCGGAGCAGCCGGAGGTCATCGTCCTCGACACCGCGGTCACCGACGTGCGCGACAATGCCATCTGGCACACCGACGTGACCTTCCTCGAGACCCCGGCGCTGGGAGCCGTGCTCGCCGCCAAGCAATTGCCGCCGTACGGCGGCGACACCCTCTGGGCGAGCAGCACGGCGGCCTACGAGGCGCTGTCGGCGCCGCTGCGGCGTCTGCTGGACGGCCTCACGGCGACCCACGACATCGGCAAGTCCTTCCCCCGCGAGCGCTTCGGCGTCACCGAGGCCGACCTGGCGCGCCTGGAGGAGGCCCGCCTGAAGAATCCGCCGCGCTCGCATCCGGTGGTGCGCACCCATCCGGTCACCGGGCGCAAGGGCCTGTTCGTCAGCGATGGCTTCACCACCCGCATCAACGAACTGGAGCCGGCCGAGAGCGATGCGCTGCTGAAGTTCCTCTTCGCCCATGCCACGCGACCTGAATTCACCGTGCGCTGGCGCTGGCAGGAAAACGACGTGGCGTTCTGGGACAACCGCGTGACGCAGCACTACGCGGTGGACGATTACCGGCCACAGCGGCGGGTCATGCATCGCGCCACCATCCTCGGCGACAAGCCCTTCTGA
Protein Properties
Protein Residues: 277
Protein Molecular Weight: 31 kDa
Protein Theoretical pI: 6.35
Hydropathicity (GRAVY score): -0.287
Charge at pH 7 (predicted): -3.59
Protein Sequence: 
>PA3935
MSLTIQPISPALGAIVSGIDLGAPLDDTGQRAIEQALLEHQVLFFRDQSLEPRSQARFAARFGDLHIHPIYPSVPEQPEVIVLDTAVTDVRDNAIWHTDVTFLETPALGAVLAAKQLPPYGGDTLWASSTAAYEALSAPLRRLLDGLTATHDIGKSFPRERFGVTEADLARLEEARLKNPPRSHPVVRTHPVTGRKGLFVSDGFTTRINELEPAESDALLKFLFAHATRPEFTVRWRWQENDVAFWDNRVTQHYAVDDYRPQRRVMHRATILGDKPF
References
External Links:
Resource Link
Genome ID: PA3935
Entrez Gene ID: 878589
NCBI Protein ID: 15599130
General Reference: PaperBLAST - Find papers about PA3935 and its homologs